Application of quantitative structure-activity relationships for modeling drug and chemical transport across the human placenta barrier: A multivariate data analysis approach

Journal of Applied Toxicology

Volumn 29, Issue 8, 2009, Pages 724-733

  Giaginis, Costas ^a,b   Zira, Athina ^a   Theocharis, Stamatios ^a   Tsantili Kakoulidou, Anna ^b  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Molecular properties; Multivariate data analysis (MVDA); Physicochemical properties; Placental transfer; Quantitative structure activity relationships (QSARs); Reproductive toxicology

Indexed keywords

ABACAVIR; ACICLOVIR; ACIPIMOX; ALFENTANIL; AMPRENAVIR; BETAMETHASONE; BUPIVACAINE; BUPRENORPHINE; CEFOPERAZONE; CEFTIZOXIME; CIMETIDINE; CLAVULANIC ACID; DEXAMETHASONE; DICLOFENAC; DIDANOSINE; FENOTEROL; GANCICLOVIR; HYDRALAZINE; INDINAVIR; INDOMETACIN; LAMIVUDINE; LOPINAVIR; MEFLOQUINE; MEROPENEM; METFORMIN; METHADONE; METOCLOPRAMIDE; MEZLOCILLIN; UNINDEXED DRUG; ZIDOVUDINE;

ACCURACY; ARTICLE; BLOOD PLACENTA BARRIER; DRUG TRANSPORT; EVALUATION; HIGH THROUGHPUT SCREENING; HUMAN; LIPOPHILICITY; MATHEMATICAL MODEL; MEMBRANE TRANSPORT; MOLECULAR DYNAMICS; MOLECULAR SIZE; MULTIVARIATE ANALYSIS; NONHUMAN; PARAMETER; PHYSICAL CHEMISTRY; POLLUTANT; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TECHNIQUE;

FEMALE; HUMANS; MATERNAL-FETAL EXCHANGE; METABOLIC CLEARANCE RATE; MULTIVARIATE ANALYSIS; PHARMACOKINETICS; PLACENTA; PREGNANCY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 74549113839     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1466     Document Type: Article

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