BRCA1, FANCD2 and Chk1 are potential molecular targets for the modulation of a radiation-induced DNA damage response in bystander cells

Cancer Letters

Volumn 356, Issue 2, 2015, Pages 454-461

  Burdak Rothkamm, Susanne ^a,c   Rothkamm, Kai ^b   McClelland, Keeva ^a   Al Rashid, Shahnaz T ^a   Prise, Kevin M ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

^c OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

BRCA; DNA damage response; Fanconi anaemia; Ionising radiation; Radiation induced bystander effect

Indexed keywords

ATM PROTEIN; ATR PROTEIN; BRCA1 PROTEIN; CHECKPOINT KINASE 1; FANCONI ANEMIA GROUP D2 PROTEIN; HISTONE H2AX; ATM PROTEIN, HUMAN; ATR PROTEIN, HUMAN; BRCA1 PROTEIN, HUMAN; FANCD2 PROTEIN, HUMAN; PROTEIN KINASE;

ARTICLE; BYSTANDER EFFECT; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE RESPONSE; DNA REPLICATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NUCLEIC ACID STRUCTURE, METABOLISM AND FUNCTION; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN TARGETING; RADIOSENSITIVITY; RADIOSENSITIZATION; RADIOTHERAPY; RECOMBINATION REPAIR; S PHASE CELL CYCLE CHECKPOINT; BRAIN NEOPLASMS; CELL PROLIFERATION; DNA REPAIR; ENZYME IMMUNOASSAY; FLOW CYTOMETRY; GENETICS; GLIOMA; METABOLISM; MUTATION; PATHOLOGY; PHOSPHORYLATION; RADIATION RESPONSE; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE; WESTERN BLOTTING; X RAY;

ATAXIA TELANGIECTASIA MUTATED PROTEINS; BLOTTING, WESTERN; BRAIN NEOPLASMS; BRCA1 PROTEIN; BYSTANDER EFFECT; CELL PROLIFERATION; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; FANCONI ANEMIA COMPLEMENTATION GROUP D2 PROTEIN; FLOW CYTOMETRY; GLIOMA; HUMANS; IMMUNOENZYME TECHNIQUES; MUTATION; PHOSPHORYLATION; PROTEIN KINASES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; X-RAYS;

EID: 84919486884     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.09.043     Document Type: Article

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