Trichosanthin down-regulates Notch signaling and inhibits proliferation of the nasopharyngeal carcinoma cell line CNE2 in vitro

Fitoterapia

Volumn 83, Issue 5, 2012, Pages 838-842

  Liu, Fenye ^a   Wang, Bing ^b   Wang, Zhixue ^a   Yu, Shudong ^c  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b Jinan Municipal Hospital of traditional Chinese Medicine   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

Nasopharyngeal carcinoma; Notch signaling; Trichosanthin

Indexed keywords

NOTCH RECEPTOR; TRICHOSANTHIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; COLONY FORMATION; DOWN REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; HUMANS; NASOPHARYNGEAL NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; SIGNAL TRANSDUCTION; TRICHOSANTHES; TRICHOSANTHIN;

EID: 84861581996     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2012.02.011     Document Type: Article

References (35)

1. Q. Tao, and A.T. Chan Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments Expert Rev Mol Med 9 2007 1 24
2. W.I. Wei, and J.S. Sham Nasopharyngeal carcinoma Lancet 365 2005 2041 2054
3. K.R. Wei, Y.L. Yu, Y.Y. Yang, M.F. Ji, B.H. Yu, and Z.H. Liang Epidemiological trends of nasopharyngeal carcinoma in China Asian Pac J Cancer Prev 11 2010 29 32
4. H. Jiang, D. Fan, G. Zhou, X. Li, H. Deng, and L. Zhen Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo J Exp Clin Cancer Res 29 2010 34
5. P.C. Shaw, K.M. Lee, and K.B. Wong Recent advances in trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties Toxicon 45 2005 683 689
6. F. Li, Y. Mei, Y. Wang, C. Chen, J. Tu, and B. Xiao Trichosanthin inhibits antigen-specific T cell expansion through nitric oxide-mediated apoptosis pathway Cell Immunol 234 2005 23 30
7. D.J. Li, J.X. Bei, S.J. Mai, J.F. Xu, L.Z. Chen, and R.H. Zhang The dominance of China 1 in the spectrum of Epstein-Barr virus strains from Cantonese patients with nasopharyngeal carcinoma J Med Virol 81 2009 1253 1260
8. W.Z. Shen, O. Sha, D.T. Yew, and W.H. Kwong Retrograde transport of a traditional Chinese medicine, alpha-trichosanthin, and its selective neural toxicity Clin Toxicol (Phila) 47 2009 876 883
9. M. Wang, J.T. Li, Y.X. Zeng, J.H. Hou, and Q.Q. Lin Expression and significance of Notch1, P21WAF1 and involucrin in nasopharyngeal carcinoma Ai Zheng 24 2005 1230 1234
10. Y. Zhang, J. Peng, H. Zhang, Y. Zhu, L. Wan, and J. Chen Notch1 signaling is activated in cells expressing embryonic stem cell proteins in human primary nasopharyngeal carcinoma J Otolaryngol Head Neck Surg 39 2010 157 166
11. Q. Huang, Y. Li, and X. Lin A survival analysis of nasopharyngeal carcinoma from 1995 to 2004 in Sihui, Guangdong Bull Chin Cancer 2007 150 151
12. D.T. Chua, J. Ma, J.S. Sham, H.Q. Mai, D.T. Choy, and M.H. Hong Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: a pooled data analysis of two phase III trials J Clin Oncol 23 2005 1118 1124
13. J. Zhao, L.H. Ben, Y.L. Wu, W. Hu, K. Ling, and S.M. Xin Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors J Exp Med 190 1999 101 111
14. M. Li, X. Li, and J.C. Li Possible mechanisms of trichosanthin-induced apoptosis of tumor cells Anat Rec (Hoboken) 293 2010 986 992
15. X. Xia, F. Hou, J. Li, Y. Ke, and H. Nie Two novel proteins bind specifically to trichosanthin on choriocarcinoma cell membrane J Biochem 139 2006 725 731
