Experimental and theoretical analysis of cytokine release for the study of radiation-induced bystander effect

International Journal of Radiation Biology

Volumn 85, Issue 8, 2009, Pages 690-699

  Facoetti, Angelica ^a,b   Mariotti, Luca ^a,b   Ballarini, Francesca ^a,b   Bertolotti, Alessia ^a,b   Nano, Rosanna ^a,b   Pasi, Francesca ^a,b   Ranza, Elena ^a,b   Ottolenghi, Andrea ^a,b  

^a UNIVERSITY OF PAVIA   (Italy)

^b INFN SEZIONE DI PAVIA   (Italy)

Author keywords

Bystander effect; Cytokines; Enzyme Linked Immunosorbent Assay (ELISA); Mathematical models; Medium transfer

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 8; SIGNAL PEPTIDE;

ARTICLE; BYSTANDER EFFECT; CELL CULTURE; CELL DENSITY; CELL TYPE; CLONOGENIC ASSAY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; EXPERIMENTAL STUDY; FIBROBLAST; GAMMA IRRADIATION; GEOMETRY; HUMAN; HUMAN CELL; IONIZING RADIATION; IRRADIATION; MATHEMATICAL MODEL; MONTE CARLO METHOD; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; STORAGE TEMPERATURE; THEORETICAL STUDY;

BYSTANDER EFFECT; CELL SURVIVAL; CELLS, CULTURED; FIBROBLASTS; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8;

EID: 68649105254     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000903020016     Document Type: Article

References (28)

1. Alloni D, Antonelli F, Ballarini F, Belli M, Bertolotti A, Campa A, Dini V, D'Ercole L, Esposito G, Facoetti A, Friedland W, Giovannini C, Grande S, Guidoni L, Liotta M, Lisciandro F, Luciani M, Mantovani L, Mariotti L, Molinelli S, Nano R, Ottolenghi A, Palma A, Paretzke HG, Pasi F, Rosi A, Sapora O, Scannicchio D, Simone G, Sorrentino E, Tabocchini MA, Viti V. 2008. Charged particle effects: Experimental and theoretical studies on the mechanisms underlying the induction of molecular and cellular damage and the modulation of intercellular signalling. Nuovo Cimento C 31:21-38.
2. Ballarini F, Alloni D, Facoetti A, Mairani A, Nano R, Ottolenghi A. 2006. Modelling radiation-induced bystander effect and cellular communication. Radiation Protection Dosimetry 122:244-251. (Pubitemid 47090458)
3. Ballarini F, Biaggi M, Ottolenghi A, Sapora O. 2002. Cellular communication and bystander effects: A critical review for modelling low-dose radiation action. Mutation Research 501:1-12.
4. Bentzen SM. 2006. Preventing or reducing late side effects of radiation therapy: Radiobiology meets molecular pathology. Nature Reviews: Cancer 6:702-713.
5. Brenner DJ, Little JB, Sachs RK. 2001. The bystander effect in radiation oncogenesis: II. A quantitative model. Radiation Research 155:402-408.
6. Hartsell WF, Scott CB, Dundas GS, Mohiuddin M, Meredith RF, Rubin P, Weigensberg IJ. 2007. Can serum markers be used to predict acute and late toxicity in patients with lung cancer? Analysis of RTOG 91-03. American Journal of Clinical Oncology 30:368-376. (Pubitemid 47356681)
7. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F. 2003. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. The Biochemical Journal 374:1-20. (Pubitemid 37046923)
8. Kim JH, Brown SL, Jenrow KA, Ryu S. 2008. Mechanisms of radiation-induced brain toxicity and implications for future clinical trials. Journal of Neuro-oncology 87:279-286.
9. Little JB. 2006. Cellular radiation effects and the bystander response. Mutation Research 597:113-118.
10. Lyng FM, Seymour CB, Mothersill C. 2000. Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis. British Journal of Cancer 83:1223-1230. (Pubitemid 30812332)
11. Morgan WF, Sowa MB. 2007. Non-targeted bystander effects induced by ionizing radiation. Mutation Research 16:159-164.
12. Mothersill C, Seymour C. 1997. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. International Journal of Radiation Biology 1:421-427. (Pubitemid 27187398)
13. Mothersill C, Seymour C. 2001. Radiation-induced bystander effects: Past history and future directions. Radiation Research 155:759-767. (Pubitemid 32494601)
14. Mothersill C, Seymour C. 2003. Radiation-induced bystander effects, carcinogenesis and models. Oncogene 22:7028-7033. (Pubitemid 37386671)
15. Mothersill C, Smith RW, Agnihotri N, Seymour CB. 2007. Characterization of a radiation-induced stress response communicated in vivo between zebrafish. Environmental Science and Technology 41:3382-3387. (Pubitemid 46713407)
16. Müller K, Meineke V. 2007. Radiation-induced alterations in cytokine production by skin cells. Experimental Hematology 35:96-104. (Pubitemid 46427987)
17. Newman DJ. 2006. A natural products chemist looks at the bystander effect! Mutation Research 597:39-42.
18. Nikjoo H, Khvostunov IK. 2003. Biophysical model of the radiation-induced bystander effect. International Journal of Radiation Biology 79:43-52. (Pubitemid 36140236)
19. Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J. 2005. Mechanism and modification of gastrointestinal soft tissue response to radiation: Role of growth factors. International Journal Of Radiation Oncology, Biology, Physics 62:273-278. (Pubitemid 40591954)
20. Petty HR. 1993. Molecular biology of membranes, 1st ed. New York: Springer.
21. Polistena A, Johnson LB, Ohiami-Masseron S, Wittgren L, Bäck S, Thornberg C, Gadaleanu V, Adawi D, Jeppsson B. 2008. Local radiotherapy of exposed murine small bowel: Apoptosis and inflammation. BioMed Central Surgery 8:1. (Pubitemid 351302470)
22. Rodemann HP, Blaese MA. 2007. Responses of normal cells to ionizing radiation. Seminars in Radiation Oncology 17:81-88. (Pubitemid 46467380)
23. Shao C, Folkard M, Prise KM. 2008a. Role of TGF-beta1 and nitric oxide in the bystander response of irradiated glioma cells. Oncogene 27:434-440.
24. Shao C, Prise KM, Folkard M. 2008b. Signaling factors for irradiated glioma cells induced bystander responses in fibroblasts. Mutation Research 638:139-145.
25. Shao C, Stewart V, Folkard M, Michael BD, Prise KM. 2003. Nitric oxide-mediated signalling in the bystander response of individually targeted glioma cells. Cancer Research 63:8437-8442. (Pubitemid 37549500)
26. Shuryak I, Sachs RK, Brenner DJ. 2007. Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues. Radiation Research 168:741-749.
27. Xanthinaki A, Nicolatou-Galitis O, Athanassiadou P, Gonidi M, Kouloulias V, Sotiropoulou-Lontou A, Pissakas G, Kyprianou K, Kouvaris J, Patsouris E. 2008. Apoptotic and inflammation markers in oral mucositis in head and neck cancer patients receiving radiotherapy: Preliminary report. Supportive Care in Cancer 16:1025-1033.
28. Zagury D, Burny A, Gallo RC. 2001. Toward a new generation of vaccines: The anti-cytokine therapeutic vaccines. Proceedings of the National Academy of Sciences of the USA 98:8024-8029. (Pubitemid 32642680)