Influence of active site location on catalytic activity in de novo -designed zinc metalloenzymes

Journal of the American Chemical Society

Volumn 135, Issue 15, 2013, Pages 5895-5903

  Zastrow, Melissa L ^a   Pecoraro, Vincent L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC EFFICIENCIES; LOCATION DEPENDENTS; METAL BINDING AFFINITY; NATIVE ENZYMES; P-NITROPHENYL ACETATE; PROTEIN DYNAMICS; SECONDARY INTERACTIONS; SYSTEMATIC VARIATION;

BINDING ENERGY; EFFICIENCY; ENZYMES; HYDROGEN BONDS; METALS;

DESIGN;

METALLOPROTEIN; ZINC;

ARTICLE; BINDING AFFINITY; ENZYME ACTIVE SITE; HYDROGEN BOND; HYDROLYSIS; METAL BINDING;

AMINO ACID SEQUENCE; BIOCATALYSIS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; DRUG DESIGN; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY;

EID: 84876498577     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja401537t     Document Type: Article

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