DNA damage and repair of leukocytes from Fanconi anaemia patients, carriers and healthy individuals as measured by the alkaline comet assay

Mutagenesis

Volumn 24, Issue 1, 2009, Pages 67-73

  Mohseni Meybodi, Anahita ^a   Mozdarani, Hossein ^a   Mozdarani, Sohail ^b  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT 60; MITOMYCIN C;

ADOLESCENT; ADULT; ARTICLE; CHILD; CHROMOSOME ANALYSIS; CHROMOSOME BREAKAGE; CLINICAL ARTICLE; COMET ASSAY; CONTROLLED STUDY; CROSS LINKING; DNA DAMAGE; DNA REPAIR; FANCONI ANEMIA; FEMALE; GAMMA IRRADIATION; HETEROZYGOTE; HUMAN; HUMAN CELL; HYPERSENSITIVITY; LEUKOCYTE; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; RADIOSENSITIVITY;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; CHROMOSOME BREAKAGE; COMET ASSAY; CYTOGENETIC ANALYSIS; DNA DAMAGE; DNA REPAIR; FANCONI ANEMIA; FEMALE; GAMMA RAYS; HETEROZYGOTE; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; RADIATION TOLERANCE;

EID: 58149130319     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gen052     Document Type: Article

References (57)

1. Taniguchi, T. and D'Andrea, A. D. (2006) Molecular pathogenesis of Fanconi anemia: recent progress. Blood, 107, 4223-4233.
2. Joenje, H. and Patel, K. J. (2001) The emerging genetic and molecular basis of Fanconi anemia. Nat. Rev. Genet., 2, 446-457.
3. Dutrillaux, B., Aurias, A., Dutrillaux, A. M., Buriot, D. and Prieur, M. (1982) The cell cycle of lymphocytes in Fanconi anemia. Hum. Genet., 62, 327-332.
4. Kubbies, M., Schindler, D., Hoehn, H., Schinzel, A. and Rabinovitch, P. S. (1985) Endogenous blockage and delay of the chromosome cycle despite normal recruitment and growth phase explain poor proliferation and frequent endomitosis in Fanconi anemia cells. Am. J. Hum. Genet., 37, 1022-1030.
5. Seyschab, H., Friedl, R., Sun, Y., Schindler, D., Hoehn, H., Hentze, S. and Schroeder-Kurth, T. (1995) Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia. Blood, 8, 2233-2237.
6. Joenje, H., Arwert, F., Eriksson, A. W., de Koning, H. and Oostra, A. B. (1981) Oxygen-dependence of chromosomal aberrations in Fanconi's anemia. Nature, 290, 142-143.
7. Schindler, D. and Hoehn, H. (1988) Fanconi anemia mutation causes cellular susceptibility to ambient oxygen. Am. J. Hum. Genet., 43, 429-435.
8. Van der Heijden, M. S., Yeo, C. J., Hruban, R. H. and Kem, S. E. (2003) Fanconi anemia gene mutations in young onset pancreatic cancer. Cancer Res., 63, 2585-2588.
9. Dhillon, V. S., Shahid, M. and Husain, S. A. (2004) CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. Mol. Cancer, 3, 33.
10. Marsit, C. J., Liu, M., Nelson, H. H., Posner, M., Suzuki, M. and Kelsey, K. T. (2004) Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene, 23, 1000-1004.
11. Schroeder, T. M., Anschutz, F. and Knopp, A. (1964) Spontane Chromosomenaberrationen bei familiärer Panmyelopathie. Humangenetik, 1, 194-196.
12. Sasaki, M. S. and Tonomura, A. (1973) A high susceptibility of Fanconi's anemia to chromosome breakage by DNA cross linking agents. Cancer Res., 33, 1829-1836.
13. Auerbach, A. D. and Wolman, S. R. (1976) Susceptibility of Fanconi's anemia fibroblasts to chromosome damage by carcinogens. Nature, 261, 494-496.
14. Higurashi, M. and Conen, P. E. (1971) In vitro chromosomal radiosensitivity in Fanconi's anemia. Blood, 38, 336-342.
15. Bigelow, S. B., Rary, J. M. and Bender, M. A. (1979) G2 chromosomal radiosensitivity in Fanconi's anemia. Mutat. Res., 63, 189-199.
16. Knox, S. J., Wilson, F. D., Greenberg, B. R., Shifrine, M., Rosenblatt, L. S., Reeves, J. D. and Misra, H. (1981) Increased radiosensitivity of a subpopulation of T-lymphocyte progenitors from patients with Fanconi's anemia. Blood, 57, 1043-1048.
17. Gluckman, E., Devergie, A. and Dutreix, J. (1983) Radiosensitivity in Fanconi anemia: application to the conditioning regimen for bone marrow transplantation. Br. J. Haematol., 54, 431-440.
18. Parshad, R., Sanford, K. K. and Jones, G. M. (1983) Chromatid damage after G2 phase x-irradiation of cells from cancer prone individuals implicates deficiency in DNA repair. Proc. Natl Acad. Sci. USA, 80, 5612-5616.
