Altered expression of β-catenin without genetic mutation in intrahepatic cholangiocarcinoma

Modern Pathology

Volumn 14, Issue 9, 2001, Pages 900-905

  Sugimachi, Keishi ^a   Taguchi, Ken Ichi ^a   Aishima, Shin Ichi ^a   Tanaka, Shinji ^a   Shimada, Mitsuo ^a   Kajiyama, Kiyoshi ^a   Sugimachi, Keizo ^a   Tsuneyoshi, Masazumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

catenin; Cell to cell adhesion; Direct sequence; Immunohistochemistry; Intrahepatic cholangiocarcinoma (ICC); Nuclear translocation; PCR SSCP

Indexed keywords

BETA CATENIN; UVOMORULIN;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CANCER GROWTH; CARCINOGENESIS; CELL ADHESION; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; EXON; FEMALE; GENE EXPRESSION; GENE MUTATION; GENE TRANSLOCATION; GENETIC ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AGED; BASE SEQUENCE; BETA CATENIN; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CHOLANGIOCARCINOMA; CYTOSKELETAL PROTEINS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; EXONS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; TRANS-ACTIVATORS;

EID: 0034835564     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1038/modpathol.3880409     Document Type: Article

References (30)

1. Primary liver cancer in Japan. Clinicopathologic features and results of surgical treatment
2. The significance of stromal desmoplasia in intrahepatic cholangiocarcinoma: A special reference of "scirrhous-type" and "nonscirrhous-type" growth
3. The role of beta-catenin in cell adhesion, signal transduction, and cancer
4. Cadherin-catenin complex: Protein interactions and their implications for cadherin function
5. The oncogenic activation of beta-catenin
6. Functional interaction of beta-catenin with the transcription factor LEF-1
7. Identification of c-MYC as a target of the APC pathway
8. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
9. The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal turnouts
10. Beta-catenin is a target for the ubiquitin-proteasome pathway
11. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
12. Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer
13. Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas
14. Activation of the β-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3
15. β-catenin mutations in human prostate cancer
16. Frequent nuclear/cytoplasmic localization of β-catenin without exon 3 mutations in malignant melanoma
17. Beta-catenin expression pattern in stage I and II ovarian carcinomas: Relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome
18. Prognostic value of the preserved expression of the E-cadherin and catenin families of adhesion molecules and of beta-catenin mutations in synovial sarcoma
19. Expression of E-cadherin, alpha-catenin, beta-catenin, and CD44 (standard and variant isoforms) in human cholangiocarcinoma: An immunohistochemical study
20. β -Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression
21. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals
22. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
23. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
24. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers
25. Dominant negative inhibition of the association between β-catenin and c-erbB-2 by N-terminally deleted β-catenin suppresses the invasion and metastasis of cancer cells
26. Clinicopathologic features of the intraductal growth type of peripheral cholangiocarcinoma
27. Evidence for the involvement of the Wnt 2 gene in human colorectal cancer
28. Wnt signaling in oncogenesis and embryogenesis, a look outside the nucleus
29. Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma