Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity

Journal of Biological Chemistry

Volumn 289, Issue 49, 2014, Pages 34267-34283

  Skala, Wolfgang ^a   Utzschneider, Daniel T ^b   Magdolen, Viktor ^b   Debela, Mekdes ^c   Guo, Shihui ^a   Craik, Charles S ^d   Brandstetter, Hans ^a   Goettig, Peter ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIGEN-ANTIBODY REACTIONS; CONFORMATIONS; UROLOGY; ZINC;

ACTIVITY REGULATION; CONFORMATIONAL SELECTION; IRREVERSIBLE INACTIVATION; PROSTATE SPECIFIC ANTIGEN; REVERSIBLE INHIBITIONS; SMALL MOLECULE INHIBITOR; STRUCTURE-FUNCTION ANALYSIS; SUBSTRATE-BINDING SITES;

BINDING SITES;

KALLIKREIN; KALLIKREIN RELATED PEPTIDASE 2; TRYPSIN; UNCLASSIFIED DRUG; ZINC; DIVALENT CATION; KLK2 PROTEIN, HUMAN; RECOMBINANT PROTEIN;

ARTICLE; AUTOLYSIS; BINDING SITE; CRYSTAL STRUCTURE; ENZYMATIC ASSAY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; PROTEIN EXPRESSION; PROTEIN REFOLDING; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CATIONS, DIVALENT; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; HUMANS; KALLIKREINS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 84917673231     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.598201     Document Type: Article

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