Host-mimetic metabolomics of endophytes: Looking back into the future

Advances in Endophytic Research

Volumn , Issue , 2014, Pages 203-218

  Verma, Vijay Chandra ^a   Prakash, Satya ^a   Singh, Rana Gopal ^a   Gange, Alan Christopher ^b  

^a BANARAS HINDU UNIVERSITY   (India)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84919480108     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-81-322-1575-2_11     Document Type: Chapter

References (127)

1. Ahmed MS, Fong HH, Soejarto DD, Dobberstein RH, Waller DP, Moreno-Azorero RJ (1981) Highperformance liquid chromatographic separation and quantitation of maytansinoids in Maytenus ilicifolia. J Chromatogr 213:340-344
2. Aldhous P (1992) Neem chemicals: The pieces fall in place. Science 258:893
3. Alper H, Jin YS, Moxley JF, Stephanopoulos G (2005) Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli. Metab Eng 7:155-164
4. Andersson JO (2005) Lateral gene transfer in eukaryotes. Cell Mol Life Sci 62:1182-1197
5. Arnold AE, Maynord Z, Gilbert G, Coley PD, Kursar TA (2000) Are tropical fungal endophytes hyperdiverse? Ecol Lett 3:167-274
6. Asai M, Mizuta E, Izawa M, Haibara K, Kishi T (1978) Isolation, chemical characterization and structure of ansamitocin, a new antitumour antibiotic. Tetrahedron 35:1079-1085
7. Bae GS et al (2010) Inhibition of lipopolysaccharideinduced infl ammatory responses by piperine. Eur J Pharmacol 642:154-162
8. Bano G, Amla V, Raina RK, Zutshi U, Chopra CL (1987) The effect of piperine on pharmacokinetics of phenytoin in healthy volunteers. Planta Med 53:568-569
9. Bezerra DP et al (2008) In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine. J Appl Toxicol 28:156-163
10. Burdon JJ, Thrall PH (2009) Co-evolution of plants and their pathogens in natural habitats. Science 324:755-756
11. Butterworth JH, Morgan ED (1968) Isolation of a substance that suppresses feeding in locusts. J Chem Soc Chem Commun 1968:23-24
12. Butterworth JH, Morgan ED, Percy GR (1972) The structure of azadirachtin; the functional groups. J Chem Soc Perkin Trans 1:2445-2450
13. Cassady JM, Chan KK, Floss HG, Leistner E (2004) Recent developments in the maytansinoids antitumour agents. Chem Pharm Bull 52:1-26
14. Chandrashekhar RB, Jithan A, Narsimha RY, Malla RV (2008) Fabrication and investigations on hepatoprotective activity of sustained release biodegradable piperine microspheres. Int J Pharm Sci NanoTechnol 1:87-96
15. Chonpathompikunlert P, Wattanathorn J, Muchimapura S (2010) Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive defi cit like condition of Alzheimer's disease. Food Chem Toxicol 48:798-802
16. Dahiya JS, Woods DL, Tiwari JP (1988) Piperine from an Ulocladium sp. Phytochemistry 27:2366
17. DeJong JM, Liu Y, Bollon AP, Jennewein S, Williams D, Croteau R (2006) Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae. Biotechnol Bioeng 93:212-224
18. Devkumar C, Kumar R (2008) Total synthesis of azadirachtin: A chemical odyssey. Curr Sci 95:573-575
19. Dymowski W, Furmanowa M (1990) Investigating cytostatic substances in tissue of plants Maytenus molina in in vitro cultures. Chromatographic test of extracts from callus of Maytenus wallichiana. Acta Pol Pharm 47:51-54
20. Engels B, Dahm P, Jennewein S (2008) Metabolic engineering of taxadiene biosynthesis in yeast as a fi rst step towards Taxol (paclitaxel) production. Metab Eng 10:201-206
21. Eyberger AL, Dondapati R, Porter JR (2006) Endophyte fungal isolates from Podophyllum peltatum produce podophyllotoxin. J Nat Prod 69:1121-1124
