PEGylation is effective in reducing immunogenicity, immunotoxicity, and hepatotoxicity of α-momorcharin in vivo

Immunopharmacology and Immunotoxicology

Volumn 34, Issue 5, 2012, Pages 866-873

  Zheng, Jue Cun ^a,e   Lei, Ning ^b   He, Qian Chuan ^c   Hu, Wei ^d   Jin, Ja Gui ^e   Meng, Yao ^e   Deng, Nian Hua ^e   Meng, Yan Fa ^a   Zhang, Chong Jie ^a   Shen, Fu Bing ^e  

^a SICHUAN UNIVERSITY   (China)

^b CHENGDU UNIVERSITY OF TECHNOLOGY   (China)

^c IL   (United States)

^d WUHAN UNIVERSITY   (China)

^e CHENGDU MEDICAL COLLEGE   (China)

Author keywords

MMC; MMC PEG; Hepatotoxicity; Immunogenicity; Immunotoxicity

Indexed keywords

ALBUMIN; ANTIVIRUS AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; GLOBULIN; IMMUNOGLOBULIN G; PEGYLATED ALPHA MOMORCHARIN; UNCLASSIFIED DRUG;

ANAPHYLACTIC SHOCK; ANAPHYLAXIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; BLOOD CHEMISTRY; CONTROLLED STUDY; DRUG PURIFICATION; FEMALE; GUINEA PIG; IMMUNOGENICITY; IMMUNOTOXICITY; IN VIVO STUDY; LEUKOCYTE COUNT; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; MALE; MICROSCOPY; MOMORDICA CHARANTIA; NONHUMAN; PASSIVE SKIN ANAPHYLAXIS; PRIORITY JOURNAL; RAT; WEIGHT CHANGE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG-INDUCED LIVER INJURY; GUINEA PIGS; HEPATOCYTES; IMMUNOGLOBULIN G; NECROSIS; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOME INACTIVATING PROTEINS;

ANIMALIA; CAVIA; CUCUMIS; MOMORDICA CHARANTIA; RATTUS;

EID: 84866248440     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2012.666979     Document Type: Article

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