Independent association of low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality

Archives of Internal Medicine

Volumn 168, Issue 12, 2008, Pages 1340-1349

  Dobnig, Harald ^a   Pilz, Stefan ^b   Scharnagl, Hubert ^a   Renner, Wilfried ^a   Seelhorst, Ursula ^c   Wellnitz, Britta ^c   Kinkeldei, Jürgen ^d   Boehm, Bernhard O ^e   Weihrauch, Gisela ^a   Maerz, Winfried ^a,d  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c LURIC Study Nonprofit LLC   (Germany)

^d SYNLAB ACADEMY   (Germany)

^e UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; C REACTIVE PROTEIN; CALCITRIOL; CALCIUM; GLUTATHIONE; INTERLEUKIN 6; PARATHYROID HORMONE; PHOSPHOLIPID; VASCULAR CELL ADHESION MOLECULE 1; 25-HYDROXYVITAMIN D; DIHYDROXYCOLECALCIFEROL; DRUG DERIVATIVE; VITAMIN D;

ADULT; AGED; ANGIOCARDIOGRAPHY; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COHORT ANALYSIS; COMORBIDITY; CORONARY ARTERY DISEASE; CROSS-SECTIONAL STUDY; FEMALE; FOLLOW UP; HUMAN; INFLAMMATION; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; MORTALITY; OXIDATIVE STRESS; PHYSICAL ACTIVITY; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEASONAL VARIATION; SMOKING; STATISTICAL ANALYSIS; VITAMIN BLOOD LEVEL; WAIST HIP RATIO; BLOOD; CLINICAL TRIAL; MIDDLE AGED; PROGNOSIS; RISK FACTOR; VITAMIN D DEFICIENCY;

AGED; CARDIOVASCULAR DISEASES; DIHYDROXYCHOLECALCIFEROLS; FEMALE; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 46449131684     PISSN: 00039926     EISSN: 15383679     Source Type: Journal    
DOI: 10.1001/archinte.168.12.1340     Document Type: Article

References (37)