22. Faeth SH, Hammon KE (1997) Fungal endophytes in oak tree; long term pattern of abundance and association with leaf miners. Ecology 78:810-819
23. Fu M, Sun ZH, Zuo HC (2010) Neuroprotective effect of piperine on primarily cultured hippocampal neurons. Biol Pharm Bull 33:598-603
24. Geylord ES, Preszler RW, Boecklen WJ (1996) Interactions between host plants, endophytic fungi, and a phytophagous insect in an Oak ( Quercus grisea × Q. gambelii ) hybrid zone. Oecologia 105:336-342
25. Govindachari TR, Sandhya G, Raj SPG (1992a) Azadirachtin H and I: Two new tetranortriterpenoid from Azadirachta indica. J Nat Prod 55:596-601
26. Govindachari TR, Sandhya G, Raj SPG (1992b) Structure of azadirachtin K, a new tetranortriterpenoid from Azadirachta indica. Indian J Chem Sect B 31:295-298
27. Govindachari TR, Gopalakrishnan G, Rajan SS, Kabaleeswaran V, Lessinger L (1996) Molecular and crystal structure of azadirachtin-H. Acta Crystallogr Sect B Struct Sci B52:145-150
28. Govindachari TR, Gopalakrishnan G, Suresh G (1997) Purifi cation of azadirachtin-B (3-tigloylazadirachtol) by preparative high performance liquid chromatography, using the recycling mode. J Liq Chromatogr Relat Technol 20:1633-1636
29. Gunatilaka AAL (2006) Natural products from plantassociated microorganisms: distribution, structural diversity, bioactivity and implications of their occurrence. J Nat Prod 69:509-526
30. Guo B, Wang Y, Sun X, Tang K (2008) Bioactive natural products from endophytes: A review. Appl Biochem Microbiol 44:136-142
31. Hans J, Hause B, Strack D, Walter MH (2004) Cloning characterization and immunolocalization of a mycorrhizal inducible 1-Deoxy-D-Xylulose 5-phosphate reductoisomerase in arbuscule containing cells of Maize. Plant Physiol 134:614-624
32. Higashide E, Asai M, Ootsu K, Tanida S, Kozay Y, Hasegawa T, Kishi T, Sugino Y, Yoneda M (1977) Ansamitocins, a group of novel maytansinoid antibiotics with anti-tumour properties from Nocardia. Nature 270:721-722
33. Hines PJ, Zahn LM (2009) What's bugging plants? Introduction to special issue. Science 324:741
34. Hu RQ, Davies JA (1997) Effects of Piper nigrum L. on epileptiform activity in cortical wedges prepared from DBA/2 mice. Phytother Res 11:222-225
35. Huang Q, Roessner CA, Croteau R, Scott AI (2001) Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of Taxol. Bioorg Med Chem 9:2237-2242
36. Isaacs J (1994) Bush food aboriginal food and herbal medicine. Lansdowne Publishing Pty. Ltd., Sydney
37. Jain R, Rivera MC, Moore JE, Lake JA (2003) Horizontal gene transfer accelerates genome innovation and evolution. Mol Biol Evol 20:1598-1602
38. Jarvis AP, Morgan ED, van der Esch SA, Vitali F, Lay SV, Pape A (1997) Identifi cation of azadirachtin in tissuecultured cells of neem ( A. indica ). Nat Prod Lett 10:95-98
39. Julsing MK, Koulman A, Woerdenbag HJ, Quax WJ, Kayser O (2006) Com-binatorial biosynthesis of medicinal plant secondary metabolites. Biomol Eng 23:265-279
40. Kalinowski HO, Ermel K, Schmutterer H (1993) Strukturaufklärung eines azadirachtin derivates aus dem Marrangobaum Azadirachta excelsa durch NMRspektroskopie. Liebigs Ann Chem 1993:1033-1035
41. Kanokmedhakul S, Kanokmedhakul K, Prajuabsuk T, Panichajakul S, Panyamee P, Prabpai S, Kongsaeree P (2005) Azadirachtin derivatives from seed kernels of Azadirachta excelsa. J Nat Prod 68:1047-1050
42. Karan RS, Bhargava VK, Garg SK (1988) Effect of piperine on the pharmacokinetic profi le of isoniazid in rabbits. Indian J Pharmacol 30:254-256
