메뉴 건너뛰기




Volumn 9, Issue 12, 2014, Pages

The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; CONSTITUTIVE ANDROSTANE RECEPTOR; HETERODIMER; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HISTONE H3; PHENOBARBITAL; PROTEIN CCRP; PROTEIN DNAJC7; PROTEIN H3K27; RETINOID X RECEPTOR ALPHA; RNA POLYMERASE II; UNCLASSIFIED DRUG; CELL RECEPTOR; CYP2B10 PROTEIN, MOUSE; DNAJC7 PROTEIN, MOUSE; HISTONE; PROTEIN BINDING; STEROID MONOOXYGENASE; UNSPECIFIC MONOOXYGENASE;

EID: 84919897827     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115663     Document Type: Article
Times cited : (20)

References (44)
  • 1
    • 0031601462 scopus 로고    scopus 로고
    • Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes
    • Honkakoski P, Negishi M (1998) Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes. J Biochem Mol Toxicol 12: 3-9.
    • (1998) J Biochem Mol Toxicol , vol.12 , pp. 3-9
    • Honkakoski, P.1    Negishi, M.2
  • 2
    • 0033525886 scopus 로고    scopus 로고
    • The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
    • Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P, Negishi M (1999) The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem 274: 6043-6046.
    • (1999) J Biol Chem , vol.274 , pp. 6043-6046
    • Sueyoshi, T.1    Kawamoto, T.2    Zelko, I.3    Honkakoski, P.4    Negishi, M.5
  • 3
    • 0034687397 scopus 로고    scopus 로고
    • The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
    • Wei P, Zhang J, Egan-Hafley M, Liang S, Moore DD (2000) The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 407: 920-923.
    • (2000) Nature , vol.407 , pp. 920-923
    • Wei, P.1    Zhang, J.2    Egan-Hafley, M.3    Liang, S.4    Moore, D.D.5
  • 4
    • 0035038008 scopus 로고    scopus 로고
    • Phenobarbital response elements of cytochrome P450 genes and nuclear receptors
    • Sueyoshi T, Negishi M (2001) Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu Rev Pharmacol Toxicol 41: 123-143.
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 123-143
    • Sueyoshi, T.1    Negishi, M.2
  • 5
    • 18444399926 scopus 로고    scopus 로고
    • Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia
    • Sugatani J, Yamakawa K, Yoshinari K, Machida T, Takagi H, et al. (2002) Identification of a defect in the UGT1A1 gene promoter and its association with hyperbilirubinemia. Biochem Biophys Res Commun 292: 492-497.
    • (2002) Biochem Biophys Res Commun , vol.292 , pp. 492-497
    • Sugatani, J.1    Yamakawa, K.2    Yoshinari, K.3    Machida, T.4    Takagi, H.5
  • 6
    • 0036142429 scopus 로고    scopus 로고
    • Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital
    • Ueda A, Hamadeh HK, Webb HK, Yamamoto Y, Sueyoshi T, et al. (2002) Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol Pharmacol 61: 1-6.
    • (2002) Mol Pharmacol , vol.61 , pp. 1-6
    • Ueda, A.1    Hamadeh, H.K.2    Webb, H.K.3    Yamamoto, Y.4    Sueyoshi, T.5
  • 7
    • 0037450418 scopus 로고    scopus 로고
    • Phenobarbital induction of drug/steroid-metabolizing enzymes and nuclear receptor CAR
    • Kakizaki S, Yamamoto Y, Ueda A, Moore R, Sueyoshi T, et al. (2003) Phenobarbital induction of drug/steroid-metabolizing enzymes and nuclear receptor CAR. Biochim Biophys Acta 1619: 239-242.
    • (2003) Biochim Biophys Acta , vol.1619 , pp. 239-242
    • Kakizaki, S.1    Yamamoto, Y.2    Ueda, A.3    Moore, R.4    Sueyoshi, T.5
  • 8
    • 5644295430 scopus 로고    scopus 로고
    • The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice
    • Yamamoto Y, Moore R, Goldsworthy TL, Negishi M, Maronpot RR (2004) The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Cancer Res 64: 7197-7200.
    • (2004) Cancer Res , vol.64 , pp. 7197-7200
    • Yamamoto, Y.1    Moore, R.2    Goldsworthy, T.L.3    Negishi, M.4    Maronpot, R.R.5
  • 9
    • 33847331654 scopus 로고    scopus 로고
    • Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis
    • Phillips JM, Yamamoto Y, Negishi M, Maronpot RR, Goodman JI (2007) Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis. Toxicol Sci 96: 72-82.
    • (2007) Toxicol Sci , vol.96 , pp. 72-82
    • Phillips, J.M.1    Yamamoto, Y.2    Negishi, M.3    Maronpot, R.R.4    Goodman, J.I.5
  • 10
    • 0032766430 scopus 로고    scopus 로고
    • Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
    • Kawamoto T, Sueyoshi T, Zelko I, Moore R, Washburn K, et al. (1999) Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 19: 6318-6322.
    • (1999) Mol Cell Biol , vol.19 , pp. 6318-6322
    • Kawamoto, T.1    Sueyoshi, T.2    Zelko, I.3    Moore, R.4    Washburn, K.5
  • 11
    • 71749090253 scopus 로고    scopus 로고
    • Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3)
    • Mutoh S, Osabe M, Inoue K, Moore R, Pedersen L, et al. (2009) Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3). J Biol Chem 284: 34785-34792.
    • (2009) J Biol Chem , vol.284 , pp. 34785-34792
    • Mutoh, S.1    Osabe, M.2    Inoue, K.3    Moore, R.4    Pedersen, L.5
  • 12
    • 34247505536 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes
    • Koike C, Moore R, Negishi M (2007) Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes. Mol Pharmacol 71: 1217-1221.
    • (2007) Mol Pharmacol , vol.71 , pp. 1217-1221
    • Koike, C.1    Moore, R.2    Negishi, M.3
  • 13
    • 84877630473 scopus 로고    scopus 로고
    • Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling
    • Mutoh S, Sobhany M, Moore R, Perera L, Pedersen L, et al. (2013) Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling. Sci Signal 6: ra31.
    • (2013) Sci Signal , vol.6 , pp. ra31
    • Mutoh, S.1    Sobhany, M.2    Moore, R.3    Perera, L.4    Pedersen, L.5
  • 14
    • 84891861293 scopus 로고    scopus 로고
    • Metformin Represses Drug-Induced Expression of CYP2B6 by Modulating the Constitutive Androstane Receptor Signaling
    • Yang H, Garzel B, Heyward S, Moeller T, Shapiro P, et al. (2014) Metformin Represses Drug-Induced Expression of CYP2B6 by Modulating the Constitutive Androstane Receptor Signaling. Mol Pharmacol 85: 249-260.
    • (2014) Mol Pharmacol , vol.85 , pp. 249-260
    • Yang, H.1    Garzel, B.2    Heyward, S.3    Moeller, T.4    Shapiro, P.5
  • 15
    • 0142210183 scopus 로고    scopus 로고
    • Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells
    • Kobayashi K, Sueyoshi T, Inoue K, Moore R, Negishi M (2003) Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. Mol Pharmacol 64: 1069-1075.
    • (2003) Mol Pharmacol , vol.64 , pp. 1069-1075
    • Kobayashi, K.1    Sueyoshi, T.2    Inoue, K.3    Moore, R.4    Negishi, M.5
  • 16
    • 0032489016 scopus 로고    scopus 로고
    • The Hsp70 and Hsp60 chaperone machines
    • Bukau B, Horwich AL (1998) The Hsp70 and Hsp60 chaperone machines. Cell 92: 351-366.
