-
1
-
-
33749025290
-
Stability of 100 homo and heterotypic coiled-coil a-a′ pairs for ten amino acids (A, L, I, V, N, K, S, T, E, and R)
-
DOI 10.1021/bi060822u
-
A. Acharya, V. Rishi, and C. Vinson Stability of 100 homo and heterotypic coiled-coil a-a′ pairs for ten amino acids (A, L, I, V, N, K, S, T, E, and R) Biochemistry 45 2006 11324 11332 (Pubitemid 44453980)
-
(2006)
Biochemistry
, vol.45
, Issue.38
, pp. 11324-11332
-
-
Acharya, A.1
Rishi, V.2
Vinson, C.3
-
2
-
-
77950171265
-
New tools for membrane protein research
-
Y. Alguel, J. Leung, S. Singh, R. Rana, L. Civiero, C. Alves, and B. Byrne New tools for membrane protein research Curr. Protein Pept. Sci. 11 2010 156 165
-
(2010)
Curr. Protein Pept. Sci.
, vol.11
, pp. 156-165
-
-
Alguel, Y.1
Leung, J.2
Singh, S.3
Rana, R.4
Civiero, L.5
Alves, C.6
Byrne, B.7
-
3
-
-
70350038016
-
Mapping the human membrane proteome: A majority of the human membrane proteins can be classified according to function and evolutionary origin
-
M.S. Almen, K.J.V. Nordstrom, R. Fredriksson, and H.B. Schioth Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin BMC Biol. 7 2009 50
-
(2009)
BMC Biol.
, vol.7
, pp. 50
-
-
Almen, M.S.1
Nordstrom, K.J.V.2
Fredriksson, R.3
Schioth, H.B.4
-
6
-
-
60849099626
-
Prediction of membrane protein structures with complex topologies using limited constraints
-
P. Barth, B. Wallner, and D. Baker Prediction of membrane protein structures with complex topologies using limited constraints Proc. Natl. Acad. Sci. USA 106 2009 1409 1414
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 1409-1414
-
-
Barth, P.1
Wallner, B.2
Baker, D.3
-
7
-
-
34848858005
-
De novo design of a single-chain diphenylporphyrin metalloprotein
-
DOI 10.1021/ja071199j
-
G.M. Bender, A. Lehmann, H. Zou, H. Cheng, H.C. Fry, D. Engel, M.J. Therien, J.K. Blasie, H. Roder, J.G. Saven, and W.F. DeGrado De novo design of a single-chain diphenylporphyrin metalloprotein J. Am. Chem. Soc. 129 2007 10732 10740 (Pubitemid 350067483)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.35
, pp. 10732-10740
-
-
Bender, G.M.1
Lehmann, A.2
Zou, H.3
Cheng, H.4
Fry, H.C.5
Engel, D.6
Therien, M.J.7
Blasie, J.K.8
Roder, H.9
Saven, J.G.10
DeGrado, W.F.11
-
8
-
-
79953900818
-
Overcoming barriers to membrane protein structure determination
-
R.M. Bill, P.J. Henderson, S. Iwata, E.R. Kunji, H. Michel, R. Neutze, S. Newstead, B. Poolman, C.G. Tate, and H. Vogel Overcoming barriers to membrane protein structure determination Nat. Biotechnol. 29 2011 335 340
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 335-340
-
-
Bill, R.M.1
Henderson, P.J.2
Iwata, S.3
Kunji, E.R.4
Michel, H.5
Neutze, R.6
Newstead, S.7
Poolman, B.8
Tate, C.G.9
Vogel, H.10
-
9
-
-
58149267953
-
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
-
N. Bocquet, H. Nury, M. Baaden, C. Le Poupon, J.P. Changeux, M. Delarue, and P.J. Corringer X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation Nature 457 2009 111 114
-
(2009)
Nature
, vol.457
, pp. 111-114
-
-
Bocquet, N.1
Nury, H.2
Baaden, M.3
Le Poupon, C.4
Changeux, J.P.5
Delarue, M.6
Corringer, P.J.7
-
10
-
-
79551683006
-
Membrane protein folding: How important are hydrogen bonds?
-
J.U. Bowie Membrane protein folding: how important are hydrogen bonds? Curr. Opin. Struct. Biol. 21 2011 42 49
-
(2011)
Curr. Opin. Struct. Biol.
, vol.21
, pp. 42-49
-
-
Bowie, J.U.1
-
11
-
-
77955455725
-
Diffraction cartography: Applying microbeams to macromolecular crystallography sample evaluation and data collection
-
M.W. Bowler, M. Guijarro, S. Petitdemange, I. Baker, O. Svensson, M. Burghammer, C. Mueller-Dieckmann, E.J. Gordon, D. Flot, S.M. McSweeney, and G.A. Leonard Diffraction cartography: applying microbeams to macromolecular crystallography sample evaluation and data collection Acta Crystallogr. D Biol. Crystallogr. 66 2010 855 864
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 855-864
-
-
Bowler, M.W.1
Guijarro, M.2
Petitdemange, S.3
Baker, I.4
Svensson, O.5
Burghammer, M.6
Mueller-Dieckmann, C.7
Gordon, E.J.8
Flot, D.9
McSweeney, S.M.10
Leonard, G.A.11
-
12
-
-
33645778590
-
Molecular dynamics simulation of WSK-3, a computationally designed, water-soluble variant of the integral membrane protein KcsA
-
J. Bronson, O.S. Lee, and J.G. Saven Molecular dynamics simulation of WSK-3, a computationally designed, water-soluble variant of the integral membrane protein KcsA Biophys. J. 90 2006 1156 1163
-
(2006)
Biophys. J.