43. Kate KT, Laird SA (eds) (2000) The commercial use of biodiversity: Access to genetic resources and benefi t sharing. Earthscan Publications Ltd., London
44. Kayser O, Quax WJ (eds) (2007) Medicinal plant biotechnology: from basic research to industrial applications. Wiley-VCH Verlag Gmbh & Co. KGaA, Weinheim
45. Keeling PJ, Palmer JD (2008) Horizontal gene transfer in eukaryotic evolution. Nat Rev Genet 9:605-618
46. Ketchum RE, Croteau R (1998) Recent progress toward an understanding of taxol biosynthesis in plant cell cultures. In: Ageta H, Aimi N, Ebizuka Y, Fujita T, Honda G (eds) Towards natural medicine research in the 21st century. Proceeding of the international symposium on natural medicines. Elsevier, Amsterdam, pp 339-348
47. Ketchum RE, Gibson DM (1996) Paclitaxel production in suspension cell cultures of Taxus. Plant Cell Tissue Organ Cult 46:9-16
48. Khajuria A, Thusus N, Zutshi U, Bedi KL (1997) Antioxidant potential of piperine on oxidant induced alterations in rat intestinal lumen. Indian Drugs 34:557-563
49. Khosroushahi AY, Valizadeh M, Ghasempour A, Khosrowshahli M, Naghdibadi H, Dadpour MR, Omidi Y (2006) Improved taxol production by combination of inducing factors in suspension cell culture of Taxus baccata. Cell Biol Int 30:262-269
50. Klenk A, Bokel M, Kraus W (1986) 3-tigloylazadirachtol (tigloyl = 2-methyl crotonoyl), an insect growth regulating constituent of Azadirachta indica. J Chem Soc Chem Commun 7:523-524
51. Koepp AE, Hezari M, Zajicek J, Vogel BS, LaFever RE, Lewis NG, Croteau R (1995) Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacifi c yew. J Biol Chem 270:8686-8690
52. Koul IB, Kapil A (1993) Evaluation of the liver protective potential of piperine, an active principle of black and long peppers. Planta Med 59:413-417
53. Kraus H, Bokel M, Klank A, Pohnl H (1985) The structure of azadirachtin and 22, 23-dihydro-23?-methoxyazadirachtin. Tetrahedron Lett 26:6435-6438
54. Kraus W, Bokel M, Bruhn A, Cramer R, Klaiber I, Klenk A, Nagl G, Pohnl H, Sadlo H, Vogler B (1987) Structure determination by NMR of azadirachtin and related compounds from Azadirachta indica A. Juss. (Meliaceae). Tetrahedron 43:2817-2830
55. Kupchan SM, Komoda Y, Court WA, Thomas GJ, Smith RM, Karim A, Gilmore CJ, Haltiwanger RC, Bryan RF (1972) Maytansine, a novel antileukaemic ansa macrolide from Maytenus ovatus. J Am Chem Soc 94:1355-1356
56. Kusari S, Spiteller M (2011) Are we ready for industrial production of bioactive plant secondary metabolites utilizing endophytes? Nat Prod Rep 28:1203-1207
57. Kusari S, Verma VC, Lamshoft M, Spiteller M (2012) An endophytic fungus from Azadirachta indica A. Juss. That produces azadirachtin. World J Microbiol Biotechnol 28:1287-1294
58. Kutney JP, Beale MH, Salisbury PJ, Stuart KL, Worth BR, Townsley PM, Chalmers WT, Nilson K, Jacoli GG (1981) Isolation and characterization of natural products from plant tissue cultures of Maytenus buchananii. Phytochemistry 4:653-657
59. Lautru S, Deeth RJ, Bailey LM, Challis GL (2005) Discovery of a new pep-tide natural product by Streptomyces coelicolor genome mining. Nat Chem Biol 1:265-269
60. Lawrence JG, Roth JR (1996) Selfi sh operons: horizontal transfer may drive the evolution of gene clusters. Genetics 143:1843-1860
61. Lee EB, Shin KH, Woo WS (1984) Pharmacological study on piperine. Arch Pharmacal Res 7:127-132
62. Ley SV (1994) Synthesis and the chemistry of the insect antifeedant azadirachtin. Pure Appl Chem 66:2099-2102
63. Ley SV, Denholm AA, Wood A (1993) The chemistry of azadirachtin. Nat Prod Rep 10:109-157
64. Li SM, Unsold IA (2006) Post-genome research on the biosynthesis of ergot alkaloids. Planta Med 72:1117-1120
65. Li S, Wang C, Wang M, Li W, Matsumoto K, Tang Y (2007) Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sci 80:1373-1381
66. Li YC, Tao WY, Cheng L (2009) Paclitaxel production using co-culture of Taxus suspension cells and paclitaxel-producing endophytic fungi in a cobioreactor. Appl Microbiol Biotechnol 83:233-239
67. Lindahl AL, Olsson ME, Mercke P, Tollbom O, Schelin J, Brodelius M, Brodelius PE (2006) Production of the artemisin in precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae. Biotechnol Lett 28:571-580
68. Luo X, Ma Y, Wu S, Wu D (1999) Two novel azadirachtin derivatives from Azadirachta indica. J Nat Prod 62:1022-1024
69. Mordue AJ, Nisbet AJ (2000) Azadirachtin from the neem tree Azadirachta indica : its action against insects. An Soc Entomol Bras 29:615-632
70. Mordue AJ, Simmonds MSJ, Ley SV, Blaney WM, Nasiruddin M, Nisbet AJ (1998) Actions of azadirachtin, a plant allelochemical against insects. Pestic Sci 54:277-284
71. Morgan ED (2009) Azadirachtin: A scientifi c goldmine. Bioorg Med Chem 17:4096-4105
72. Naill MC, Roberts SC (2005) Cell cycle analysis of Taxus suspension cultures at the single cell level as an indicator of culture heterogeneity. Biotechnol Bioeng 90: 491-500
73. Nims E, Dubois CP, Roberts SC, Walker EL (2006) Expression profi ling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering. Metab Eng 8:385-394
74. Petrini O, Sieber TN, Toti L, Viret O (1992) Ecology, metabolite production, and substrate utilization in endophytic fungi. Nat Toxins 1:185-196
75. Pie YQ (1983) A review of pharmacology and clinical use of piperine and its derivatives. Epilepsia 24:177-183
76. Powel RG, Weisleder D, Smith CR, Kozlowski J, Rohwedder WK (1982) Trefl orine, trenudine, and N-methyltrenudone: novel maytansinoids tumour inhibitors containing two fused macrocyclic rings. J Am Chem Soc 104:4929-4934
77. Prakash UN, Srinivasan K (2010) Gastrointestinal protective effect of dietary spices during ethanol-induced oxidant stress in experimental rats. Appl Physiol Nutr Metab 35:134-141
78. Prakash G, Bhojwani SS, Shrivastava AK (2002) Production of azadirachtin from tissue culture: state of the art and future prospects. Biotechnol Bioprocess Eng 7:185-193
79. Pullen CB, Schmitz P, Hoffmann D, Meurer K, Boettcher T, von Bamberg D, Pereira AM, de Castro França S, Hauser M, Geertsema H, van Wyk A, Mahmud T, Floss HG, Leistner E (2003) Occurrence and nondetectability of maytansinoids in individual plants of the genera Maytenus and Putterlickia. Phytochemistry 62:377-387
80. Puri SC, Verma V, Amna T, Qazi GN, Spiteller M (2005) An endophytic fungus from Nothapodytes foetida that produces camptothecin. J Nat Prod 68: 1717-1719
81. Puri SC, Nazir A, Chawla R, Arora R, Riyaz-ulHasan S, Amna T, Ahmed B, Verma V, Singh S, Sagar R, Sharma A, Kumar R, Sharma RK, Qazi GN (2006) The endophytic fungus Trametes hirsuta as a novel alternative source of podophyllotoxin and related aryl tetralin lignans. J Biotechnol 122:494-510
82. Rafi q M, Dahot M (2010) Callus and azadirachtin related limnoids production through in vitro culture of neem ( Azadirachta indica A. Juss). Afr J Biotechnol 9:449-453
83. Ramaji N, Venkatakrishnan K, Madyastha KM (1996) 11-Epi-azadirachtin H from Azadirachta indica. Phytochemistry 42:561-562
84. Rambold H (1988) Isomeric azadirachtin and their mode of action. In: Jacobson J (ed) Focus on phytochemical pesticides, vol 1, The neem tree. CRC Press, London
