E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting forkhead box O transcription factors

Journal of Biological Chemistry

Volumn 289, Issue 49, 2014, Pages 34205-34213

  Xie, Qi ^a   Peng, Shengyi ^a,e   Tao, Li ^b   Ruan, Haihe ^a   Yang, Yanglu ^a,e   Li, Tie Mei ^b   Adams, Ursula ^d   Meng, Songshu ^c   Bi, Xiaolin ^c   Dong, Meng Qiu ^b   Yuan, Zengqiang ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^c DALIAN MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF CHICAGO   (United States)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CHEMICAL ACTIVATION; DRUG THERAPY; FIBROBLASTS; GENES; TRANSCRIPTION FACTORS;

CAENORHABDITIS ELEGANS; CELLULAR SENESCENCE; ECTOPIC EXPRESSIONS; HUMAN FIBROBLAST CELLS; MURINE EMBRYONIC FIBROBLASTS; PHYSICAL INTERACTIONS; REACTIVE OXYGEN SPECIES; SUBCELLULAR LOCALIZATIONS;

TRANSCRIPTION;

CATALASE; MANGANESE SUPEROXIDE DISMUTASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR FKHRL1; CAENORHABDITIS ELEGANS PROTEIN; DAF-16 PROTEIN, C ELEGANS; E2F1 PROTEIN, MOUSE; EFL-1 PROTEIN, C ELEGANS; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, MOUSE; PROTEIN BINDING; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE ACTIVATION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; LIFE EXTENSION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SENESCENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; AGING; ANIMAL; ANIMAL EMBRYO; ANTAGONISTS AND INHIBITORS; CAENORHABDITIS ELEGANS; CELL AGING; CELL LINE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; LONGEVITY; METABOLISM; PROTEIN DOMAIN;

CAENORHABDITIS ELEGANS; MURINAE;

AGING; ANIMALS; BINDING SITES; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CATALASE; CELL AGING; CELL LINE; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; EMBRYO, MAMMALIAN; FIBROBLASTS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEK293 CELLS; HUMANS; LONGEVITY; MICE; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS;

EID: 84916917545     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.587170     Document Type: Article

References (34)