, vol.90
, pp. 1156-1163
-
-
Bronson, J.1
Lee, O.S.2
Saven, J.G.3
-
14
-
-
0345304457
-
Computational Design and Characterization of a Monomeric Helical Dinuclear Metalloprotein
-
DOI 10.1016/j.jmb.2003.10.004
-
J.R. Calhoun, H. Kono, S. Lahr, W. Wang, W.F. DeGrado, and J.G. Saven Computational design and characterization of a monomeric helical dinuclear metalloprotein J. Mol. Biol. 334 2003 1101 1115 (Pubitemid 37485692)
-
(2003)
Journal of Molecular Biology
, vol.334
, Issue.5
, pp. 1101-1115
-
-
Calhoun, J.R.1
Kono, H.2
Lahr, S.3
Wang, W.4
DeGrado, W.F.5
Saven, J.G.6
-
15
-
-
49749131164
-
Computationally designed peptide inhibitors of protein-protein interactions in membranes
-
G.A. Caputo, R.I. Litvinov, W. Li, J.S. Bennett, W.F. Degrado, and H. Yin Computationally designed peptide inhibitors of protein-protein interactions in membranes Biochemistry 47 2008 8600 8606
-
(2008)
Biochemistry
, vol.47
, pp. 8600-8606
-
-
Caputo, G.A.1
Litvinov, R.I.2
Li, W.3
Bennett, J.S.4
Degrado, W.F.5
Yin, H.6
-
16
-
-
36448995359
-
2-adrenergic G protein-coupled receptor
-
DOI 10.1126/science.1150577
-
V. Cherezov, D.M. Rosenbaum, M.A. Hanson, S.G.F. Rasmussen, F.S. Thian, T.S. Kobilka, H.J. Choi, P. Kuhn, W.I. Weis, B.K. Kobilka, and R.C. Stevens High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor Science 318 2007 1258 1265 (Pubitemid 350172884)
-
(2007)
Science
, vol.318
, Issue.5854
, pp. 1258-1265
-
-
Cherezov, V.1
Rosenbaum, D.M.2
Hanson, M.A.3
Rasmussen, S.G.F.4
Foon, S.T.5
Kobilka, T.S.6
Choi, H.-J.7
Kuhn, P.8
Weis, W.I.9
Kobilka, B.K.10
Stevens, R.C.11
-
17
-
-
78449305788
-
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist
-
E.Y.T. Chien, W. Liu, Q.A. Zhao, V. Katritch, G.W. Han, M.A. Hanson, L. Shi, A.H. Newman, J.A. Javitch, V. Cherezov, and R.C. Stevens Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist Science 330 2010 1091 1095
-
(2010)
Science
, vol.330
, pp. 1091-1095
-
-
Chien, E.Y.T.1
Liu, W.2
Zhao, Q.A.3
Katritch, V.4
Han, G.W.5
Hanson, M.A.6
Shi, L.7
Newman, A.H.8
Javitch, J.A.9
Cherezov, V.10
Stevens, R.C.11
-
18
-
-
0033983453
-
Asparagine-mediated self-association of a model transmembrane helix
-
DOI 10.1038/72440
-
C. Choma, H. Gratkowski, J.D. Lear, and W.F. DeGrado Asparagine-mediated self-association of a model transmembrane helix Nat. Struct. Biol. 7 2000 161 166 (Pubitemid 30082515)
-
(2000)
Nature Structural Biology
, vol.7
, Issue.2
, pp. 161-166
-
-
Choma, C.1
Gratkowski, H.2
Lear, J.D.3
DeGrado, W.F.4
-
19
-
-
13444302392
-
Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor
-
DOI 10.1021/ja044129a
-
F.V. Cochran, S.P. Wu, W. Wang, V. Nanda, J.G. Saven, M.J. Therien, and W.F. DeGrado Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor J. Am. Chem. Soc. 127 2005 1346 1347 (Pubitemid 40204489)
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.5
, pp. 1346-1347
-
-
Cochran, F.V.1
Wu, S.P.2
Wang, W.3
Nanda, V.4
Saven, J.G.5
Therien, M.J.6
DeGrado, W.F.7
-
20
-
-
33846436807
-
Design of a functional membrane protein by engineering a heme-binding site in glycophorin A
-
DOI 10.1021/ja057495i
-
J.M. Cordova, P.L. Noack, S.A. Hilcove, J.D. Lear, and G. Ghirlanda Design of a functional membrane protein by engineering a heme-binding site in glycophorin A J. Am. Chem. Soc. 129 2007 512 518 (Pubitemid 46147750)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.3
, pp. 512-518
-
-
Cordova, J.M.1
Noack, P.L.2
Hilcove, S.A.3
Lear, J.D.4
Ghirlanda, G.5
-
21
-
-
84862776644
-
NMR structure and dynamics of designed water-soluble transmembrane domains of nicotinic acetylcholine receptor
-
10.1016/j.bbamem.2011.11.021 Published online December 3, 2011
-
T. Cui, D. Mowrey, V. Bondarenko, T. Tillman, D. Ma, E. Landrum, J.M. Perez-Aguilar, J. He, W. Wang, and J.G. Saven NMR structure and dynamics of designed water-soluble transmembrane domains of nicotinic acetylcholine receptor Biochim. Biophys. Acta. 2012 10.1016/j.bbamem.2011.11.021 Published online December 3, 2011
-
(2012)
Biochim. Biophys. Acta.
