메뉴 건너뛰기




Volumn 9, Issue 2, 2014, Pages 688-700

The tumor suppressor Smad4/DPC4 is regulated by phosphorylations that integrate FGF, Wnt, and TGF-β signaling

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; GLYCOGEN SYNTHASE KINASE 3; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN;

EID: 84919678319     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.09.020     Document Type: Article
Times cited : (72)

References (53)
  • 2
    • 84901229628 scopus 로고    scopus 로고
    • Mitotic wnt signaling promotes protein stabilization and regulates cell size
    • Acebron, S.P., Karaulanov, E., Berger, B.S., Huang, Y.L., and Niehrs, C. (2014). Mitotic wnt signaling promotes protein stabilization and regulates cell size. Mol. Cell 54, 663-674.
    • (2014) Mol. Cell , vol.54 , pp. 663-674
    • Acebron, S.P.1    Karaulanov, E.2    Berger, B.S.3    Huang, Y.L.4    Niehrs, C.5
  • 5
    • 84861986053 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling and disease
    • Clevers, H., and Nusse, R. (2012). Wnt/β-catenin signaling and disease. Cell 149, 1192-1205.
    • (2012) Cell , vol.149 , pp. 1192-1205
    • Clevers, H.1    Nusse, R.2
  • 8
    • 8444237836 scopus 로고    scopus 로고
    • Dorsal-ventral patterning and neural induction in Xenopus embryos
    • De Robertis, E.M., and Kuroda, H. (2004). Dorsal-ventral patterning and neural induction in Xenopus embryos. Annu. Rev. Cell Dev. Biol. 20, 285-308.
    • (2004) Annu. Rev. Cell Dev. Biol , vol.20 , pp. 285-308
    • De Robertis, E.M.1    Kuroda, H.2
  • 9
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J.M. (1998). Direct binding of Smad3 and Smad4 to critical TGF β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17, 3091-3100.
    • (1998) EMBO J , vol.17 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    ten Dijke, P.4    Huet, S.5    Gauthier, J.M.6
  • 10
    • 79951512852 scopus 로고    scopus 로고
    • SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression
    • Ding, Z., Wu, C.J., Chu, G.C., Xiao, Y., Ho, D., Zhang, J., Perry, S.R., Labrot, E.S., Wu, X., Lis, R., et al. (2011). SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature 470, 269-273.
    • (2011) Nature , vol.470 , pp. 269-273
    • Ding, Z.1    Wu, C.J.2    Chu, G.C.3    Xiao, Y.4    Ho, D.5    Zhang, J.6    Perry, S.R.7    Labrot, E.S.8    Wu, X.9    Lis, R.10
  • 11
    • 17044365440 scopus 로고    scopus 로고
    • Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase
    • Dupont, S., Zacchigna, L., Cordenonsi, M., Soligo, S., Adorno, M., Rugge, M., and Piccolo, S. (2005). Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell 121, 87-99.
    • (2005) Cell , vol.121 , pp. 87-99
    • Dupont, S.1    Zacchigna, L.2    Cordenonsi, M.3    Soligo, S.4    Adorno, M.5    Rugge, M.6    Piccolo, S.7
  • 13
    • 1942502180 scopus 로고    scopus 로고
    • The many faces of b-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer
    • Fuchs, S.Y., Spiegelman, V.S., and Kumar, K.G. (2004). The many faces of b-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene 23, 2028-2036.
    • (2004) Oncogene , vol.23 , pp. 2028-2036
    • Fuchs, S.Y.1    Spiegelman, V.S.2    Kumar, K.G.3
  • 14
    • 36248995245 scopus 로고    scopus 로고
    • Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal
    • Fuentealba, L.C., Eivers, E., Ikeda, A., Hurtado, C., Kuroda, H., Pera, E.M., and De Robertis, E.M. (2007). Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell 131, 980-993.