1. Vieth R, Bischoff-Ferrari H, Boucher BJ, et al. The urgent need to recommend an intake of vitamin D that is effective [published correction appears in Am J Clin Nutr. 2007;86(3):809]. Am J Clin Nutr. 2007;85(3):649-650.
2. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-281.
3. Norman AW, Bouillon R, Whiting SJ, Vieth R, Lips P. 13th Workshop Consensus for Vitamin D Nutritional Guidelines. J Steroid Biochem Mol Biol. 2007; 103(3-5):204-205.
4. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes [published corrections appear in Am J Clin Nutr. 2006;84 (5):1253 and 2007;86(3):809]. Am J Clin Nutr. 2006;84(1):18-28.
5. Bischoff-Ferrari HA, Zhang Y, Kiel DP, Felson DT. Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis. Arthritis Rheum. 2005;53(6):821-826.
6. Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of vitamin D on falls: a meta-analysis. JAMA. 2004;291(16):1999-2006.
7. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005;293(18):2257- 2264.
8. Garland CF, Garland FC, Gorham ED, et al. The role of vitamin D in cancer prevention. Am J Public Health. 2006;96(2):252-261.
9. Liu PT, Stenger S, Li H, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311(5768):1770-1773.
10. Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol. 2006;92(1):39-48.
11. Martins D, Wolf M, Pan D, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007;167 (11):1159-1165.
12. Forman JP, Giovannucci E, Holmes MD, et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension. 2007;49(5):1063-1069.
13. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and β cell dysfunction. Am J Clin Nutr. 2004;79(5):820-825.
14. Chonchol M, Scragg R. 25-Hydroxyvitamin D, insulin resistance, and kidney function in the Third National Health and Nutrition Examination Survey. Kidney Int. 2007;71(2):134-139.
15. Wu-Wong JR, Nakane M, Ma J, Ruan X, Kroeger PE. Effects of vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells. Atherosclerosis. 2006;186(1):20-28.
16. 3-1α-hydroxylase in human health and disease. J Steroid Biochem Mol Biol. 2007; 103(3-5):316-321.
17. Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol. 2005; 289(1):F8-F28.
18. Teng M, Wolf M, Lowrie E, Ofsthun N, Lazarus JM, Thadhani R. Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy. N Engl J Med. 2003;349(5):446-456.
19. Tentori F, Hunt WC, Stidley CA, et al. Mortality risk among hemodialysis patients receiving different vitamin D analogs. Kidney Int. 2006;70(10):1858-1865.
20. Wolf M, Shah A, Gutierrez O, et al. Vitamin D levels and early mortality among incident hemodialysis patients. Kidney Int. 2007;72(8):1004-1013.
21. Sambrook PN, Chen JS, March LM, et al. Serum parathyroid hormone is associated with increased mortality independent of 25-hydroxy vitamin D status, bone mass, and renal function in the frail and very old: a cohort study. J Clin Endocrinol Metab. 2004;89(11):5477-5481.
22. Winkelmann BR, März W, Boehm BO, et al; LURIC Study Group (Ludwigshafen Risk and Cardiovascular Health). Rationale and design of the LURIC study: a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease. Pharmacogenomics. 2001;2(1)(suppl 1):S1-S73.
23. de Groot V, Beckerman H, Lankhorst GJ, Bouter LM. How to measure comorbidity: a critical review of available methods. J Clin Epidemiol. 2003;56(3):221-229.
24. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002; 39(2)(suppl 1):S1-S266.
25. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001;22(4):477-501.
26. Wicherts IS, van Schoor NM, Boeke AJ, et al. Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab. 2007; 92(6):2058-2065.
27. Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged ≥60 y. Am J Clin Nutr. 2004;80(3):752-758.
28. Chapuy MC, Schott AM, Garnero P, Hans D, Delmas PD, Meunier PJ; Epidemiology of Osteoporosis (EPIDOS) Study Group. Healthy elderly French women living at home have secondary hyperparathyroidism and high bone turnover in winter. J Clin Endocrinol Metab. 1996;81(3):1129-1133.
29. Bettica P, Bevilacqua M, Vago T, Norbiato G. High prevalence of hypovitaminosis D among free-living postmenopausal women referred to an osteoporosis outpatient clinic in northern Italy for initial screening. Osteoporos Int. 1999;9(3):226-229.
30. Woitge HW, Scheidt-Nave C, Kissling C, et al. Seasonal variation of biochemical indexes of bone turnover: results of a population-based study. J Clin Endocrinol Metab. 1998;83(1):68-75.
31. Slovik DM, Adams JS, Neer RM, Holick MF, Potts JT Jr. Deficient production of 1,25-dihydroxyvitamin D in elderly osteoporotic patients. N Engl J Med. 1981;305(7):372-374.
32. Timms PM, Mannan N, Hitman GA, et al. Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders? QJM. 2002;95(12):787-796.
33. Van den Berghe G, Van Roosbroeck D, Vanhove P, Wouters PJ, De Pourcq L, Bouillon R. Bone turnover in prolonged critical illness: effect of vitamin D. J Clin Endocrinol Metab. 2003;88(10):4623-4632.
34. Rahman A, Hershey S, Ahmed S, Nibbelink K, Simpson RU. Heart extracellular matrix gene expression profile in the vitamin D receptor knockout mice. J Steroid Biochem Mol Biol. 2007;103(3-5):416-419.
35. Giachelli CM, Jono S, Shioi A, Nishizawa Y, Mori K, Morii H. Vascular calcification and inorganic phosphate. Am J Kidney Dis. 2001;38(4)(suppl 1):S34-S37.
36. Watson KE, Abrolat ML, Malone LL, et al. Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation. 1997;96(6):1755-1760.
37. Xiang W, Kong J, Chen S, et al. Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems.AmJ Physiol Endocrinol Metab. 2005;288(1):e125-e132. http://www.ncbi.nlm.nih.gov /pubmed/15367398?ordinalpos=6&itool= EntrezSystem2.PEntrez.PubMed.Pubmed_ResultsPanel.Pubmed_RVDocSum. Accessed May 8, 2008.