-
-
Cui, T.1
Mowrey, D.2
Bondarenko, V.3
Tillman, T.4
Ma, D.5
Landrum, E.6
Perez-Aguilar, J.M.7
He, J.8
Wang, W.9
Saven, J.G.10
-
22
-
-
0030793767
-
De novo protein design: Fully automated sequence selection
-
DOI 10.1126/science.278.5335.82
-
B.I. Dahiyat, and S.L. Mayo De novo protein design: fully automated sequence selection Science 278 1997 82 87 (Pubitemid 27446279)
-
(1997)
Science
, vol.278
, Issue.5335
, pp. 82-87
-
-
Dahiyat, B.I.1
Mayo, S.L.2
-
23
-
-
0028858499
-
De novo design of the hydrophobic cores of proteins
-
J.R. Desjarlais, and T.M. Handel De novo design of the hydrophobic cores of proteins Protein Sci. 4 1995 2006 2018
-
(1995)
Protein Sci.
, vol.4
, pp. 2006-2018
-
-
Desjarlais, J.R.1
Handel, T.M.2
-
24
-
-
0026589733
-
The dead-end elimination theorem and its use in protein side-chain positioning
-
J. Desmet, M. De Maeyer, B. Hazes, and I. Lasters The dead-end elimination theorem and its use in protein side-chain positioning Nature 356 1992 539 542
-
(1992)
Nature
, vol.356
, pp. 539-542
-
-
Desmet, J.1
De Maeyer, M.2
Hazes, B.3
Lasters, I.4
-
25
-
-
43149098999
-
GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae
-
DOI 10.1038/nprot.2008.44, PII NPROT.2008.44
-
D. Drew, S. Newstead, Y. Sonoda, H. Kim, G. von Heijne, and S. Iwata GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae Nat. Protoc. 3 2008 784 798 (Pubitemid 351639023)
-
(2008)
Nature Protocols
, vol.3
, Issue.5
, pp. 784-798
-
-
Drew, D.1
Newstead, S.2
Sonoda, Y.3
Kim, H.4
Von Heijne, G.5
Iwata, S.6
-
26
-
-
79961044901
-
Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family
-
G. Duret, C. Van Renterghem, Y. Weng, M. Prevost, G. Moraga-Cid, C. Huon, J.M. Sonner, and P.J. Corringer Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family Proc. Natl. Acad. Sci. USA 108 2011 12143 12148
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 12143-12148
-
-
Duret, G.1
Van Renterghem, C.2
Weng, Y.3
Prevost, M.4
Moraga-Cid, G.5
Huon, C.6
Sonner, J.M.7
Corringer, P.J.8
-
27
-
-
0037418859
-
Gating the selectivity filter in ClC chloride channels
-
DOI 10.1126/science.1082708
-
R. Dutzler, E.B. Campbell, and R. MacKinnon Gating the selectivity filter in ClC chloride channels Science 300 2003 108 112 (Pubitemid 36423038)
-
(2003)
Science
, vol.300
, Issue.5616
, pp. 108-112
-
-
Dutzler, R.1
Campbell, E.B.2
MacKinnon, R.3
-
28
-
-
77949854939
-
Computational design and elaboration of a de novo heterotetrameric α-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore
-
H.C. Fry, A. Lehmann, J.G. Saven, W.F. DeGrado, and M.J. Therien Computational design and elaboration of a de novo heterotetrameric α-helical protein that selectively binds an emissive abiological (porphinato)zinc chromophore J. Am. Chem. Soc. 132 2010 3997 4005
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 3997-4005
-
-
Fry, H.C.1
Lehmann, A.2
Saven, J.G.3
Degrado, W.F.4
Therien, M.J.5
-
29
-
-
70549100011
-
Design of membrane proteins: Toward functional systems
-
G. Ghirlanda Design of membrane proteins: toward functional systems Curr. Opin. Chem. Biol. 13 2009 643 651
-
(2009)
Curr. Opin. Chem. Biol.