    • (2007) Cell , vol.131 , pp. 980-993
    • Fuentealba, L.C.1    Eivers, E.2    Ikeda, A.3    Hurtado, C.4    Kuroda, H.5    Pera, E.M.6    De Robertis, E.M.7
  • 17
    • 38149054804 scopus 로고    scopus 로고
    • Axin and GSK3-control Smad3 protein stability and modulate TGF-signaling
    • Guo, X., Ramirez, A., Waddell, D.S., Li, Z., Liu, X., and Wang, X.F. (2008). Axin and GSK3-control Smad3 protein stability and modulate TGF-signaling. Genes Dev. 22, 106-120.
    • (2008) Genes Dev , vol.22 , pp. 106-120
    • Guo, X.1    Ramirez, A.2    Waddell, D.S.3    Li, Z.4    Liu, X.5    Wang, X.F.6
  • 18
    • 20344385003 scopus 로고    scopus 로고
    • A specific inhibitor of TGF-β receptor kinase, SB-431542, as a potent antitumor agent for human cancers
    • Halder, S.K., Beauchamp, R.D., and Datta, P.K. (2005). A specific inhibitor of TGF-β receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia 7, 509-521.
    • (2005) Neoplasia , vol.7 , pp. 509-521
    • Halder, S.K.1    Beauchamp, R.D.2    Datta, P.K.3
  • 19
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., and Weinberg, R.A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 20
    • 0022622039 scopus 로고
    • Lithium-induced respecification of pattern in Xenopus laevis embryos
    • Kao, K.R., Masui, Y., and Elinson, R.P. (1986). Lithium-induced respecification of pattern in Xenopus laevis embryos. Nature 322, 371-373.
    • (1986) Nature , vol.322 , pp. 371-373
    • Kao, K.R.1    Masui, Y.2    Elinson, R.P.3
  • 21
    • 65249128611 scopus 로고    scopus 로고
    • Identification of targets of the Wnt pathway destruction complex in addition to β-catenin
    • Kim, N.G., Xu, C., and Gumbiner, B.M. (2009). Identification of targets of the Wnt pathway destruction complex in addition to β-catenin. Proc. Natl. Acad. Sci. USA 106, 5165-5170.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 5165-5170
    • Kim, N.G.1    Xu, C.2    Gumbiner, B.M.3
  • 23
    • 0037085441 scopus 로고    scopus 로고
    • Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
    • Korchynskyi, O., and ten Dijke, P. (2002). Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J. Biol. Chem. 277, 4883-4891.
    • (2002) J. Biol. Chem , vol.277 , pp. 4883-4891
    • Korchynskyi, O.1    ten Dijke, P.2
  • 24
    • 0030773834 scopus 로고    scopus 로고
    • Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
    • Kretzschmar, M., Doody, J., and Massagué, J. (1997). Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1. Nature 389, 618-622.
    • (1997) Nature , vol.389 , pp. 618-622
    • Kretzschmar, M.1    Doody, J.2    Massagué, J.3
  • 25
    • 18244372451 scopus 로고    scopus 로고
    • Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation
    • Kuroda, H., Fuentealba, L., Ikeda, A., Reversade, B., and De Robertis, E.M. (2005). Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation. Genes Dev. 19, 1022-1027.
    • (2005) Genes Dev , vol.19 , pp. 1022-1027
    • Kuroda, H.1    Fuentealba, L.2    Ikeda, A.3    Reversade, B.4    De Robertis, E.M.5
  • 26
    • 0034682515 scopus 로고    scopus 로고
    • Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-β and wnt pathways
    • Labbé, E., Letamendia, A., and Attisano, L. (2000). Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-β and wnt pathways. Proc. Natl. Acad. Sci. USA 97, 8358-8363.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8358-8363
    • Labbé, E.1    Letamendia, A.2    Attisano, L.3
  • 27
    • 30944444113 scopus 로고    scopus 로고
    • Alterations in components of the TGF-β superfamily signaling pathways in human cancer
    • Levy, L., and Hill, C.S. (2006). Alterations in components of the TGF-β superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev. 17, 41-58.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 41-58
    • Levy, L.1    Hill, C.S.2
  • 28
    • 84866742560 scopus 로고    scopus 로고
    • TGF-β signalling in context
    • Massagué, J. (2012). TGF-β signalling in context. Nat. Rev. Mol. Cell Biol. 13, 616-630.