19. Burnet, N. G., Wurm, R., Tait, D. M. and Peacock, J. H. (1994) Cellular sensitivity and low dose-rate recovery in Fanconi anemia fibroblasts. Br. J. Radiol., 67, 579-583.
20. Barquinero, J. F., Barrios, L., Ribas, M. et al. (2001) Cytogenetic sensitivity of three Fanconi anemia heterozygotes to bleomycin and ionizing radiation. Cancer Genet. Cytogenet., 124, 80-83.
21. Natarajan, A. T., Vossen, J. M. J. J. and van Rijn, J. L. S. (1984) Cytogenetic response of Fanconi's anemia lymphocytes to mitomycin C, X-rays and DNA repair inhibitors. Clin. Genet., 25, 210.
22. Mohseni-Meybodi, A., Mozdarani, H. and Vosough, P. (2007) Cytogenetic sensitivity of G0 lymphocytes of Fanconi anemia patients and obligate carriers to mitomycin C and ionizing radiation. Cytogenet. Genome Res., 119, 191-195.
23. Duckworth-Rysiecki, G. and Taylor, A. M. (1985) Effects of ionizing radiation on cells from Fanconi's anemia patients. Cancer Res., 45, 416-420.
24. Kalb, R., Duerr, M., Wagner, M., Herterich, S., Gross, M., Digweed, M., Joenje, H., Hoehn, H. and Schindler, D. (2004) Lack of sensitivity of primary Fanconi's anemia fibroblasts to UV and ionizing radiation. Radiat. Res., 161, 318-325.
25. Carreau, M., Alon, N., Bosnoyan-Collins, L., Joenje, H. and Buchwald, M. (1999) Drug sensitivity spectra in Fanconi anemia lymphoblastoid cell lines of defined complementation groups. Mutat. Res., 435, 103-109.
26. Djuzenova, C. S., Rothfuss, A., Oppitz, U., Speit, G., Schindler, D., Hoehn, H. and Flentje, M. (2001) Response to X-irradiation of Fanconi anemia homozygous and heterozygous cells assessed by the single-cell gel electrophoresis (comet) assay. Lab. Invest., 81, 185-192.
27. Djuzenova, C. S. and Fentje, M. (2002) Characterization of Fanconi anemia fibroblasts in terms of clonogenic survival and DNA damage assessed by the comet assay. Med. Sci. Monit., 8, BR421-BR430.
28. Heim, R. A., Lench, N. J. and Swift, M. (1992) Heterozygous manifestations in four autosomal recessive human cancer prone syndromes: ataxia telangiectasia, xeroderma pigmentosum, Fanconi anemia, and Bloom syndrome. Mutat. Res., 284, 25-36.
29. Rothfuss, A., Schutz, P., Bochum, S., Volm, T., Eberhardt, E., Kreienberg, R., Vogel, W. and Speit, G. (2000) Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res., 60, 390-394.
30. McMillan, T. J., Tobi, S., Mateos, S. and Lemon, C. (2001) The use of DNA double-strand breaks quantification in radiotherapy. Int. J. Radiat. Oncol. Biol. Phys., 49, 373-377.
31. Pichierri, P., Franchitto, A. and Palitti, F. (2000) Predisposition to cancer and radiosensitivity. Genet. Mol. Biol., 23, 1101-1105.
32. Dikomey, E., Dahm-Daphi, J., Brammer, I., Martensen, R. and Kaina, B. (1998) Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines. Int. J. Radiat. Biol., 73, 269-278.
33. Collins, A. R. (2004) The comet assay for DNA damage and repair, principles, applications, and limitations. Mol. Biotechnol., 26, 249-261.
34. Jaloszynski, P., Kujawski, M., Czub-Swierczek, M., Markowska, J. and Szyfter, K. (1997) Bleomycin-induced DNA damage and its removal in lymphocytes of breast cancer patients studied by comet assay. Mutat. Res., 385, 223-233.
35. Kobayashi, H., Sugiyama, C., Morikawa, Y., Hayashi, M. and Sofuni, T. (1995) A comparison between manual microscopic analysis and computerized image analysis in the single cell gel electrophoresis assay. MMS. Commun., 3, 103-115.
36. Visvardis, E. E., Tassiou, A. M. and Piperakis, S. M. (1997) Study of DNA damage induction and repair capacity of fresh and cryopreserved lymphocytes exposed to H2O2 and gamma-irradiation with the alkaline comet assay. Mutat. Res., 383, 71-80.
37. Dusinska, M., Vallova, B., Ursinyova, M., Smolkova, B., Wsolova, L., Raslova, K. and Collins, A. R. (2002) DNA damage and antioxidants: fluctuations through the year in a central European population group. Food Chem. Toxicol., 40, 1119-1123.
38. Shahidi, M., Mozdarani, H. and Bryant, P. E. (2007) Radiation sensitivity of leukocytes from healthy individuals and breast cancer patients as measured by the alkaline and neutral comet assay. Cancer Lett., 257, 263-273.