, vol.13
, pp. 643-651
-
-
Ghirlanda, G.1
-
30
-
-
0027756896
-
A switch between two-stranded, three-stranded and four-stranded coiled coils in Gcn4 leucine-zipper mutants
-
P.B. Harbury, T. Zhang, P.S. Kim, and T. Alber A switch between two-stranded, three-stranded and four-stranded coiled coils in Gcn4 leucine-zipper mutants Science 262 1993 1401 1407
-
(1993)
Science
, vol.262
, pp. 1401-1407
-
-
Harbury, P.B.1
Zhang, T.2
Kim, P.S.3
Alber, T.4
-
32
-
-
79957953215
-
Principles of activation and permeation in an anion-selective Cys-loop receptor
-
R.E. Hibbs, and E. Gouaux Principles of activation and permeation in an anion-selective Cys-loop receptor Nature 474 2011 54 60
-
(2011)
Nature
, vol.474
, pp. 54-60
-
-
Hibbs, R.E.1
Gouaux, E.2
-
33
-
-
41149168686
-
X-ray structure of a prokaryotic pentameric ligand-gated ion channel
-
DOI 10.1038/nature06717, PII NATURE06717
-
R.J.C. Hilf, and R. Dutzler X-ray structure of a prokaryotic pentameric ligand-gated ion channel Nature 452 2008 375 379 (Pubitemid 351430790)
-
(2008)
Nature
, vol.452
, Issue.7185
, pp. 375-379
-
-
Hilf, R.J.C.1
Dutzler, R.2
-
34
-
-
58149242730
-
Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel
-
R.J.C. Hilf, and R. Dutzler Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel Nature 457 2009 115 118
-
(2009)
Nature
, vol.457
, pp. 115-118
-
-
Hilf, R.J.C.1
Dutzler, R.2
-
35
-
-
0034660152
-
1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment
-
DOI 10.1016/S0969-2126(00)00152-0
-
C. Hunte, J. Koepke, C. Lange, T. Rossmanith, and H. Michel Structure at 2.3 resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment Structure 8 2000 669 684 (Pubitemid 30409318)
-
(2000)
Structure
, vol.8
, Issue.6
, pp. 669-684
-
-
Hunte, C.1
Koepke, J.2
Lange, C.3
Rossmanith, T.4
Michel, H.5
-
36
-
-
0028890031
-
Structure at 2.8 resolution of cytochrome c oxidase from Paracoccus denitrificans
-
S. Iwata, C. Ostermeier, B. Ludwig, and H. Michel Structure at 2.8 resolution of cytochrome c oxidase from Paracoccus denitrificans Nature 376 1995 660 669
-
(1995)
Nature
, vol.376
, pp. 660-669
-
-
Iwata, S.1
Ostermeier, C.2
Ludwig, B.3
Michel, H.4
-
37
-
-
56749103466
-
2A adenosine receptor bound to an antagonist
-
2A adenosine receptor bound to an antagonist Science 322 2008 1211 1217
-
(2008)
Science
, vol.322
, pp. 1211-1217
-
-
Jaakola, V.P.1
Griffith, M.T.2
Hanson, M.A.3
Cherezov, V.4
Chien, E.Y.T.5
Lane, J.R.6
Ijzerman, A.P.7
Stevens, R.C.8
-
38
-
-
34250691635
-
Computational protein design: structure, function and combinatorial diversity
-
DOI 10.1016/j.cbpa.2007.05.006, PII S1367593107000531
-
S.G. Kang, and J.G. Saven Computational protein design: structure, function and combinatorial diversity Curr. Opin. Chem. Biol. 11 2007 329 334 (Pubitemid 46963073)
-
(2007)
Current Opinion in Chemical Biology
, vol.11
, Issue.3
, pp. 329-334
-
-
Kang, S.-g.1
Saven, J.G.2
-
39
-
-
0035936702
-
Statistical theory for protein combinatorial libraries. Packing interactions, backbone flexibility, and the sequence variability of a main-chain structure
-
DOI 10.1006/jmbi.2000.4422
-
H. Kono, and J.G. Saven Statistical theory for protein combinatorial libraries. Packing interactions, backbone flexibility, and the sequence variability of a main-chain structure J. Mol. Biol. 306 2001 607 628 (Pubitemid 33027726)
-
(2001)
Journal of Molecular Biology
, vol.306
, Issue.3
, pp. 607-628
-
-
Kono, H.1
Saven, J.G.2
-
40
-
-
78149266496
-
De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex
-
I.V. Korendovych, A. Senes, Y.H. Kim, J.D. Lear, H.C. Fry, M.J. Therien, J.K. Blasie, F.A. Walker, and W.F. Degrado De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex J. Am. Chem. Soc. 132 2010 15516 15518
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 15516-15518
-
-
Korendovych, I.V.1
Senes, A.2
Kim, Y.H.3
Lear, J.D.4
Fry, H.C.5
Therien, M.J.6
Blasie, J.K.7
Walker, F.A.8
Degrado, W.F.9
-
41
-
-
0034641749
-
Native protein sequences are close to optimal for their structures
-
B. Kuhlman, and D. Baker Native protein sequences are close to optimal for their structures Proc. Natl. Acad. Sci. USA 97 2000 10383 10388
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 10383-10388
-
-
Kuhlman, B.1
Baker, D.2
-
42
-
-
0038675609
-
Effective energy function for proteins in lipid membranes
-
DOI 10.1002/prot.10410
-
T. Lazaridis Effective energy function for proteins in lipid membranes Proteins 52 2003 176 192 (Pubitemid 36828942)
-
(2003)
Proteins: Structure, Function and Genetics
, vol.52
, Issue.2
, pp. 176-192
-
-
Lazaridis, T.1
-
43
-
-
0023907575
-
Synthetic amphiphilic peptide models for protein ion channels
-
J.D. Lear, Z.R. Wasserman, and W.F. DeGrado Synthetic amphiphilic peptide models for protein ion channels Science 240 1988 1177 1181
-
(1988)
Science
, vol.240
, pp. 1177-1181
-
-
Lear, J.D.1
Wasserman, Z.R.2
Degrado, W.F.3
-
46
-
-
55949095008
-
NMR studies of a channel protein without membranes: Structure and dynamics of water-solubilized KcsA
-