    • (2012) Nat. Rev. Mol. Cell Biol , vol.13 , pp. 616-630
    • Massagué, J.1
  • 29
    • 67749106488 scopus 로고    scopus 로고
    • A negative feedback control of transforming growth factor-β signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204
    • Millet, C., Yamashita, M., Heller, M., Yu, L.R., Veenstra, T.D., and Zhang, Y.E. (2009). A negative feedback control of transforming growth factor-β signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204. J. Biol. Chem. 284, 19808-19816.
    • (2009) J. Biol. Chem , vol.284 , pp. 19808-19816
    • Millet, C.1    Yamashita, M.2    Heller, M.3    Yu, L.R.4    Veenstra, T.D.5    Zhang, Y.E.6
  • 31
    • 0026470018 scopus 로고
    • Competence modifiers synergize with growth factors during mesoderm induction and patterning in Xenopus
    • Moon, R.T., and Christian, J.L. (1992). Competence modifiers synergize with growth factors during mesoderm induction and patterning in Xenopus. Cell 71, 709-712.
    • (1992) Cell , vol.71 , pp. 709-712
    • Moon, R.T.1    Christian, J.L.2
  • 32
    • 21244474783 scopus 로고    scopus 로고
    • Multiple roles of the F-box protein Slimb in Drosophila egg chamber development
    • Muzzopappa, M., and Wappner, P. (2005). Multiple roles of the F-box protein Slimb in Drosophila egg chamber development. Development 132, 2561-2571.
    • (2005) Development , vol.132 , pp. 2561-2571
    • Muzzopappa, M.1    Wappner, P.2
  • 33
    • 0034212379 scopus 로고    scopus 로고
    • SCF(b)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase
    • Orian, A., Gonen, H., Bercovich, B., Fajerman, I., Eytan, E., Israël, A., Mercurio, F., Iwai, K., Schwartz, A.L., and Ciechanover, A. (2000). SCF(b)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. EMBO J. 19, 2580-2591.
    • (2000) EMBO J , vol.19 , pp. 2580-2591
    • Orian, A.1    Gonen, H.2    Bercovich, B.3    Fajerman, I.4    Eytan, E.5    Israël, A.6    Mercurio, F.7    Iwai, K.8    Schwartz, A.L.9    Ciechanover, A.10
  • 34
    • 0346594337 scopus 로고    scopus 로고
    • Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction
    • Pera, E.M., Ikeda, A., Eivers, E., and De Robertis, E.M. (2003). Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes Dev. 17, 3023-3028.
    • (2003) Genes Dev , vol.17 , pp. 3023-3028
    • Pera, E.M.1    Ikeda, A.2    Eivers, E.3    De Robertis, E.M.4
  • 35
    • 84864068245 scopus 로고    scopus 로고
    • Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer
    • Reid, C.D., Zhang, Y., Sheets, M.D., and Kessler, D.S. (2012). Transcriptional integration of Wnt and Nodal pathways in establishment of the Spemann organizer. Dev. Biol. 368, 231-241.
    • (2012) Dev. Biol , vol.368 , pp. 231-241
    • Reid, C.D.1    Zhang, Y.2    Sheets, M.D.3    Kessler, D.S.4
  • 37
    • 0035800838 scopus 로고    scopus 로고
    • Oncogenic ras represses transforming growth factor-β /Smad signaling by degrading tumor suppressor Smad4
    • Saha, D., Datta, P.K., and Beauchamp, R.D. (2001). Oncogenic ras represses transforming growth factor-β /Smad signaling by degrading tumor suppressor Smad4. J. Biol. Chem. 276, 29531-29537.
