Therapeutic efficacy of E2F1 in pancreatic cancer correlates with TP73 induction

Cancer Research

Volumn 61, Issue 19, 2001, Pages 7052-7055

  Rodicker F ^a   Stiewe, T ^a   Zimmermann, S ^a   Putzer B M ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GEMCITABINE; PROTEIN P53; PROTEIN P73; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN INDUCTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TUMOR VOLUME;

ADENOCARCINOMA; ADENOVIRIDAE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CELL CYCLE PROTEINS; COMBINED MODALITY THERAPY; DEOXYCYTIDINE; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; GENES, TUMOR SUPPRESSOR; GENETIC VECTORS; HUMANS; MICE; MICE, NUDE; NUCLEAR PROTEINS; PANCREATIC NEOPLASMS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035477398     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

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2. Improved safety through tamoxifen-regulated induction of cytotoxic genes delivered by Ad vectors for cancer gene therapy
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7. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
8. Role of the p53-homologue p73 in E2F1-induced apoptosis
9. Clinical and preclinical activity of 2′,2′-difluorodeoxycytidine (gemcitabine)
10. Effect of a template-located 2′,2′-difluorodeoxycytidine on the kinetics and fidelity of base insertion by Klenow (3′->5′exonuclease-)fragment
11. p14ARF links the tumour suppressors RB and p53
12. Human ARF binds E2F1 and inhibits its transcriptional activity