Engineering Angiogenesis for Myocardial Infarction Repair: Recent Developments, Challenges, and Future Directions

Cardiovascular Engineering and Technology

Volumn 5, Issue 4, 2014, Pages 281-307

  Izadifar, Mohammad ^a   Kelly, Michael E ^a,b   Chen, Xiongbiao ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Angiogenesis; Cardiac tissue engineering; Cardiovascular; Myocardial infarction; Tissue engineering; Vascularization

Indexed keywords

BLOOD VESSELS; CARDIOLOGY; HEART; REGENERATIVE MEDICINE; SCAFFOLDS (BIOLOGY); TISSUE ENGINEERING;

ANGIOGENESIS; CARDIAC TISSUE ENGINEERING; CARDIOVASCULAR; MYOCARDIAL INFARCTION; VASCULARIZATION;

TISSUE;

ALGINIC ACID; BIOMATERIAL; BONE MORPHOGENETIC PROTEIN; COLLAGEN; COLONY STIMULATING FACTOR 1; ERYTHROPOIETIN; FIBROBLAST GROWTH FACTOR 2; GLYCOSAMINOGLYCAN; GRANULOCYTE COLONY STIMULATING FACTOR; HYPOXIA INDUCIBLE FACTOR; LEUKEMIA INHIBITORY FACTOR; LIPOSOME; MATRIGEL; MATRIX METALLOPROTEINASE; MICROSPHERE; NANOSPHERE; NITRIC OXIDE; PLATELET DERIVED GROWTH FACTOR; POLYGLACTIN; POLYURETHAN; RHO KINASE; SCATTER FACTOR; SOMATOMEDIN C; THYMOSIN BETA4; VASCULOTROPIN;

ANGIOGENESIS; CARDIAC STEM CELL; CELL ADHESION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELL SUSPENSION; DRUG DELIVERY SYSTEM; EMBRYONIC STEM CELL; ENDOTHELIAL PROGENITOR CELL; EXTRACELLULAR MATRIX; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART PROTECTION; HUMAN; MICROVASCULATURE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; REVIEW; THREE DIMENSIONAL IMAGING; TISSUE ENGINEERING; TISSUE REGENERATION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

EID: 84916930411     PISSN: 1869408X     EISSN: 18694098     Source Type: Journal    
DOI: 10.1007/s13239-014-0193-7     Document Type: Review

References (253)

1. Adams, W. J., Y. Zhang, J. Cloutier, P. Kuchimanchi, G. Newton, S. Sehrawat, W. C. Aird, T. N. Mayadas, F. W. Luscinskas, and G. Garcia-Cardena. Functional vascular endothelium derived from human induced pluripotent stem cells. Stem Cell Rep. 1:105–113, 2013.
2. Aicher, A., A. M. Zeiher, and S. Dimmeler. Mobilizing endothelial progenitor cells. Hypertension 45:321–325, 2005.
3. Alperin, C., P. W. Zandstra, and K. A. Woodhouse. Polyurethane films seeded with embryonic stem cell-derived cardiomyocytes for use in cardiac tissue engineering. Biomaterials 26:7377–7386, 2005.
4. Amsden, B. G., L. Timbart, D. Marecak, R. Chapanian, M. Y. Tse, and S. C. Pang. VEGF-induced angiogenesis following localized delivery via injectable, low viscosity poly(trimethylene carbonate). J. Control Release 145:109–115, 2010.
5. Andrae, J., R. Gallini, and C. Betsholtz. Role of platelet derived growth factors in physiology and medicine. Genes Dev. 22:1276–1312, 2008.
6. Anzai, T. Post-infarction inflammation and left ventricular remodeling: a double-edged sword. Circ. J. 77:580–587, 2013.
7. Askari, A. T., S. Unzek, Z. B. Popovic, C. K. Goldman, F. Forudi, M. Kiedrowski, A. Rovner, S. G. Ellis, J. D. Thomas, P. E. DiCorleto, E. J. Topol, and M. S. Penn. Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet 362:697–703, 2003.
8. Athanasuleas, C. L., G. D. Buckberg, A. W. Stanley, W. Siler, V. Dor, M. Di Donato, L. Menicanti, S. Almeida de Oliveira, F. Beyersdorf, I. L. Kron, H. Suma, N. T. Kouchoukos, W. Moore, P. M. McCarthy, M. C. Oz, F. Fontan, M. L. Scott, and K. A. Accola. Surgical ventricular restoration in the treatment of congestive heart failure due to post-infarction ventricular dilation. J. Am. Coll. Cardiol. 44:1439–1445, 2004.
9. Auger, F. A., L. Gibot, and D. Lacroix. The pivotal role of vascularization in tissue engineering. Annu. Rev. Biomed. Eng. 15:177–200, 2013.
10. Baranski, J. D., R. R. Chaturvedi, K. R. Stevens, J. Eyckmans, B. Carvalho, R. D. Solorzano, M. T. Yang, J. S. Miller, S. N. Bhatia, and C. S. Chen. Geometric control of vascular networks to enhance engineered tissue integration and function. Proc. Natl Acad. Sci. U.S.A. 110:7586–7591, 2013.
11. Bauer, S. M., R. J. Bauer, Z. J. Liu, H. Chen, L. Goldstein, and O. C. Velazquez. Vascular endothelial growth factor-C promotes vasculogenesis, angiogenesis, and collagen constriction in three-dimensional collagen gels. J. Vasc. Surg. 41:699–707, 2005.
12. Beltrami, A. P., L. Barlucchi, D. Torella, M. Baker, F. Limana, S. Chimenti, H. Kasahara, M. Rota, E. Musso, K. Urbanek, A. Leri, J. Kajstura, B. Nadal-Ginard, and P. Anversa. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114:763–776, 2003.
13. Berthod, F., J. Symes, N. Tremblay, J. A. Medin, and F. A. Auger. Spontaneous fibroblast-derived pericyte recruitment in a human tissue-engineered angiogenesis model in vitro. J. Cell. Physiol. 227:2130–2137, 2012.
14. Bettinger, C. J. J., E. J. J. Weinberg, K. M. Kulig, J. P. Vacanti, Y. Wang, J. T. Borenstein, and R. Langer. Three-dimensional microfluidic tissue-engineering scaffolds using a flexible biodegradable polymer. Adv. Mater. 18:165–169, 2006.
15. Beulens, J. W., M. L. Bots, F. Atsma, M. L. Bartelink, M. Prokop, J. M. Geleijnse, J. C. Witteman, D. E. Grobbee, and Y. T. van der Schouw. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis 203:489–493, 2009.
16. Black, A. F., F. Berthod, N. L’Heureux, L. Germain, and F. A. Auger. In vitro reconstruction of a human capillary-like network in a tissue-engineered skin equivalent. FASEB J. 12:1331–1340, 1998.
17. Bonora, E., S. Kiechl, J. Willeit, F. Oberhollenzer, G. Egger, J. B. Meigs, R. C. Bonadonna, and M. Muggeo. Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in Caucasian subjects from the general population the bruneck study. Diabetes Care 30:318–324, 2007.
18. Bonow, R. O., G. Maurer, K. L. Lee, T. A. Holly, P. F. Binkley, P. Desvigne-Nickens, J. Drozdz, P. S. Farsky, A. M. Feldman, T. Doenst, R. E. Michler, D. S. Berman, J. C. Nicolau, P. A. Pellikka, K. Wrobel, N. Alotti, F. M. Asch, L. E. Favaloro, L. She, E. J. Velazquez, R. H. Jones, and J. A. Panza. Myocardial viability and survival in ischemic left ventricular dysfunction. N. Engl. J. Med. 364:1617–1625, 2011.
19. Bramfeldt, H., G. Sabra, V. Centis, and P. Vermette. Scaffold vascularization: a challenge for three-dimensional tissue engineering. Curr. Med. Chem. 17:3944–3967, 2010.
20. Brutsaert, D. L. Cardiac endothelial-myocardial signalling: its role in cardiac growth, contractile performance, and rhythmicity. Physiol. Rev. 83:59–115, 2003.
21. Calvillo, L., R. Latini, J. Kajstura, A. Leri, P. Anversa, P. Ghezzi, M. Salio, A. Cerami, and M. Brines. Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling. Proc. Natl Acad. Sci. U.S.A. 100:4802–4806, 2003.
22. Camelliti, P., T. K. Borg, and P. Kohl. Structural and functional characterisation of cardiac fibroblasts. Cardiovasc. Res. 65:40–51, 2005.
23. Campbell, P. G., and L. E. Weiss. Tissue engineering with the aid of inkjet printers. Expert Opin. Biol. Ther. 7:1123–1127, 2007.
