Angiogenesis in rheumatoid arthritis: Implications for future therapeutic strategies

Springer Seminars in Immunopathology

Volumn 20, Issue 1-2, 1998, Pages 73-94

  Paleolog, Ewa M ^a   Fava, Roy A ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIN; CELL ADHESION MOLECULE; CHEMOKINE; ENDOTHELIN; FIBROBLAST GROWTH FACTOR; NITRIC OXIDE; PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; SCATTER FACTOR; THROMBOSPONDIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL INFILTRATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIUM;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, CD31; ARTHRITIS, RHEUMATOID; BIOLOGICAL FACTORS; BIOPSY; BURSA, SYNOVIAL; CHEMOKINES; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GROWTH SUBSTANCES; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, VITRONECTIN; TIME FACTORS;

EID: 0031725440     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00832000     Document Type: Article

References (97)

1. Badolato R, Ponzi AN, Millesimo M, Notarangelo LD, Musso T (1997) Interleukin-15 (IL-15) induces IL-8 and monocyte chemotactic protein 1 production in human monocytes. Blood 90 : 2804
2. Baggiolini M, Dewald B, Moser B (1997) Human chemokines: an update. Annu Rev Immunol 15 : 675
3. Benjamin LE, Keshet E (1997) Condilional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc Natl Acad Sci USA 94: 8761
4. Blake DR, Merry P, Unsworth J, Kidd BL, Outhwaite JM, Ballard R, Morris CJ, Gray L, Lunec J (1989) Hypoxic-reperfusion injury in the inflamed human joint. Lancet 1: 289
5. Bornstein P, Sage EH (1994) Thrombospondins. Methods Enzymol 245 : 62
6. Brennan FM, Chantry D, Jackson A, Maini R, Feldmann M (1989) Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet II : 244
7. Brennan FM, Zachariae CO, Chantry D, Larsen CG, Turner M, Maini RN, Matsushima K, Feldmann M (1990) Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells. Eur J Immunol 20 : 2141
8. 2+ and von Willebrand factor release in human endothelial cells. Am J Pathol 138 : 213
9. Brooks PC (1996) Role of integrins in angiogenesis. Eur J Cancer 32A : 2423
10. Brown LF, Detmar M, Claffey K, Nagy JA, Feng D, Dvorak AM, Dvorak HF (1997) Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine. EXS 79 : 233
11. Brown RA, Weiss JB, Tomlinson IW, Phillips P, Kumar S (1980) Angiogenic factor from synovial fluid resembling that from tumours. Lancet 1 : 682
12. Burgess WH, Maciag T (1989) The heparin-binding (fibroblast) growth factor family of proteins. Annu Rev Biochem 58 : 575
13. Cao Y, Chen C, Weatherbee JA, Tsang M, Folkman J (1995) gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice. J Exp Med 182 : 2069
14. Chu CQ, Field M, Allard S, Abney E, Feldmann M, Maini RN (1992) Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair. Br J Rheumatlol 31 : 653
15. Claesson-Welsh L (1994) Platelet-derived growth factor receptor signals. J Biol Chem 269 : 32023
16. Cox DA, Maurer T (1997) Transforming growth factor-beta. Clin Immunol Immunopathol 83 : 25
17. Dawson DW, Pearce SF, Zhong R, Silverstein RL, Frazier WA, Bouck NP (1997) CD36 mediates the in vitro inhibitory effects of thrombospondin-1 on endothelial cells. J Cell Biol 138 : 707
18. DiPietro LA, Polverini PJ (1993) Angiogenic macrophages produce the angiogenic inhibitor thrombospondin 1. Am J Pathol 143 : 678
19. DiPietro LA, Nebgen DR, Polverini PJ (1994) Downregulation of endothelial cell thrombospondin 1 enhances in vitro angiogenesis. J Vasc Res 31 : 178
20. Fava RA, Olsen NJ, Postlethwaite AH, Broadley KN, Davidson JM, Nanney LB, Lucas C, Townes AS (1991) Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia. J Exp Med 173 : 1121
21. Fava RA, Olsen NJ, Spencer-Green G, Yeo KT, Yeo TK, Berse B, Jackman RW, Senger DR, Dvorak HF, Brown LF (1994) Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med 180 : 341
22. Fava RA, Hunt JA, Yeo KT, Brown F, Berse B (1995) Induction of vascular permeability factor (vascular endothelial growth factor) by TGFβ in synovial fibroblasts. Arthritis Rheum 38 : S 343
23. Feldmann M, Brennan FM, Maini RN (1996) Rheumatoid arthritis. Cell 85 : 307
24. Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1 : 27
