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Volumn 11, Issue 11, 2006, Pages 2053-2063

Norepinephrine induces apoptosis in neonatal rat endothelial cells via a ROS-dependent JNK activation pathway

Author keywords

Apoptosis; Endothelial cells; JNK; Norepinephrine; Reactive oxygen species; Superoxide dismutase

Indexed keywords

ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIOXIDANT; ASCORBIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NORADRENALIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE;

EID: 33750614775     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-006-0192-8     Document Type: Article
Times cited : (35)

References (53)
  • 1
    • 0033304295 scopus 로고    scopus 로고
    • Clinical epidemiology of heart failure
    • Tavazzi L, Opasich C (1999) Clinical epidemiology of heart failure. Congest Heart Fail 5:260-269
    • (1999) Congest Heart Fail , vol.5 , pp. 260-269
    • Tavazzi, L.1    Opasich, C.2
  • 2
    • 0033535129 scopus 로고    scopus 로고
    • Sympathetic activation in heart failure and its treatment with beta-blockade
    • Pepper GS, Lee RW (1999) Sympathetic activation in heart failure and its treatment with beta-blockade. Arch Intern Med 159:225-234
    • (1999) Arch Intern Med , vol.159 , pp. 225-234
    • Pepper, G.S.1    Lee, R.W.2
  • 3
    • 0030916152 scopus 로고    scopus 로고
    • Mechanisms and implications of endothelial dysfunction in congestive heart failure
    • Katz SD (1997) Mechanisms and implications of endothelial dysfunction in congestive heart failure. Curr Opin Cardiol 12:259-264
    • (1997) Curr Opin Cardiol , vol.12 , pp. 259-264
    • Katz, S.D.1
  • 4
    • 0036083638 scopus 로고    scopus 로고
    • Oxidative stress and endothelial dysfunction in heart failure
    • Sharma R, Davidoff MN (2002) Oxidative stress and endothelial dysfunction in heart failure. Congest Heart Fail 8:165-172
    • (2002) Congest Heart Fail , vol.8 , pp. 165-172
    • Sharma, R.1    Davidoff, M.N.2
  • 5
    • 0033662177 scopus 로고    scopus 로고
    • Congestive heart failure induces endothelial cell apoptosis: Protective role of carvedilol
    • Rossig L, Haendeler J, Mallat Z et al (2000) Congestive heart failure induces endothelial cell apoptosis: protective role of carvedilol. J Am Coll Cardiol 36:2081-2089
    • (2000) J Am Coll Cardiol , vol.36 , pp. 2081-2089
    • Rossig, L.1    Haendeler, J.2    Mallat, Z.3
  • 6
    • 0035672065 scopus 로고    scopus 로고
    • Heart failure, redox alterations, and endothelial dysfunction
    • Lopez Farre A, Casado S (2001) Heart failure, redox alterations, and endothelial dysfunction. Hypertension 38:1400-1405
    • (2001) Hypertension , vol.38 , pp. 1400-1405
    • Lopez Farre, A.1    Casado, S.2
  • 7
    • 0347987900 scopus 로고    scopus 로고
    • Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways
    • Fu YC, Chi CS, Yin SC, Hwang B, Chiu YT, Hsu SL (2004) Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways. Cardiovasc Res 61:143-151
    • (2004) Cardiovasc Res , vol.61 , pp. 143-151
    • Fu, Y.C.1    Chi, C.S.2    Yin, S.C.3    Hwang, B.4    Chiu, Y.T.5    Hsu, S.L.6
  • 8
    • 0036139524 scopus 로고    scopus 로고
    • Reactive oxygen species and signal transduction
    • Finkel T (2001) Reactive oxygen species and signal transduction. IUBMB Life 52:3-6
    • (2001) IUBMB Life , vol.52 , pp. 3-6
    • Finkel, T.1
  • 9
    • 0034468736 scopus 로고    scopus 로고
    • Role of reactive oxygen species (ROS) in apoptosis induction
    • Simon HU, Haj-Yehia A, Levi-Schaffer F (2000) Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5:415-418
    • (2000) Apoptosis , vol.5 , pp. 415-418
    • Simon, H.U.1    Haj-Yehia, A.2    Levi-Schaffer, F.3
  • 10
    • 0346040214 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen intermediates contribute to Haemophilus somnus lipooligosaccharide-mediated apoptosis of bovine endothelial cells
    • Sylte MJ, Inzana TJ, Czuprynski CJ (2004) Reactive oxygen and nitrogen intermediates contribute to Haemophilus somnus lipooligosaccharide-mediated apoptosis of bovine endothelial cells. Vet Immunol Immunopathol 97:207-217
    • (2004) Vet Immunol Immunopathol , vol.97 , pp. 207-217
    • Sylte, M.J.1    Inzana, T.J.2    Czuprynski, C.J.3
  • 11
    • 0034721770 scopus 로고    scopus 로고
    • Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species
    • Kotamraju S, Konorev EA, Joseph J, Kalyanaraman B (2000) Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species. J Biol Chem 275:33585-33592
    • (2000) J Biol Chem , vol.275 , pp. 33585-33592
    • Kotamraju, S.1    Konorev, E.A.2    Joseph, J.3    Kalyanaraman, B.4
  • 12
    • 0344850195 scopus 로고    scopus 로고
    • Generation of reactive oxygen intermediates, activation of NF-kappaB, and induction of apoptosis in human endothelial cells by glucose: Role of nitric oxide synthase?