24. Carmeliet, P., and R. K. Jain. Angiogenesis in cancer and other diseases. Nature 407:249–257, 2000.
25. Carmeliet, P., and R. K. Jain. Molecular mechanisms and clinical applications of angiogenesis. Nature 473:298–307, 2011.
26. Carrier, R. L., M. Rupnick, R. Langer, F. J. Schoen, L. E. Freed, and G. Vunjak-Novakovic. Perfusion improves tissue architecture of engineered cardiac muscle. Tissue Eng. 8:175–188, 2002.
27. Caspi, O., A. Lesman, Y. Basevitch, A. Gepstein, G. Arbel, I. Huber, L. Gepstein, and S. Levenberg. Tissue engineering of vascularized cardiac muscle from human embryonic stem cells. Circ. Res. 100:263–272, 2007.
28. Chamberlain, M. D., R. Gupta, and M. V. Sefton. Chimeric vessel tissue engineering driven by endothelialized modules in immunosuppressed Sprague-Dawley rats. Tissue Eng. Part A 17:151–160, 2011.
29. Chen, Q. Z., S. E. Harding, N. N. Ali, A. R. Lyon, and A. R. Boccaccini. Myocardial tissue engineering. In: Tissue Engineering Using Ceramics and Polymers, edited by A. R. Boccaccini and J. Gough. Woodhead Publishing Limited, 2008.
30. Chen, X., A. S. Aledia, C. M. Ghajar, C. K. Griffith, A. J. Putnam, C. C. Hughes, and S. C. George. Revascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. Tissue Eng. Part A 15:1363–1371, 2009.
31. Chen, Q. Z., S. E. Harding, N. N. Ali, A. R. Lyon, and A. R. Boccaccini. Biomaterials in cardiac tissue engineering: ten years of research survey. Mater. Sci. Eng. 59:1–37, 2008.
32. Chiu, L. L., M. Radisic, and G. Vunjak-Novakovic. Bioactive scaffolds for engineering vascularized cardiac tissues. Macromol. Biosci. 10:1286–1301, 2010.
33. Chiu, L. L., M. Montgomery, Y. Liang, H. Liu, and M. Radisic. Perfusable branching microvessel bed for vascularization of engineered tissues. Proc. Natl Acad. Sci. U.S.A. 109:E3414–E3423, 2012.
34. Chiu, L. L., and M. Radisic. Scaffolds with covalently immobilized VEGF and Angiopoietin-1 for vascularization of engineered tissues. Biomaterials 31:226–241, 2010.
35. Chiu, L. L., M. Radisic, and G. Vunjak-Novakovic. Bioactive scaffolds for engineering vascularized cardiac tissues. Macromol. Biosci. 10:1286–1301, 2010.
36. Chiu, L. L., L. A. Reis, A. Momen, and M. Radisic. Controlled release of thymosin beta4 from injected collagen-chitosan hydrogels promotes angiogenesis and prevents tissue loss after myocardial infarction. Regen. Med. 7:523–533, 2012.
37. Chiu, L. L., R. D. Weisel, R. K. Li, and M. Radisic. Defining conditions for covalent immobilization of angiogenic growth factors onto scaffolds for tissue engineering. J. Tissue. Eng. Regen. Med. 5:69–84, 2011.
38. Cho, S. W., S. H. Moon, S. H. Lee, S. W. Kang, J. Kim, J. M. Lim, H. S. Kim, B. S. Kim, and H. M. Chung. Improvement of postnatal neovascularization by human embryonic stem cell derived endothelial-like cell transplantation in a mouse model of hindlimb ischemia. Circulation 116:2409–2419, 2007.
39. Choi, S. W., Y. Zhang, M. R. Macewan, and Y. Xia. Neovascularization in biodegradable inverse opal scaffolds with uniform and precisely controlled pore sizes. Adv. Healthc. Mater. 2:145–154, 2013.
40. Chong, J. J. H., X. Yang, C. W. Don, E. Minami, Y. W. Liu, J. J. Weyers, W. M. Mahoney, B. V. Biber, S. M. Cook, N. J. Palpant, J. A. Gantz, J. A. Fugate, V. Muskheli, G. M. Gough, K. W. Vogel, C. A. Astley, C. E. Hotchkiss, A. Baldessari, L. Pabon, H. Reinecke, E. A. Gill, V. Nelson, H. P. Kiem, M. A. Laflamme, and C. E. Murry. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature 510:273–277, 2014.
41. Chrobak, K. M., D. R. Potter, and J. Tien. Formation of perfused, functional microvascular tubes in vitro. Microvasc. Res. 71:185–196, 2006.
42. Chu, H., and Y. Wang. Therapeutic angiogenesis: controlled delivery of angiogenic factors. Ther. Deliv. 3:693–714, 2012.
43. Chung, Y. I., S. K. Kim, Y. K. Lee, S. J. Park, K. O. Cho, S. H. Yuk, G. Tae, and Y. H. Kim. Efficient revascularization by VEGF administration via heparin-functionalized nanoparticle-fibrin complex. J. Control Release 143:282–289, 2010.
44. Chung, J. C. Y., and D. Shum-Tim. Neovascularization in tissue engineering. Cells 1:1246–1260, 2012.
45. Co, C. C., Y. C. Wang, and C. C. Ho. Biocompatible micropatterning of two different cell types. J. Am. Chem. Soc. 127:1598–1599, 2005.
46. Cohen, D. J., B. Van Hout, P. W. Serruys, F. W. Mohr, C. Macaya, P. den Heijer, M. M. Vrakking, K. Wang, E. M. Mahoney, S. Audi, K. Leadley, K. D. Dawkins, and A. P. Kappetein. Quality of life after PCI with drug-eluting stents or coronary-artery bypass surgery. N. Engl. J. Med. 364:1016–1026, 2011.
47. Copeland, J. G., R. G. Smith, F. A. Arabia, P. E. Nolan, G. K. Sethi, P. H. Tsau, D. McClellan, and M. J. Slepian. Cardiac replacement with a total artificial heart as a bridge to transplantation. N. Engl. J. Med. 351:859–867, 2004.
48. Cui, X., and T. Boland. Human microvasculature fabrication using thermal inkjet printing technology. Biomaterials 30:6221–6227, 2009.
49. Culver, J. C., J. C. Hoffmann, R. A. Poche, J. H. Slater, J. L. West, and M. E. Dickinson. Three dimensional biomimetic patterning in hydrogels to guide cellular organization. Adv. Mater. 24:2344–2348, 2012.
50. Dar, A., M. Shachar, J. Leor, and S. Cohen. Optimization of cardiac cell seeding and distribution in 3D porous alginate scaffolds. Biotechnol. Bioeng. 80:305–312, 2002.
51. Deb, A., S. Wang, K. A. Skelding, D. Miller, D. Simper, and N. M. Caplice. Bone marrow-derived cardiomyocytes are present in adult human heart: a study of gender-mismatched bone marrow transplantation patients. Circulation 107:1247–1249, 2003.
52. Defilippi, P., C. Olivo, M. Venturino, L. Dolce, L. Silengo, and G. Tarone. Actin cytoskeleton organization in response to integrin-mediated adhesion. Microsc. Res. Tech. 47:67–78, 1999.
53. Discher, D. E., D. J. Mooney, and P. W. Zandstra. Growth factors, matrices, and forces combine and control stem cells. Science 324:1673–1677, 2009.
54. Dobaczewski, M., C. Gonzalez-Quesada, and N. G. Frangogiannis. The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J. Mol. Cell. Cardiol. 48:504–511, 2010.
55. Dobnig, H., S. Pilz, H. Scharnagl, W. Renner, U. Seelhorst, B. Wellnitz, J. Kinkeldei, B. O. Boehm, G. Weihrauch, and W. Maerz. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch. Intern. Med. 168:1340–1349, 2008.
56. Dvir, T., A. Kedem, E. Ruvinov, O. Levy, I. Freeman, N. Landad, R. Holbovad, M. S. Feinbergd, S. Drore, Y. Etzione, J. Leord, and S. Cohena. Prevascularization of cardiac patch on the omentum improves its therapeutic outcome. Proc. Natl Acad. Sci. U.S.A. 106:14990–14995, 2009.
57. Eppler, S. M., D. L. Combs, T. D. Henry, J. J. Lopez, S. G. Ellis, J. H. Yi, B. H. Annex, E. R. Mccluskey, and T. F. Zioncheck. A target-mediated model to describe the pharmacokinetics and hemodynamic effects of recombinant human vascular endothelial growth factor in humans. Clin. Pharmacol. Ther. 72:20–32, 2002.
58. Etzion, S., L. H. Kedes, R. A. Kloner, and J. Leor. Myocardial regeneration: present and future trends. Am. J. Cardiovasc. Drugs 1:233–244, 2001.
59. Evans, S. M., C. Mummery, and P. A. Doevendans. Progenitor cells for cardiac repair. Semin. Cell Dev. Biol. 18:153–160, 2007.
