High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Thomas, Holly R ^a   Percival, Stefanie M ^a   Yoder, Bradley K ^b   Parant, John M ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED PROTEIN; DNA; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; ZINC FINGER NUCLEASE; DEOXYRIBONUCLEASE; ZINC FINGER PROTEIN;

ADULT; AMPLICON; ANIMAL EXPERIMENT; ARTICLE; CHIMERA; CONTROLLED STUDY; DNA DETERMINATION; EMBRYO; GENE FREQUENCY; GENE IDENTIFICATION; GENE ISOLATION; GENE REPRESSION; GENE SEGREGATION; GENE TARGETING; GENOME ANALYSIS; GENOTYPE PHENOTYPE CORRELATION; GERMLINE MUTATION; HETERODUPLEX ANALYSIS; HIGH RESOLUTION MELTING ANALYSIS; HIGH THROUGHPUT GENOME EDITING; MUTANT; MUTATIONAL ANALYSIS; NONHUMAN; NULL ALLELE; PHENOTYPE; PROGENY; SEQUENCE HOMOLOGY; SOMATIC MUTATION; ANIMAL; CHEMISTRY; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DNA BASE COMPOSITION; DNA DAMAGE; DNA DENATURATION; DNA MUTATIONAL ANALYSIS; GENETIC ENGINEERING; GENETICS; GENOMICS; GENOTYPING TECHNIQUE; HYBRIDIZATION; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PROCEDURES; TRANSITION TEMPERATURE; ZEBRA FISH;

DANIO RERIO;

ANIMALS; BASE COMPOSITION; BASE SEQUENCE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; DEOXYRIBONUCLEASES; DNA DAMAGE; DNA MUTATIONAL ANALYSIS; GENETIC ENGINEERING; GENOMICS; GENOTYPING TECHNIQUES; HYBRIDIZATION, GENETIC; MUTATION; NUCLEIC ACID DENATURATION; PHENOTYPE; TRANSITION TEMPERATURE; ZEBRAFISH; ZINC FINGERS;

EID: 84917710578     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0114632     Document Type: Article

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