D.J. Ma, T.S. Tillman, P. Tang, E. Meirovitch, R. Eckenhoff, A. Carnini, and Y. Xu NMR studies of a channel protein without membranes: structure and dynamics of water-solubilized KcsA Proc. Natl. Acad. Sci. USA 105 2008 16537 16542
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 16537-16542
-
-
Ma, D.J.1
Tillman, T.S.2
Tang, P.3
Meirovitch, E.4
Eckenhoff, R.5
Carnini, A.6
Xu, Y.7
-
48
-
-
51749093323
-
Using α-helical coiled-coils to design nanostructured metalloporphyrin arrays
-
K.A. McAllister, H.L. Zou, F.V. Cochran, G.M. Bender, A. Senes, H.C. Fry, V. Nanda, P.A. Keenan, J.D. Lear, and J.G. Saven Using α-helical coiled-coils to design nanostructured metalloporphyrin arrays J. Am. Chem. Soc. 130 2008 11921 11927
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 11921-11927
-
-
McAllister, K.A.1
Zou, H.L.2
Cochran, F.V.3
Bender, G.M.4
Senes, A.5
Fry, H.C.6
Nanda, V.7
Keenan, P.A.8
Lear, J.D.9
Saven, J.G.10
-
49
-
-
0038112088
-
Structure and gating mechanism of the acetylcholine receptor pore
-
DOI 10.1038/nature01748
-
A. Miyazawa, Y. Fujiyoshi, and N. Unwin Structure and gating mechanism of the acetylcholine receptor pore Nature 423 2003 949 955 (Pubitemid 36806903)
-
(2003)
Nature
, vol.423
, Issue.6943
, pp. 949-955
-
-
Miyazawa, A.1
Fujiyoshi, Y.2
Unwin, N.3
-
50
-
-
77949860707
-
Designing artificial enzymes by intuition and computation
-
V. Nanda, and R.L. Koder Designing artificial enzymes by intuition and computation Nat. Chem. 2 2010 15 24
-
(2010)
Nat. Chem.
, vol.2
, pp. 15-24
-
-
Nanda, V.1
Koder, R.L.2
-
51
-
-
35348832935
-
High-throughput fluorescent-based optimization of eukaryotic membrane protein overexpression and purification in Saccharomyces cerevisiae
-
DOI 10.1073/pnas.0704546104
-
S. Newstead, H. Kim, G. von Heijne, S. Iwata, and D. Drew High-throughput fluorescent-based optimization of eukaryotic membrane protein overexpression and purification in Saccharomyces cerevisiae Proc. Natl. Acad. Sci. USA 104 2007 13936 13941 (Pubitemid 350003316)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.35
, pp. 13936-13941
-
-
Newstead, S.1
Kim, H.2
Von Heijne, G.3
Iwata, S.4
Drew, D.5
-
52
-
-
33744807250
-
Characterization of a Membrane Protein Folding Motif, the Ser Zipper, Using Designed Peptides
-
DOI 10.1016/j.jmb.2006.04.001, PII S0022283606004487
-
B. North, L. Cristian, X. Fu Stowell, J.D. Lear, J.G. Saven, and W.F. Degrado Characterization of a membrane protein folding motif, the Ser zipper, using designed peptides J. Mol. Biol. 359 2006 930 939 (Pubitemid 43831918)
-
(2006)
Journal of Molecular Biology
, vol.359
, Issue.4
, pp. 930-939
-
-
North, B.1
Cristian, L.2
Fu Stowell, X.3
Lear, J.D.4
Saven, J.G.5
DeGrado, W.F.6
-
53
-
-
78751673139
-
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
-
H. Nury, C. Van Renterghem, Y. Weng, A. Tran, M. Baaden, V. Dufresne, J.P. Changeux, J.M. Sonner, M. Delarue, and P.J. Corringer X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel Nature 469 2011 428 431
-
(2011)
Nature
, vol.469
, pp. 428-431
-
-
Nury, H.1
Van Renterghem, C.2
Weng, Y.3
Tran, A.4
Baaden, M.5
Dufresne, V.6
Changeux, J.P.7
Sonner, J.M.8
Delarue, M.9
Corringer, P.J.10
-
55
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
DOI 10.1126/science.289.5480.739
-
K. Palczewski, T. Kumasaka, T. Hori, C.A. Behnke, H. Motoshima, B.A. Fox, I. Le Trong, D.C. Teller, T. Okada, and R.E. Stenkamp Crystal structure of rhodopsin: A G protein-coupled receptor Science 289 2000 739 745 (Pubitemid 30650186)
-
(2000)
Science
, vol.289
, Issue.5480
, pp. 739-745
-
-
Palczewski, K.1
Kumasaka, T.2
Hori, T.3
Behnke, C.A.4
Motoshima, H.5
Fox, B.A.6
Le Trong, I.7
Teller, D.C.8
Okada, T.9
Stenkamp, R.E.10
Yamamoto, M.11
Miyano, M.12
-
56
-
-
15744367732
-
Progress in the development and application of computational methods for probabilistic protein design
-
DOI 10.1016/j.compchemeng.2004.07.037, PII S0098135404002339, Computational Challenges in Biology
-
S. Park, H. Kono, W. Wang, E.T. Boder, and J.G. Saven Progress in the development and application of computational methods for probabilistic protein design Comput. Chem. Eng. 29 2005 407 421 (Pubitemid 40417791)
-
(2005)
Computers and Chemical Engineering
, vol.29
, Issue.3
, pp. 407-421
-
-
Park, S.1
Kono, H.2
Wang, W.3
Boder, E.T.4
Saven, J.G.5
-
57
-
-
0037601089
-
Amphipols: Polymeric surfactants for membrane biology research
-
DOI 10.1007/s00018-003-3169-6
-
J.L. Popot, E.A. Berry, D. Charvolin, C. Creuzenet, C. Ebel, D.M. Engelman, M. Flötenmeyer, F. Giusti, Y. Gohon, and Q. Hong Amphipols: polymeric surfactants for membrane biology research Cell. Mol. Life Sci. 60 2003 1559 1574 (Pubitemid 37041355)
-
(2003)
Cellular and Molecular Life Sciences
, vol.60
, Issue.8
, pp. 1559-1574
-
-
Popot, J.-L.1
Berry, E.A.2
Charvolin, D.3
Creuzenet, C.4
Ebel, C.5
Engelman, D.M.6
Flotenmeyer, M.7
Giusti, F.8
Gohon, Y.9
Herve, P.10
Hong, Q.11
Lakey, J.H.12
Leonard, K.13
Shuman, H.A.14
Timmins, P.15
Warschawski, D.E.16
Zito, F.17
Zoonens, M.18
Pucci, B.19
Tribet, C.20
more..