85. Rembold H, Forster H, Sonnenbichler (1987) Z.Z. Naturforsch C, 42: 4-6
86. Rinehart KL, Shield LS (1976) Chemistry of the ansamycin antibiotics. In: Herz W, Grisebach H, Kirby GW (eds) Progress in the chemistry of organic natural products. Springer, New York, pp 232-300
87. Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J, Chang MC, Withers ST, Shiba Y, Sarpong R, Keasling JD (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440:940-943
88. Rosewich UL, Kistler HC (2000) Role of horizontal gene transfer in the evolution of fungi. Ann Rev Phytopathol 38:325-363
89. Saikkonen K, Faeth SH, Helander ML, Sullivan TJ (1998) Fungal endophytes: A continuum of interactions with host plants. Ann Rev Ecol Syst 29:319-343
90. Satdive RK, Fulzele DP, Eapen S (2007) Enhanced production of azadirachtin by hairy root cultures of Azadirachta indica A Juss. by elicitation and media optimization. J Biotechnol 128:281-289
91. Schloss PD, Handelsman J (2005) Metagenomics for studying unculturable microorganisms: cutting the Gordian knot. Genome Biol 6:229-233
92. Schmeer H, Jennewein S (2009) Bioorganic synthesis of the key taxoid pre-cursor taxa-4(5),11(12)-diene using a one-pot, two enzyme catalyzed re-actions. Enzyme Engineering XX, Groningen, the Netherlands
93. Schmidt EW, Nelson JT, Rasko DA, Sudek S, Eisen JA, Haygood MG, Ravel J (2005) Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni , the cyanobacterial symbiont of Lissoclinum patella. Proc Nat Acad Sci USA 102:7315-7320
94. Shweta S, Zühlke S, Ramesha BT, Priti V, Kumar PM, Ravikanth G, Spiteller M, Vasudeva R, Shaanker RU (2010) Endophytic fungal strains of Fusarium solani , from Apodytes dimidiate E. Mey. ex Arn (Icacinaceae) produce camptothecin, 10-hydroxycamptothecin and 9-methoxycamptothecin. Phytochemistry 71:117-122
95. Soliman SSM, Tsao R, Raizada MN (2011) Chemical inhibitors suggests endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonatelike pathways. J Nat Prod 74:2497-2504
96. Srinivasan K (2007) Black pepper and its pungent principle-piperine: A review of diverse physiological effects. Crit Rev Food Sci Nutr 47:735-748
97. Staniek A, Woerdenbag HJ, Kayser O (2008) Endophytes: exploiting biodiversity for the improvement of natural product-based drug discovery. J Plant Interact 3:75-93
98. Staniek A, Woerdenbag HJ, Kayser O (2009) Taxomyces andreanae : A presumed paclitaxel producer demystifi ed? Planta Med 75:1561-1566
99. Stephanopoulos G, Alper H, Moxley J (2004) Exploiting biological complexity for strain improvement through systems biology. Nat Biotechnol 22:1261-1267
100. Stierle A, Strobel GA, Stierle D (1993) Taxol and taxane production by Taxomyces andreanae , an endophytic fungus of Pacifi c yew. Science 260:214-216
101. Strobel GA (2002) Microbial gifts from the rain forest. Can J Plant Pathol 24:14-20
102. Strobel GA, Daisy B, Castillo U, Harper J (2004) Natural products from endophytic fungi. J Nat Prod 67:257-268
103. Takumi I, Mizuho I, Siho T, Yuzi I, Hideyuki Y (2008) Piperine, a pepper ingredient, improves the hepatic increase in free fatty acids caused by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. J Health Sci 54:551-558
104. Tan RX, Zou WX (2001) Endophytes: A rich source of functional metabolites. Nat Prod Rep 18:448-459
105. Timmers L (1994) Herbal medicines used against epilepsy in developing countries; Publication Number PUG/94-4. Publicaties Wetenschapswinkel Geneesmiddelen, Vrouwen
