Quercetin, a powerful antioxidant bioflavonoid, prevents oxidative damage in different tissues of long-term diabetic rats

Balkan Medical Journal

Volumn 29, Issue 1, 2012, Pages 49-55

  Edremitlioǧlu, Mustafa ^a   Andiç, Mehmet Fatih ^b   Korkut, Oǧuzhan ^c  

^a ÇANAKKALE ONSEKIZ MART UNIVERSITY   (Turkey)

^b Application and Research Hospital   (Turkey)

^c BALIKESIR UNIVERSITY   (Turkey)

Author keywords

Antioxidant enzymes; Diabetic rat; Oxidative damage; Quercetin

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CATALASE; CREATININE; GLUCOSE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MALONALDEHYDE; PROTEIN; QUERCETIN; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AORTA INJURY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; BRAIN INJURY; BRAIN PROTECTION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DISEASE DURATION; DRUG EFFECT; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HEART INJURY; HEART PROTECTION; KIDNEY INJURY; LIVER INJURY; LIVER PROTECTION; LUNG INJURY; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN BLOOD LEVEL; RAT; RENAL PROTECTION; STREPTOZOCIN DIABETES;

EID: 84862086444     PISSN: 21463123     EISSN: 21463131     Source Type: Journal    
DOI: 10.5152/balkanmedj.2011.002     Document Type: Article

References (33)

1. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39:44-84.[CrossRef]
2. Altan N, Dinçel AS, Koca C. Diabetes mellitus ve oksidatif stres. Turk J Biochem 2006;31:51-6.
3. Forbes JM, Coughlan MT, Cooper ME. Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes 2008;57: 1446-54.[CrossRef]
4. Derubertis FR, Craven PA. Activation of protein kinase C in glomerular cells in diabetes. Mechanisms and potential links to the pathogenesis of diabetic glomerulopathy. Diabetes 1994;43:1-8.[CrossRef]
5. Asaba K, Tojo A, Onozato ML, Goto A, Quinn MT, Fujita T, et al. Effects of NADPH oxidase inhibitor in diabetic nephropathy. Kidney Int 2005;67:1890-8.[CrossRef]
6. Yi X, Nickeleit V, James LR, Maeda N. Alpha-Lipoic acid protects diabetic apolipoprotein E-deficient mice from nephropathy. J Diabetes Complications 2011;25:193-201.[CrossRef]
7. Manfredini V, Biancini GB, Vanzin CS, Dal Vesco AM, Cipriani F, Biasi L, et al. Simvastatin treatment prevents oxidative damage to DNA in whole blood leukocytes of dyslipidemic type 2 diabetic patients. Cell Biochem Funct 2010;28:360-6.[CrossRef]
8. Hamilton SJ, Chew GT, Watts GF. Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients. Diabetes Care 2009;32:810-2.[CrossRef]
9. Chang KC, Tseng CD, Lu SC, Liang JT, Wu MS, Tsai MS, et al. Effects of acetyl-L-carnitine and oxfenicine on aorta stiffness in diabetic rats. Eur J Clin Invest 2010;40:1002-10.[CrossRef]
10. Bischoff SC. Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 2008;11:733-40.[CrossRef]
11. Hanasaki Y, Ogawa S, Fukui S. The correlation between active oxygen scavenging and antioxidative effects of flavonoids. Free Radic Biol Med 1994;16:845-50.[CrossRef]
12. Plumb W, Price KR, Wiiliamson G. Antioxidant properties of flavonol glycosides from green beans. Redox Rep 1999;4:123-7.[CrossRef]
13. Fiorani M, De Sanctis R, Menghinello P, Cucchiarini L, Cellini B, Dachà M. Quercetin prevents glutathione depletion induced by dehydroascorbic acid in rabbit red blood cells. Free Radic Res 2001;34:639-48.[CrossRef]
14. Morand C, Crespy V, Manach C, Besson C, Demigné C, Rémésy C. Plasma metabolites of quercetin and their antioxidant properties. Am J Physiol 1998;75:R212-9.
15. Coskun O, Kanter M, Korkmaz A, Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res 2005;51:117-23.[CrossRef]
16. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8.[CrossRef]
17. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988;34:497-500.
18. Aebi H. Catalase. In: Bergmeyer HU, editor. Methods of enzymatic analysis, vol II. New York, Academic, 1974. p. 673-84.
19. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158-69.
20. Di Naso FC, Forgiarini Junior LA, Forgiarini LF, Porawski M, Dias AS, Marroni NA. Aminoguanidine reduces oxidative stress and structural lung changes in experimental diabetes mellitus. J Bras Pneumol 2010;36:485-9.
21. Ozansoy G, Güven C, Ceylan A, Can B, Aktan F, Oz E, et al. Effects of simvastatin treatment on oxidant/antioxidant state and ultrastructure of streptozotocin-diabetic rat lung. Cell Biochem Funct 2005;23:421-6.[CrossRef]
22. Shull S, Heintz NH, Periasamy M, Manohar M, Janssen YM, Marsh JP, et al. Differential regulation of antioxidant enzymes in response to oxidants. J Biol Chem 1991;266:24398-403.
23. Baud O, Greene AE, Li J, Wang H, Volpe JJ, Rosenberg PA. Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes. J Neurosci 2004;24:1531-40.[CrossRef]
24. Noyan T, Balaharoǧlu R, Kömüroǧlu U. The oxidant and antioxidant effects of 25-hydroxyvitamin D3 in liver, kidney and heart tissues of diabetic rats. Clin Exp Med 2005;5:31-6.[CrossRef]
25. Aliciguzel Y, Ozen I, Aslan M, Karayalcin U. Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats. J Lab Clin Med 2003;142:172-7.[CrossRef]
26. Hünkar T, Aktan F, Ceylan A, Karasu C; Antioxidants in Diabetes-Induced Complications (ADIC) Study Group. Effects of cod liver oil on tissue antioxidant pathways in normal and streptozotocindiabetic rats. Cell Biochem Funct 2002;20:297-302.[CrossRef]
27. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from anti-oxidant to nutraceutical. Eur J Pharmacol 2008;585:325-37.[CrossRef]
28. Sanders RA, Rauscher FM, Watkins JB 3rd. Effects of quercetin on antioxidant defense in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 2001;15:143-9.[CrossRef]
29. Anjaneyulu M, Chopra K. Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol 2004;31:244-8.[CrossRef]
30. Coldiron AD Jr, Sanders RA, Watkins JB 3rd. Effects of combined quercetin and coenzyme Q(10) treatment on oxidative stress in normal and diabetic rats. J Biochem Mol Toxicol 2002;16: 197-202.[CrossRef]
31. Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 2007;45:2179-205.[CrossRef]
32. Crespo I, García-Mediavilla MV, Almar M, González P, Tuñón MJ, Sánchez-Campos S, et al. Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells. Food Chem Toxicol 2008;46: 1555-69.[CrossRef]
33. Martínez-Flórez S, Gutiérrez-Fernández B, Sánchez-Campos S, González-Gallego J, Tuñón MJ. Quercetin attenuates nuclear factor-kappaB activation and nitric oxide production in interleukin-1beta-activated rat hepatocytes. J Nutr 2005;135:1359-65.