    • Du X, Stocklauser-Farber K, Rosen P (1999) Generation of reactive oxygen intermediates, activation of NF-kappaB, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase? Free Radic Biol Med 27:752-763
    • (1999) Free Radic Biol Med , vol.27 , pp. 752-763
    • Du, X.1    Stocklauser-Farber, K.2    Rosen, P.3
  • 13
    • 0032910085 scopus 로고    scopus 로고
    • Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: Mediation by reactive oxygen species
    • Rauen U, Polzar B, Stephan H, Mannherz HG, de Groot H (1999) Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species. FASEB J 13:155-168
    • (1999) FASEB J , vol.13 , pp. 155-168
    • Rauen, U.1    Polzar, B.2    Stephan, H.3    Mannherz, H.G.4    De Groot, H.5
  • 14
    • 0033813282 scopus 로고    scopus 로고
    • Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: Dual regulation by reactive oxygen species
    • Deshpande SS, Angkeow P, Huang J, Ozaki M, Irani K (2000) Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species. FASEB J 14:1705-1714
    • (2000) FASEB J , vol.14 , pp. 1705-1714
    • Deshpande, S.S.1    Angkeow, P.2    Huang, J.3    Ozaki, M.4    Irani, K.5
  • 15
    • 0034733776 scopus 로고    scopus 로고
    • Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and proatherosclerotic factors
    • Dimmeler S, Zeiher AM (2000) Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and proatherosclerotic factors. Regul Pept 90:19-25
    • (2000) Regul Pept , vol.90 , pp. 19-25
    • Dimmeler, S.1    Zeiher, A.M.2
  • 16
    • 2342562556 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in apoptosis regulation
    • Wada T, Penninger JM (2004) Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23:2838-2849
    • (2004) Oncogene , vol.23 , pp. 2838-2849
    • Wada, T.1    Penninger, J.M.2
  • 18
    • 0035257624 scopus 로고    scopus 로고
    • Signal transduction of reactive oxygen species and mitogen-activated protein kinases in cardiovascular disease
    • Yoshizumi M, Tsuchiya K, Tamaki T (2001) Signal transduction of reactive oxygen species and mitogen-activated protein kinases in cardiovascular disease. J Med Invest 48:11-24
    • (2001) J Med Invest , vol.48 , pp. 11-24
    • Yoshizumi, M.1    Tsuchiya, K.2    Tamaki, T.3
  • 19
    • 0036916586 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases contribute to reactive oxygen species-induced cell death in renal proximal tubule epithelial cells
    • Ramachandiran S, Huang Q, Dong J, Lau SS, Monks TJ (2002) Mitogen-activated protein kinases contribute to reactive oxygen species-induced cell death in renal proximal tubule epithelial cells. Chem Res Toxicol 15:1635-1642
    • (2002) Chem Res Toxicol , vol.15 , pp. 1635-1642
    • Ramachandiran, S.1    Huang, Q.2    Dong, J.3    Lau, S.S.4    Monks, T.J.5
  • 20
    • 0033743875 scopus 로고    scopus 로고
    • Reactive oxygen species activate mitogen-activated protein kinases in pancreatic acinar cells
    • Dabrowski A, Boguslowicz C, Dabrowska M, Tribillo I, Gabryelewicz A (2000) Reactive oxygen species activate mitogen-activated protein kinases in pancreatic acinar cells. Pancreas 21:376-384
    • (2000) Pancreas , vol.21 , pp. 376-384
    • Dabrowski, A.1    Boguslowicz, C.2    Dabrowska, M.3    Tribillo, I.4    Gabryelewicz, A.5
  • 21
    • 0033805442 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis
    • Kannan K, Jain SK (2000) Oxidative stress and apoptosis. Pathophysiology 7:153-163
    • (2000) Pathophysiology , vol.7 , pp. 153-163
    • Kannan, K.1    Jain, S.K.2
  • 22
    • 0033967128 scopus 로고    scopus 로고
    • Apoptosis in cardiac diseases: Stress- and mitogen-activated signaling pathways
