Disease-associated mutations in the fourth cytoplasmic loop of cystic fibrosis transmembrane conductance regulator compromise biosynthetic processing and chloride channel activity

Journal of Biological Chemistry

Volumn 271, Issue 25, 1996, Pages 15139-15145

  Seibert, Fabian S ^a   Linsdell, Paul ^b   Loo, Tip W ^a   Hanrahan, John W ^b   Clarke, David M ^a   Riordan, John R ^c  

^a UNIVERSITY OF TORONTO   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNEL; CYCLIC AMP; GLYCOSYLATED PROTEIN; MUTANT PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CHO CELL; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; KIDNEY CELL; NONHUMAN; PATCH CLAMP; POINT MUTATION; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EXONS; HUMANS; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; PATCH-CLAMP TECHNIQUES; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; TRANSFECTION; VARIATION (GENETICS);

ANIMALIA;

EID: 17544374096     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.25.15139     Document Type: Article

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