1. Wu, Z., Zheng, S., and Yu, Q. (2009) The E2F family and the role of E2F1 in apoptosis. Int. J. Biochem. Cell Biol. 41, 2389-2397
2. Matsumura, I., Tanaka, H., and Kanakura, Y. (2003) E2F1 and c-Myc in cell growth and death. Cell Cycle 2, 333-338
3. Dimri, G. P., Itahana, K., Acosta, M., and Campisi, J. (2000) Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol. Cell. Biol. 20, 273-285
4. DeGregori, J., Kowalik, T., and Nevins, J. R. (1995) Cellular targets for activation by the E2F1 transcription factor include DNA synthesis-and G1/S-regulatory genes. Mol. Cell. Biol. 15, 4215-4224
5. Field, S. J., Tsai, F. Y., Kuo, F., Zubiaga, A. M., Kaelin, W. G., Jr., Livingston, D. M., Orkin, S. H., and Greenberg, M. E. (1996) E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85, 549-561
6. Yamasaki, L., Jacks, T., Bronson, R., Goillot, E., Harlow, E., and Dyson, N. J. (1996) Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85, 537-548
7. Rödicker, F., Stiewe, T., Zimmermann, S., and Pützer, B. M. (2001) Therapeutic efficacy of E2F1 in pancreatic cancer correlates with TP73 induction. Cancer Res. 61, 7052-7055
8. Zhao, Y., Tan, J., Zhuang, L., Jiang, X., Liu, E. T., and Yu, Q. (2005) Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc. Natl. Acad. Sci. U.S.A. 102, 16090-16095
9. Calnan, D. R., and Brunet, A. (2008) The FoxO code. Oncogene 27, 2276-2288
10. van der Horst, A., and Burgering, B. M. (2007) Stressing the role of FoxO proteins in lifespan and disease. Nat. Rev. Mol. Cell Biol. 8, 440-450
11. Lin, K., Dorman, J. B., Rodan, A., and Kenyon, C. (1997) daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278, 1319-1322
12. Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A., and Ruvkun, G. (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994-999
13. Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., and Kenyon, C. (2003) Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277-283
14. Nogueira, V., Park, Y., Chen, C. C., Xu, P. Z., Chen, M. L., Tonic, I., Unterman, T., and Hay, N. (2008) Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 14, 458-470
15. Xie, Q., Chen, J., and Yuan, Z. (2012) Post-translational regulation of FOXO. Acta Biochim. Biophys. Sin 44, 897-901
16. Tang, E. D., Nuñez, G., Barr, F. G., and Guan, K. L. (1999) Negative regulation of the forkhead transcription factor FKHR by Akt. J. Biol. Chem. 274, 16741-16746
17. Song, Y. S., Lee, B. Y., and Hwang, E. S. (2005) Dinstinct ROS and biochemical profiles in cells undergoing DNA damage-induced senescence and apoptosis. Mech Ageing Dev 126, 580-590
18. Kodama, R., Kato, M., Furuta, S., Ueno, S., Zhang, Y., Matsuno, K., Yabe-Nishimura, C., Tanaka, E., and Kamata, T. (2013) ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence. Genes Cells 18, 32-41
19. Espada, L., Meo-Evoli, N., Sancho, P., Real, S., Fabregat, I., Ambrosio, S., and Tauler, A. (2012) ROS production is essential for the apoptotic function of E2F1 in pheochromocytoma and neuroblastoma cell lines. PLoS One 0051544
20. Raimundo, N., Song, L., Shutt, T. E., McKay, S. E., Cotney, J., Guan, M. X., Gilliland, T. C., Hohuan, D., Santos-Sacchi, J., and Shadel, G. S. (2012) Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness. Cell 148, 716-726
21. Weyemi, U., Lagente-Chevallier, O., Boufraqech, M., Prenois, F., Courtin, F., Caillou, B., Talbot, M., Dardalhon, M., Al Ghuzlan, A., Bidart, J. M., Schlumberger, M., and Dupuy, C. (2012) ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence. Oncogene 31, 1117-1129
22. Han, Y. H., Kwon, J. H., Yu, D. Y., and Moon, E. Y. (2006) Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NFκB pathway in mouse embryonic fibroblast (MEF) senescence. Free Radic. Res. 40, 1182-1189
23. Kops, G. J., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W., Coffer, P. J., Huang, T. T., Bos, J. L., Medema, R. H., and Burgering, B. M. (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419, 316-321
24. Perrot, V., and Rechler, M. M. (2003) Characterization of insulin inhibition of transactivation by a C-terminal fragment of the forkhead transcription factor Foxo1 in rat hepatoma cells. J. Biol. Chem. 278, 26111-26119
25. You, H., and Mak, T. W. (2005) Crosstalk between p53 and FOXO transcription factors. Cell Cycle 4, 37-38
26. Pan, H., Yin, C., Dyson, N. J., Harlow, E., Yamasaki, L., and Van Dyke, T. (1998) Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol. Cell 2, 283-292
27. Yang, J. Y., Zong, C. S., Xia, W., Yamaguchi, H., Ding, Q., Xie, X., Lang, J. Y., Lai, C. C., Chang, C. J., Huang, W. C., Huang, H., Kuo, H. P., Lee, D. F., Li, L. Y., Lien, H. C., Cheng, X., Chang, K. J., Hsiao, C. D., Tsai, F. J., Tsai, C. H., Sahin, A. A., Muller, W. J., Mills, G. B., Yu, D., Hortobagyi, G. N., and Hung, M. C. (2008) ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat. Cell Biol. 10, 138-148
28. Hu, M. C., Lee, D. F., Xia, W., Golfman, L. S., Ou-Yang, F., Yang, J. Y., Zou, Y., Bao, S., Hanada, N., Saso, H., Kobayashi, R., and Hung, M. C. (2004) IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117, 225-237
29. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868
30. Ceol, C. J., and Horvitz, H. R. (2001) dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development. Mol. Cell 7, 461-473
31. Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., and Spiegelman, B. M. (2003) Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction. Nature 423, 550-555
32. Essers, M. A., de Vries-Smits, L. M., Barker, N., Polderman, P. E., Burgering, B. M., and Korswagen, H. C. (2005) Functional interaction between β-catenin andFOXOin oxidative stress signaling. Science 308, 1181-1184
33. Li, J., Ebata, A., Dong, Y., Rizki, G., Iwata, T., and Lee, S. S. (2008) Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLoS Biol. 0060233
34. Shats, I., Gatza, M. L., Liu, B., Angus, S. P., You, L., and Nevins, J. R. (2013) FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function. Cancer Res. 73, 6056-6067