Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis

Journal of Biological Chemistry

Volumn 289, Issue 33, 2014, Pages 22835-22849

  Ilyas, Sumera I ^a   Mertens, Joachim C ^b   Bronk, Steven F ^a   Hirsova, Petra ^a   Dai, Haiming ^a   Roberts, Lewis R ^a   Kaufmann, Scott H ^a   Gores, Gregory J ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL DEATH; CHEMICAL ACTIVATION; DISEASES; ISOMERS; MACROPHAGES; PLANTS (BOTANY); PLATELETS; TUMORS;

APOPTOTIC; CELL-BE; CELL/B.E; CELL/BE; CHOLANGIOCARCINOMA; HUMAN SPECIMENS; MIMETICS; MYOFIBROBLASTS; PLATELET-DERIVED GROWTH FACTORS; SENSITISATION;

FIBROBLASTS;

PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR D; PROTEIN BAK; PROTEIN BCL 2; PUMA PROTEIN; SHORT HAIRPIN RNA; 4-(4-((2-(4-CHLOROPHENYL)-4,4-DIMETHYLCYCLOHEX-1-EN-1-YL)METHYL)PIPERAZIN-1-YL)-N-((3-NITRO-4-((TETRAHYDRO-2H-PYRAN-4-YLMETHYL)AMINO)PHENYL)SULFONYL)-2-(1H-PYRROLO(2,3-B)PYRIDIN-5-YLOXY)BENZAMIDE; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; BAK1 PROTEIN, HUMAN; BAX PROTEIN (53-86); FUSED HETEROCYCLIC RINGS; NAVITOCLAX; ONCOPROTEIN; PEPTIDE FRAGMENT; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER ASSOCIATED FIBROBLAST; CELL ACTIVATION; CELL FUNCTION; CELL LEVEL; CHOLANGIOCARCINOMA CELL LINE; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; BILE DUCT NEOPLASMS; CELL LINE; CHOLANGIOCARCINOMA; GENETICS; METABOLISM; PATHOLOGY;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BICYCLO COMPOUNDS, HETEROCYCLIC; BILE DUCT NEOPLASMS; CELL LINE; CHOLANGIOCARCINOMA; FIBROBLASTS; HUMANS; PEPTIDE FRAGMENTS; PLATELET-DERIVED GROWTH FACTOR; PROTO-ONCOGENE PROTEINS; SULFONAMIDES;

EID: 84905993872     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.563064     Document Type: Article

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