Alpha-momorcharin (α-MMC) exerts effective anti-human breast tumor activities but has a narrow therapeutic window in vivo

Fitoterapia

Volumn 100, Issue , 2015, Pages 139-149

  Cao, Dongliang ^a   Sun, Yun ^a   Wang, Ling ^a   He, Qianchuan ^b   Zheng, Juecun ^a   Deng, Fei ^a   Deng, Shanshan ^a   Chang, Shuching ^b   Yu, Xiaoping ^a   Li, Minhui ^a   Meng, Yao ^a   Jin, Jiagui ^a   Shen, Fubing ^a  

^a CHENGDU MEDICAL COLLEGE   (China)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Alpha momorcharin; Apoptosis; Human breast tumor; Ribosome inactivating protein; Therapeutic window

Indexed keywords

ALPHA MOMORCHARIN; ANTINEOPLASTIC AGENT; CASPASE 3; PLANT EXTRACT; UNCLASSIFIED DRUG; MMC PROTEIN, MOMORDICA CHARANTIA; RIBOSOME INACTIVATING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; MCF 7 CELL LINE; MOUSE; NONHUMAN; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; BREAST TUMOR; CELL CYCLE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; MOMORDICA CHARANTIA; NUDE MOUSE; PATHOLOGY; PLANT SEED; TOXICITY TESTING; TUMOR CELL LINE;

MOMORDICA CHARANTIA; MUS; MUS MUSCULUS;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; FEMALE; HUMANS; MICE, INBRED BALB C; MICE, NUDE; MOMORDICA CHARANTIA; RIBOSOME INACTIVATING PROTEINS; SEEDS; TOXICITY TESTS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84918513826     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2014.11.009     Document Type: Article

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