    • (1998) Cell , vol.92 , pp. 351-366
    • Bukau, B.1    Horwich, A.L.2
  • 17
    • 0032568541 scopus 로고    scopus 로고
    • Role of the J-domain in the cooperation of Hsp40 with Hsp70
    • Greene MK, Maskos K, Landry SJ (1998) Role of the J-domain in the cooperation of Hsp40 with Hsp70. Proc Natl Acad Sci U S A 95: 6108-6113.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6108-6113
    • Greene, M.K.1    Maskos, K.2    Landry, S.J.3
  • 18
    • 0028998441 scopus 로고
    • Tetratrico Peptide Repeat Interactions: To TPR or Not to TPR?
    • Lamb JR, Tugendreich S, Hieter P (1995) Tetratrico peptide repeat interactions: to TPR or not to TPR? Trends Biochem Sci 20: 257-259.
    • (1995) Trends Biochem Sci , vol.20 , pp. 257-259
    • Lamb, J.R.1    Tugendreich, S.2    Hieter, P.3
  • 19
    • 0034646511 scopus 로고    scopus 로고
    • Structure of TPR domain-peptide complexes: Critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
    • Scheufler C, Brinker A, Bourenkov G, Pegoraro S, Moroder L, et al. (2000) Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell 101: 199-210.
    • (2000) Cell , vol.101 , pp. 199-210
    • Scheufler, C.1    Brinker, A.2    Bourenkov, G.3    Pegoraro, S.4    Moroder, L.5
  • 20
    • 0042815093 scopus 로고    scopus 로고
    • Cofactor Tpr2 Combines Two TPR Domains and a J Domain to Regulate the Hsp70/Hsp90 Chaperone System
    • Brychzy A, Rein T, Winklhofer KF, Hartl FU, Young JC, et al. (2003) Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. EMBO J 22: 3613-3623.
    • (2003) EMBO J , vol.22 , pp. 3613-3623
    • Brychzy, A.1    Rein, T.2    Winklhofer, K.F.3    Hartl, F.U.4    Young, J.C.5
  • 21
    • 52049099157 scopus 로고    scopus 로고
    • Generation of a conditional mutant allele for Tab1 in mouse
    • Inagaki M, Komatsu Y, Scott G, Yamada G, Ray M, et al. (2008) Generation of a conditional mutant allele for Tab1 in mouse. Genesis 46: 431-439.
    • (2008) Genesis , vol.46 , pp. 431-439
    • Inagaki, M.1    Komatsu, Y.2    Scott, G.3    Yamada, G.4    Ray, M.5
  • 22
    • 0029059087 scopus 로고
    • A nuclear factor (NF2d9) that binds to the male-specific P450 (Cyp 2d-9) gene in mouse liver
    • Sueyoshi T, Kobayashi R, Nishio K, Aida K, Moore R, et al. (1995) A nuclear factor (NF2d9) that binds to the male-specific P450 (Cyp 2d-9) gene in mouse liver. Mol Cell Biol 15: 4158-4166.
    • (1995) Mol Cell Biol , vol.15 , pp. 4158-4166
    • Sueyoshi, T.1    Kobayashi, R.2    Nishio, K.3    Aida, K.4    Moore, R.5
  • 24
    • 84876474460 scopus 로고    scopus 로고
    • Nuclear receptor CAR specifically activates the two-pore K+ channel Kcnk1 gene in male mouse livers, which attenuates phenobarbital-induced hepatic hyperplasia
    • Saito K, Moore R, Negishi M (2013) Nuclear receptor CAR specifically activates the two-pore K+ channel Kcnk1 gene in male mouse livers, which attenuates phenobarbital-induced hepatic hyperplasia. Toxicol Sci 132: 151-161.
    • (2013) Toxicol Sci , vol.132 , pp. 151-161
    • Saito, K.1    Moore, R.2    Negishi, M.3
  • 25
    • 34248202757 scopus 로고    scopus 로고
    • Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver
    • Nakamura K, Moore R, Negishi M, Sueyoshi T (2007) Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver. J Biol Chem 282: 9768-9776.
