Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 12, 2010, Pages 2487-2494

  Wan, Jian Bo ^a   Huang, Li Li ^a,b   Rong, Rong ^a   Tan, Rui ^a   Wang, Jingdong ^a   Kang, Jing X ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

atherosclerosis; fat 1 transgenic mice; inflammation; n 3 fatty acids; n 6 n 3 fatty acid ratio

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; CYCLOOXYGENASE 2; HIGH DENSITY LIPOPROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PROSTAGLANDIN E2; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; INFLAMMATION; LIPOPROTEIN BLOOD LEVEL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN BLOOD LEVEL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; TRIACYLGLYCEROL BLOOD LEVEL; VASCULITIS;

ANIMALS; AORTIC DISEASES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BODY WEIGHT; CAENORHABDITIS ELEGANS PROTEINS; CHEMOKINE CCL2; CHOLESTEROL; CYCLOOXYGENASE 2; DINOPROSTONE; DISEASE MODELS, ANIMAL; EATING; FATTY ACID DESATURASES; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; GENE EXPRESSION REGULATION; INFLAMMATION; INFLAMMATION MEDIATORS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; LIPOPROTEINS, LDL; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; TIME FACTORS; TISSUE CULTURE TECHNIQUES; TRANSCRIPTION FACTOR RELA;

EID: 78650420062     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.210054     Document Type: Article

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