Preferential cytotoxicity of the type i ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia

Biochemical Pharmacology

Volumn 89, Issue 3, 2014, Pages 329-339

  Pan, Wen Liang ^a   Wong, Jack Ho ^a   Fang, Evandro Fei ^b   Chan, Yau Sang ^a   Ng, Tzi Bun ^a   Cheung, Randy Chi Fai ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

alpha; Momorcharin; Hypoxic tumors; Nasopharyngeal carcinoma; Ribosome inactivating protein; Unfolded protein response

Indexed keywords

ALPHA MOMORCHARIN; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; COBALT CHLORIDE; DEATH RECEPTOR; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN IRE1; PROTEIN IRE1ALPHA; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE RNA ACTIVATED LIKE ENDOPLASMIC RETICULUM KINASE; RIBOSOME INACTIVATING PROTEIN 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CELL GROWTH; CELL MEMBRANE DEPOLARIZATION; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CHROMATIN CONDENSATION; CLONOGENIC ASSAY; COLONY FORMATION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA FRAGMENTATION; DOSE RESPONSE; DOWN REGULATION; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HYPOXIC CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOMORDICA CHARANTIA; MTT ASSAY; NASOPHARYNX CARCINOMA; PLANT SEED; PRIORITY JOURNAL; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UNFOLDED PROTEIN RESPONSE; UPREGULATION; WESTERN BLOTTING;

HYPOXIC TUMORS; NASOPHARYNGEAL CARCINOMA; RIBOSOME INACTIVATING PROTEIN; UNFOLDED PROTEIN RESPONSE; Α-MOMORCHARIN;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DOWN-REGULATION; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MITOCHONDRIA; NASOPHARYNGEAL NEOPLASMS; OXYGEN; RECEPTORS, DEATH DOMAIN; RIBOSOME INACTIVATING PROTEINS; SIGNAL TRANSDUCTION;

EID: 84899952397     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.03.004     Document Type: Article

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