    • (2007) J Biol Chem , vol.282 , pp. 9768-9776
    • Nakamura, K.1    Moore, R.2    Negishi, M.3    Sueyoshi, T.4
  • 26
    • 79953035873 scopus 로고    scopus 로고
    • Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice
    • Lempiäinen H, Müller A, Brasa S, Teo SS, Roloff TC, et al. (2011) Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice. PLoS One 6: e18216.
    • (2011) PLoS One , vol.6 , pp. e18216
    • Lempiäinen, H.1    Müller, A.2    Brasa, S.3    Teo, S.S.4    Roloff, T.C.5
  • 27
    • 68849118800 scopus 로고    scopus 로고
    • Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta
    • Echeverría PC, Mazaira G, Erlejman A, Gomez-Sanchez C, Piwien Pilipuk G, et al. (2009) Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol Cell Biol 29: 4788-4797.
    • (2009) Mol Cell Biol , vol.29 , pp. 4788-4797
    • Echeverría, P.C.1    Mazaira, G.2    Erlejman, A.3    Gomez-Sanchez, C.4    Piwien Pilipuk, G.5
  • 28
    • 0037416154 scopus 로고    scopus 로고
    • The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo
    • Riggs DL, Roberts PJ, Chirillo SC, Cheung-Flynn J, Prapapanich V, et al. (2003) The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo. EMBO J 22: 1158-1167.
    • (2003) EMBO J , vol.22 , pp. 1158-1167
    • Riggs, D.L.1    Roberts, P.J.2    Chirillo, S.C.3    Cheung-Flynn, J.4    Prapapanich, V.5
  • 29
    • 33744530085 scopus 로고    scopus 로고
    • Proteomic identification of glucocorticoid receptor interacting proteins
    • Hedman E, Widén C, Asadi A, Dinnetz I, Schröder WP, et al. (2006) Proteomic identification of glucocorticoid receptor interacting proteins. Proteomics 6: 3114-3126.
    • (2006) Proteomics , vol.6 , pp. 3114-3126
    • Hedman, E.1    Widén, C.2    Asadi, A.3    Dinnetz, I.4    Schröder, W.P.5
  • 30
    • 77954580926 scopus 로고    scopus 로고
    • Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice
    • Warrier M, Hinds TD, Ledford KJ, Cash HA, Patel PR, et al. (2010) Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice. Endocrinology 151: 3225-3236.
    • (2010) Endocrinology , vol.151 , pp. 3225-3236
    • Warrier, M.1    Hinds, T.D.2    Ledford, K.J.3    Cash, H.A.4    Patel, P.R.5
  • 31
    • 0031882767 scopus 로고    scopus 로고
    • Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity
    • Meyer BK, Pray-Grant MG, Vanden Heuvel JP, Perdew GH (1998) Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Mol Cell Biol 18: 978-988.
    • (1998) Mol Cell Biol , vol.18 , pp. 978-988
    • Meyer, B.K.1    Pray-Grant, M.G.2    Vanden Heuvel, J.P.3    Perdew, G.H.4
  • 32
    • 0033551511 scopus 로고    scopus 로고
    • Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization
    • Meyer BK, Perdew GH (1999) Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization. Biochemistry 38: 8907-8917.
    • (1999) Biochemistry , vol.38 , pp. 8907-8917
    • Meyer, B.K.1    Perdew, G.H.2
  • 33
    • 0034532301 scopus 로고    scopus 로고
    • Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2
    • Petrulis JR, Hord NG, Perdew GH (2000) Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2. J Biol Chem 275: 37448-37453.
    • (2000) J Biol Chem , vol.275 , pp. 37448-37453
    • Petrulis, J.R.1    Hord, N.G.2    Perdew, G.H.3
  • 34
    • 0034680878 scopus 로고    scopus 로고
    • Binding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein. The role of hsp90
    • Bell DR, Poland A (2000) Binding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein. The role of hsp90. J Biol Chem 275: 36407-36414.
