Activation of phenylalanine hydroxylase by phenylalanine does not require binding in the active site

Biochemistry

Volumn 53, Issue 49, 2014, Pages 7846-7853

  Roberts, Kenneth M ^a   Khan, Crystal A ^a   Hinck, Cynthia S ^a   Fitzpatrick, Paul F ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; CHEMICAL ACTIVATION; EMISSION SPECTROSCOPY; ENZYMES; HORMONES; RATE CONSTANTS;

ALLOSTERIC SITE; CATALYTIC DOMAINS; CHEMICAL EQUATIONS; INHIBITORY PEPTIDES; PHENYLALANINE HYDROXYLASE; REGULATORY DOMAIN; TRYPTOPHAN FLUORESCENCE; WILD-TYPE ENZYMES;

AMINO ACIDS;

ADRENALIN; ARGININE; DOPAMINE; IRON; LYSINE; MUTANT PROTEIN; NORADRENALIN; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; TRYPTOPHAN; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; FLUORESCENCE IMAGING; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; AGONISTS; ALLOSTERISM; AMINO ACID SUBSTITUTION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; KINETICS; METABOLISM; PROTEIN CONFORMATION; RAT; SITE DIRECTED MUTAGENESIS; SPECTROFLUOROMETRY;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; CATALYTIC DOMAIN; ENZYME ACTIVATION; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PHENYLALANINE; PHENYLALANINE HYDROXYLASE; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; RATS; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE;

EID: 84918557920     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi501183x     Document Type: Article

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