Use of the ES-D3 cell differentiation assay, combined with the BeWo transport model, to predict relative in vivo developmental toxicity of antifungal compounds

Toxicology in Vitro

Volumn 29, Issue 2, 2015, Pages 320-328

  Li, Hequn ^a   Rietjens, Ivonne M C M ^a   Louisse, Jochem ^a   Blok, Martine ^a   Wang, Xinyi ^a   Snijders, Linda ^a   van Ravenzwaay, Bennard ^a,b  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b BASF SE   (Germany)

Author keywords

Alternatives to animal testing; BeWo cells; Developmental toxicity; Embryonic stem cell test; Placental transfer

Indexed keywords

ANTIFUNGAL AGENT; FENARIMOL; KETOCONAZOLE; PROPICONAZOLE; PROTHIOCONAZOLE; TEBUCONAZOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BEWO B30 CELL LINE; BLOOD PLACENTA BARRIER; CELL DIFFERENTIATION ASSAY; CHORIOCARCINOMA CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DEVELOPMENTAL TOXICITY; DRUG TRANSPORT; EMBRYONIC STEM CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PLACENTAL TRANSFER; TOXICITY TESTING; TOXICOKINETICS; WST-1 ASSAY; ANIMAL; BIOASSAY; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; HEART MUSCLE CELL; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; ANTIFUNGAL AGENTS; BIOLOGICAL ASSAY; BIOLOGICAL TRANSPORT; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; EMBRYONIC STEM CELLS; HUMANS; MICE; MYOCYTES, CARDIAC;

EID: 84919905685     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.11.012     Document Type: Article

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