39. Bergqvist, M., Brattstrom, D., Stalberg, M., Vaghef, H., Brodin, O. and Hellman, B. (1998) Evaluation of radiation induced DNA damage and DNA repair in human lung cancer cell lines with different radiosensitivity using alkaline and neutral single cell gel electrophoresis. Cancer Lett., 133, 9-18.
40. Rajeswari, N., Ahuja, Y. R., Malini, U. S., Chandrashekar, N., Balakrishna, K. V. and Rao, A. K. (2000) Risk assessment in first degree female relatives of breast cancer patients using the alkaline comet assay. Carcinogenesis, 21, 557-561.
41. Cassado, J. A., Núñez, M. I., Segovia, C. J., de Almodóvar, M. J. R. and Bueren, J. A. (2005) Non-homologous end-joining defect in Fanconi anemia hematopoietic cells exposed to ionizing radiation. Radiat. Res., 164, 635-641.
42. Gluckman, E. (1990) Radiosensitivity in Fanconi anemia: application to the conditioning for bone marrow transplantation. Radiother. Oncol., 8, 88-93.
43. Leong, T., Borg, M. and McKay, M. (2004) Clinical and cellular radiosensitivity in inherited human syndromes. Clin. Oncol., 16, 206-209.
44. Marcou, Y., D'Andrea, A., Jeggo, P. A. and Plowman, P. N. (2001) Normal cellular radio-sensitivity in an adult Fanconi anemia patient with marked clinical radiosensitivity. Radiother. Oncol., 60, 75-79.
45. Noz, K. C., Bauwens, M., Van Buul, P. P., Vrolijk, H., Schothorst, A. A., Pavel, S., Tanke, H. J. and Vermeer, B. J. (1996) Comet assay demonstrates a higher ultraviolet B sensitivity to DNA damage in dysplastic nevus cells than in common melanocytic nevus cells and foreskin melanocytes. J. Invest. Dermatol., 106, 1198-1202.
46. Speit, G. and Hartmann, A. (1999) The comet assay (single-cell gel test). In Henderson, D. S. (ed.), Methods in Molecular Biology, DNA Repair Protocols: Eukaryotic Systems, 113. Humana Press Inc., Totowa, NJ, pp. 203-212.
47. Newton, G. L., Aguilera, J. A., Ward, J. F. and Fahey, R. C. (1996) Polyamine-induced compaction and aggregation of DNA: a major factor in radioprotection of chromatin under physiological conditions. Radiat. Res., 145, 776-780.
48. Woudstra, E. C., Roesink, J. M., Rosemann, M., Brunsting, J. F., Driessen, C., Orta, T., Konings, A. W., Peacock, J. H. and Kampinga, H. H. (1996) Chromatin structure and cellular radiosensitivity: a comparison of two human tumor cell lines. Int. J. Radiat. Biol., 70, 693-703.
49. Hoatlin, M. E., Zhi, Y., Ball, H. et al. (1999) A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Blood, 94, 3737-3747.
50. Banath, J. P., Fushiki, M. and Olive, P. L. (1998) Rejoining of DNA single and double-strand breaks in human white blood cells exposed to ionizing radiation. Int. J. Radiat. Biol., 73, 649-660.
51. Nascimento, P. A., Da Silva, M. A., Oliveria, E. M., Suzuki, M. F. and Okazaki, K. (2001) Evaluation of radiation induced damage and repair capacity in blood lymphocytes of breast cancer patients. Braz. J. Med. Biol. Res., 34, 165-176.
52. McCurdy, D., Tai, L. Q., Frias, S. and Wang, Z. (1997) Delayed repair of DNA damage by ionizing radiation in cells from patients with juvenile systemic lupus erythematosus and rheumatoid arthritis. Radiat. Res., 147, 48-54.
53. Eastham, A. M., Atkinson, J. and West, C. M. (2001) Relationships between clonogenic cell survival, DNA damage and chromosomal radiosensitivity in nine human cervix carcinoma cell lines. Int. J. Radiat. Biol., 77, 295-302.
54. Zaffaroni, N., Orlandi, L., Villa, R., Bearzatto, A., Rofstad, E. K. and Silvestrini, R. (1994) DNA double-strand breaks repair and radiation response in human tumor primary cultures. Int. J. Radiat. Biol., 66, 279-285.
55. Eguchi-Kasai, K., Kosaka, T., Sato, K. and Kaneko, I. (1991) Reparability of DNA double-strand breaks and radiation sensitivity in five mammalian cell lines. Int. J. Radiat. Biol., 59, 97-104.
56. Collins, S. J., DeWeese, T. L., Jeggo, P. A. and Parker, A. R. (2005) The life and death of DNA-PK. Oncogene, 24, 949-961.
57. Houghtaling, S., Newell, A., Akkari, Y., Taniguchi, T., Olson, S. and Grompe, M. (2005) Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining. Hum. Mol. Genet., 14, 3027-3033.