-
58
-
-
36248970132
-
2 adrenergic G-protein-coupled receptor
-
DOI 10.1038/nature06325, PII NATURE06325
-
S.G.F. Rasmussen, H.J. Choi, D.M. Rosenbaum, T.S. Kobilka, F.S. Thian, P.C. Edwards, M. Burghammer, V.R.P. Ratnala, R. Sanishvili, and R.F. Fischetti Crystal structure of the human β2 adrenergic G-protein-coupled receptor Nature 450 2007 383 387 (Pubitemid 350126755)
-
(2007)
Nature
, vol.450
, Issue.7168
, pp. 383-387
-
-
Rasmussen, S.G.F.1
Choi, H.-J.2
Rosenbaum, D.M.3
Kobilka, T.S.4
Thian, F.S.5
Edwards, P.C.6
Burghammer, M.7
Ratnala, V.R.P.8
Sanishvili, R.9
Fischetti, R.F.10
Schertler, G.F.X.11
Weis, W.I.12
Kobilka, B.K.13
-
59
-
-
80051658642
-
Crystal structure of the β2 adrenergic receptor-Gs protein complex
-
S.G.F. Rasmussen, B.T. DeVree, Y.Z. Zou, A.C. Kruse, K.Y. Chung, T.S. Kobilka, F.S. Thian, P.S. Chae, E. Pardon, and D. Calinski Crystal structure of the β2 adrenergic receptor-Gs protein complex Nature 477 2011 549 555
-
(2011)
Nature
, vol.477
, pp. 549-555
-
-
Rasmussen, S.G.F.1
Devree, B.T.2
Zou, Y.Z.3
Kruse, A.C.4
Chung, K.Y.5
Kobilka, T.S.6
Thian, F.S.7
Chae, P.S.8
Pardon, E.9
Calinski, D.10
-
60
-
-
36448978229
-
2-adrenergic receptor function
-
DOI 10.1126/science.1150609
-
D.M. Rosenbaum, V. Cherezov, M.A. Hanson, S.G.F. Rasmussen, F.S. Thian, T.S. Kobilka, H.J. Choi, X.J. Yao, W.I. Weis, R.C. Stevens, and B.K. Kobilka GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function Science 318 2007 1266 1273 (Pubitemid 350172885)
-
(2007)
Science
, vol.318
, Issue.5854
, pp. 1266-1273
-
-
Rosenbaum, D.M.1
Cherezov, V.2
Hanson, M.A.3
Rasmussen, S.G.F.4
Foon, S.T.5
Kobilka, T.S.6
Choi, H.-J.7
Yao, X.-J.8
Weis, W.I.9
Stevens, R.C.10
Kobilka, B.K.11
-
61
-
-
0034711953
-
The GxxxG motif: A framework for transmembrane helix-helix association
-
W.P. Russ, and D.M. Engelman The GxxxG motif: a framework for transmembrane helix-helix association J. Mol. Biol. 296 2000 911 919
-
(2000)
J. Mol. Biol.
, vol.296
, pp. 911-919
-
-
Russ, W.P.1
Engelman, D.M.2
-
63
-
-
79958003499
-
Computational protein design: Engineering molecular diversity, nonnatural enzymes, nonbiological cofactor complexes, and membrane proteins
-
J.G. Saven Computational protein design: engineering molecular diversity, nonnatural enzymes, nonbiological cofactor complexes, and membrane proteins Curr. Opin. Chem. Biol. 15 2011 452 457
-
(2011)
Curr. Opin. Chem. Biol.
, vol.15
, pp. 452-457
-
-
Saven, J.G.1
-
64
-
-
80052103199
-
Computational design of membrane proteins
-
A. Senes Computational design of membrane proteins Curr. Opin. Struct. Biol. 21 2011 460 466
-
(2011)
Curr. Opin. Struct. Biol.
, vol.21
, pp. 460-466
-
-
Senes, A.1
-
65
-
-
33846399142
-
z, a Depth-dependent Potential for Assessing the Energies of Insertion of Amino Acid Side-chains into Membranes: Derivation and Applications to Determining the Orientation of Transmembrane and Interfacial Helices
-
DOI 10.1016/j.jmb.2006.09.020, PII S0022283606012095
-
A. Senes, D.C. Chadi, P.B. Law, R.F.S. Walters, V. Nanda, and W.F. Degrado E(z), a depth-dependent potential for assessing the energies of insertion of amino acid side-chains into membranes: derivation and applications to determining the orientation of transmembrane and interfacial helices J. Mol. Biol. 366 2007 436 448 (Pubitemid 46136195)
-
(2007)
Journal of Molecular Biology
, vol.366
, Issue.2
, pp. 436-448
-
-
Senes, A.1
Chadi, D.C.2
Law, P.B.3
Walters, R.F.S.4
Nanda, V.5
DeGrado, W.F.6
-
67
-
-
38949158505
-
Conformational thermostabilization of the β1-adrenergic receptor in a detergent-resistant form
-
DOI 10.1073/pnas.0711253105
-
M.J. Serrano-Vega, F. Magnani, Y. Shibata, and C.G. Tate Conformational thermostabilization of the β1-adrenergic receptor in a detergent-resistant form Proc. Natl. Acad. Sci. USA 105 2008 877 882 (Pubitemid 351282049)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.3
, pp. 877-882
-
-
Serrano-Vega, M.J.1
Magnani, F.2
Shibata, Y.3
Tate, C.G.4
-
68
-
-
0027438090
-
A new approach to the design of stable proteins
-
E.I. Shakhnovich, and A.M. Gutin A new approach to the design of stable proteins Protein Eng. 6 1993 793 800 (Pubitemid 23347353)
-
(1993)
Protein Engineering
, vol.6
, Issue.8
, pp. 793-800
-
-
Shakhnovich, E.I.1
Gutin, A.M.2
-
69
-
-
67349173167
-
Thermostabilization of the neurotensin receptor NTS1
-
Y. Shibata, J.F. White, M.J. Serrano-Vega, F. Magnani, A.L. Aloia, R. Grisshammer, and C.G. Tate Thermostabilization of the neurotensin receptor NTS1 J. Mol. Biol. 390 2009 262 277
-
(2009)
J. Mol. Biol.
, vol.390
, pp. 262-277
-
-
Shibata, Y.1
White, J.F.2
Serrano-Vega, M.J.3
Magnani, F.4
Aloia, A.L.5
Grisshammer, R.6
Tate, C.G.7
-
70
-
-
79960070651
-
Structure of the human histamine H1 receptor complex with doxepin
-
T. Shimamura, M. Shiroishi, S. Weyand, H. Tsujimoto, G. Winter, V. Katritch, R. Abagyan, V. Cherezov, W. Liu, and G.W. Han Structure of the human histamine H1 receptor complex with doxepin Nature 475 2011 65 70
-
(2011)
Nature
, vol.475
, pp. 65-70
-
-
Shimamura, T.1
Shiroishi, M.2
Weyand, S.3
Tsujimoto, H.4
Winter, G.5
Katritch, V.6
Abagyan, R.7
Cherezov, V.8
Liu, W.9
Han, G.W.10
-
71
-
-
69549094069
-
Metal-binding dependent disruption of membranes by designed helices
-
R.S. Signarvic, and W.F. Degrado Metal-binding dependent disruption of membranes by designed helices J. Am. Chem. Soc. 131 2009 3377 3384
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 3377-3384
-
-
Signarvic, R.S.1
Degrado, W.F.2
-
72
-
-
1242274445
-
Computational design of water-soluble analogues of the potassium channel KcsA
-
DOI 10.1073/pnas.0306417101
-
A.M. Slovic, H. Kono, J.D. Lear, J.G. Saven, and W.F. DeGrado Computational design of water-soluble analogues of the potassium channel KcsA Proc. Natl. Acad. Sci. USA 101 2004 1828 1833 (Pubitemid 38228976)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.7
, pp. 1828-1833
-
-
Slovic, A.M.1
Kono, H.2
Lear, J.D.3
Saven, J.G.4
DeGrado, W.F.5
-
73
-
-
41649088047
-
Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework
-
M.S. Taylor, H.K. Fung, R. Rajgaria, M. Filizola, H. Weinstein, and C.A. Floudas Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework Biophys. J. 94 2008 2470 2481
-
(2008)
Biophys. J.
