Metformin and erlotinib synergize to inhibit basal breast cancer

Oncotarget

Volumn 5, Issue 21, 2014, Pages 10503-10517

  Lau, Ying Ka Ingar ^a   Du, Xing ^a   Rayannavar, Vinayak ^a   Hopkins, Benjamin ^b   Shaw, Jacquelyn ^a,c   Bessler, Eliana ^a   Thomas, Tiffany ^a   Pires, Maira M ^b   Keniry, Megan ^b,d   Parsons, Ramon E ^b   Cremers, Serge ^a   Szabolcs, Matthias ^a   Maurer, Matthew A ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS PAN AMERICAN   (United States)

Author keywords

Breast cancer; EGFR; Erlotinib; Metformin; PTEN

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; INITIATION FACTOR 4E BINDING PROTEIN 1; INSULIN; METFORMIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN S6; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; PTEN PROTEIN, HUMAN; QUINAZOLINE DERIVATIVE; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASAL LIKE BREAST CANCER; BREAST CANCER CELL LINE; CANCER INHIBITION; CLONOGENESIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENTIATION; DRUG SENSITIVITY; HUMAN; HUMAN CELL; INSULIN BLOOD LEVEL; MAXIMUM PLASMA CONCENTRATION; MINIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR REGRESSION; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; ENZYME IMMUNOASSAY; FEMALE; FLOW CYTOMETRY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BIOMARKERS, TUMOR; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL PROLIFERATION; DRUG SYNERGISM; ERLOTINIB HYDROCHLORIDE; FEMALE; FLOW CYTOMETRY; HUMANS; HYPOGLYCEMIC AGENTS; IMMUNOENZYME TECHNIQUES; METFORMIN; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84916897482     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2391     Document Type: Article

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