Simple Methods for Generating and Detecting Locus-Specific Mutations Induced with TALENs in the Zebrafish Genome

PLoS Genetics

Volumn 8, Issue 8, 2012, Pages

  Dahlem, Timothy J ^a   Hoshijima, Kazuyuki ^a   Jurynec, Michael J ^a   Gunther, Derrick ^a   Starker, Colby G ^b   Locke, Alexandra S ^a   Weis, Allison M ^a   Voytas, Daniel F ^b   Grunwald, David Jonah ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEASE; RNA; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UNCLASSIFIED DRUG;

ADULTHOOD; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COMPUTER PROGRAM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA MICROARRAY; DNA POLYMORPHISM; DNA REPAIR; DNA SEQUENCE; DOUBLE STRANDED DNA BREAK; EMBRYO; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SYNTHESIS; EXPERIMENTAL DESIGN; GENE; GENE FUNCTION; GENE LOCUS; GENE TARGETING; GENOME; GERM LINE; GOLDEN GENE; HIGH RESOLUTION MELTING ANALYSIS; HOST; INDEL MUTATION; MOLECULAR CLONING; MOLECULAR INTERACTION; MUTANT; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROGENY; PROTEIN DNA BINDING; SENSITIVITY AND SPECIFICITY; SOMATIC MUTATION; WILD TYPE; ZEBRA FISH;

ANIMALS; BASE SEQUENCE; BINDING SITES; CLONING, MOLECULAR; DNA BREAKS, DOUBLE-STRANDED; EMBRYO, NONMAMMALIAN; ENDONUCLEASES; GENE TARGETING; GENETIC LOCI; GERM-LINE MUTATION; MICROINJECTIONS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID DENATURATION; POLYMORPHISM, GENETIC; PROTEIN BINDING; RECOMBINANT PROTEINS; SOFTWARE; ZEBRAFISH;

ANIMALIA; DANIO RERIO; VERTEBRATA;

EID: 84866156176     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002861     Document Type: Article

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