Functional vascular endothelium derived from human induced pluripotent stem cells

Stem Cell Reports

Volumn 1, Issue 2, 2013, Pages 105-113

  Adams, William J ^a,b,d   Zhang, Yuzhi ^a   Cloutier, Jennifer ^a   Kuchimanchi, Pranati ^a   Newton, Gail ^a   Sehrawat, Seema ^a   Aird, William C ^c   Mayadas, Tanya N ^a   Luscinskas, Francis W ^a   García Cardeña, Guillermo ^a,b,e  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d HARVARD UNIVERSITY   (United States)

^e HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2; ARGININOSUCCINATE SYNTHASE; CD18 ANTIGEN; CD31 ANTIGEN; CXCL9 CHEMOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIN 1; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 8; KRUPPEL LIKE FACTOR 2; KRUPPEL LIKE FACTOR 4; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; PADGEM PROTEIN; PROSTAGLANDIN E2; RANTES; SIMVASTATIN; SPHINGOSINE 1 PHOSPHATE; THROMBOMODULIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; VON WILLEBRAND FACTOR;

ARTICLE; ATHEROSCLEROSIS; CELL DIFFERENTIATION; CELL FUNCTION; CELL JUNCTION; CELL POPULATION; CELL SURFACE; CONFOCAL MICROSCOPY; CYTOKINE PRODUCTION; DOWN REGULATION; ELECTRON MICROSCOPY; EMBRYOID BODY; ENDOTHELIUM CELL; EXOCYTOSIS; FLOW CYTOMETRY; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOGOLD LABELING; IN VITRO STUDY; PATHOPHYSIOLOGY; PHENOTYPE; PHENOTYPIC PLASTICITY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SHEAR STRESS; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; UPREGULATION; VASCULAR ENDOTHELIUM; CELL LINE; CULTURE TECHNIQUE; CYTOLOGY; METABOLISM;

CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; ENDOTHELIUM, VASCULAR; HUMANS; INDUCED PLURIPOTENT STEM CELLS; PHENOTYPE;

EID: 84881366718     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2013.06.007     Document Type: Article

References (38)