    • (2001) J. Biol. Chem , vol.276 , pp. 29531-29537
    • Saha, D.1    Datta, P.K.2    Beauchamp, R.D.3
  • 38
    • 33846688094 scopus 로고    scopus 로고
    • Balancing BMP signaling through integrated inputs into the Smad1 linker
    • Sapkota, G., Alarcón, C., Spagnoli, F.M., Brivanlou, A.H., and Massagué, J. (2007). Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol. Cell 25, 441-454.
    • (2007) Mol. Cell , vol.25 , pp. 441-454
    • Sapkota, G.1    Alarcón, C.2    Spagnoli, F.M.3    Brivanlou, A.H.4    Massagué, J.5
  • 39
    • 0036333102 scopus 로고    scopus 로고
    • β-catenin, MAPK and Smad signaling during early Xenopus development
    • Schohl, A., and Fagotto, F. (2002). β-catenin, MAPK and Smad signaling during early Xenopus development. Development 129, 37-52.
    • (2002) Development , vol.129 , pp. 37-52
    • Schohl, A.1    Fagotto, F.2
  • 40
    • 0026453179 scopus 로고
    • Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus
    • Sokol, S.Y., and Melton, D.A. (1992). Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus. Dev. Biol. 154, 348-355.
    • (1992) Dev. Biol , vol.154 , pp. 348-355
    • Sokol, S.Y.1    Melton, D.A.2
  • 41
    • 84905752998 scopus 로고    scopus 로고
    • Encoding of Temporal Signals by the TGF-β Pathway and Implications for Embryonic Patterning
    • Sorre, B., Warmflash, A., Brivanlou, A.H., and Siggia, E.D. (2014). Encoding of Temporal Signals by the TGF-β Pathway and Implications for Embryonic Patterning. Dev. Cell 30, 334-342.
    • (2014) Dev. Cell , vol.30 , pp. 334-342
    • Sorre, B.1    Warmflash, A.2    Brivanlou, A.H.3    Siggia, E.D.4
  • 49
    • 84863977346 scopus 로고    scopus 로고
    • Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4
    • Warmflash, A., Zhang, Q., Sorre, B., Vonica, A., Siggia, E.D., and Brivanlou, A.H. (2012). Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4. Proc. Natl. Acad. Sci. USA 109, E1947-E1956.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. E1947-E1956
    • Warmflash, A.1    Zhang, Q.2    Sorre, B.3    Vonica, A.4    Siggia, E.D.5    Brivanlou, A.H.6
  • 51
    • 0034712832 scopus 로고    scopus 로고
    • Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor b signaling by targeting Smads to the ubiquitin-proteasome pathway
    • Xu, J., and Attisano, L. (2000). Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor b signaling by targeting Smads to the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA 97, 4820-4825.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 4820-4825
    • Xu, J.1    Attisano, L.2
  • 52
    • 33748344500 scopus 로고    scopus 로고
    • Acute myelogenous leukemia-derived SMAD4 mutations target the protein to ubiquitin-proteasome degradation
    • Yang, L., Wang, N., Tang, Y., Cao, X., and Wan, M. (2006). Acute myelogenous leukemia-derived SMAD4 mutations target the protein to ubiquitin-proteasome degradation. Hum. Mutat. 27, 897-905.
    • (2006) Hum. Mutat , vol.27 , pp. 897-905
    • Yang, L.1    Wang, N.2    Tang, Y.3    Cao, X.4    Wan, M.5
  • 53
    • 0033549789 scopus 로고    scopus 로고
    • A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
    • Zhu, H., Kavsak, P., Abdollah, S., Wrana, J.L., and Thomsen, G.H. (1999). A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400, 687-693.
    • (1999) Nature , vol.400 , pp. 687-693
    • Zhu, H.1    Kavsak, P.2    Abdollah, S.3    Wrana, J.L.4    Thomsen, G.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.