25. Fox SB, Moghaddam A, Westwood M, Turley H, Bicknell R, Gatter KC, Harris AL (1995) Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study. J Pathol 176: 183
26. Frater-Schroder M, Risau W, Hallmann R, Gautschi P, Bohlen P (1987) Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo. Proc Natl Acad Sci USA 84 : 5277
27. Gamble JR, Vadas MA (1991) Endothelial cell adhesiveness for human T lymphocytes is inhibited by transforming growth factor-beta 1. J Immunol 146 : 1149
28. Gimbrone MA Jr, Leapman SB, Cotran RS, Folkman J (1972) Tumor dormancy in vivo by prevention of neovascularization. J Exp Med 136 : 261
29. Gong JH, Ratkay LG, Waterfield JD, Clark-Lewis I (1997) An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model. J Exp Med 186 : 131
30. Gotis-Graham I, Hogg PJ, McNeil HP (1997) Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium. Arthritis Rheum 40 : 1780
31. Grabowski PS, Wright PK, Van 't Hof RJ, Helfrich MH, Ohshima H, Ralston SH (1997) Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis. Br J Rheumatol 36 : 651
32. Hosaka S, Akahoshi T, Wada C, Kondo H (1994) Expression of the chemokine superfamily in rheumatoid arthritis. Clin Exp Immunol 97 : 451
33. Hosaka S, Shah MR, Barquin N, Haines GK, Koch AE (1995) Expression of basic fibroblast growth factor and angiogenin in arthritis. Pathobiology 63 : 249
34. Hu DE, Hiley CR, Fan TP (1996) Comparative studies of the angiogenic activity of vasoactive intestinal peptide, endothelins-1 and -3 and angiotensin II in a rat sponge model. Br J Pharmacol 117 : 545
35. Hu GF, Riordan JF, Vallee BL (1997) A putative angiogenin receptor in angiogenin-responsive human endothelial cells. Proc Natl Acad Sci USA 94 : 2204
36. Iruela-Arispe ML, Dvorak HF (1997) Angiogenesis: a dynamic balance of stimulators and inhibitors. Thromb Haemost 78 : 672
37. Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V, Eriksson U, Alitalo K (1997) Vascular endothelial growth factors VEGF-B and VEGF-C. J Cell Physiol 173 : 211
38. Kasugai K, Joh T, Kataoka H, Sasaki M, Tada T, Asai K, Kato T, Itoh M (1997) Evidence for participation of gliostatin/platelet-derived endothelial cell growth factor in gastric ulcer healing. Life Sci 61 : 1899
39. Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Elner VM, Elner SG, Strieter RM (1992) Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258 : 1798
40. Koch AE, Friedman J, Burrows JC, Haines GK, Bouck NP (1993) Localization of the angiogenesis inhibitor thrombospondin in human synovial tissues. Pathobiology 61 : 1
41. Koch AE, Harlow LA, Haines GK, Amento EP, Unemori EN, Wong WL, Pope RM, Ferrara N (1994) Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol 152 : 4149
42. Koch AE, Kunkel SL, Harlow LA, Mazarakis DD, Haines GK, Burdick MD, Pope RM, Walz A, Strieter RM (1994) Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis. J Clin Invest 94 : 1012
43. Koch AE, Kunkel SL, Shah MR, Hosaka S, Halloran MM, Haines GK, Burdick MD, Pope RM, Strieter RM (1995) Growth-related gene product alpha. A chemotactic cytokine for neutrophils in rheumatoid arthritis. J Immunol 155 : 3660
44. Koch AE, Halloran MM, Haskell CJ, Shah MR, Polverini PJ (1995) Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature 376 : 517
45. Koch AE, Halloran MM, Hosaka S, Shah MR, Haskell CJ, Baker SK, Panos RJ, Haines GK, Bennett GL, Pope RM, Ferrara N (1996) Hepatocyte growth factor. A cytokine mediating endothelial migration in inflammatory arthritis. Arthritis Rheum 39 : 1566
46. Koolwijk P, Erck MG van, Vree WJ de, Vermeer MA, Weich HA, Hanemaaijer R, Hinsbergh VW van (1996) Cooperative effect of TNFalpha, bFGF, and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity. J Cell Biol 132 : 1177
47. Kuruvilla AP, Shah R, Hochwald GM, Liggitt HD, Palladino MA, Thorbecke GJ (1991) Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice. Proc Natl Acad Sci USA 88 : 2918
48. Leibovich SJ, Polverini PJ, Shepard HM, Wiseman DM, Shively V, Nuseir N (1987) Macrophage-induced angiogenesis is mediated by tumour necrosis factor-alpha. Nature 329 : 630
49. Lupia E, Montrucchio G, Battaglia E, Modena V, Camussi G (1996) Role of tumor necrosis factor-α and platelet-activating factor in neoangiogenesis induced by synovial fluids of patients with rheumatoid arthritis. Eur J Immunol 26 : 1690
50. Massague J (1990) The transforming growth factor-beta family. Annu Rev Cell Biol 6 : 597
51. Mawatari M, Kohno K, Mizoguchi H, Matsuda T, Asoh K, Van Damme J, Welgus HG, Kuwano M (1989) Effects of tumor necrosis factor and epidermal growth factor on cell morphology, cell surface receptors, and the production of tissue inhibitor of metalloproteinases and IL-6 in human microvascular endothelial cells. J Immunol 143 : 1619
52. McCartney-Francis N, Allen JB, Mizel DE, Albina JE, Xie QW, Nathan CF, Wahl SM (1993) Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med 178 : 749
53. McInnes IB, Leung BP, Field M, Wei XQ, Huang FP, Sturrock RD, Kinninmonth A, Weidner J, Mumlord R, Liew FY (1996) Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. J Exp Med 184 : 1519
54. Miyasaka N, Hirata Y, Ando K, Sato K, Morita H, Shichiri M, Kanno K, Tomita K, Marumo F (1992) Increased production of endothelin-1 in patients with inflammatory arthritides. Arthritis Rheum 35 : 397
55. Moenner M, Gusse M, Hatzi E, Badet J (1994) The widespread expression of angiogenin in different human cells suggests a biological function not only related to angiogenesis. Eur J Biochem 226 : 483
56. Moghaddam A, Zhang HT, Fan TP, Hu DE, Lees VC, Turley H, Fox SB, Gatter KC, Harris AL, Bicknell R (1995) Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc Natl Acad Sci USA 92 : 998
57. Montesano R, Vassalli JD, Baird A, Guillemin R, Orci L (1986) Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci USA 83 : 7297
58. Moses MA, Sudhalter J, Langer R (1990) Identification of an inhibitor of neovascularization from cartilage. Science 248 : 1408
59. Muller G, Behrens J, Nussbaumer U, Bohlen P, Birchmeier W (1987) Inhibitory action of transforming growth factor beta on endothelial cells. Proc Natl Acad Sci USA 84 : 5600
60. Nguyen M, Strubel NA, Bischoff J (1993) A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis. Nature 365 : 267
61. Nicosia RF, Tuszynski GP (1994) Matrix-bound thrombospondin promotes angiogenesis in vitro. J Cell Biol 124 : 183
62. Nicosia RF, Nicosia SV, Smith M (1994) Vascular enilothelial growth factor, platelet-derived growth factor, and insulin-like growth factor-1 promote rat aortic angiogenesis in vitro. Am J Pathol 145 : 1023
63. Ogata H, Takeya M, Yoshimura T, Takagi K, Takahashi K (1997) The role of monocyte chemoattractant protein-1 (MCP-1) in the pathogenesis of collagen-induced arthritis in rats. J Pathol 182 : 106
64. Oliver SJ, Cheng TP, Banquerigo ML, Brahn E (1995) Suppression of collagen-induced arthritis by an angiogenesis inhibitor, AGM-1470, in combination with cyclosporin: reduction of vascular endothelial growth factor (VEGF). Cell Immunol 166 : 196
65. Paleolog EM (1996) Angiogenesis: a critical process in the pathogenesis of RA - a role for VEGF? Br J Rheumatol 35 : 917
66. Paleolog EM, Hunt M, Elliott MJ, Feldmann M, Maini RN, Woody JN (1996) Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis. Arthritis Rheum 39 : 1082
67. Paleolog EM, Young S, Stark AC, McCloskey RV, Feldmann M, Maini RN (1998) Modulation of angiogenic vascular endothelial growth factor (VEGF) by TNFα and IL-1 in rheumatoid arthritis. Arthritis Rheum 41 : 1258
68. Pedrani A, Razandi M, Hu RM, Levin ER (1997) Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion. J Biol Chem 272 : 17097
69. Pepper MS, Montesano R, Vassalli JD, Orci L (1991) Chondrocytes inhibit endothelial sprout formation in vitro: evidence for involvement of a transforming growth factor-beta. J Cell Physiol 146 : 170
70. Pepper MS, Ferrara N, Orci L, Montesano R (1992) Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun 189 : 824
71. Pepper MS, Vassalli JD, Orci L, Montesano R (1993) Biphasic effect of transforming growth factor-beta 1 on in vitro angiogenesis. Exp Cell Res 204 : 356
72. Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K (1994) Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem 269 : 6271
73. Pipili-Synetos E, Sakkoula E, Maragoudakis ME (1993) Nitric oxide is involved in the regulation of angiogenesis. Br J Pharmacol 108 : 855