    • Feuerstein GZ, Young PR (2000) Apoptosis in cardiac diseases: stress- and mitogen-activated signaling pathways. Cardiovasc Res 45:560-569
    • (2000) Cardiovasc Res , vol.45 , pp. 560-569
    • Feuerstein, G.Z.1    Young, P.R.2
  • 23
    • 0037423550 scopus 로고    scopus 로고
    • Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway
    • Remondino A, Kwon SH, Communal C et al (2003) Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway. Circ Res 92:136-138
    • (2003) Circ Res , vol.92 , pp. 136-138
    • Remondino, A.1    Kwon, S.H.2    Communal, C.3
  • 24
    • 0022446897 scopus 로고
    • Matrix fibronectin disruption in association with altered endothelial cell adhesion induced by activated polymorphonuclear leukocytes
    • Richards PS, Saba TM, Del Vecchio PJ, Vincent PA, Gray VC (1986) Matrix fibronectin disruption in association with altered endothelial cell adhesion induced by activated polymorphonuclear leukocytes. Exp Mol Pathol 45:1-21
    • (1986) Exp Mol Pathol , vol.45 , pp. 1-21
    • Richards, P.S.1    Saba, T.M.2    Del Vecchio, P.J.3    Vincent, P.A.4    Gray, V.C.5
  • 25
    • 0023677722 scopus 로고
    • Single cell analysis of transfected gene expression in primary heart cultures containing multiple cell types
    • Antin PB, Mar JH, Ordahl CP (1988) Single cell analysis of transfected gene expression in primary heart cultures containing multiple cell types. Biotechniques 6:640-649
    • (1988) Biotechniques , vol.6 , pp. 640-649
    • Antin, P.B.1    Mar, J.H.2    Ordahl, C.P.3
  • 26
    • 0037369376 scopus 로고    scopus 로고
    • Reactive oxygen species and extracellular signal-regulated kinase1/2mitogen-activated protein kinase hyperoxia-induced cell death in lung epithelium
    • Zhang X, Shan P, Sasidhar M et al (2003) Reactive oxygen species and extracellular signal-regulated kinase1/2mitogen-activated protein kinase hyperoxia-induced cell death in lung epithelium. Am J Respir Cell Mol Biol 28:305-315
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 305-315
    • Zhang, X.1    Shan, P.2    Sasidhar, M.3
  • 27
    • 0032538051 scopus 로고    scopus 로고
    • Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells
    • Rottenberg H, Wu S (1998) Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells. Biochim Biophys Acta 1404:393-404
    • (1998) Biochim Biophys Acta , vol.1404 , pp. 393-404
    • Rottenberg, H.1    Wu, S.2
  • 28
    • 22744457678 scopus 로고    scopus 로고
    • Role of a1-adrenoreceptors in cocaine-induced NADPH oxidase expression and cardiac dysfunction
    • Isabelle M, Monteil C, Moritz F et al (2005) Role of a1-adrenoreceptors in cocaine-induced NADPH oxidase expression and cardiac dysfunction. Cardiovasc Res 67:699-704
    • (2005) Cardiovasc Res , vol.67 , pp. 699-704
    • Isabelle, M.1    Monteil, C.2    Moritz, F.3
  • 29
    • 0034677947 scopus 로고    scopus 로고
    • NADPH oxidase: Role in cardiovascular biology and disease
    • Griendling KK, Sorescu D, Ushio-Fukai M (2000) NADPH oxidase: role in cardiovascular biology and disease. Circ Res 86:494-501
    • (2000) Circ Res , vol.86 , pp. 494-501
    • Griendling, K.K.1    Sorescu, D.2    Ushio-Fukai, M.3
  • 30
    • 0030005713 scopus 로고    scopus 로고
    • Angiotensin II-mediated hypertension in the rat increases vascular superoxide production viamembrane NADH/NADPH oxidase activation: Contribution to alterations of vasomotor tone
    • Rajagopalan S, Kurz S, Munzel T et al (1996) Angiotensin II-mediated hypertension in the rat increases vascular superoxide production viamembrane NADH/NADPH oxidase activation: contribution to alterations of vasomotor tone. J Clin Invest 97:1916-1923
    • (1996) J Clin Invest , vol.97 , pp. 1916-1923
    • Rajagopalan, S.1    Kurz, S.2    Munzel, T.3
