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Volumn 30, Issue , 2015, Pages 70-78

Simulating cancer growth with multiscale agent-based modeling

Author keywords

Drug discovery; Mathematical modeling; Signaling pathway; Translational research; Tumor growth and invasion

Indexed keywords

OXYGEN;

EID: 84919647463     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2014.04.001     Document Type: Review
Times cited : (185)

References (92)
  • 1
    • 0037157786 scopus 로고    scopus 로고
    • Cancer genetics
    • Knudson A.G. Cancer genetics. Am J Med Genet 2002, 111:96-102.
    • (2002) Am J Med Genet , vol.111 , pp. 96-102
    • Knudson, A.G.1
  • 2
    • 84884896705 scopus 로고    scopus 로고
    • How changes in extracellular matrix mechanics and gene expression variability might combine to drive cancer progression
    • Werfel J., Krause S., Bischof A.G., Mannix R.J., Tobin H., Bar-Yam Y., et al. How changes in extracellular matrix mechanics and gene expression variability might combine to drive cancer progression. PLoS ONE 2013, 8:0076122.
    • (2013) PLoS ONE , vol.8 , pp. 0076122
    • Werfel, J.1    Krause, S.2    Bischof, A.G.3    Mannix, R.J.4    Tobin, H.5    Bar-Yam, Y.6
  • 6
    • 68149138796 scopus 로고    scopus 로고
    • Biophysical models of tumour growth
    • Tracqui P. Biophysical models of tumour growth. Rep Prog Phys 2009, 72:056701.
    • (2009) Rep Prog Phys , vol.72 , pp. 056701
    • Tracqui, P.1
  • 8
    • 33847626655 scopus 로고    scopus 로고
    • Multiscale modeling in biology - new insights into cancer illustrate how mathematical tools are enhancing the understanding of life from the smallest scale to the grandest
    • Schnell S., Grima R., Maini P.K. Multiscale modeling in biology - new insights into cancer illustrate how mathematical tools are enhancing the understanding of life from the smallest scale to the grandest. Am Sci 2007, 95:134-142.
    • (2007) Am Sci , vol.95 , pp. 134-142
    • Schnell, S.1    Grima, R.2    Maini, P.K.3
  • 10
    • 58349117422 scopus 로고    scopus 로고
    • Individual-based and continuum models of growing cell populations: a comparison
    • Byrne H., Drasdo D. Individual-based and continuum models of growing cell populations: a comparison. J Math Biol 2009, 58:657-687.
    • (2009) J Math Biol , vol.58 , pp. 657-687
    • Byrne, H.1    Drasdo, D.2
  • 13
    • 34547724111 scopus 로고    scopus 로고
    • Agent-based simulation platforms: review and development recommendations
    • Railsback S.F., Lytinen S.L., Jackson S.K. Agent-based simulation platforms: review and development recommendations. Simulation 2006, 82:609-623.
    • (2006) Simulation , vol.82 , pp. 609-623
    • Railsback, S.F.1    Lytinen, S.L.2    Jackson, S.K.3
  • 14
    • 67449089661 scopus 로고    scopus 로고
    • The virtual cell - a candidate co-ordinator for 'middle-out' modelling of biological systems
    • Walker D.C., Southgate J. The virtual cell - a candidate co-ordinator for 'middle-out' modelling of biological systems. Brief Bioinform 2009, 10:450-461.
    • (2009) Brief Bioinform , vol.10 , pp. 450-461
    • Walker, D.C.1    Southgate, J.2
  • 20
    • 61349156235 scopus 로고    scopus 로고
    • Computational modeling of brain tumors: discrete, continuum or hybrid
    • Wang Z., Deisboeck T.S. Computational modeling of brain tumors: discrete, continuum or hybrid. Sci Model Simul 2008, 15:381-393.
    • (2008) Sci Model Simul , vol.15 , pp. 381-393
    • Wang, Z.1    Deisboeck, T.S.2
  • 21
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 22
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 23
    • 34547771792 scopus 로고    scopus 로고
    • Predictive oncology: a review of multidisciplinary, multiscale in silico modeling linking phenotype, morphology and growth
    • Sanga S., Frieboes H.B., Zheng X., Gatenby R., Bearer E.L., Cristini V. Predictive oncology: a review of multidisciplinary, multiscale in silico modeling linking phenotype, morphology and growth. NeuroImage 2007, 37(Suppl. 1):S120-S134.
