Restoration of NBD1 thermal stability is necessary and sufficient to correct Δf508 CFTR folding and assembly

Journal of Molecular Biology

Volumn 427, Issue 1, 2015, Pages 106-120

  He, Lihua ^a   Aleksandrov, Andrei A ^a   An, Jianli ^b   Cui, Liying ^a   Yang, Zhengrong ^b   Brouillette, Christie G ^b   Riordan, John R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

CFTR; cystic fibrosis; ion channel; protein folding; thermal stability

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ION CHANNEL; NUCLEOTIDE BINDING DOMAIN 1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; CFTR PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CELL MATURATION; DISEASE ASSOCIATION; ENZYME STABILITY; GENE MUTATION; HUMAN; HUMAN CELL; MEMBRANE STABILIZATION; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; QUALITY CONTROL; THERMOSTABILITY; BINDING SITE; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; CYSTIC FIBROSIS; DIFFERENTIAL SCANNING CALORIMETRY; GENE DELETION; GENETICS; KINETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; TEMPERATURE; WESTERN BLOTTING;

BINDING SITES; BLOTTING, WESTERN; CALORIMETRY, DIFFERENTIAL SCANNING; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; ION CHANNEL GATING; KINETICS; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TEMPERATURE;

EID: 84919666834     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2014.07.026     Document Type: Article

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