60. Fernandes, S., A. V. Naumova, W. Z. Zhu, M. A. Laflamme, J. Gold, and C. E. Murry. Human embryonic stem cell-derived cardiomyocytes engraft but do not alter cardiac remodeling after chronic infarction in rats. J. Mol. Cell. Cardiol. 49:941–949, 2010.
61. Folkman, J., and C. Haudenschild. Angiogenesis in vitro. Nature 288:551–556, 1980.
62. Formiga, F. R., B. Pelacho, E. Garbayo, G. Abizanda, J. J. Gavira, T. Simon-Yarza, M. Mazo, E. Tamayo, C. Jauquicoa, C. Ortiz-de-Solorzano, F. Pro´sper, and M. J. Blanco-Prieto. Sustained release of VEGF through PLGA microparticles improves vasculogenesis and tissue remodeling in an acute myocardial ischemia-reperfusion model. J. Control Release 147:30–37, 2010.
63. Formiga, F. R., B. Pelacho, E. Garbayo, I. Imbuluzqueta, P. Díaz-Herráez, G. Abizanda, J. J. Gavira, T. Simón-Yarza, E. Albiasub, E. Tamayoa, F. Prósper, and M. J. Blanco-Prieto. Controlled delivery of fibroblast growth factor-1 and neuregulin-1 from biodegradablemicroparticles promotes cardiac repair in a rat myocardial infarction model through activation of endogenous regeneration. J. Control Release 73:132–139, 2014.
64. Frangogiannis, N. G., L. H. Mendoza, G. Ren, S. Akrivakis, P. L. Jackson, L. H. Michael, C. W. Smith, and M. L. Entman. MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype. Am. J. Physiol. Heart Circ. Physiol. 285:H483–H492, 2003.
65. Frangogiannis, N. G., C. W. Smith, and M. L. Entman. The inflammatory response in myocardial infarction. Cardiovasc. Res. 53:31–47, 2002.
66. Freeman, I., and S. Cohen. The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization. Biomaterials 30:2122–2131, 2009.
67. Gao, J., J. Liu, Y. Gao, C. Wang, Y. Zhao, B. Chen, Z. Xiao, Q. Miao, and J. Dai. A myocardial patch made of collagen membranes loaded with collagen-binding human vascular endothelial growth factor accelerates healing of the injured rabbit heart. Tissue Eng. Part A 17:2739–2747, 2011.
68. Geiger, F., H. Lorenz, W. Xu, K. Szalay, P. Kasten, L. Claes, P. Augat, and W. Richter. VEGF producing bone marrow stromal cells (BMSC) enhance vascularization and resorption of a natural coral bone substitute. Bone 41:516–522, 2007.
69. Gerhardt, H., M. Golding, M. Fruttiger, C. Ruhrberg, A. Lundkvist, A. Abramsson, M. Jeltsch, C. Mitchell, K. Alitalo, D. Shima, and C. Betsholtz. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell Biol. 161:1163–1177, 2003.
70. Go, A. S., D. Mozaffarian, V. L. Roger, E. J. Benjamin, J. D. Berry, M. J. Blaha, S. Dai, E. S. Ford, C. S. Fox, S. Franco, H. J. Fullerton, C. Gillespie, S. M. Hailpern, J. A. Heit, V. J. Howard, M. D. Huffman, S. E. Judd, B. M. Kissela, S. J. Kittner, D. T. Lackland, J. H. Lichtman, L. D. Lisabeth, R. H. Mackey, D. J. Magid, G. M. Marcus, A. Marelli, D. B. Matchar, D. K. McGuire, E. R. Mohler, III, C. S. Moy, M. E. Mussolino, R. W. Neumar, G. Nichol, D. K. Pandey, N. P. Paynter, M. J. Reeves, P. D. Sorlie, J. Stein, A. Towfighi, T. N. Turan, S. S. Virani, N. D. Wong, D. Woo, and M. B. Turner. Heart disease and stroke statistics-2014 update: a report from the American Heart Association. Circulation 129:e28–e292, 2014.
71. Golub, J. S., Y. T. Kim, C. L. Duvall, R. V. Bellamkonda, D. Gupta, A. S. Lin, D. Weiss, W. Robert Taylor, and R. E. Guldberg. Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth. Am. J. Physiol. Heart Circ. Physiol. 298:H1959–H1965, 2010.
72. Guo, H. D., G. H. Cui, J. J. Yang, C. Wang, J. Zhu, L. S. Zhang, J. Jiang, and S. J. Shao. Sustained delivery of VEGF from designer self-assembling peptides improves cardiac function after myocardial infarction. Biochem. Biophys. Res. Commun. 424:105–111, 2012.
73. Gupta, R., and M. V. Sefton. Application of an endothelialized modular construct for islet transplantation in syngeneic and allogeneic immunosuppressed rat models. Tissue Eng. Part A 17:2005–2015, 2011.
74. Hahn, M. S., J. S. Miller, and J. L. West. Laser scanning lithography for surface micropatterning on hydrogels. Adv. Mater. 17:2939–2942, 2005.
75. Hahn, M. S., J. S. Miller, and J. L. West. Three-dimensional biochemical and biomechanical patterning of hydrogels for guiding cell behavior. Adv. Mater. 18:2679–2684, 2006.
76. Hahn, M. S., L. J. Taite, J. J. Moon, M. C. Rowland, K. A. Ruffino, and J. L. West. Photolithographic patterning of polyethylene glycol hydrogels. Biomaterials 27:2519–2524, 2006.
77. Hao, X., E. A. Silva, A. Mansson-Broberg, K. H. Grinnemo, A. J. Siddiqui, G. Dellgren, E. Wa¨rdell, L. A. Brodin, D. J. Mooney, and C. Sylve´n. Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction. Cardiovasc. Res. 75:178–185, 2007.
78. Heeschen, C., A. Aicher, R. Lehmann, S. Fichtlscherer, M. Vasa, C. Urbich, C. Mildner-Rihm, H. Martin, A. M. Zeiher, and S. Dimmeler. Erythropoietin is a potent physiological stimulus for endothelial progenitor cell mobilization. Blood 102:1340–1346, 2003.
79. Hench, L. L., and J. M. Polak. Third-generation biomedical materials. Science 295:1014–1017, 2004.
80. Henry, T. D., K. Rocha-Singh, J. M. Isner, D. J. Kereiakes, F. J. Giordano, M. Simons, D. W. Losordo, R. C. Hendel, R. O. Bonow, S. M. Eppler, T. F. Zioncheck, E. B. Holmgren, and E. R. McCluskey. Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease. Am. Heart J. 142:872–880, 2001.
81. Hiasa, K., M. Ishibashi, K. Ohtani, S. Inoue, Q. Zhao, S. Kitamoto, M. Sata, T. Ichiki, A. Takeshita, and K. Egashira. Gene transfer of stromal cell-derived factor-1{alpha} enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: Next-generation chemokine therapy for therapeutic neovascularization. Circulation 109:2454–2461, 2004.
82. Holdings I Inc. IK-5001 for the prevention of remodeling of the ventricle and congestive heart failure after acute myocardial infarction. In: Clinical Trial Detail. 2010. http://clinicaltrials.gov/show/NCT01226563.
83. Hou, L., and N. Huang. Extracellular matrix-mediated endothelial differentiation of human induced pluripotent stem cells. FASEB J. 28(1152):4, 2014.
84. Huang, Y. C., D. Kaigler, K. G. Rice, P. H. Krebsbach, and D. J. Mooney. Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration. J. Bone Miner. Res. 20:848–857, 2005.
85. Huang, N. F., H. Niiyama, C. Peter, A. De, Y. Natkunam, F. Fleissner, Z. Li, M. D. Rollins, J. C. Wu, S. S. Gambhir, and J. P. Cooke. Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion. Arterioscler. Thromb. Vasc. Biol. 30:984–991, 2010.
86. Huang, H., S. Oizumi, N. Kojima, T. Niino, and Y. Sakai. Avidin-biotin binding-based cell seeding and perfusion culture of liverderived cells in a porous scaffold with a three-dimensional interconnected flow channel network. Biomaterials 28:3815–3823, 2007.
87. Hur, J., C. H. Yoon, H. S. Kim, J. H. Choi, H. J. Kang, K. K. Hwang, B. H. Oh, M. M. Lee, and Y. B. Park. Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arterioscler. Thromb. Vasc. Biol. 24:288–293, 2004.
88. Hutton, D. L., and W. L. Grayson. Stem cell-based approaches to engineering vascularised bone. Curr. Opin. Chem. Biol. 3:75–82, 2014.
89. Hwang, N. S., S. Varghese, and J. Elisseeff. Controlled differentiation of stem cells. Adv. Drug Deliv. Rev. 60:199, 2008.
