Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors

Prostate

Volumn 34, Issue 1, 1998, Pages 44-50

  Mikolajczyk, Stephen D ^a   Millar, Lisa S ^a   Kumar, Abhay ^a   Saedi, Mohammad S ^a  

^a Hybritech Incorporated   (United States)

Author keywords

1 antichymotrypsin; Glandular kallikrein; Prostate cancer; Prostate specific antigen; Serine protease

Indexed keywords

KALLIKREIN; PROSTATE SPECIFIC ANTIGEN; PROTEINASE INHIBITOR; TRYPSIN; TUMOR MARKER;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITOR INTERACTION; HAMSTER; IMMUNOAFFINITY CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION;

ALPHA 1-ANTICHYMOTRYPSIN; ALPHA 1-ANTITRYPSIN; AMINO ACID SEQUENCE; ANIMALS; ANTIPLASMIN; ANTITHROMBIN III; ARGININE; CELL LINE; CHROMOGENIC COMPOUNDS; CRICETINAE; HUMANS; KALLIKREINS; MALE; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDES; PROSTATIC NEOPLASMS; RECOMBINANT FUSION PROTEINS; SERINE PROTEINASE INHIBITORS; SERPINS; SUBSTRATE SPECIFICITY; TISSUE KALLIKREINS; TUMOR MARKERS, BIOLOGICAL;

EID: 0031983565     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0045(19980101)34:1<44::AID-PROS6>3.0.CO;2-K     Document Type: Article

References (28)

1. Schedlich LJ, Bennetts B, Morris BJ: Primary structure of a human glandular kallikrein gene. DNA 1987;6:429-137.
2. Morris BJ: A kallikrein gene expressed in human prostate. Clin Exp Pharmacol Physiol 1989;16:345-351.
3. Bridon D, Dowell B: Structural comparison of prostate-specific antigen and human glandular kallikrein using molecular modeling. Urology 1995;45:801-806.
4. McCormack RT, Rittenhouse HG, Finlay JA, Sokoloff RL, Wang TJ, Wolfert RL, Lilja H, Oesterling JE: Molecular forms of prostate-specific antigen and the human kallikrein gene family: A new era. Urology 1995;45:729-744.
5. Vihinen M: Modeling of prostate specific antigen and human glandular kallikrein structures. Biochem Biophys Res Commun 1994;204:1251-1256.
6. Clements J: The glandular kallikrein family of enzymes: Tissue specific expression and hormonal regulation. Endocr Rev 1989; 10:393-419.
7. Catalona WJ, Smith DS, Ratliff TL, Dodds KM, Coplen DE, Yuan JJ, Tetros JA, Andriole GL: Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Engl J Med 1991;324:1156-1161.
8. Chapdelaine P, Paradis G, Tremblay R, Dube J: High level of expression in the prostate of a human glandular kallikrein mRNA related to prostate-specific antigen. FEBS Lett 1988;236: 205-208.
9. Grauer L, Charlesworth MC, Saedi MS, Finlay JA, Liu R, Kuus-Reichel K, Tindall DJ: Identification of human glandular kallikrein hK2 from LNCaP cells. J Androl 1996;17:266.
10. Young CY-F, Andrews PE, Montgomery BT, Tindall DJ: Tissue-specific and hormonal regulation of human prostate-specific glandular kallikrein. Biochemistry 1992;31:818-824.
11. Rittenhouse H, Tindall D, Klee G, Bostwick D, Saedi M, Grauer L, Mikolajczyk S, Finlay J, Kuus-Reichel K, Kumar A, Wolfert R: Characterization and evaluation of hK2: A potential prostate cancer marker, closely related to PSA. In Murphy GP, Khoury S (eds): "Proceedings of the First International Consultation on Prostate Cancer," 1997.
12. Stamey TA, Teplow DB, Graves HCB: Identity of PSA purified from seminal fluid by different methods: Comparison by amino acid analysis and assigned extinction coefficients. Prostate 1995; 27:198-203.
13. Kumar A, Goel A, Hill T, Mikolajczyk S, Millar L, Kuus-Reichel K, Saedi M: Expression of human glandular kallikrein, hK2, in mammalian cells. Cancer Res 1996;56:5397-5402.
14. Christensson A, Laurell C-B, Lilja H: Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors. Eur J Biochem 1990;194:755-763.
15. Moreau T, Brillard-Bourdet M, Bouhnik J, Gauthier F: Protein products of the rat kallikrein family: J Biol Chem 1992;267: 10045-10051.
16. Young CYF, Seay T, Hogen K, Charlesworth MC, Roche PC, Klee GG, Tindall DJ: Prostate-specific human kallikrein (hK2) as a novel marker for prostate cancer. Prostate [Suppl] 1996;7:17-24.
17. Cohen RJ, Haffejee Z, Steele GS, Nayler SJ: Advanced prostate cancer with normal serum prostate specific cancer values. Arch Pathol Lab Med 1994;118:1123-1126.
18. Cohen P, Graves HCB, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG: Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab 1992;76:1046-1053.
19. Takada Y, Skidgel RA, Erdos EG: Purification of human urinary prokallikrein: Identification of the site of activation by the metalloproteinase thermolysin. Biochem J 1985;232:851-858.
20. Noda Y, Takada Y, Erdos EG: Activation of human and rabbit prokallikrein by serine and metalloprotease. Kidney Int 1985;27: 630-635.
21. Chandra T, Stackhouse R, Kidd V, Robson K, Woo SLC: Sequence homology between human alphal-antichymotrypsin, alpha1-antitrypsin, and antithrombin III. Biochemistry 1983;22: 5055-5061.
22. Carrell R, Travis J: Alpha1-antitrypsin and the serpins: Variation and countervariation. TIBS 1985;10:20-24.
23. Mast AE, Enghild JJ, Pizzo SV, Salvesen G: Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed, and reactive site cleaved serpins: Comparison of alpha1-proteinase inhibitor, alpha1-antichymotrypsin, antithrombin III, alpha2-antiplasmin, angiotensinogen, and ovalbumin. Biochemistry 1991;30:1723-1730.
24. Deperthes D, Chapdelaine P, Tremblay RR, Brunet C, Berton J, Herbert J, Lazure C, Dube JY: Isolation of prostatic kallikrein hK2, also known as hGK-1, in human seminal plasma. Biochim Biophys Acta 1995;1245:311-316.
25. Deperthes D, Frenette G, Brillard-Bourdet M, Bourgeois L, Gauthier F, Tremblay RR, Dube JY: Potential involvement of kallikrein hK2 in the hydrolysis of the human seminal vesicle proteins after ejaculation. J Androl 1996;17:659-665.
26. Zhang WM, Leinonen J, Stenman U-H: Prostate-specific antigen (PSA) complexes with and cleaves alpha-1-protease inhibitor in vitro. J Urol [Suppl] 1996;155:Abstract 1259.
27. Stenman UH, Leinonen J, Alfthan H, Rannikko S, Tuhkanen K, Alfthan O: A complex between prostate specific antigen and alpha 1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostatic cancer: Assay of the complex improves clinical sensitivity for cancer. Cancer Res 1991;51:222-226.
28. Mikolajczyk SD, Millar LS, Kumar A, Saedi MS: Ala217 is important for the catalytic function and autoactivation of prostate-specific human kallikrein 2. Eur J Biochem 1997;246:440-446.