1. W.J. Adams, and G. García-Cardeña Novel stem cell-based drug discovery platforms for cardiovascular disease J. Biomol. Screen. 17 2012 1117 1127
2. J.L. Bos Epac proteins: multi-purpose cAMP targets Trends Biochem. Sci. 31 2006 680 686 (Pubitemid 44791945)
3. X.L. Chen, J.O. Nam, C. Jean, C. Lawson, C.T. Walsh, E. Goka, S.T. Lim, A. Tomar, I. Tancioni, and S. Uryu VEGF-induced vascular permeability is mediated by FAK Dev. Cell 22 2012 146 157
4. J.J. Chiu, and S. Chien Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives Physiol. Rev. 91 2011 327 387
5. K.D. Choi, J. Yu, K. Smuga-Otto, G. Salvagiotto, W. Rehrauer, M. Vodyanik, J. Thomson, and I. Slukvin Hematopoietic and endothelial differentiation of human induced pluripotent stem cells Stem Cells 27 2009 559 567
6. X. Cullere, S.K. Shaw, L. Andersson, J. Hirahashi, F.W. Luscinskas, and T.N. Mayadas Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase Blood 105 2005 1950 1955 (Pubitemid 40731777)
7. G. Dai, M.R. Kaazempur-Mofrad, S. Natarajan, Y. Zhang, S. Vaughn, B.R. Blackman, R.D. Kamm, G. García-Cardeña, and M.A. Gimbrone Jr. Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature Proc. Natl. Acad. Sci. USA 101 2004 14871 14876 (Pubitemid 39410767)
8. P.F. Davies Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology Nat. Clin. Pract. Cardiovasc. Med. 6 2009 16 26
9. E. Dejana, R. Spagnuolo, and G. Bazzoni Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration Thromb. Haemost. 86 2001 308 315 (Pubitemid 32663961)
10. R.J. Dekker, R.A. Boon, M.G. Rondaij, A. Kragt, O.L. Volger, Y.W. Elderkamp, J.C. Meijers, J. Voorberg, H. Pannekoek, and A.J. Horrevoets KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium Blood 107 2006 4354 4363 (Pubitemid 43801361)
11. J. Doukas, and J.S. Pober IFN-gamma enhances endothelial activation induced by tumor necrosis factor but not IL-1 J. Immunol. 145 1990 1727 1733 (Pubitemid 20336736)
12. M.A. Gimbrone Jr. Endothelial dysfunction, hemodynamic forces, and atherosclerosis Thromb. Haemost. 82 1999 722 726
13. M.A. Gimbrone Jr., and G. García-Cardeña Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis Cardiovasc. Pathol. 22 2013 9 15
14. M.A. Gimbrone Jr., J.N. Topper, T. Nagel, K.R. Anderson, and G. Garcia-Cardeña Endothelial dysfunction, hemodynamic forces, and atherogenesis Ann. N Y Acad. Sci. 902 2000 230 239
15. M. Grskovic, A. Javaherian, B. Strulovici, and G.Q. Daley Induced pluripotent stem cells - opportunities for disease modelling and drug discovery Nat. Rev. Drug Discov. 10 2011 915 929
16. C. Hahn, and M.A. Schwartz Mechanotransduction in vascular physiology and atherogenesis Nat. Rev. Mol. Cell Biol. 10 2009 53 62
17. G.K. Hansson Inflammation, atherosclerosis, and coronary artery disease N. Engl. J. Med. 352 2005 1685 1695
18. K. Homma, M. Sone, D. Taura, K. Yamahara, Y. Suzuki, K. Takahashi, T. Sonoyama, M. Inuzuka, Y. Fukunaga, and N. Tamura Sirt1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells Atherosclerosis 212 2010 42 47
19. E. Kiskinis, and K. Eggan Progress toward the clinical application of patient-specific pluripotent stem cells J. Clin. Invest. 120 2010 51 59
20. Z. Li, S. Hu, Z. Ghosh, Z. Han, and J.C. Wu Functional characterization and expression profiling of human induced pluripotent stem cell- and embryonic stem cell-derived endothelial cells Stem Cells Dev. 20 2011 1701 1710
21. Z. Lin, A. Kumar, S. SenBanerjee, K. Staniszewski, K. Parmar, D.E. Vaughan, M.A. Gimbrone Jr., V. Balasubramanian, G. García-Cardeña, and M.K. Jain Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function Circ. Res. 96 2005 e48 e57
22. D. Mehta, and A.B. Malik Signaling mechanisms regulating endothelial permeability Physiol. Rev. 86 2006 279 367
23. S.W. Park, Y. Jun Koh, J. Jeon, Y.H. Cho, M.J. Jang, Y. Kang, M.J. Kim, C. Choi, Y. Sook Cho, and H.M. Chung Efficient differentiation of human pluripotent stem cells into functional CD34+ progenitor cells by combined modulation of the MEK/ERK and BMP4 signaling pathways Blood 116 2010 5762 5772
24. K.M. Parmar, V. Nambudiri, G. Dai, H.B. Larman, M.A. Gimbrone Jr., and G. García-Cardeña Statins exert endothelial atheroprotective effects via the KLF2 transcription factor J. Biol. Chem. 280 2005 26714 26719 (Pubitemid 41040703)
25. K.M. Parmar, H.B. Larman, G. Dai, Y. Zhang, E.T. Wang, S.N. Moorthy, J.R. Kratz, Z. Lin, M.K. Jain, M.A. Gimbrone Jr., and G. García-Cardeña Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2 J. Clin. Invest. 116 2006 49 58 (Pubitemid 43121790)
26. R.M. Rao, L. Yang, G. Garcia-Cardena, and F.W. Luscinskas Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall Circ. Res. 101 2007 234 247 (Pubitemid 47344073)
27. A.J. Rufaihah, N.F. Huang, S. Jamé, J.C. Lee, H.N. Nguyen, B. Byers, A. De, J. Okogbaa, M. Rollins, and R. Reijo-Pera Endothelial cells derived from human iPSCS increase capillary density and improve perfusion in a mouse model of peripheral arterial disease Arterioscler. Thromb. Vasc. Biol. 31 2011 e72 e79
28. A.J. Rufaihah, N.F. Huang, J. Kim, J. Herold, K.S. Volz, T.S. Park, J.C. Lee, E.T. Zambidis, R. Reijo-Pera, and J.P. Cooke Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity Am. J. Transl. Res. 5 2013 21 35
29. S. SenBanerjee, Z. Lin, G.B. Atkins, D.M. Greif, R.M. Rao, A. Kumar, M.W. Feinberg, Z. Chen, D.I. Simon, and F.W. Luscinskas KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation J. Exp. Med. 199 2004 1305 1315 (Pubitemid 38685723)
30. S. Sen-Banerjee, S. Mir, Z. Lin, A. Hamik, G.B. Atkins, H. Das, P. Banerjee, A. Kumar, and M.K. Jain Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells Circulation 112 2005 720 726 (Pubitemid 41099052)
31. F. Soldner, and R. Jaenisch Medicine. iPSC disease modeling Science 338 2012 1155 1156
32. K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676 (Pubitemid 44233629)
33. D. Taura, M. Sone, K. Homma, N. Oyamada, K. Takahashi, N. Tamura, S. Yamanaka, and K. Nakao Induction and isolation of vascular cells from human induced pluripotent stem cells - brief report Arterioscler. Thromb. Vasc. Biol. 29 2009 1100 1103
34. K.M. Valentijn, J.E. Sadler, J.A. Valentijn, J. Voorberg, and J. Eikenboom Functional architecture of Weibel-Palade bodies Blood 117 2011 5033 5043
35. G. Villarreal Jr., Y. Zhang, H.B. Larman, J. Gracia-Sancho, A. Koo, and G. García-Cardeña Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells Biochem. Biophys. Res. Commun. 391 2010 984 989
36. D.D. Wagner, and P.S. Frenette The vessel wall and its interactions Blood 111 2008 5271 5281
37. M.P. White, A.J. Rufaihah, L. Liu, Y.T. Ghebremariam, K.N. Ivey, J.P. Cooke, and D. Srivastava Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells Stem Cells 31 2013 92 103
38. H.L. Zenner, L.M. Collinson, G. Michaux, and D.F. Cutler High-pressure freezing provides insights into Weibel-Palade body biogenesis J. Cell Sci. 120 2007 2117 2125 (Pubitemid 47010006)