90. Izadifar, M., A. Haddadi, and X. B. Chen. Rate-programming of nano-particulate delivery systems for smart bioactive scaffolds in tissue engineering. Nanotechnology 2014 (in review).
91. Jessup, M., and S. Brozena. Heart failure. N. Engl. J. Med. 348:2007–2018, 2003.
92. Johnston, T. D., and K. L. Christman. Injectable hydrogel therapies and their delivery strategies for treating myocardial infarction. Expert Opin. Drug Deliv. 10:59–72, 2013.
93. Jones, R. H., E. J. Velazquez, R. E. Michler, G. Sopko, J. K. Oh, C. M. O’Connor, J. A. Hill, L. Menicanti, Z. Sadowski, P. Desvigne-Nickens, J. L. Rouleau, and K. L. Lee. Coronary bypass surgery with or without surgical ventricular reconstruction. N. Engl. J. Med. 360:1705–1717, 2009.
94. Kadner, A., G. Zund, C. Maurus, C. Breymann, S. Yakarisik, G. Kadner, M. Turina, and S. P. Hoerstrup. Human umbilical cord cells for cardiovascular tissue engineering: A comparative study. Eur. J. Cardiothorac. Surg. 25:635–641, 2004.
95. Kakio, T., A. Matsumori, K. Ono, H. Ito, K. Matsushima, and S. Sasayama. Roles and relationship of macrophages and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in the ischemic and reperfused rat heart. Lab. Invest. 80:1127–1136, 2000.
96. Kalka, C., H. Masuda, T. Takahashi, W. M. Kalka-Moll, M. Silver, M. Kearney, T. Li, J. M. Isner, and T. Asahara. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularisation. Proc. Natl Acad. Sci. U.S.A. 97:3422–3427, 2000.
97. Kamelger, F. S., R. Marksteiner, E. Margreiter, G. Klima, G. Wechselberger, S. Hering, and H. Piza. A comparative study of three different biomaterials in the engineering of skeletal muscle using a rat animal model. Biomaterials 25:1649–1655, 2004.
98. Kelm, J. M., V. Lorber, J. G. Snedeker, D. Schmidt, A. Broggini-Tenzer, M. Weisstanner, B. Odermatt, A. Mol, G. Zünd, and S. P. Hoerstrup. A novel concept for scaffold-free vessel tissue engineering: self-assembly of micro tissue building blocks. J. Biotechnol. 148:46–55, 2010.
99. Kennedy, J. P., S. P. McCandless, A. Rauf, L. M. Williams, J. Hillam, and R. W. Hitchcock. Engineered channels enhance cellular density in perfused scaffolds. Acta Biomater. 7:3896–3904, 2011.
100. Kocher, A. A., M. D. Schuster, M. J. Szabolcs, S. Takuma, D. Burk-hoff, J. Wang, S. Homma, N. M. Edwards, and S. Itescu. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat. Med. 7:430–436, 2001.
101. Kofidis, T., P. Akhyari, B. Wachsmann, J. Boublik, K. Mueller-Stahl, R. Leyh, S. Fischer, and A. Haverich. A novel bioartificial myocardial tissue and its prospective use in cardiac surgery. Eur. J. Cardio-Thorac. Surg. 2:238–243, 2002.
102. Koike, N., D. Fukumura, O. Gralla, P. Au, J. S. Schechner, and R. K. Jain. Tissue engineering: creation of long-lasting blood vessels. Nature 428:138–139, 2004.
103. Kotov, N. A., Y. Liu, S. Wang, C. Cumming, M. Eghtedari, G. Vargas, M. Motamedi, J. Nichols, and J. Cortiella. Inverted colloidal crystals as three-dimensional cell scaffolds. Langmuir 20:7887–7892, 2004.
104. Kunz-Schughart, L. A., J. A. Schroeder, M. Wondrak, F. van Rey, K. Lehle, F. Hofstaedter, and D. N. Wheatley. Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro. Am. J. Physiol. Cell Physiol. 290:C1385–C1398, 2006.
105. Laflamme, M. A., K. Y. Chen, A. V. Naumova, V. Muskheli, J. A. Fugate, S. K. Dupras, H. Reinecke, C. Xu, M. Hassanipour, S. Police, C. O’Sullivan, L. Collins, Y. Chen, E. Minami, E. A. Gill, S. Ueno, C. Yuan, J. Gold, and C. E. Murry. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat. Biotechnol. 25:1015–1024, 2007.
106. Laflamme, M. A., D. Myerson, J. E. Saffitz, and C. E. Murry. Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts. Circ. Res. 90:634–640, 2002.
107. Lambert, J. M., E. F. Lopez, and M. L. Lindsey. Macrophage roles following myocardial infarction. Int. J. Cardiol. 130:147–158, 2008.
108. Laschke, M. W., S. Kleer, C. Scheuer, S. Schuler, P. Garcia, D. Eglin, M. Alini, and M. D. Menger. Vascularization of porous scaffolds is improved by incorporation of adipose tissue-derived microvasculature fragments. Eur. Cell Mater. 24:266–277, 2012.
109. Laschke, M. W., H. Mussawy, S. Schuler, A. Kazakov, M. Rucker, D. Eglin, M. Alini, and M. D. Menger. Short-term cultivation of in situ prevascularized tissue constructs accelerates inosculation of their preformed microvascular networks after implantation into the host tissue. Tissue Eng. Part A 17:841–852, 2011.
110. Laschke, M. W., M. Rucker, G. Jensen, C. Carvalho, R. Mulhaupt, N. C. Gellrich, and M. D. Menger. Improvement of vascularization of PLGA scaffolds by inosculation of in situ-preformed functional blood vessels with the host microvasculature. Ann. Surg. 248:939–948, 2008.
111. Laschke, M. W., M. Rücker, G. Jensen, C. Carvalho, R. Mülhaupt, N. C. Gellrich, and M. D. Menger. Incorporation of growth factor containing Matrigel promotes vascularization of porous PLGA scaffolds. J. Biomed. Mater. Res. A. 85:397–407, 2008.
112. Laschke, M. W., B. Vollmar, and M. D. Menger. Inosculation: connecting the life-sustaining pipelines. Tissue Eng. Part B 15:455–465, 2009.
113. Laugwitz, K. L., A. Moretti, L. Caron, A. Nakano, and K. R. Chien. Islet1 cardiovascular progenitors: a single source for heart lineages. Development 135:193–205, 2008.
114. Lazarous, D. F., E. F. Unger, S. E. Epstein, A. Stine, J. L. Arevalo, E. Y. Chew, and A. A. Quyyumi. Basic fibroblast growth factor in patients with intermittent claudication: results of a phase I trial. J. Am. Coll. Cardiol. 36:1239–1244, 2000.
115. Le Huu, A., A. Paul, L. Xu, S. Prakash, and D. Shum-Tim. Recent advancements in tissue engineering for stem cell-based cardiac therapies. Ther. Deliv. 4:503–516, 2013.
116. Lee, S. H., J. J. Moon, and J. L. West. Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration. Biomaterials 29:2962–2968, 2008.
117. Leeper, N. J., A. L. Hunter, and J. P. Cooke. Stem cell therapy for vascular regeneration: adult, embryonic, and induced pluripotent stem cells. Circulation 22:517–526, 2010.
118. Leeper, N. J., A. L. Hunter, and J. P. Cooke. Stem cell therapy for vascular regeneration: adult, embryonic, and induced pluripotent stem cells. Circulation 122:517–526, 2010.
119. Leor, J., S. Aboulafia-Etzion, A. Dar, L. Shapiro, I. M. Barbash, A. Battler, T. Granot, and S. Cohen. Bioengineered cardiac grafts: a new approach to repair the infarcted myocardium. Circulation 102:56–61, 2000.
120. Leor, J., S. Aboulafia-Etzion, A. Dar, L. Shapiro, I. M. Barbash, A. Battler, Y. Granot, and S. Cohen. Bioengineered cardiac grafts: a new approach to repair the infarcted myocardium? Circulation 102:III56–III61, 2000.
121. Leor, J., S. Tuvia, V. Guetta, F. Manczur, D. Castel, U. Willenz, O. Petneházy, N. Landa, M. S. Feinberg, E. Konen, O. Goitein, O. Tsur-Gang, M. Shaul, L. Klapper, and S. Cohen. Intracoronary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in swine. J. Am. Coll. Cardiol. 54:1014–1023, 2009.
122. Leri, A., J. Kajstura, and P. Anversa. Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biology. Circ. Res. 109:941–961, 2011.
123. Leslie-Barbick, J. E., C. Shen, C. Chen, and J. L. West. Micron-scale spatially patterned, covalently immobilized vascular endothelial growth factor on hydrogels accelerates endothelial tubulogenesis and increases cellular angiogenic responses. Tissue Eng. Part A 17:221–229, 2010.