    • (2007) NeuroImage , vol.37 , pp. S120-S134
    • Sanga, S.1    Frieboes, H.B.2    Zheng, X.3    Gatenby, R.4    Bearer, E.L.5    Cristini, V.6
  • 24
    • 83455238005 scopus 로고    scopus 로고
    • Developing a multiscale, multi-resolution agent-based brain tumor model by graphics processing units
    • Zhang L., Jiang B., Wu Y., Strouthos C., Sun P.Z., Su J., et al. Developing a multiscale, multi-resolution agent-based brain tumor model by graphics processing units. Theor Biol Med Model 2011, 8:1742-4682.
    • (2011) Theor Biol Med Model , vol.8 , pp. 1742-4682
    • Zhang, L.1    Jiang, B.2    Wu, Y.3    Strouthos, C.4    Sun, P.Z.5    Su, J.6
  • 25
    • 40149101292 scopus 로고    scopus 로고
    • Simulating non-small cell lung cancer with a multiscale agent-based model
    • Wang Z., Zhang L., Sagotsky J., Deisboeck T.S. Simulating non-small cell lung cancer with a multiscale agent-based model. Theor Biol Med Model 2007, 4:50.
    • (2007) Theor Biol Med Model , vol.4 , pp. 50
    • Wang, Z.1    Zhang, L.2    Sagotsky, J.3    Deisboeck, T.S.4
  • 26
    • 69849103228 scopus 로고    scopus 로고
    • Cross-scale, cross-pathway evaluation using an agent-based non-small cell lung cancer model
    • Wang Z., Birch C.M., Sagotsky J., Deisboeck T.S. Cross-scale, cross-pathway evaluation using an agent-based non-small cell lung cancer model. Bioinformatics 2009, 25:2389-2396.
    • (2009) Bioinformatics , vol.25 , pp. 2389-2396
    • Wang, Z.1    Birch, C.M.2    Sagotsky, J.3    Deisboeck, T.S.4
  • 27
    • 43049167278 scopus 로고    scopus 로고
    • Cross-scale sensitivity analysis of a non-small cell lung cancer model: linking molecular signaling properties to cellular behavior
    • Wang Z., Birch C.M., Deisboeck T.S. Cross-scale sensitivity analysis of a non-small cell lung cancer model: linking molecular signaling properties to cellular behavior. BioSystems 2008, 92:249-258.
    • (2008) BioSystems , vol.92 , pp. 249-258
    • Wang, Z.1    Birch, C.M.2    Deisboeck, T.S.3
  • 28
    • 84866388429 scopus 로고    scopus 로고
    • Identification of critical molecular components in a multiscale cancer model based on the integration of Monte Carlo, resampling, and ANOVA
    • Wang Z., Bordas V., Deisboeck T.S. Identification of critical molecular components in a multiscale cancer model based on the integration of Monte Carlo, resampling, and ANOVA. Front Physiol 2011, 2:35.
    • (2011) Front Physiol , vol.2 , pp. 35
    • Wang, Z.1    Bordas, V.2    Deisboeck, T.S.3
  • 29
    • 84863229594 scopus 로고    scopus 로고
    • Identifying therapeutic targets in a combined EGFR-TGFbetaR signalling cascade using a multiscale agent-based cancer model
    • Wang Z., Bordas V., Sagotsky J., Deisboeck T.S. Identifying therapeutic targets in a combined EGFR-TGFbetaR signalling cascade using a multiscale agent-based cancer model. Math Med Biol 2012, 29:95-108.
    • (2012) Math Med Biol , vol.29 , pp. 95-108
    • Wang, Z.1    Bordas, V.2    Sagotsky, J.3    Deisboeck, T.S.4
  • 30
    • 84895922732 scopus 로고    scopus 로고
    • Mathematical modeling in cancer drug discovery
    • Wang Z., Deisboeck T.S. Mathematical modeling in cancer drug discovery. Drug Discov Today 2014, 19:145-150.