106. Tyo KE, Alper HS, Stephanopoulos GN (2007) Expanding the metabolic engineering toolbox: more options to engineer cells. Trends Biotechnol 25:132-137
107. Veitch GE, Beckmann E, Burke BJ, Boyer A, Ayats C, Ley SV (2007a) A relay route for the synthesis of azadirachtin. Angew Chem Int Ed 46:7633-7635
108. Veitch GE, Beckmann E, Burke BJ, Boyer A, Ayats C, Ley SV (2007b) Synthesis of azadirachtin: A long but successful journey. Angew Chem Int Ed 46:7629-7632
109. Veitch GE, Boyer A, Ley SV (2008) The azadirachtin story. Angew Chem Int Ed 47:9402-9429
110. Verma VC, Kharwar RN, Strobel GA (2009) Chemical and functional diversity of natural products from plant associated endophytic fungi. Nat Prod Commun 4:1511-1532
111. Verma VC, Lobkovsky E, Gange AC, Singh SK, Prakash S (2011) Piperine production by endophytic Periconia sp. isolated from Piper longum L. J Antibiot 64: 427-431
112. Vongpaseuth K, Roberts SC (2007) Advancements in the understanding of paclitaxel metabolism in tissue culture. Curr Pharm Biotechnol 8:219-236
113. Walker K, Croteau R (2001) Taxol biosynthetic genes. Phytochemistry 58:1-7
114. Walker K, Long R, Croteau R (2002) The fi nal acylation step in taxol biosynthesis: cloning of the taxoid C13-side chain N-benzoyltransferase from Taxus. Proc Nat Acad Sci USA 99:9166-9171
115. Wani MC, Taylor HL, Wall ME (1973) Plant antitumour agents: colubrinol acetate and colubrinol, antileukaemic ansa macrolides from Colubrina texensis. J Chem Soc Chem Commun 1973:390
116. Wenzel SC, Gross F, Zhang Y, Fu J, Stewart F, Müller R (2005) Heterologous expression of a myxobacterial natural products assembly line in Pseudomonads via Red/ET recombineering. Chem Biol 12:349-356
117. Weuster-Botzl D, Hekmat D, Puskeiler R, Franco-Lara E (2007) Enabling technologies: fermentation and downstream processing. Adv Biochem Eng Biotechnol 105:205-247
118. Wildung MR, Croteau R (1996) A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis. J Biol Chem 271:9201-9204
119. Wu J, Lin L (2003) Enhancement of taxol production and release in Taxus chinensis cell cultures by ultrasound, methyl jasmonate and in situsol-vent extraction. Appl Microbiol Biotechnol 62:151-155
120. Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG (2002) The biosynthetic gene cluster of the maytansinoid antitumour agent ansamitocin from Actinosynnema pretiosum. Proc Nat Acad Sci USA 99:7968-7973
121. Yukimune Y, Hara Y, Nomura E, Seto H, Yoshida S (2000) The confi guration of methyl jasmonate affects paclitaxel and baccatin III production in Taxus cells. Phytochemistry 54:13-17
122. Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM (2003) A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nat Biotechnol 21:187-190
123. Zengler K, Walcher M, Clark G, Haller I, Toledo G, Holland T, Mathur EJ, Woodnutt G, Short J, Keller M (2005) High-throughput cultivation of microorganisms using microcapsules. Method Enzymol 397:124-130
124. Zhang P, Zhou P, Jiang C, Yu H, Yu LJ (2008) Screening of taxol-producing fungi based on PCR amplifi cation from Taxus. Biotechnol Lett 30:2119-2123
125. Zhao J, Shan T, Mou Y, Zhao L (2011) Plant derived bioactive compounds produced by endophytic fungi. Mini Rev Med Chem 11:159-168
126. Zhou X, Wang Z, Jiang K, Wei Y, Lin J, Sun X, Tang K (2007) Screening of taxol-producing endophytic fungi from Taxus chinensis var. mairei. Prikl Biokhim Mikrobiol 43:490-494
127. Zutshi RK, Singh R, Zutshi U, Johri RK, Atal CK (1985) Infl uence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis. J Assoc Phys India 33:223-224