124. Leucker, T. M., M. Bienengraeber, M. Muravyeva, I. Baotic, D. Weihrauch, A. K. Brzezinska, D. C. Warltier, J. R. Kersten, and P. F. Pratt, Jr. Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection. J. Mol. Cell. Cardiol. 51:803–811, 2011.
125. Leung, B., and M. Sefton. A modular tissue engineering construct containing smooth muscle cells and endothelial cells. Ann. Biomed. Eng. 35:2039–2049, 2007.
126. Levenberg, S., N. F. Huang, E. Lavik, A. B. Rogers, J. Itskovitz-Eldor, and R. Langer. Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc. Natl Acad. Sci. U.S.A. 100:12741–12746, 2003.
127. Levenberg, S., J. Rouwkema, M. Macdonald, E. S. Garfein, D. S. Kohane, D. C. Darland, R. Marini, C. A. van Blitterswijk, R. C. Mulligan, P. A. D’Amore, and R. Langer. Engineering vascularized skeletal muscle tissue. Nat. Biotechnol. 23:879–884, 2005.
128. Li, Z., K. D. Wilson, B. Smith, D. L. Kraft, F. Jia, M. Huang, X. Xie, R. C. Robbins, S. S. Gambhir, I. L. Weissman, and J. C. Wu. Functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction. PLoS ONE 2009. doi:10.1371/journal.pone.0008443.
129. Li, R. K., T. M. Yau, R. D. Weisel, D. A. Mickle, T. Sakai, A. Choi, and Z. Q. Jia. Construction of a bioengineered cardiac graft. J. Thorac. Cardiovasc. Surg. 119:368–375, 2000.
130. Lim, S. Y., D. Hernández, and G. J. Dusting. Growing vascularized heart tissue from stem cells. J. Cardiovasc. Pharmacol. 62:122–129, 2013.
131. Lo Vasco, V. R., L. Pacini, T. Di Raimo, D. D’arcangelo, and R. Businaro. Expression of phosphoinositide-specific phospholipase C isoforms in human umbilical vein endothelial cells. J. Clin. Pathol. 64:911–915, 2011.
132. Lokmic, Z., F. Stillaert, W. A. Morrison, E. W. Thompson, and G. M. Mitchell. An arteriovenous loop in a protected space generates a permanent, highly vascular, tissue-engineered construct. FASEB J. 21:511–522, 2007.
133. Luikart, S. D., B. Levay-Young, T. Hinkel, J. Shearer, C. Mills, M. D. Caldwell, M. R. Gyetko, and T. R. Oegema. Mactinin treatment promotes wound-healing-associated inflammation in urokinase knockout mice. Wound Repair Regen. 14:123–128, 2006.
134. Luo, Z. P., Y. L. Sun, T. Fujii, and K. N. An. Single molecule mechanical properties of type II. Biorheology 41:247–254, 2004.
135. Manning, M. C., K. Patel, and R. T. Borchardt. Stability of protein pharmaceuticals: an update. Pharm. Res. 27:544–575, 2010.
136. Mao, M., J. He, Y. Liu, X. Li, and D. Li. Icetemplate-induced silk fibroin-chitosan scaffolds with predefined microfluidic channels and fully porous structures. Acta Biomater. 8:2175–2184, 2012.
137. Marga, F., K. Jakab, C. Khatiwala, B. Shephard, S. Dorfman, B. Hubbard, S. Colbert, and F. Gabor. Toward engineering functional organ modules by additive manufacturing. Biofabrication 2012. doi:10.1088/1758-5082/4/2/022001.
138. Marra, K. G., A. J. Defail, J. A. Clavijo-Alvarez, S. F. Badylak, A. Taieb, B. Schipper, J. Bennett, and J. P. Rubin. FGF-2 enhances vascularization for adipose tissue engineering. Plast. Reconstr. Surg. 121:1153–1164, 2008.
139. Martens, T. P., A. F. G. Godier, J. J. Parks, L. Q. Wan, M. S. Koeckert, G. M. Eng, B. I. Hudson, W. Sherman, and G. Vunjak-Novakovic. Percutaneous cell delivery into the heart using hydrogels polymerizing in situ. Cell Transpl. 18:297–304, 2009.
140. Matsubayashi, K., P. W. Fedak, D. A. Mickle, R. D. Weisel, T. Ozawa, and R. K. Li. Improved left ventricular aneurysm repair with bioengineered vascular smooth muscle grafts. Circulation 108:II219–II225, 2003.
141. Matsuura, K., T. Nagai, N. Nishigaki, T. Oyama, J. Nishi, H. Wada, M. Sano, H. Toko, H. Akazawa, T. Sato, H. Nakaya, H. Kasanuki, and I. Komuro. Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J. Biol. Chem. 279:11384–11391, 2004.
142. McGuigan, A. P., and M. V. Sefton. Vascularized organoid engineered by modular assembly enables blood perfusion. Proc. Natl Acad. Sci. 103:1461–1466, 2006.
143. McGuigan, A. P., and M. V. Sefton. The thrombogenicity of human umbilical vein endothelial cell seeded collagen modules. Biomaterials 29:2453–2463, 2008.
144. Mehdizadeh, H., S. Sumo, E. S. Bayrak, E. M. Brey, and A. Cinar. Three-dimensional modeling of angiogenesis in porous biomaterial scaffolds. Biomaterials 4:2875–2887, 2013.
145. Minatoguchi, S., G. Takemura, X. H. Chen, N. Wang, Y. Uno, M. Koda, M. Arai, Y. Misao, C. Lu, K. Suzuki, K. Goto, A. Komada, T. Takahashi, K. Kosai, T. Fujiwara, and H. Fujiwara. Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony stimulating factor treatment. Circulation 109:2572–2580, 2004.
146. Mironov, V., V. Kasyanov, and R. R. Markwald. Organ printing: from bioprinter to organ biofabrication line. Curr. Opin. Biotechnol. 22:667–673, 2011.
147. Miyagi, Y., L. L. Chiu, M. Cimini, R. D. Weisel, M. Radisic, and R. K. Li. Biodegradable collagen patch with covalently immobilized VEGF for myocardial repair. Biomaterials 32:1280–1290, 2011.
148. Mohri, T., Y. Fujio, M. Maeda, T. Ito, T. Iwakura, Y. Oshima, Y. Uozumi, M. Segawa, H. Yamamoto, T. Kishimoto, and J. Azum. Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells. J. Biol. Chem. 281:6442–6447, 2006.
149. Moldovan, N. I., P. J. Goldschmidt-Clermont, J. Parker-Thornburg, S. D. Shapiro, and P. E. Kolattukudy. Contribution of monocytes/macrophages to compensatory neovascularization: the drilling of metalloelastase-positive tunnels in ischemic myocardium. Circ. Res. 87:378–384, 2000.
150. Montano, I., C. Schiestl, J. Schneider, L. Pontiggia, J. Luginbuhl, T. Biedermann, S. Böttcher-Haberzeth, E. Braziulis, M. Meuli, and E. Reichmann. Formation of human capillaries in vitro: the engineering of prevascularized matrices. Tissue Eng. Part A 16:269–282, 2010.
151. Moon, J. J., M. S. Hahn, I. Kim, B. A. Nsiah, and J. L. West. Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis. Tissue Eng. Part A 15:579, 2009.
152. Morice, M. C., P. W. Serruys, A. P. Kappetein, T. E. Feldman, E. Stahle, A. Colombo, M. J. Mack, D. R. Holmes, L. Torracca, G. A. van Es, K. Leadley, K. D. Dawkins, and F. Mohr. Outcomes in patients with de novo left main disease treated with either percutaneous coronary intervention using paclitaxel-eluting stents or coronary artery bypass graft treatment in the synergy between percutaneous coronary intervention with TAXUS and cardiac surgery (SYNTAX) trial. Circulation 121:2645–2653, 2010.
153. Morritt, A. N., S. K. Bortolotto, R. J. Dilley, X. Han, A. R. Kompa, and D. McCombe. Cardiac tissue engineering in an in vivo vascularized chamber. Circulation 115:353–360, 2007.
154. Murphy, W. L., R. G. Dennis, J. L. Kileny, and D. J. Mooney. Salt fusion: an approach to improve pore interconnectivity within tissue engineering scaffolds. Tissue Eng. 8:43–52, 2002.
155. Musaro, A., C. Giacinti, G. Borsellino, G. Dobrowolny, L. Pelosi, L. Cairns, S. Ottolenghi, G. Cossu, G. Bernardi, L. Battistini, M. Molinaro, and N. Rosenthal. Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1. Proc. Natl Acad. Sci. U.S.A. 101:1206–1210, 2004.