    • (2014) Drug Discov Today , vol.19 , pp. 145-150
    • Wang, Z.1    Deisboeck, T.S.2
  • 31
    • 84907700291 scopus 로고    scopus 로고
    • Development of a sampling-based global sensitivity analysis workflow for multiscale computational cancer models
    • [in press]
    • Wang Z., Deisboeck T.S., Cristini V. Development of a sampling-based global sensitivity analysis workflow for multiscale computational cancer models. IET Syst Biol 2014, [in press]. 10.1049/iet-syb.2013.0026.
    • (2014) IET Syst Biol
    • Wang, Z.1    Deisboeck, T.S.2    Cristini, V.3
  • 32
    • 84865477904 scopus 로고    scopus 로고
    • Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: incorporating EGFR signaling pathway and angiogenesis
    • Sun X., Zhang L., Tan H., Bao J., Strouthos C., Zhou X. Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: incorporating EGFR signaling pathway and angiogenesis. BMC Bioinform 2012, 13:1471-2105.
    • (2012) BMC Bioinform , vol.13 , pp. 1471-2105
    • Sun, X.1    Zhang, L.2    Tan, H.3    Bao, J.4    Strouthos, C.5    Zhou, X.6
  • 33
    • 0347694776 scopus 로고    scopus 로고
    • Cancer metabolism: facts, fantasy, and fiction
    • Zu X.L., Guppy M. Cancer metabolism: facts, fantasy, and fiction. Biochem Biophys Res Commun 2004, 313:459-465.
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 459-465
    • Zu, X.L.1    Guppy, M.2
  • 34
    • 33746879141 scopus 로고    scopus 로고
    • Glycolysis inhibition for anticancer treatment
    • Pelicano H., Martin D.S., Xu R.H., Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006, 25:4633-4646.
    • (2006) Oncogene , vol.25 , pp. 4633-4646
    • Pelicano, H.1    Martin, D.S.2    Xu, R.H.3    Huang, P.4
  • 38
    • 34548317034 scopus 로고    scopus 로고
    • Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
    • Gatenby R.A., Smallbone K., Maini P.K., Rose F., Averill J., Nagle R.B., et al. Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer. Br J Cancer 2007, 97:646-653.
    • (2007) Br J Cancer , vol.97 , pp. 646-653
    • Gatenby, R.A.1    Smallbone, K.2    Maini, P.K.3    Rose, F.4    Averill, J.5    Nagle, R.B.6
  • 39
    • 77950925366 scopus 로고    scopus 로고
    • A theoretical quantitative model for evolution of cancer chemotherapy resistance
    • Silva A.S., Gatenby R.A. A theoretical quantitative model for evolution of cancer chemotherapy resistance. Biol Direct 2010, 5:25.
    • (2010) Biol Direct , vol.5 , pp. 25
    • Silva, A.S.1    Gatenby, R.A.2
  • 40
    • 38649099056 scopus 로고    scopus 로고
    • A hybrid cellular automaton model of clonal evolution in cancer: the emergence of the glycolytic phenotype
    • Gerlee P., Anderson A.R. A hybrid cellular automaton model of clonal evolution in cancer: the emergence of the glycolytic phenotype. J Theor Biol 2008, 250:705-722.
    • (2008) J Theor Biol , vol.250 , pp. 705-722
    • Gerlee, P.1    Anderson, A.R.2
  • 42
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown J.M., Wilson W.R. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer 2004, 4:437-447.
    • (2004) Nat Rev Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 43
    • 34248216634 scopus 로고    scopus 로고
    • An evolutionary hybrid cellular automaton model of solid tumour growth
    • Gerlee P., Anderson A.R. An evolutionary hybrid cellular automaton model of solid tumour growth. J Theor Biol 2007, 246:583-603.
    • (2007) J Theor Biol , vol.246 , pp. 583-603
    • Gerlee, P.1    Anderson, A.R.2
  • 44
    • 67349212164 scopus 로고    scopus 로고
    • Evolution of cell motility in an individual-based model of tumour growth
    • Gerlee P., Anderson A.R. Evolution of cell motility in an individual-based model of tumour growth. J Theor Biol 2009, 259:67-83.
    • (2009) J Theor Biol , vol.259 , pp. 67-83
    • Gerlee, P.1    Anderson, A.R.2
  • 45
    • 84883116821 scopus 로고    scopus 로고
    • The role of chromosome missegregation in cancer development: a theoretical approach using agent-based modelling
    • Araujo A., Baum B., Bentley P. The role of chromosome missegregation in cancer development: a theoretical approach using agent-based modelling. PLoS ONE 2013, 8:0072206.