74. Randen I, Mellbye OJ, Forre O, Natvig JB (1995) The identification of germinal centres and follicular dendritic cell networks in rheumatoid synovial tissue. Scand J Immunol 41 : 481
75. Remmers EF, Sano H, Lafyatis R, Case JP, Kumkumian GK, Hla T, Maciag T, Wilder RL (1991) Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRN A and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1. J Rheumatol 18 : 7
76. Rooney M, Condell D, Quinlan W, Daly L, Whelan A, Feighery C, Bresnihan B (1988) Analysis of the histologic variation of synovitis in rheumatoid arthritis. Arthritis Rheum 31 : 956
77. Rosen EM, Goldberg ID (1997) Regulation of angiogenesis by scatter factor. EXS 79 : 193
78. Rubin K, Terracio L, Ronnstrand L, Heldin CH, Klareskog L (1988) Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial inflammation. Scand J Immunol 27 : 285
79. Salven P, Teerenhovi L, Joensuu H (1997) A high pre-treatment serum vascular endothelial growth factor concentration is associated with poor outcome in non-Hodgkin's lymphoma. Blood 90 : 3167
80. Sano H, Forough R, Maier JA, Case JP, Jackson A, Engleka K, Maciag T, Wilder RL (1990) Detection of high levels of heparin binding growth factor-1 (acidic fibroblast growth factor) in inflammatory arthritic joints. J Cell Biol 110 : 1417
81. Sano H, Engleka K, Mathern P, Hla T, Crofford LJ, Remmers EF, Jelsema CL, Goldmuntz E, Maciag T, Wilder RL (1993) Coexpression of phosphotyrosine-containing proteins, platelet-derived growth factor-B, and fibroblast growth factor-1 in situ in synovial tissues of patients with rheumatoid arthritis and Lewis rats with adjuvant or streptococcal cell wall arthritis. J Clin Invest 91 : 553
82. Schlessinger J (1997) Direct binding and activation of receptor tyrosine kinases by collagen. Cell 91 : 869
83. Semble EL, Turner RA, McCrickard EL (1985) Rheumatoid arthritis and osteoarthritis synovial fluid effects on primary human endothelial cell cultures. J Rheumatol 12 : 237
84. Senger DR, Ledbetter SR, Claffey KP, Papadopoulos-Sergiou A, Peruzzi CA, Detmar M (1996) Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin. Am J Pathol 149 : 293
85. Shweiki D, Itin A, Soffer D, Keshet E (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359 : 843
86. Soncin F, Strydom DJ, Shapiro R (1997) Interaction of heparin with human angiogenin. J Biol Chem 272 : 9818
87. Stevens CR, Williams RB, Farrell AJ, Blake DR (1991) Hypoxia and inflammatory synovitis: observations and speculation. Ann Rheum Dis 50 : 124
88. Storgard CM, Stupack DG, Cheresh DA (1997) Angiogenesis inhibition with αVβ3 antagonist ameliorates early and chronic arthritis. Arthritis Rheum 40 : S 97
89. Usuki K, Gonez LJ, Wernstedt C, Moren A, Miyazono K, Claesson-Welsh L, Heldin CH (1994) Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells. Biochim Biophys Acta 1222 : 411
90. Waguri Y, Otsuka T, Sugimura I, Matsui N, Asai K, Moriyama A, Kato T (1997) Gliostatin/platelet-derived endothelial cell growth factor as a clinical marker of rheumatoid arthritis and its regulation in fibroblast-like synoviocytes. Br J Rheumatol 36 : 315
91. Wahl SM, Allen JB, Costa GL, Wong HL, Dasch JR (1993) Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta. J Exp Med 177 : 225
92. Wharton J, Rutherford RA, Walsh DA, Mapp PI, Knock GA, Blake DR, Polak JM (1992) Autoradiographic localization and analysis of endothelin-1 binding sites in human synovial tissue. Arthritis Rheum 35 : 894
93. Yamaguchi Y, Mann DM, Ruoslahti E, Mann DM, Yamaguchi Y, Bourdon MA, Ruoslahti E (1990) Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Analysis of glycosaminoglycan substitution in decorin by site-directed mutagenesis. Nature 346 : 281
94. Yang EY, Moses UL (1990) Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane. J Cell Biol 111 : 731
95. Yoshida S, Ono M, Shono T, Izumi H, Ishibashi T, Suzuki H, Kuwano M (1997) Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol Cell Biol 17 : 4015
96. Ziche M, Morbidelli E, Masini E, Amerini S, Granger HJ, Maggi CA, Geppetti P, Ledda F (1994) Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest 94 : 2036
97. Ziche M, Morbidelli L, Choudhuri R, Zhang HT, Donnini S, Granger HJ, Bicknell R (1997) Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest 99 : 2625