156. Nagai, N., N. Kumasaka, T. Kawashima, H. Kaji, M. Nishizawa, and T. Abe. Preparation and characterization of collagen microspheres for sustained release of VEGF. J. Mater. Sci. Mater. Med. 21:1891–1898, 2010.
157. Narazaki, G., H. Uosaki, M. Teranishi, K. Okita, B. Kim, S. Matsuoka, S. Yamanaka, and J. K. Yamashita. Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation 18:498–506, 2008.
158. Nguyen, H., J. J. Qian, R. S. Bhatnagar, and S. Li. Enhanced cell attachment and osteoblastic activity by P-15 peptide-coated matrix in hydrogels. Biochem. Biophys. Res. Commun. 311:179–186, 2003.
159. Nian, M., P. Lee, N. Khaper, and P. Liu. Inflammatory cytokines and postmyocardial infarction remodeling. Circ. Res. 94:1543–1553, 2004.
160. Nitenberg, A. Hypertension, endothelial dysfunction and cardiovascular risk. Arch. Mal. Coeur Vaiss. 99:915–921, 2006.
161. Noireaud, J., and R. Andriantsitohaina. Recent insights in the paracrine modulation of cardiomyocyte contractility by cardiac endothelial cells. Biomed. Res. Int. 2014;2014:doi:10.1155/2014/923805.
162. Norotte, C., F. S. Marga, L. E. Niklason, and G. Forgacs. Scaffold-free vascular tissue engineering using bioprinting. Biomaterials 30:5910–5917, 2009.
163. Novakovic, G. V., N. Tandon, A. Godier, R. Maidhof, A. Marsano, T. P. Martens, and M. Radisic. Challenges in cardiac tissue engineering. Tissue Eng. Part B 16:169–187, 2010.
164. Oh, H., S. B. Bradfute, T. D. Gallardo, T. Nakamura, V. Gaussin, Y. Mishina, J. Pocius, L. H. Michael, R. R. Behringer, D. J. Garry, M. L. Entman, and M. D. Schneider. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc. Natl Acad. Sci. U.S.A. 100:12313–12318, 2003.
165. Oh, K. S., J. Y. Song, S. J. Yoon, Y. Park, D. Kim, and S. H. Yuk. Temperature-induced gel formation of core/shell nanoparticles for the regeneration of ischemic heart. J. Control Release 146:207–211, 2010.
166. Ohtsuka, M., H. Takano, Y. Zou, H. Toko, H. Akazawa, Y. Qin, M. Suzuki, H. Hasegawa, H. Nakaya, and I. Komuro. Cytokine therapy prevents left ventricular remodeling and dysfunction after myocardial infarction through neovascularization. FASEB J. 18:851–853, 2004.
167. Opie, L. H., P. J. Commerford, B. J. Gersh, and M. A. Pfeffer. Controversies in ventricular remodelling. Lancet 367:356–367, 2006.
168. Orlic, D., J. Kajstura, S. Chimenti, I. Jakoniuk, S. M. Anderson, B. Li, J. Pickel, R. McKay, B. Nadal-Ginard, D. M. Bodine, A. Leri, and P. Anversa. Bone marrow cells regenerate infarcted myocardium. Nature 410:701–705, 2001.
169. Orlic, D., J. Kajstura, S. Chimenti, F. Limana, I. Jakoniuk, F. Quaini, B. Nadal-Ginard, D. M. Bodine, A. Leri, and P. Anversa. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl Acad. Sci. U.S.A. 98:10344–10349, 2001.
170. Orr, A. W., C. A. Elzie, D. F. Kucik, and J. E. Murphy-Ullrich. Thrombospondin signaling through the alreticulin LDL receptor-related protein co-complex stimulates random and directed cell migration. J. Cell Sci. 116:2917, 2003.
171. Ozawa, C. R., A. Banfi, N. L. Glazer, G. Thurston, M. L. Springer, P. E. Kraft, D. M. McDonald, and H. M. Blau. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J. Clin. Invest. 113:516–527, 2004.
172. Padin-Iruegas, M. E., Y. Misao, M. E. Davis, V. F. M. Segers, G. Esposito, T. Tokunou, K. Urbanek, T. Hosoda, M. Rota, P. Anversa, A. Leri, R. T. Lee, and J. Kajstura. Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction. Circulation 120:876–887, 2009.
173. Papadaki, M., N. Bursac, R. Langer, J. Merok, G. Vunjak-Novakovic, and L. E. Freed. Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies. Am. J. Physiol. Heart Circ. Physiol. 280:H168–H178, 2001.
174. Park, J. H., B. G. Chung, W. G. Lee, J. Kim, M. D. Brigham, J. Shim, S. Lee, C. M. Hwang, N. G. Durmus, U. Demirci, and A. Khademhosseini. Microporous cell-laden hydrogels for engineered tissue constructs. Biotechnol. Bioeng. 106:138–148, 2010.
175. Parolari, A., L. L. Pesce, M. Trezzi, C. Loardi, S. Kassem, C. Brambillasca, B. Miguel, E. Tremoli, P. Biglioli, and F. Alamanni. Performance of EuroSCORE in CABG and off-pump coronary artery bypass grafting: single institution experience and meta-analysis. Eur. Heart J. 30:297–304, 2009.
176. Passier, R., L. W. van Laake, and C. L. Mummery. Stem-cell based therapy and lessons from the heart. Nature 453:322–329, 2008.
177. Perets, A., Y. Baruch, F. Weisbuch, G. Shoshany, G. Neufeld, and S. Cohen. Enhancing the vascularization of three dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres. J. Biomed. Mater. Res. A. 65:489, 2003.
178. Planat-Benard, V., C. Menard, M. Andre, M. Puceat, A. Perez, J. M. Garcia-Verdugo, L. Pénicaud, and L. Casteilla. Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells. Circ. Res. 94:223–229, 2004.
179. Quaini, F., K. Urbanek, A. P. Beltrami, N. Finato, C. A. Beltrami, B. Nadal-Ginard, J. Kajstura, A. Leri, and P. Anversa. Chimerism of the transplanted heart. N. Engl. J. Med. 346:5–15, 2002.
180. Radisic, M., and V.-N. G. Serbian. Cardiac tissue engineering. J. Chem. Soc. 70:541–556, 2005.
181. Raghavan, S., C. M. Nelson, J. D. Baranski, E. Lim, and C. S. Chen. Geometrically controlled endothelial tubulogenesis in micropatterned gels. Tissue Eng. Part A 16:2255–2263, 2010.
182. Rakusan, K., M. F. Flanagan, T. Geva, J. Southern, and R. Van-Praagh. Morphometry of human coronary capillaries during normal growth and the effect of age in left ventricular pressure-overload hypertrophy. Circulation 86:38–46, 1992.
183. Reis, L. A., L. L. Chiu, Y. Liang, K. Hyunh, A. Momen, and M. Radisic. A peptide-modified chitosan-collagen hydrogel for cardiac cell culture and delivery. Acta Biomater. 8:1022–1036, 2012.
184. Ren, G. Inflammatory mechanisms in myocardial infarction. Curr. Drug Targets Inflamm. Allergy 2:242–256, 2003.
185. Richardson, T. P., W. L. Murphy, and D. J. Mooney. Polymeric delivery of proteins and plasmid DNA for tissue engineering and gene therapy. Crit. Rev. Eukaryot. Gene Expr. 11:47–58, 2001.
186. Richardson, T. P., M. C. Peters, A. B. Ennett, and D. J. Mooney. Polymeric system for dual growth factor delivery. Nat. Biotechnol. 19:1029–1034, 2001.
187. Ripa, R. S., J. C. Nilsson, Y. Wang, L. Sondergaard, E. Jorgensen, and J. Kastrup. Short- and long-term changes in myocardial function, morphology, edema, and infarct mass after ST-segment elevation myocardial infarction evaluated by serial magnetic resonance imaging. Am. Heart J. 154:929–936, 2007.
188. Roger, V. L., A. S. Go, D. M. Lloyd-Jones, E. J. Benjamin, J. D. Berry, W. B. Borden, D. M. Bravata, S. Dai, E. S. Ford, C. S. Fox, H. J. Fullerton, C. Gillespie, S. M. Hailpern, J. A. Heit, V. J. Howard, B. M. Kissela, S. J. Kittner, D. T. Lackland, J. H. Lichtman, L. D. Lisabeth, D. M. Makuc, G. M. Marcus, A. Marelli, D. B. Matchar, C. S. Moy, D. Mozaffarian, M. E. Mussolino, G. Nichol, N. P. Paynter, E. Z. Soliman, P. D. Sorlie, N. Sotoodehnia, T. N. Turan, S. S. Virani, N. D. Wong, D. Woo, and M. B. Turner. Heart disease and stroke statistics-2012 update: a report from the American Heart Association. Circulation 125:e2–e220, 2012.
