The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes

Journal of Biological Chemistry

Volumn 285, Issue 46, 2010, Pages 35599-35605

  Nukaya, Manabu ^a,b   Lin, Bernice C ^a   Glover, Edward ^a   Moran, Susan M ^a   Kennedy, Gregory D ^b   Bradfield, Christopher A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARYL HYDROCARBON RECEPTOR; CYTOSOLIC; CYTOSOLIC COMPLEXES; ENVIRONMENTAL POLLUTANTS; HEPATOCYTES; HEPATOTOXICITY; MAMMALIAN GENOMES; MAMMALIAN LIVER; MOLECULAR CHAPERONES; MOUSE MODELS; TETRACHLORODIBENZO P DIOXINS; TOXIC RESPONSE; UP-REGULATION; VASCULAR DEVELOPMENT; XENOBIOTIC-METABOLIZING ENZYMES;

ENVIRONMENTAL REGULATIONS; GENE EXPRESSION; HYDROCARBONS; MAMMALS; PROTEINS; SIGNALING; TOXIC MATERIALS;

GENE EXPRESSION REGULATION;

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; AROMATIC HYDROCARBON RECEPTOR INTERACTING PROTEIN; BINDING PROTEIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE LOCUS; LIVER CELL; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOSOL; DIOXINS; DRUG-INDUCED LIVER INJURY; FEMALE; HEPATOCYTES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, ARYL HYDROCARBON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTIONAL ACTIVATION;

MAMMALIA;

EID: 78149263942     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.132043     Document Type: Article

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