  • 31
    • 0028233138 scopus 로고
    • NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium
    • Mohazzab KM, Kaminski PM, Wolin MS (1994) NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. Am J Physiol 266:H2568-H2572
    • (1994) Am J Physiol , vol.266
    • Mohazzab, K.M.1    Kaminski, P.M.2    Wolin, M.S.3
  • 32
    • 0033105874 scopus 로고    scopus 로고
    • NADPH oxidase: An update
    • Babior BM (1999) NADPH oxidase: an update. Blood 93:1464-1476
    • (1999) Blood , vol.93 , pp. 1464-1476
    • Babior, B.M.1
  • 33
    • 0035672065 scopus 로고    scopus 로고
    • Heart failure, redox alterations, and endothelial dysfunction
    • Farre AL, Casado S (2001) Heart failure, redox alterations, and endothelial dysfunction. Hypertension 38:1400-1405
    • (2001) Hypertension , vol.38 , pp. 1400-1405
    • Farre, A.L.1    Casado, S.2
  • 34
    • 2442492707 scopus 로고    scopus 로고
    • Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNFα-caspase signaling pathway
    • Fu YC, Chi CS, Yin SC, Hwang B, Chiu YT, Hsu SL (2004) Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNFα-caspase signaling pathway. Cardiovasc Res 62:558-567
    • (2004) Cardiovasc Res , vol.62 , pp. 558-567
    • Fu, Y.C.1    Chi, C.S.2    Yin, S.C.3    Hwang, B.4    Chiu, Y.T.5    Hsu, S.L.6
  • 35
    • 0034868229 scopus 로고    scopus 로고
    • Antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets
    • Qin F, Rounds NK, Mao W, Kawai K, Liang CS (2001) Antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets. Cardiovasc Res 51:736-748
    • (2001) Cardiovasc Res , vol.51 , pp. 736-748
    • Qin, F.1    Rounds, N.K.2    Mao, W.3    Kawai, K.4    Liang, C.S.5
  • 36
    • 0346059582 scopus 로고    scopus 로고
    • Catecholamine-induced vascular wall growth is dependent on generation of reactive oxygen species
    • Bleeke T, Zhang H, Madamanchi N, Patterson C, Faber JE (2004) Catecholamine-induced vascular wall growth is dependent on generation of reactive oxygen species. Circ Res 94:37-45
    • (2004) Circ Res , vol.94 , pp. 37-45
    • Bleeke, T.1    Zhang, H.2    Madamanchi, N.3    Patterson, C.4    Faber, J.E.5
  • 37
    • 0026662216 scopus 로고
    • Biochemical and toxicological properties of the oxidation products of catecholamines
    • Bindoli A, Rigobello MP, Deeble DJ (1992) Biochemical and toxicological properties of the oxidation products of catecholamines. Free Radical Boil Med 13:391-405
    • (1992) Free Radical Boil Med , vol.13 , pp. 391-405
    • Bindoli, A.1    Rigobello, M.P.2    Deeble, D.J.3
  • 38
    • 0024394697 scopus 로고
    • The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
    • Aruoma OI, Halliwell B, Joey BM, Butler J (1989) The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 6:593-597
    • (1989) Free Radic Biol Med , vol.6 , pp. 593-597
    • Aruoma, O.I.1    Halliwell, B.2    Joey, B.M.3    Butler, J.4
  • 39
    • 0028490693 scopus 로고
    • Thiol reducing agents modulate induced apoptosis in porcine endothelial cells
    • Abello PA, Fidler SA, Buchman TG (1994) Thiol reducing agents modulate induced apoptosis in porcine endothelial cells. Shock 2:79-83
    • (1994) Shock , vol.2 , pp. 79-83
    • Abello, P.A.1    Fidler, S.A.2    Buchman, T.G.3
  • 40
    • 0033051392 scopus 로고    scopus 로고
    • Atherogenic lipoproteins, oxidative stress and cell death
    • Galle J, Heermeier K, Wanner C (1999) Atherogenic lipoproteins, oxidative stress and cell death. Kidney Int Suppl 71:S62-S65
    • (1999) Kidney Int Suppl , vol.71
    • Galle, J.1    Heermeier, K.2    Wanner, C.3
  • 41
    • 0034190373 scopus 로고    scopus 로고
    • How does ascorbic acid prevent endothelial dysfunction?
    • May JM (2000) How does ascorbic acid prevent endothelial dysfunction? Free Rad Biol Med 28:1421-1429
    • (2000) Free Rad Biol Med , vol.28 , pp. 1421-1429
    • May, J.M.1
  • 42
    • 0034697148 scopus 로고    scopus 로고
    • Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species
    • Yoshizumi M, Abe J, Haendeler J, Huang Q, Berk BC (2000) Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species. J Biol Chem 275:11706-11712
    • (2000) J Biol Chem , vol.275 , pp. 11706-11712
    • Yoshizumi, M.1    Abe, J.2    Haendeler, J.3    Huang, Q.4    Berk, B.C.5
  • 43
    • 0037155837 scopus 로고    scopus 로고
    • Direct activation of mitochondrial apoptosis machinery by c Jun N-terminal kinase in adult cardiac myocytes
    • Aoki H, Kang PM, Hampe J et al (2002) Direct activation of mitochondrial apoptosis machinery by c Jun N-terminal kinase in adult cardiac myocytes. J Biol Chem 277:10244-10250
    • (2002) J Biol Chem , vol.277 , pp. 10244-10250
    • Aoki, H.1    Kang, P.M.2    Hampe, J.3
  • 44
    • 0037623838 scopus 로고    scopus 로고
    • Antioxidants attenuate myocyte apoptosis and improve cardiac function in CHF: Association with changes in MAPK pathways
    • Qin F, Shite J, Liang C (2003) Antioxidants attenuate myocyte apoptosis and improve cardiac function in CHF: association with changes in MAPK pathways. Am J Physiol Heart Physiol 285:H822-H832
    • (2003) Am J Physiol Heart Physiol , vol.285
    • Qin, F.1    Shite, J.2    Liang, C.3
  • 46
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z, Dickens M, Raingeaud J, Davis R, Greenberg M (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.4    Greenberg, M.5
  • 47
    • 0030041536 scopus 로고    scopus 로고
    • Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis
    • Chen YR, Meyer CF, Tan TH (1996) Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J Biol Chem 271:631-634
    • (1996) J Biol Chem , vol.271 , pp. 631-634
    • Chen, Y.R.1    Meyer, C.F.2    Tan, T.H.3
  • 48
    • 0032488992 scopus 로고    scopus 로고
    • Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway
    • Luo Y, Umegaki H, Wang X, Abe R, Roth GS (1998) Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway. J Biol Chem 273:3756-3764
    • (1998) J Biol Chem , vol.273 , pp. 3756-3764
    • Luo, Y.1    Umegaki, H.2    Wang, X.3    Abe, R.4    Roth, G.S.5
  • 49
    • 0037275601 scopus 로고    scopus 로고
    • Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells
    • Yang SE, Hsieh MT, Tsai TH, Hsu SL (2003) Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells. British J Pharmacol 138:193-201
    • (2003) British J Pharmacol , vol.138 , pp. 193-201
    • Yang, S.E.1    Hsieh, M.T.2    Tsai, T.H.3    Hsu, S.L.4
  • 50
    • 0037188941 scopus 로고    scopus 로고
    • Role of Akt signaling in vascular homeostasis and angiogenesis
    • Shiojima I, Walsh K (2002) Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 90:1243-1250
    • (2002) Circ Res , vol.90 , pp. 1243-1250
    • Shiojima, I.1    Walsh, K.2
  • 51
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signaling pathway in human malignancy
    • Nicholson KM, Anderson NG (2002) The protein kinase B/Akt signaling pathway in human malignancy. Cell Signalling 14:381-395
    • (2002) Cell Signalling , vol.14 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 53
    • 0034604226 scopus 로고    scopus 로고
    • Alterations by norepinephrine of cardiac sympathetic nerve terminal function and myocardial b-adrenergic receptor sensitivity in the ferret: Normalization by antioxidant vitamins
    • Liang CS, Rounds NK, Dong E, Stevens SY, Shite J, Qin F (2000) Alterations by norepinephrine of cardiac sympathetic nerve terminal function and myocardial b-adrenergic receptor sensitivity in the ferret: normalization by antioxidant vitamins. Circulation 102:96-103
    • (2000) Circulation , vol.102 , pp. 96-103
    • Liang, C.S.1    Rounds, N.K.2    Dong, E.3    Stevens, S.Y.4    Shite, J.5    Qin, F.6


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