189. Rosamond, W., K. Flegal, K. Furie, A. Go, K. Greenlund, N. Haase, S. M. Hailpern, M. Ho, V. Howard, B. Kissela, S. Kittner, D. Lloyd-Jones, M. McDermott, J. Meigs, C. Moy, G. Nichol, C. O’Donnell, V. Roger, P. Sorlie, J. Steinberger, T. Thom, M. Wilson, and Y. Hong. Heart disease and stroke statistics-2008 update: a report from the American Heart Association. Circulation 117:e25–e146, 2008.
190. Rücker, M., M. W. Laschke, D. Junker, C. Carvalho, A. Schramm, R. Mulhaupt, N. C. Gellrich, and M. D. Menger. Angiogenic and inflammatory response to biodegradable scaffolds in dorsal skinfold chambers of mice. Biomaterials 27:5027–5038, 2006.
191. Rücker, M., M. W. Laschke, D. Junker, C. Carvalho, F. Tavassol, R. Mülhaupt, N. C. Gellrich, and M. D. Menger. Vascularization and biocompatibility of scaffolds consisting of different calcium phosphate compounds. J. Biomed. Mater. Res. A 86:1002–1011, 2008.
192. Rufaihah, A. J., N. F. Huang, S. Jame, J. C. Lee, H. N. Nguyen, B. Byers, A. De, J. Okogbaa, M. Rollins, R. Reijo-Pera, S. S. Gambhir, and J. P. Cooke. Endothelial cells derived from human iPSCS increase capillary density and improve perfusion in a mouse model of peripheral arterial disease. Arterioscler. Thromb. Vasc. Biol. 31:e72–e79, 2011.
193. Rufaihah, A. J., N. F. Huang, J. Kim, J. Herold, K. S. Volz, T. S. Park, J. C. Lee, E. T. Zambidis, R. Reijo-Pera, and J. P. Cooke. Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity. Am. J. Transl. Res. 5:21–35, 2013.
194. Ruvinov, E., J. Leor, and S. Cohen. The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction. Biomaterials 32:565–578, 2011.
195. Ryu, J. H., I. K. Kim, S. W. Cho, M. C. Cho, K. K. Hwang, H. Piao, S. H. Lim, Y. S. Hong, C. Y. Choi, K. J. Yoo, and B. S. Kim. Implantation of bone marrow mononuclear cells using injectable fibrin matrix enhances neovascularization in infarcted myocardium. Biomaterials 26:319–326, 2005.
196. Sadr, N., M. Zhu, T. Osaki, T. Kakegawa, Y. Yang, M. Moretti, J. Fukuda, and A. Khademhosseini. SAM-based cell transfer to photopatterned hydrogels for microengineering vascular- like structures. Biomaterials 32:7479–7490, 2011.
197. Said, S. S., J. G. Pickering, and K. Mequanint. Advances in growth factor delivery for therapeutic angiogenesis. J. Vasc. Res. 50:35–51, 2013.
198. Santini, M. P., L. Tsao, L. Monassier, C. Theodoropoulos, J. Carter, E. Lara-Pezzi, E. Slonimsky, E. Salimova, P. Delafontaine, Y. H. Song, M. Bergmann, C. Freund, K. Suzuki, and N. Rosenthal. Enhancing repair of the mammalian heart. Circ. Res. 100:1732–1740, 2007.
199. Santos, M. I., and R. L. Reis. Vascularization in bone tissue engineering: physiology, current strategies, major hurdles and future challenges. Macromol. Biosci. 10:12–27, 2010.
200. Scott, R. C., J. M. Rosano, Z. Ivanov, B. Wang, P. L. Chong, A. C. Issekutz, D. L. Crabbe, and M. F. Kiani. Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac function. FASEB J. 23:3361–3367, 2009.
201. She, M., A. P. McGuigan, and M. V. Sefton. Tissue factor and thrombomodulin expression on endothelial cell-seeded collagen modules for tissue engineering. J. Biomed. Mater. Res. Part A 80:497–504, 2007.
202. Shepherd, B. R., J. B. Hoying, and S. K. Williams. Microvascular transplantation after acute myocardial infarction. Tissue Eng. 13:2871–2879, 2007.
203. Shiba, Y., S. Fernandes, W. Z. Zhu, D. Filice, V. Muskheli, J. Kim, N. J. Palpant, J. Gantz, K. W. Moyes, H. Reinecke, B. V. Biber, T. Dardas, J. L. Mignone, A. Izawa, R. Hanna, M. Viswanathan, J. D. Gold, M. I. Kotlikoff, N. Sarvazyan, M. W. Kay, C. E. Murry, and M. A. Laflamme. Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature 489:322–325, 2012.
204. Shimizu, T., H. Sekine, J. Yang, Y. Isoi, M. Yamato, A. Kikuchi, E. Kobayashi, and T. Okano. Polysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues. FASEB J. 20:708–710, 2006.
205. Shimizu, T., M. Yamato, Y. Isoi, T. Akutsu, T. Setomaru, K. Abe, A. Kikuchi, M. Umezu, and T. Okano. Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces. Circ. Res. 90:e40, 2002.
206. Shin, M., O. Ishii, T. Sueda, and J. P. Vacanti. Contractile cardiac grafts using a novel nanofibrous. Biomaterials 25:3717–3723, 2004.
207. Shin, S. H., J. Lee, K. S. Lim, T. Rhim, S. K. Lee, Y. H. Kim, and K. Y. Lee. Sequential delivery of TAT-HSP27 and VEGF using microsphere/hydrogel hybrid systems for therapeutic angiogenesis. J. Control Release 166:38–45, 2013.
208. Sieminski, A. L., R. P. Hebbel, and K. J. Gooch. The relative magnitudes of endothelial force generation and matrix stiffness modulate capillary morphogenesis in vitro. Exp. Cell Res. 297:574–584, 2004.
209. Silvestre, J. S. Pro-angiogenic cell-based therapy for the treatment of ischemic cardiovascular diseases. Thromb. Res. 130:S90–S94, 2012.
210. Siminiak, T., P. Burchardt, and M. Kurpisz. Postinfarction heart failure: surgical and trans-coronary-venous transplantation of autologous myoblasts. Nat. Clin. Pract. Cardiovasc. Med. 3:S46–S51, 2006.
211. Singelyn, J. M., J. A. DeQuach, S. B. Seif-Naraghi, R. B. Littlefield, P. J. Schup-Magoffin, and K. L. Christman. Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering. Biomaterials 30:5409–5416, 2009.
212. Smith, R. R., L. Barile, H. C. Cho, M. K. Leppo, J. M. Hare, E. Messina, A. Giacomello, M. R. Abraham, and E. Marban. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation 115:896–908, 2007.
213. Sottile, J. Regulation of angiogenesis by extracellular matrix. Biochim. Biophys. Acta 1654:13–22, 2004.
214. Stevens, K. R., K. L. Kreutziger, S. K. Dupras, F. S. Korte, M. Regnier, V. Muskhelib, M. B. Nourseb, K. Bendixenb, H. Reineckeb, and C. E. Murrya. Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue. Proc. Natl Acad. Sci. U.S.A. 106:16568–16573, 2009.
215. Stevens, K. R., L. Pabon, V. Muskheli, and C. E. Murry. Scaffold-free human cardiac tissue patch created from embryonic stem cells. Tissue Eng. Part A 15:1211–1222, 2009.
216. Storm, C., J. J. Pastore, F. C. MacKintosh, T. C. Lubensky, and P. A. Janmey. Nonlinear elasticity in biological gels. Nature 435:191–194, 2005.
217. Sun, Q., E. A. Silva, A. Wang, J. C. Fritton, D. J. Mooney, M. B. Schaffler, P. M. Grossman, and S. Rajagopalan. Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis. Pharm. Res. 27:264–271, 2010.
218. Sunderkotter, C., K. Steinbrink, M. Goebeler, R. Bhardwaj, and C. Sorg. Macrophages and angiogenesis. J. Leukoc. Biol. 55:410–422, 1994.
219. v 1.2 subunit. Circ. Res. 94:1242–1248, 2004.
220. Takano, H., M. Ohtsuka, H. Akazawa, H. Toko, M. Harada, H. Hasegawa, T. Nagai, and I. Komuro. Pleiotropic effects of cytokines on acute myocardialinfarction: g-CSF as a novel therapy for acute myocardial infarction. Curr. Pharm. Des. 9:1121–1127, 2003.
221. Tang, D. W., S. H. Yu, Y. C. Ho, F. L. Mi, P. L. Kuo, and H. W. Sung. Heparinized chitosan/poly(gamma-glutamic acid) nanoparticles for multi-functional delivery of fibroblast growth factor and heparin. Biomaterials 31:9320–9332, 2010.
