Expression analysis of Notch-related molecules in peripheral blood T helper cells of patients with rheumatoid arthritis

Scandinavian Journal of Rheumatology

Volumn 39, Issue 1, 2010, Pages 26-32

  Jiao, Z ^a   Wang, W ^a   Guo, M ^b   Zhang, T ^b   Chen, L ^a   Wang, Y ^a   You, H ^a   Li, J ^a  

^a JIANGSU UNIVERSITY   (China)

^b JIANGYIN PEOPLE S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; NOTCH RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; NOTCH4 RECEPTOR; RHEUMATOID FACTOR; TRANSCRIPTION FACTOR HES 1;

ADULT; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE TARGETING; HELPER CELL; HUMAN; IMMUNOBLOTTING; MAJOR CLINICAL STUDY; MALE; MODULATION; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATOR GENE; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CELLS, CULTURED; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; MALE; MIDDLE AGED; PROBABILITY; RECEPTOR, NOTCH1; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SYNOVIAL FLUID; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 76749106118     PISSN: 03009742     EISSN: 15027732     Source Type: Journal    
DOI: 10.3109/03009740903124424     Document Type: Article

References (22)

1. Isaacs JD. Therapeutic T-cell manipulation in rheumatoid arthritis: past, present and future. Rheumatology (Oxford) 2008;/47:/1461-8.
2. Toh ML, Miossec P. The role of T cells in rheumatoid arthritis: new subsets and new targets. Curr Opin Rheumatol 2007;/ 19:/284-8.
3. Hirota K, Hashimoto M, Yoshitomi H, Tanaka S, Nomura T, Yamaguchi T, et al. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17- Th cells that cause autoimmune arthritis. J Exp Med 2007;/204:/41-7.
4. Stamp LK, James MJ, Cleland LG. Interleukin-17: the missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis? Immunol Cell Biol 2004;/82:/1-9.
5. Jiao Z, Wang W, Jia R, Li J, You H, Chen L, et al. Accumulation of FoxP3-expressing CD4-CD25- T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis. Scand J Rheumatol 2007;/36:/ 428-33.
6. Amsen D, Antov A, Flavell RA. The different faces of Notch in T-helper-cell differentiation. Nat Rev Immunol 2009;/9:/116-24.
7. Fiuza UM, Arias AM. Cell and molecular biology of Notch. J Endocrinol 2007;/194:/459-74.
8. Ishii H, Nakazawa M, Yoshino S, Nakamura H, Nishioka K, Nakajima T. Expression of Notch homologues in the synovium of rheumatoid arthritis and osteoarthritis patients. Rheumatol Int 2001;/21:/10-4. (Pubitemid 32835362)
9. Yabe Y, Matsumoto T, Tsurumoto T, Shindo H. Immunohistological localization of Notch receptors and their ligands Delta and Jagged in synovial tissues of rheumatoid arthritis. J Orthop Sci 2005;/10:/589-94.
10. Ando K, Kanazawa S, Tetsuka T, Ohta S, Jiang X, Tada T, et al. Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblasts. Oncogene 2003;/22:/ 7796-803.
11. Nakazawa M, Ishii H, Nakamura H, Yoshino SI, Fukamizu A, Nishioka K, et al. NFkappaB2 (p52) promoter activation via Notch signaling pathway in rheumatoid synoviocytes. Int J Mol Med 2001;/7:/31-5.
12. Nakazawa M, Ishii H, Aono H, Takai M, Honda T, Aratani S, et al. Role of Notch-1 intracellular domain in activation of rheumatoid synoviocytes. Arthritis Rheum 2001;/44:/1545-54.
13. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;/31:/315-24.
14. Bouras T, Pal B, Vaillant F, Harburg G, Asselin-Labat ML, Oakes SR, et al. Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell 2008;/3:/429-41.
15. Teachey DT, Seif AE, Brown VI, Bruno M, Bunte RM, Chang YJ, et al. Targeting Notch signaling in autoimmune and lymphoproliferative disease. Blood 2008;/111:/705-14.
16. Wakui M, Nakano K, Matsushita S. Notch ligand mRNA levels of human APCs predict Th1/Th2-promoting activities. Biochem Biophys Res Commun 2007;/358:/596-601.
17. Bugeon L, Gardner LM, Rose A, Gentle M, Dallman MJ. Cutting edge: Notch signaling induces a distinct cytokine profile in dendritic cells that supports T cell-mediated regulation and IL-2-dependent IL-17 production. J Immunol 2008;/ 181:/8189-93.
18. Laky K, Fowlkes BJ. Notch signaling in CD4 and CD8 T cell development. Curr Opin Immunol 2008;/20:/197-202.
19. Maekawa Y, Tsukumo S, Chiba S, Hirai H, Hayashi Y, Okada H, et al. Delta1-Notch3 interactions bias the functional differentiation of activated CD4- T cells. Immunity 2003;/19:/ 549-59.
20. Jurynczyk M, Jurewicz A, Raine CS, Selmaj K. Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase Ctheta and attenuates experimental autoimmune encephalomyelitis. J Immunol 2008;/180:/2634-40.
21. Gordon WR, Arnett KL, Blacklow SC. The molecular logic of Notch signaling: a structural and biochemical perspective. J Cell Sci 2008;/121:/3109-19.
22. McKenzie GJ, Khan M, Briend E, Stallwood Y, Champion BR. Notch: a unique therapeutic target for immunomodulation. Expert Opin Ther Targets 2005;/9:/395-410.