Preliminary interlaboratory comparison of the ex vivo dual human placental perfusion system

Reproductive Toxicology

Volumn 30, Issue 1, 2010, Pages 94-102

  Myllynen, Päivi ^a   Mathiesen, Line ^b   Weimer, Marc ^c   Annola, Kirsi ^d   Immonen, Elina ^a   Karttunen, Vesa ^d   Kummu, Maria ^a   Mørck, Thit Juul ^b   Nielsen, Jeanette Kolstrup Søgaard ^b   Knudsen, Lisbeth Ehlert ^b   Vähäkangas, Kirsi ^d  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Antipyrine; In vitro testing; Placental perfusion; Placental transfer; Prevalidation

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; BENZO[A]PYRENE; PHENAZONE; POLLUTANT;

ANALYTIC METHOD; ANALYTICAL PARAMETERS; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EX VIVO STUDY; FETUS CIRCULATION; HUMAN; PLACENTA CIRCULATION; PLACENTA PERFUSION; PLACENTAL TRANSFER; REPERFUSION; REPRODUCTIVE TOXICITY; VALIDATION STUDY; COMPARATIVE STUDY; DRUG EFFECTS; FEMALE; FETOMATERNAL TRANSFUSION; IN VITRO STUDY; LABORATORY; METABOLISM; PERFUSION; PLACENTA; POLLUTANT; PREGNANCY; PROCEDURES; REPRODUCIBILITY; REPRODUCTION; STANDARDS; TOXICITY TESTING;

ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; LABORATORIES; MATERNAL-FETAL EXCHANGE; PERFUSION; PLACENTA; PLACENTAL CIRCULATION; PREGNANCY; REPRODUCIBILITY OF RESULTS; REPRODUCTION; TOXICITY TESTS; IN VITRO TECHNIQUES;

EID: 77954089154     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2010.04.006     Document Type: Article

References (29)

1. Nanovskaya T., Nekhayeva I., Karunaratne N., Audus K., Hankins G.D., Ahmed M.S. Role of P-glycoprotein in transplacental transfer of methadone. Biochem Pharmacol 2005, 69:1869-1878.
2. May K., Minarikova V., Linnemann K., Zygmunt M., Kroemer H.K., Fusch C., et al. Role of the multidrug transporter proteins ABCB1 and ABCC2 in the diaplacental transport of talinolol in the term human placenta. Drug Metab Dispos 2008, 36:740-744.
3. Rahi M., Heikkinen T., Härtter S., Hakkola J., Hakala K., Wallerman O., et al. Placental transfer of quetiapine in relation to P-glycoprotein activity. J Psychopharmacol 2007, 21:751-756.
4. Myllynen P.K., Pienimäki P.K., Vähäkangas K. Transplacental passage of lamotrigine in a human placental perfusion system in vitro and in maternal and cord blood in vivo. Eur J Clin Pharmacol 2003, 58:677-682.
5. Myren M., Mose T., Mathiesen L., Knudsen L.E. The human placenta-an alternative for studying foetal exposure. Toxicol in Vitro 2007, 7:1332-1340.
6. Vähäkangas K., Myllynen P. Experimental methods to study human transplacental exposure to genotoxic agents. Mutat Res 2006, 608:129-135.
7. Panigel M. Placental perfusion experiments. Am J Obstet Gynecol 1962, 84:1664-1683.
8. Schneider H., Panigel M., Dancis J. Transfer across the perfused human placenta of antipyrine, sodium and leucine. Am J Obstet Gynecol 1972, 114:822-828.
9. Omarini D., Pistotti V., Bonati M. Placental perfusion. An overview of the literature. J Pharmacol Toxicol Methods 1992, 28:61-66.
10. Myllynen P., Pienimäki P., Vähäkangas K. Human placental perfusion method in the assessment of transplacental passage of antiepileptic drugs. Toxicol Appl Pharmacol 2005, 207:489-494.
11. Schneider H. Tolerance of human placental tissue to severe hypoxia and its relevance for dual ex vivo perfusion. Placenta 2009, 30(Suppl. A):S71-S76.
12. Mose T., Knudsen L.E., Hedegaard M., Mortensen G.K. Transplacental transfer of monomethyl phthalate and mono(2-ethylhexyl) phthalate in a human placenta perfusion system. Int J Toxicol 2007, 26:221-229.
13. Annola K., Karttunen V., Keski-Rahkonen P., Myllynen P., Segerbäck D., Heinonen S., et al. Transplacental transfer of acrylamide and glycidamide are comparable to that of antipyrine in perfused human placenta. Toxicol Lett 2008, 182:50-56.
14. Myllynen P., Kummu M., Kangas T., Ilves M., Immonen E., Rysä J., et al. ABCG2/BCRP decreases the transfer of a food-born chemical carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in perfused term human placenta. Toxicol Appl Pharmacol 2008, 232:210-217.
15. Mathiesen L., Rytting E., Mose T., Knudsen L.E. Transport of benzo[alpha]pyrene in the dually perfused human placenta perfusion model: effect of albumin in the perfusion medium. Basic Clin Pharmacol Toxicol 2009, 105:181-187.
16. Gluckman P.D., Hanson M.A., Cooper C., Thornburg K.L. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 2008, 359:61-73.
17. Hartung T., Bremer S., Casati S., Coecke S., Corvi R., Fortaner S., et al. A modular approach to the ECVAM principles on test validity. Altern Lab Anim 2004, 32:467-472.
18. Bassily M., Ghabrial H., Smallwood R.A., Morgan D.J. Determinants of placental drug transfer: studies in the isolated perfused human placenta. J Pharm Sci 1995, 84:1054-1060.
19. van Herwaarden A.E., Wagenaar E., Karnekamp B., Merino G., Jonker J.W., Schinkel A.H. Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk. Carcinogenesis 2006, 27:123-130.
20. van Herwaarden A.E., Jonker J.W., Wagenaar E., Brinkhuis R.F., Schellens J.H., Beijnen J.H., et al. The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Res 2003, 63:6447-6452.
21. Vähäkangas K., Raunio H., Pasanen M., Sivonen P., Park S.-S., Gelboin H., et al. Comparison of the formation of benzo(a)pyrene diolepoxide-DNA adducts in rat and human tissues. Evidence for the involvement of cytochrome P450IA1. J Biochem Toxicol 1989, 4:79-86.
22. Karttunen V, Myllynen P, Bacova G, Pelkonen O, Segerbäck D, Vähäkangas K. Placental transfer and DNA-binding of benzo(a)pyrene in human placental perfusion. Toxicol Lett. 2010; (May 10) [Epub ahead of print] doi:10.1016/j.toxlet.2010.04.028.
23. Immonen E, Kummu M, Petsalo A, Pihlaja T, Mathiesen L, Nielsen J, et al. Toxicokinetics of the food-toxin IQ in human placental perfusion is not affected by ABCG2 or xenobiotic metabolism; Placenta, accepted for publication. doi:10.1016/j.placenta.2010.05.002.
24. Mathiesen L., Mose T., Mørck T.J., Nielsen J.K., Nielsen L.K., Maroun L.L., et al. Quality assessment of a placental perfusion protocol. Reprod Toxicol 2010, (January). [Epub ahead of print], doi:10.1016/j.reprotox.2010.01.006.
25. Challier J.C., D'Athis P., Guerre-Millo M., Nandakumaran M. Flow-dependent transfer of antipyrine in the human placenta in vitro. Reprod Nutr Dev 1983, 23(1):41-50.
26. Myllynen P., Vähäkangas K. An examination of whether human placental perfusion allows accurate prediction of placental drug transport: studies with diazepam. J Pharmacol Toxicol Methods 2002, 48(3):131-138.
27. Poulsen M.S., Rytting E., Mose T., Knudsen L.E. Modeling placental transport: correlation of in vitro BeWo cell permeability and ex vivo human placental perfusion. Toxicol in Vitro 2009, 23:1380-1386.
28. Mose T., Kjaerstad M.B., Mathiesen L., Nielsen J.B., Edelfors S., Knudsen L.E. Placental passage of benzoic acid, caffeine, and glyphosate in an ex vivo human perfusion system. J Toxicol Environ Health A 2008, 71:984-991.
29. Mørck TJ, Sorda, G, Bechi N, Rasmussen B, Jesper B, Nielsen JB, et al. Knudsen Placental transport and in vitro effects of Bisphenol A; Reprod Toxicol 2010; (March 7) [Epub ahead of print] doi:10.1016/j.reprotox.2010.02.007.