    • (2013) PLoS ONE , vol.8 , pp. 0072206
    • Araujo, A.1    Baum, B.2    Bentley, P.3
  • 46
    • 0031969264 scopus 로고    scopus 로고
    • Angiogenesis and tumor metastasis
    • Zetter B.R. Angiogenesis and tumor metastasis. Annu Rev Med 1998, 49:407-424.
    • (1998) Annu Rev Med , vol.49 , pp. 407-424
    • Zetter, B.R.1
  • 47
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman J., Klagsbrun M. Angiogenic factors. Science 1987, 235:442-447.
    • (1987) Science , vol.235 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 48
    • 0032170064 scopus 로고    scopus 로고
    • Continuous and discrete mathematical models of tumor-induced angiogenesis
    • Anderson A.R., Chaplain M.A. Continuous and discrete mathematical models of tumor-induced angiogenesis. Bull Math Biol 1998, 60:857-899.
    • (1998) Bull Math Biol , vol.60 , pp. 857-899
    • Anderson, A.R.1    Chaplain, M.A.2
  • 49
    • 84896769493 scopus 로고    scopus 로고
    • Multiscale agent-based model of tumor angiogenesis
    • Olsen M.M., Siegelmann H.T. Multiscale agent-based model of tumor angiogenesis. Proc Comput Sci 2013, 18:1016-1025.
    • (2013) Proc Comput Sci , vol.18 , pp. 1016-1025
    • Olsen, M.M.1    Siegelmann, H.T.2
  • 50
    • 77952954625 scopus 로고    scopus 로고
    • Three-dimensional multispecies nonlinear tumor growth-II: tumor invasion and angiogenesis
    • Frieboes H.B., Jin F., Chuang Y.L., Wise S.M., Lowengrub J.S., Cristini V. Three-dimensional multispecies nonlinear tumor growth-II: tumor invasion and angiogenesis. J Theor Biol 2010, 264:1254-1278.
    • (2010) J Theor Biol , vol.264 , pp. 1254-1278
    • Frieboes, H.B.1    Jin, F.2    Chuang, Y.L.3    Wise, S.M.4    Lowengrub, J.S.5    Cristini, V.6
  • 52
    • 84872477242 scopus 로고    scopus 로고
    • The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems
    • Wu M., Frieboes H.B., McDougall S.R., Chaplain M.A., Cristini V., Lowengrub J. The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems. J Theor Biol 2013, 320:131-151.
    • (2013) J Theor Biol , vol.320 , pp. 131-151
    • Wu, M.1    Frieboes, H.B.2    McDougall, S.R.3    Chaplain, M.A.4    Cristini, V.5    Lowengrub, J.6
  • 53
    • 49149101639 scopus 로고    scopus 로고
    • Evolution of cell interactions with extracellular matrix during carcinogenesis
    • Alexandrova A.Y. Evolution of cell interactions with extracellular matrix during carcinogenesis. Biochemistry (Moscow) 2008, 73:733-741.
    • (2008) Biochemistry (Moscow) , vol.73 , pp. 733-741
    • Alexandrova, A.Y.1
  • 54
    • 25144494216 scopus 로고    scopus 로고
    • A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion
    • Anderson A.R. A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion. Math Med Biol 2005, 22:163-186.
    • (2005) Math Med Biol , vol.22 , pp. 163-186
    • Anderson, A.R.1
  • 55
    • 84857660748 scopus 로고    scopus 로고
    • Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): from microscopic measurements to macroscopic predictions of clinical progression
    • Macklin P., Edgerton M.E., Thompson A.M., Cristini V. Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): from microscopic measurements to macroscopic predictions of clinical progression. J Theor Biol 2012, 301:122-140.
    • (2012) J Theor Biol , vol.301 , pp. 122-140
    • Macklin, P.1    Edgerton, M.E.2    Thompson, A.M.3    Cristini, V.4
  • 56
    • 84872371412 scopus 로고    scopus 로고
    • Improved patient-specific calibration for agent-based cancer modeling
    • Hyun A.Z., Macklin P. Improved patient-specific calibration for agent-based cancer modeling. J Theor Biol 2013, 317:422-424.