, vol.94
, pp. 2470-2481
-
-
Taylor, M.S.1
Fung, H.K.2
Rajgaria, R.3
Filizola, M.4
Weinstein, H.5
Floudas, C.A.6
-
74
-
-
0032720311
-
The role of position a in determining the stability and oligomerization state of α-helical coiled coils: 20 Amino acid stability coefficients in the hydrophobic core of proteins
-
K. Wagschal, B. Tripet, P. Lavigne, C. Mant, and R.S. Hodges The role of position a in determining the stability and oligomerization state of α-helical coiled coils: 20 amino acid stability coefficients in the hydrophobic core of proteins Protein Sci. 8 1999 2312 2329 (Pubitemid 29536397)
-
(1999)
Protein Science
, vol.8
, Issue.11
, pp. 2312-2329
-
-
Wagschal, K.1
Tripet, B.2
Lavigne, P.3
Mant, C.4
Hodges, R.S.5
-
75
-
-
0031954925
-
Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms
-
E. Wallin, and G. von Heijne Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms Protein Sci. 7 1998 1029 1038 (Pubitemid 28216544)
-
(1998)
Protein Science
, vol.7
, Issue.4
, pp. 1029-1038
-
-
Wallin, E.1
Von Heijne, G.2
-
77
-
-
47949129742
-
Structure of a β1-adrenergic G-protein-coupled receptor
-
T. Warne, M.J. Serrano-Vega, J.G. Baker, R. Moukhametzianov, P.C. Edwards, R. Henderson, A.G.W. Leslie, C.G. Tate, and G.F.X. Schertler Structure of a β1-adrenergic G-protein-coupled receptor Nature 454 2008 486 491
-
(2008)
Nature
, vol.454
, pp. 486-491
-
-
Warne, T.1
Serrano-Vega, M.J.2
Baker, J.G.3
Moukhametzianov, R.4
Edwards, P.C.5
Henderson, R.6
Leslie, A.G.W.7
Tate, C.G.8
Schertler, G.F.X.9
-
78
-
-
66249121383
-
Biophysical dissection of membrane proteins
-
S.H. White Biophysical dissection of membrane proteins Nature 459 2009 344 346
-
(2009)
Nature
, vol.459
, pp. 344-346
-
-
White, S.H.1
-
80
-
-
85027927015
-
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
-
B.L. Wu, E.Y.T. Chien, C.D. Mol, G. Fenalti, W. Liu, V. Katritch, R. Abagyan, A. Brooun, P. Wells, and F.C. Bi Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists Science 330 2010 1066 1071
-
(2010)
Science
, vol.330
, pp. 1066-1071
-
-
Wu, B.L.1
Chien, E.Y.T.2
Mol, C.D.3
Fenalti, G.4
Liu, W.5
Katritch, V.6
Abagyan, R.7
Brooun, A.8
Wells, P.9
Bi, F.C.10
-
81
-
-
10644297499
-
Computational methods for protein design and protein sequence variability: Biased Monte Carlo and replica exchange
-
X. Yang, and J.G. Saven Computational methods for protein design and protein sequence variability: biased Monte Carlo and replica exchange Chem. Phys. Lett. 401 2005 205 210
-
(2005)
Chem. Phys. Lett.
, vol.401
, pp. 205-210
-
-
Yang, X.1
Saven, J.G.2
-
82
-
-
33845995843
-
Activation of platelet αIIbβ3 by an exogenous peptide corresponding to the transmembrane domain of αIIb
-
DOI 10.1074/jbc.M605877200
-
IIb J. Biol. Chem. 281 2006 36732 36741 (Pubitemid 46042140)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.48
, pp. 36732-36741
-
-
Yin, H.1
Litvinov, R.I.2
Vilaire, G.3
Zhu, H.4
Li, W.5
Caputo, G.A.6
Moore, D.T.7
Lear, J.D.8
Weisel, J.W.9
DeGrado, W.F.10
Bennett, J.S.11
-
83
-
-
34147130190
-
Computational design of peptides that target transmembrane helices
-
DOI 10.1126/science.1136782
-
H. Yin, J.S. Slusky, B.W. Berger, R.S. Walters, G. Vilaire, R.I. Litvinov, J.D. Lear, G.A. Caputo, J.S. Bennett, and W.F. DeGrado Computational design of peptides that target transmembrane helices Science 315 2007 1817 1822 (Pubitemid 46580135)
-
(2007)
Science
, vol.315
, Issue.5820
, pp. 1817-1822
-
-
Yin, H.1
Slusky, J.S.2
Berger, B.W.3
Walters, R.S.4
Vilaire, G.5
Litvinov, R.I.6
Lear, J.D.7
Caputo, G.A.8
Bennett, J.S.9
DeGrado, W.F.10
-
84
-
-
0034495206
-
An improved tripod amphiphile for membrane protein solubilization
-
S.M. Yu, D.T. McQuade, M.A. Quinn, C.P.R. Hackenberger, M.P. Krebs, A.S. Polans, and S.H. Gellman An improved tripod amphiphile for membrane protein solubilization Protein Sci. 9 2000 2518 2527 (Pubitemid 32105734)
-
(2000)
Protein Science
, vol.9
, Issue.12
, pp. 2518-2527
-
-
Yu, S.M.1
McQuade, D.T.2
Quinn, M.A.3
Hackenberger, C.P.R.4
Krebs, M.P.5
Polans, A.S.6
Gellman, S.H.7
-
85
-
-
68849086734
-
Experimental and computational evaluation of forces directing the association of transmembrane helices
-
Y. Zhang, D.W. Kulp, J.D. Lear, and W.F. DeGrado Experimental and computational evaluation of forces directing the association of transmembrane helices J. Am. Chem. Soc. 131 2009 11341 11343
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 11341-11343
-
-
Zhang, Y.1
Kulp, D.W.2
Lear, J.D.3
Degrado, W.F.4
-
86
-
-
0007949690
-
Interhelical hydrogen bonding drives strong interactions in membrane proteins
-
DOI 10.1038/72430
-
F.X. Zhou, M.J. Cocco, W.P. Russ, A.T. Brunger, and D.M. Engelman Interhelical hydrogen bonding drives strong interactions in membrane proteins Nat. Struct. Biol. 7 2000 154 160 (Pubitemid 30082514)
-
(2000)
Nature Structural Biology
, vol.7
, Issue.2
, pp. 154-160
-
-
Zhou, F.X.1
Cocco, M.J.2
Russ, W.P.3
Brunger, A.T.4
Engelman, D.M.5
|