Relative embryotoxic potency of p-substituted phenols in the embryonic stem cell test (EST) and comparison to their toxic potency in vivo and in the whole embryo culture (WEC) assay

Toxicology Letters

Volumn 213, Issue 2, 2012, Pages 235-242

  Strikwold, Marije ^a,b   Woutersen, Ruud A ^a,c   Spenkelink, Bert ^a   Punt, Ans ^a   Rietjens, Ivonne M C M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b VAN HALL LARENSTEIN UNIVERSITY OF APPLIED SCIENCES   (Netherlands)

^c TNO   (Netherlands)

Author keywords

Alternative toxicity testing; Developmental toxicity; Embryonic stem cell test; Embryotoxicity; Potency ranking; Substituted phenols

Indexed keywords

4 FLUOROPHENOL; 4 HEPTYLOXYPHENOL; 4 MERCAPTOPHENOL; 4 METHYLKETOPHENOL; HYDROQUINONE; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ABSORPTION; ANIMAL CELL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL DIFFERENTIATION; CONCENTRATION (PARAMETERS); EMBRYO; EMBRYO CULTURE; EMBRYONIC STEM CELL TEST; EMBRYOTOXICITY; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO CULTURE TECHNIQUES; EMBRYONIC STEM CELLS; MICE; PHENOLS; TERATOGENS; TOXICITY TESTS;

EID: 84864400837     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.07.005     Document Type: Article

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