Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

Molecular Neurodegeneration

Volumn 7, Issue 1, 2012, Pages

  Tong, Youren ^a   Giaime, Emilie ^a   Yamaguchi, Hiroo ^a   Ichimura, Takaharu ^a   Liu, Yumin ^a   Si, Huiqing ^a   Cai, Huaibin ^b   Bonventre, Joseph V ^a   Shen, Jie ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

cathepsins; knockout; LC3; lipofuscin; LRRK2; lysosomal proteins; p62; Parkinson's disease

Indexed keywords

CREATININE; KIDNEY INJURY MOLECULE 1; LEUCINE RICH REPEAT KINASE 2; ALPHA SYNUCLEIN; LRRK2 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOPHAGY; BODY WEIGHT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; INFLAMMATION; KIDNEY; KIDNEY COLOR; KIDNEY MASS; KIDNEY SIZE; KIDNEY TEXTURE; KIDNEY TUBULE; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RENAL SYSTEM PARAMETERS; SENSITIVITY AND SPECIFICITY; UPREGULATION; UREA NITROGEN BLOOD LEVEL; 129 MOUSE; AGE; ANIMAL; GENETICS; HUMAN; KIDNEY PROXIMAL TUBULE; LYSOSOME; METABOLISM; MOUSE MUTANT; MUTATION; PARKINSON DISEASE; PHYSIOLOGY; ULTRASTRUCTURE;

MUS;

AGE FACTORS; ALPHA-SYNUCLEIN; ANIMALS; APOPTOSIS; AUTOPHAGY; HUMANS; KIDNEY; KIDNEY TUBULES, PROXIMAL; LYSOSOMES; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; MUTATION; PARKINSON DISEASE; PROTEIN-SERINE-THREONINE KINASES; PROTEOLYSIS; UP-REGULATION;

EID: 84863294414     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-7-2     Document Type: Article

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