    • (2013) J Theor Biol , vol.317 , pp. 422-424
    • Hyun, A.Z.1    Macklin, P.2
  • 57
    • 84877991231 scopus 로고    scopus 로고
    • Examining the pathogenesis of breast cancer using a novel agent-based model of mammary ductal epithelium dynamics
    • Chapa J., Bourgo R.J., Greene G.L., Kulkarni S., An G. Examining the pathogenesis of breast cancer using a novel agent-based model of mammary ductal epithelium dynamics. PLoS ONE 2013, 8(5):e64091.
    • (2013) PLoS ONE , vol.8 , Issue.5 , pp. e64091
    • Chapa, J.1    Bourgo, R.J.2    Greene, G.L.3    Kulkarni, S.4    An, G.5
  • 58
    • 33751217466 scopus 로고    scopus 로고
    • Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment
    • Anderson A.R., Weaver A.M., Cummings P.T., Quaranta V. Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 2006, 127:905-915.
    • (2006) Cell , vol.127 , pp. 905-915
    • Anderson, A.R.1    Weaver, A.M.2    Cummings, P.T.3    Quaranta, V.4
  • 59
    • 80053157914 scopus 로고    scopus 로고
    • Unravelling the complexity of metastasis - molecular understanding and targeted therapies
    • Sethi N., Kang Y. Unravelling the complexity of metastasis - molecular understanding and targeted therapies. Nat Rev Cancer 2011, 11:735-748.
    • (2011) Nat Rev Cancer , vol.11 , pp. 735-748
    • Sethi, N.1    Kang, Y.2
  • 60
    • 84863586949 scopus 로고    scopus 로고
    • Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour
    • Wynn M.L., Kulesa P.M., Schnell S. Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour. J R Soc Interface 2012, 9:1576-1588.
    • (2012) J R Soc Interface , vol.9 , pp. 1576-1588
    • Wynn, M.L.1    Kulesa, P.M.2    Schnell, S.3
  • 61
    • 62849112168 scopus 로고    scopus 로고
    • Collective behavior in cancer cell populations
    • Deisboeck T.S., Couzin I.D. Collective behavior in cancer cell populations. BioEssays 2009, 31:190-197.
    • (2009) BioEssays , vol.31 , pp. 190-197
    • Deisboeck, T.S.1    Couzin, I.D.2
  • 62
    • 84894581126 scopus 로고    scopus 로고
    • Collective invasion in breast cancer requires a conserved basal epithelial program
    • Cheung K.J., Gabrielson E., Werb Z., Ewald A.J. Collective invasion in breast cancer requires a conserved basal epithelial program. Cell 2013, 155:1639-1651.
    • (2013) Cell , vol.155 , pp. 1639-1651
    • Cheung, K.J.1    Gabrielson, E.2    Werb, Z.3    Ewald, A.J.4
  • 64
    • 84857497457 scopus 로고    scopus 로고
    • Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences
    • Siddique H.R., Saleem M. Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences. Stem Cells 2012, 30:372-378.
    • (2012) Stem Cells , vol.30 , pp. 372-378
    • Siddique, H.R.1    Saleem, M.2
  • 65
    • 84856900563 scopus 로고    scopus 로고
    • Understanding and overcoming chemoresistance in ovarian cancer: emerging role of the endothelin axis
    • Bagnato A., Rosanò L. Understanding and overcoming chemoresistance in ovarian cancer: emerging role of the endothelin axis. Curr Oncol 2012, 19:36.
    • (2012) Curr Oncol , vol.19 , pp. 36
    • Bagnato, A.1    Rosanò, L.2
  • 66
    • 79551651833 scopus 로고    scopus 로고
    • Cancer cell reprogramming: stem cell differentiation stage factors and an agent based model to optimize cancer treatment
    • Biava P.M., Basevi M., Biggiero L., Borgonovo A., Borgonovo E., Burigana F. Cancer cell reprogramming: stem cell differentiation stage factors and an agent based model to optimize cancer treatment. Curr Pharm Biotechnol 2011, 12:231-242.
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 231-242
    • Biava, P.M.1    Basevi, M.2    Biggiero, L.3    Borgonovo, A.4    Borgonovo, E.5    Burigana, F.6
  • 68
    • 67349111353 scopus 로고    scopus 로고
    • Migration rules: tumours are conglomerates of self-metastases
    • Enderling H., Hlatky L., Hahnfeldt P. Migration rules: tumours are conglomerates of self-metastases. Br J Cancer 2009, 100:1917-1925.