222. Tavassol, F., P. Schumann, D. Lindhorst, B. Sinikovic, A. Voss, C. von See, A. Kampmann, K. H. Bormann, C. Carvalho, R. Mülhaupt, Y. Harder, M. W. Laschke, M. D. Menger, N. C. Gellrich, and M. Rücker. Accelerated angiogenic host tissue response to poly(L-lactide-co-glycolide) scaffolds by vitalization with osteoblast-like cells. Tissue Eng. Part A 16:2265–2279, 2010.
223. Tee, R., Z. Lokmic, W. A. Morrison, and R. J. Dilley. Strategies in cardiac tissue engineering. ANZ J. Surg. 80:683–693, 2010.
224. Teng, R., J. W. Calvert, N. Sibmooh, B. Piknova, N. Suzuki, J. Sun, K. Martinez, M. Yamamoto, A. N. Schechter, D. J. Lefer, and C. T. Noguchi. Acute erythropoietin cardioprotection is mediated by endothelial response. Basic Res. Cardiol. 106:343–354, 2011.
225. Tongers, J., D. W. Losordo, and U. Landmesser. Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges. Eur. Heart J. 32:1197–1206, 2011.
226. Torella, D., M. Rota, D. Nurzynska, E. Musso, A. Monsen, I. Shiraishi, E. Zias, K. Walsh, A. Rosenzweig, M. A. Sussman, K. Urbanek, B. Nadal-Ginard, J. Kajstura, P. Anversa, and A. Leri. Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ. Res. 94:514–524, 2004.
227. Tremblay, P. L., V. Hudon, F. Berthod, L. Germain, and F. A. Auger. Inosculation of tissue-engineered capillaries with the host’s vasculature in a reconstructed skin transplanted on mice. Am. J. Transpl. 5:1002–1010, 2005.
228. Unger, R. E., K. Peters, M. Wolf, A. Motta, C. Migliaresi, and C. J. Kirkpatrick. Endothelialization of a non-woven silk fibroin net for use in tissue engineering: growth and gene regulation of human endothelial cells. Biomaterials 25:5137–5146, 2004.
229. Vailhe, B., D. Vittet, and J. J. Feige. In vitro models of vasculogenesis and angiogenesis. Lab. Invest. 81:439–452, 2001.
230. Van Bommel, R. J., V. Delgado, M. J. Schalij, and J. J. Bax. Critical appraisal of the use of cardiac resynchronization therapy beyond current guidelines. J. Am. Coll. Cardiol. 56:754–762, 2010.
231. Van-Wijk, B., A. F. M. Moorman, and M. J. B. van den Hoff. Role of bone morphogenetic proteins in cardiac differentiation. Cardiovasc. Res. 74:244–255, 2007.
232. Velazquez, E. J., K. L. Lee, M. A. Deja, A. Jain, G. Sopko, A. Marchenko, I. S. Ali, G. Pohost, S. Gradinac, W. T. Abraham, M. Yii, D. Prabhakaran, H. Szwed, P. Ferrazzi, M. C. Petrie, C. M. O’Connor, P. Panchavinnin, L. She, R. O. Bonow, G. R. Rankin, R. H. Jones, and J. L. Rouleau. Coronary artery bypass surgery in patients with left ventricular dysfunction. N. Engl. J. Med. 364:1607–1616, 2011.
233. Ventre, M., F. Causa, and P. A. Netti. Determinants of cell-material crosstalk at the interface: towards engineering of cell instructive materials. J. R. Soc. Interface 9:2017–2032, 2012.
234. Volz, K. S., E. Miljan, A. Khoo, and J. P. Cooke. Development of pluripotent stem cells for vascular therapy. Vasc. Pharmacol. 56:288–296, 2012.
235. Wan, J. B., L. L. Huang, R. Rong, R. Tan, J. Wang, and J. X. Kang. Endogenously decreasing tissue n − 6/n − 3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation. Arterioscler. Thromb. Vasc. Biol. 30:2487–2494, 2010.
236. Wang, Z. Z., P. Au, T. Chen, Y. Shao, L. M. Daheron, H. Bai, M. Arzigian, D. Fukumura, R. K. Jain, and D. T. Scadden. Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nat. Biotechnol. 25:317–318, 2007.
237. Watanabe, K., M. Ueno, D. Kamiya, A. Nishiyama, M. Matsumura, T. Wataya, J. B. Takahashi, S. Nishikawa, K. Muguruma, and Y. Sasai. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat. Biotechnol. 25:681–686, 2007.
238. Winn, N., A. Paul, A. Musaro, and N. Rosenthal. Insulin-like growth factor isoforms in skeletal muscle aging, regeneration, and disease. Cold Spring Harbor Symp. Quant. Biol. 67:507–518, 2002.
239. Wu, W., A. DeConinck, and J. A. Lewis. Omnidirectional printing of 3D microvascular networks. Adv. Mater. 23:H178–H183, 2011.
240. Wu, X., E. Rabkin-Aikawa, K. J. Guleserian, T. E. Perry, Y. Masuda, F. W. Sutherland, F. J. Schoen, J. E. Mayer, Jr, and J. Bischoff. Tissue-engineered microvessels on three-dimensional biodegradable scaffolds using human endothelial progenitor cells. Am. J. Physiol. Heart Circ. Physiol. 287:H480–H487, 2004.
241. Xiang, Z., R. L. Liao, M. S. Kelly, and M. Spector. Collagen-gag scaffolds grafted onto myocardial infarcts in a rat model: a delivery vehicle for mesenchymal stem cells. Tissue Eng. 12:2467–2478, 2006.
242. Xie, J., H. Wang, Y. Wang, F. Ren, W. Yi, K. Zhao, Z. Li, Q. Zhao, Z. Liu, H. Wu, C. Gu, and D. Yi. Induction of angiogenesis by controlled delivery of vascular endothelial growth factor using nanoparticles. Cardiovasc. Ther. 31:e12–e18, 2013.
243. Yamaguchi, J., K. F. Kusano, O. Masuo, A. Kawamoto, M. Silver, S. Murasawa, M. Bosch-Marce, H. Masuda, D. W. Losordo, J. M. Isner, and T. Asahara. Stromal cell-derived factor-1 effects on exvivo expanded endothelial progenitor cell recruitment for ischemic neovascularization. Circulation 107:1322–1328, 2003.
244. Yamahara, K., and H. Itoh. Potential use of endothelial progenitor cells for regeneration of the vasculature. Ther. Adv. Cardiovasc. Dis. 3:17–27, 2009.
245. Yamamoto, K., T. Takahashi, T. Asahara, N. Ohura, T. Sokabe, A. Kamiya, and J. Ando. Proliferation, differentiation, and tube formation by endothelial progenitor cells in response to shear stress. J. Appl. Physiol. 95:2081–2088, 2003.
246. Yang, L., M. H. Soonpaa, E. D. Adler, T. K. Roepke, S. J. Kattman, M. Kennedy, E. Henckaerts, K. Bonham, G. W. Abbott, R. M. Linden, L. J. Field, and G. M. Keller. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell derived population. Nature 453:524–528, 2008.
247. Zhang, M., D. Methot, V. Poppa, Y. Fujio, K. Walsh, and C. E. Murry. Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies. J. Mol. Cell. Cardiol. 33:907–921, 2001.
248. Zhao, W., Q. Han, H. Lin, Y. Gao, W. Sun, Y. Zhao, B. Wang, B. Chen, Z. Xiao, and J. Dai. Improved neovascularisation and wound repair by targeting human basic fibroblast growth factor (bFGF) to fibrin. J. Mol. Med. 86:1127–1138, 2008.
249. Zimmermann, W. H., I. Melnychenko, and T. Eschenhagen. Engineered heart tissue for regeneration of diseased hearts. Biomaterials 25:1639–1647, 2004.
250. Zimmermann, W. H., K. Schneiderbanger, P. Schubert, M. Didie, F. Munzel, J. F. Heubach, S. Kostin, W. L. Neuhuber, and T. Eschenhagen. Tissue engineering of a differentiated cardiac muscle construct. Circ Res. 90:223–230, 2002.
251. Zisch, A. H., M. P. Lutolf, M. Ehrbar, G. P. Raeber, S. C. Rizzi, N. Davies, H. Schmokel, D. Bezuidenhout, V. Djonov, P. Zilla, and J. A. Hubbell. Cell-demanded release of VEGF from synthetic, biointeractive cell ingrowth matrices for vascularized tissue growth. FASEB J. 17:2260–2262, 2003.
252. Zisch, A. H., M. P. Lutolf, and J. A. Hubbell. Biopolymeric delivery matrices for angiogenic growth factors. Cardiovasc. Pathol. 12:295–310, 2003.
253. Zou, Y., H. Takano, M. Mizukami, H. Akazawa, Y. Qin, H. Toko, M. Sakamoto, T. Minamino, T. Nagai, and I. Komuro. Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction. Circulation 108:748–753, 2003.