16. Y.T. Zheng, W.F. Zhang, K.L. Ben, and J.H. Wang In vitro immunotoxicity and cytotoxicity of trichosanthin against human normal immunocytes and leukemia-lymphoma cells Immunopharmacol Immunotoxicol 17 1995 69 79
17. J. Xu, D.F. Gao, G.L. Yan, and J.M. Fan Induced apoptotic action of recombinant trichosanthin in human stomach adenocarcinoma MCG803 cells Mol Biol Rep 36 2009 1559 1564
18. P. Wang, L.L. Chen, H. Yan, and J.C. Li Trichosanthin suppresses HeLa cell proliferation through inhibition of the PKC/MAPK signaling pathway Cell Biol Toxicol 25 2009 479 488
19. M. Li, F. Chen, C.P. Liu, D.M. Li, X. Li, and C. Wang Dexamethasone enhances trichosanthin-induced apoptosis in the HepG2 hepatoma cell line Life Sci 86 2010 10 16
20. Y. Cai, S. Xiong, Y. Zheng, F. Luo, P. Jiang, and Y. Chu Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancermodel by boosting the interaction between TSLC1 and CRTAM Cell Mol Immunol 8 2011 359 367
21. J. Liu The investigation on the development of trichosanthin and its therapeutic effects Shanghai Med Inf Res 78 2005 6 9
22. A.K. Lo, K.W. Lo, S.W. Tsao, H.L. Wong, J.W. Hui, and K.F. To Epstein-Barr virus infection alters cellular signal cascades in human nasopharyngeal epithelial cells Neoplasia 8 2006 173 180
23. A. Masmoudi, N. Toumi, A. Khanfir, L. Kallel-Slimi, J. Daoud, and H. Karray Epstein-Barr virus-targeted immunotherapy for nasopharyngeal carcinoma Cancer Treat Rev 33 2007 499 505
24. N. Raab-Traub Epstein-Barr virus in the pathogenesis of NPC Semin Cancer Biol 12 2002 431 441
25. L.S. Young, and P.G. Murray Epstein-Barr virus and oncogenesis: from latent genes to tumours Oncogene 22 2003 5108 5121
26. L.J. Anderson, and R. Longnecker An auto-regulatory loop for EBV LMP2A involves activation of Notch Virology 371 2008 257 266
27. L.J. Anderson, and R. Longnecker Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo Blood 113 2009 108 116
28. M.F. Pang, K.W. Lin, and S.C. Peh The signaling pathways of Epstein-Barr virus-encoded latent membrane protein 2A (LMP2A) in latency and cancer Cell Mol Biol Lett 14 2009 222 247
29. J.H. Wang, H.L. Nie, S.C. Tam, H. Huang, and Y.T. Zheng Anti-HIV-1 property of trichosanthin correlates with its ribosome inactivating activity FEBS Lett 531 2002 295 298
30. J. Zhao, L.H. Ben, Y.L. Wu, W. Hu, K. Ling, S.M. Xin, H.L. Nie, L. Ma, and G. Pei Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors J Exp Med 190 1999 101 111
31. D.X. He, and S.C. Tam Trichosanthin affects HSV-1 replication in Hep-2 cells Biochem Biophys Res Commun 402 2010 670 675
32. T. Akihisa, H. Tokuda, E. Ichiishi, T. Mukainaka, M. Toriumi, M. Ukiya, K. Yasukawa, and H. Nishino Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines Cancer Lett 173 2001 9 14
33. P. Wang, H. Yan, and J.C. Li CREB-mediated Bcl-2 expression in trichosanthin-induced Hela cell apoptosis Biochem Biophys Res Commun 363 2007 101 105
34. J. Li, X. Xia, Y. Ke, H. Nie, M.A. Smith, and X. Zhu Trichosanthin induced apoptosis in HL-60 cells via mitochondrial and endoplasmic reticulum stress signaling pathways Biochim Biophys Acta 1770 2007 1169 1180
35. H. Huang, H. Chan, Y.Y. Wang, D.Y. Ouyang, Y.T. Zheng, and S.C. Tam Trichosanthin suppresses the elevation of p38 MAPK, and Bcl-2 induced by HSV-1 infection in Vero cells Life Sci 79 2006 1287 1292