    • (2009) Br J Cancer , vol.100 , pp. 1917-1925
    • Enderling, H.1    Hlatky, L.2    Hahnfeldt, P.3
  • 69
    • 84858238012 scopus 로고    scopus 로고
    • The promoting role of a tumour-secreted chemorepellent in self-metastatic tumour progression
    • Enderling H., Hlatky L., Hahnfeldt P. The promoting role of a tumour-secreted chemorepellent in self-metastatic tumour progression. Math Med Biol 2012, 29:21-29.
    • (2012) Math Med Biol , vol.29 , pp. 21-29
    • Enderling, H.1    Hlatky, L.2    Hahnfeldt, P.3
  • 70
    • 77957662412 scopus 로고    scopus 로고
    • Cell migration at the interface of a dual chemical-mechanical gradient
    • Hale N.A., Yang Y., Rajagopalan P. Cell migration at the interface of a dual chemical-mechanical gradient. ACS Appl Mater Interfaces 2010, 2:2317-2324.
    • (2010) ACS Appl Mater Interfaces , vol.2 , pp. 2317-2324
    • Hale, N.A.1    Yang, Y.2    Rajagopalan, P.3
  • 71
    • 34247169981 scopus 로고    scopus 로고
    • A mathematical model of breast cancer development, local treatment and recurrence
    • Enderling H., Chaplain M.A., Anderson A.R., Vaidya J.S. A mathematical model of breast cancer development, local treatment and recurrence. J Theor Biol 2007, 246:245-259.
    • (2007) J Theor Biol , vol.246 , pp. 245-259
    • Enderling, H.1    Chaplain, M.A.2    Anderson, A.R.3    Vaidya, J.S.4
  • 72
    • 77956026315 scopus 로고    scopus 로고
    • Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies
    • Mukhopadhyay R., Costes S.V., Bazarov A.V., Hines W.C., Barcellos-Hoff M.H., Yaswen P. Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies. Breast Cancer Res 2010, 12:10.
    • (2010) Breast Cancer Res , vol.12 , pp. 10
    • Mukhopadhyay, R.1    Costes, S.V.2    Bazarov, A.V.3    Hines, W.C.4    Barcellos-Hoff, M.H.5    Yaswen, P.6
  • 73
    • 84861994004 scopus 로고    scopus 로고
    • Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: biological insights from a hybrid multiscale cellular automaton model
    • Powathil G.G., Gordon K.E., Hill L.A., Chaplain M.A. Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: biological insights from a hybrid multiscale cellular automaton model. J Theor Biol 2012, 308:1-19.
    • (2012) J Theor Biol , vol.308 , pp. 1-19
    • Powathil, G.G.1    Gordon, K.E.2    Hill, L.A.3    Chaplain, M.A.4
  • 74
    • 4444349425 scopus 로고    scopus 로고
    • A model for restriction point control of the mammalian cell cycle
    • Novak B., Tyson J.J. A model for restriction point control of the mammalian cell cycle. J Theor Biol 2004, 230:563-579.
    • (2004) J Theor Biol , vol.230 , pp. 563-579
    • Novak, B.1    Tyson, J.J.2
  • 75
    • 0035926571 scopus 로고    scopus 로고
    • Regulation of the eukaryotic cell cycle: molecular antagonism, hysteresis, and irreversible transitions
    • Tyson J.J., Novak B. Regulation of the eukaryotic cell cycle: molecular antagonism, hysteresis, and irreversible transitions. J Theor Biol 2001, 210:249-263.
    • (2001) J Theor Biol , vol.210 , pp. 249-263
    • Tyson, J.J.1    Novak, B.2
  • 76
    • 79952207874 scopus 로고    scopus 로고
    • Theoretical modeling techniques and their impact on tumor immunology
    • 271794
    • Woelke A.L., Murgueitio M.S., Preissner R. Theoretical modeling techniques and their impact on tumor immunology. Clin Dev Immunol 2010, 271794:23.
    • (2010) Clin Dev Immunol , pp. 23
    • Woelke, A.L.1    Murgueitio, M.S.2    Preissner, R.3
  • 77
    • 84868101858 scopus 로고    scopus 로고
    • Modeling protective anti-tumor immunity via preventative cancer vaccines using a hybrid agent-based and delay differential equation approach
    • Kim P.S., Lee P.P. Modeling protective anti-tumor immunity via preventative cancer vaccines using a hybrid agent-based and delay differential equation approach. PLoS Comput Biol 2012, 8:e1002742.
    • (2012) PLoS Comput Biol , vol.8 , pp. e1002742
    • Kim, P.S.1    Lee, P.P.2
  • 79
    • 33748126338 scopus 로고    scopus 로고
    • Discovery of cancer vaccination protocols with a genetic algorithm driving an agent based simulator
    • Lollini P.L., Motta S., Pappalardo F. Discovery of cancer vaccination protocols with a genetic algorithm driving an agent based simulator. BMC Bioinform 2006, 7:352.
    • (2006) BMC Bioinform , vol.7 , pp. 352
    • Lollini, P.L.1    Motta, S.2    Pappalardo, F.3
  • 80
    • 79551524395 scopus 로고    scopus 로고
    • Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes
    • Palazon A., Teijeira A., Martinez-Forero I., Hervas-Stubbs S., Roncal C., Penuelas I., et al. Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes. Cancer Res 2011, 71:801-811.
    • (2011) Cancer Res , vol.71 , pp. 801-811
    • Palazon, A.1    Teijeira, A.2    Martinez-Forero, I.3    Hervas-Stubbs, S.4    Roncal, C.5    Penuelas, I.6
  • 83
    • 80051779239 scopus 로고    scopus 로고
    • Development of immune-specific interaction potentials and their application in the multi-agent-system VaccImm
    • Woelke A.L., von Eichborn J., Murgueitio M.S., Worth C.L., Castiglione F., Preissner R. Development of immune-specific interaction potentials and their application in the multi-agent-system VaccImm. PLoS ONE 2011, 6:17.
    • (2011) PLoS ONE , vol.6 , pp. 17
    • Woelke, A.L.1    von Eichborn, J.2    Murgueitio, M.S.3    Worth, C.L.4    Castiglione, F.5    Preissner, R.6
  • 87
    • 14644394843 scopus 로고    scopus 로고
    • Heterogeneous multiscale method for the modeling of complex fluids and micro-fluidics
    • Ren W.Q., WN.F E. Heterogeneous multiscale method for the modeling of complex fluids and micro-fluidics. J Comput Phys 2005, 204:1-26.
    • (2005) J Comput Phys , vol.204 , pp. 1-26
    • Ren, W.Q.1    WN.F, E.2
  • 88
    • 67449101766 scopus 로고    scopus 로고
    • Equation-free multiscale computation: algorithms and applications
    • Kevrekidis I.G., Samaey G. Equation-free multiscale computation: algorithms and applications. Annu Rev Phys Chem 2009, 60:321-344.
    • (2009) Annu Rev Phys Chem , vol.60 , pp. 321-344
    • Kevrekidis, I.G.1    Samaey, G.2
  • 89
    • 4644296284 scopus 로고    scopus 로고
    • Dynamical density functional theory and its application to spinodal decomposition
    • Archer A.J., Evans R. Dynamical density functional theory and its application to spinodal decomposition. J Chem Phys 2004, 121:4246-4254.
    • (2004) J Chem Phys , vol.121 , pp. 4246-4254
    • Archer, A.J.1    Evans, R.2
  • 91
    • 0036832606 scopus 로고    scopus 로고
    • Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR
    • Dittmar T., Husemann A., Schewe Y., Nofer J.R., Niggemann B., Zanker K.S., et al. Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR. FASEB J 2002, 16:1823-1825.
    • (2002) FASEB J , vol.16 , pp. 1823-1825
    • Dittmar, T.1    Husemann, A.2    Schewe, Y.3    Nofer, J.R.4    Niggemann, B.5    Zanker, K.S.6
  • 92
    • 33847355217 scopus 로고    scopus 로고
    • Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
    • Santos S.D., Verveer P.J., Bastiaens P.I. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol 2007, 9:324-330.
    • (2007) Nat Cell Biol , vol.9 , pp. 324-330
    • Santos, S.D.1    Verveer, P.J.2    Bastiaens, P.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.