    • (2000) J Biol Chem , vol.275 , pp. 36407-36414
    • Bell, D.R.1    Poland, A.2
  • 35
    • 37249016342 scopus 로고    scopus 로고
    • Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality
    • Lin BC, Sullivan R, Lee Y, Moran S, Glover E, et al. (2007) Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. J Biol Chem 282: 35924-35932.
    • (2007) J Biol Chem , vol.282 , pp. 35924-35932
    • Lin, B.C.1    Sullivan, R.2    Lee, Y.3    Moran, S.4    Glover, E.5
  • 36
    • 78149263942 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes
    • Nukaya M, Lin BC, Glover E, Moran SM, Kennedy GD, et al. (2010) The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes. J Biol Chem 285: 35599-35605.
    • (2010) J Biol Chem , vol.285 , pp. 35599-35605
    • Nukaya, M.1    Lin, B.C.2    Glover, E.3    Moran, S.M.4    Kennedy, G.D.5
  • 37
    • 8344219885 scopus 로고    scopus 로고
    • Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver
    • Squires EJ, Sueyoshi T, Negishi M (2004) Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. J Biol Chem 279: 49307-49314.
    • (2004) J Biol Chem , vol.279 , pp. 49307-49314
    • Squires, E.J.1    Sueyoshi, T.2    Negishi, M.3
  • 39
    • 77955400148 scopus 로고    scopus 로고
    • Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors
    • Schülke JP, Wochnik GM, Lang-Rollin I, Gassen NC, Knapp RT, et al. (2010) Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors. PLoS One 5: e11717.
    • (2010) PLoS One , vol.5 , pp. e11717
    • Schülke, J.P.1    Wochnik, G.M.2    Lang-Rollin, I.3    Gassen, N.C.4    Knapp, R.T.5
  • 40
    • 84872490799 scopus 로고    scopus 로고
    • Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2
    • Kubo N, Wu D, Yoshihara Y, Sang M, Nakagawara A, et al. (2013) Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2. Biochem Biophys Res Commun 430: 1034-1039.
    • (2013) Biochem Biophys Res Commun , vol.430 , pp. 1034-1039
    • Kubo, N.1    Wu, D.2    Yoshihara, Y.3    Sang, M.4    Nakagawara, A.5
  • 41
    • 0142027829 scopus 로고    scopus 로고
    • Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor
    • Hestermann EV, Brown M (2003) Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor. Mol Cell Biol 23: 7920-7925.
    • (2003) Mol Cell Biol , vol.23 , pp. 7920-7925
    • Hestermann, E.V.1    Brown, M.2
  • 42
    • 0032031725 scopus 로고    scopus 로고
    • Molecular chaperones as HSF1-specific transcriptional repressors
    • Shi Y, Mosser DD, Morimoto RI (1998) Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev 12: 654-666.
    • (1998) Genes Dev , vol.12 , pp. 654-666
    • Shi, Y.1    Mosser, D.D.2    Morimoto, R.I.3
  • 43
    • 3142765079 scopus 로고    scopus 로고
    • Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice
    • Wiwi CA, Gupte M, Waxman DJ (2004) Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice. Mol Endocrinol 18: 1975-1987.
    • (2004) Mol Endocrinol , vol.18 , pp. 1975-1987
    • Wiwi, C.A.1    Gupte, M.2    Waxman, D.J.3
  • 44
    • 0037223832 scopus 로고    scopus 로고
    • The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity
    • Yamamoto Y, Kawamoto T, Negishi M (2003) The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity. Arch Biochem Biophys 409: 207-211.
    • (2003) Arch Biochem Biophys , vol.409 , pp. 207-211
    • Yamamoto, Y.1    Kawamoto, T.2    Negishi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.