Pulsed EPR study of amino acid and tetrahydropterin binding in a tyrosine hydroxylase nitric oxide complex: Evidence for substrate rearrangements in the formation of the oxygen-reactive complex

Biochemistry

Volumn 52, Issue 47, 2013, Pages 8430-8441

  Krzyaniak, Matthew D ^a,d   Eser, Bekir E ^b   Ellis, Holly R ^b,e   Fitzpatrick, Paul F ^c   McCracken, John ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d UNIVERSITY OF ALABAMA   (United States)

^e AUBURN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; CRYSTALLOGRAPHIC STUDIES; DIHYDROXYPHENYLALANINE; NON-HEME IRON ENZYMES; PARAMAGNETIC CENTERS; PHENYLALANINE HYDROXYLASE; QUATERNARY COMPLEXES; TYROSINE HYDROXYLASE;

BIOCHEMISTRY; CATALYSIS; DEUTERIUM; ENZYMES; IRON COMPOUNDS; NITRIC OXIDE; SUBSTRATES; X RAY CRYSTALLOGRAPHY;

AMINO ACIDS;

6 METHYLTETRAHYDROPTERIN; AMINO ACID; DEUTERIUM; ENZYME VARIANT; NITRIC OXIDE; OXYGEN; PHENYLALANINE 4 MONOOXYGENASE; TYROSINE; TYROSINE 3 MONOOXYGENASE;

ARTICLE; BINDING KINETICS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; MAGNETIC FIELD; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; APOENZYMES; BIOCATALYSIS; CATALYTIC DOMAIN; DEUTERIUM; ELECTRON SPIN RESONANCE SPECTROSCOPY; FERROUS COMPOUNDS; HUMANS; HYDROXYLATION; IRON; MOLECULAR CONFORMATION; MUTANT PROTEINS; NERVE TISSUE PROTEINS; NITRIC OXIDE; OXIDATION-REDUCTION; PROTEIN BINDING; PTERINS; QUATERNARY AMMONIUM COMPOUNDS; RECOMBINANT PROTEINS; TYROSINE; TYROSINE 3-MONOOXYGENASE;

EID: 84888585744     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4010914     Document Type: Article

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