Synthesis of a 3-(α-Styryl)benzo[ b ]-thiophene Library via Bromocyclization of Alkynes and Palladium-Catalyzed Tosylhydrazones Cross-Couplings: Evaluation as Antitubulin Agents

ACS Combinatorial Science

Volumn 16, Issue 12, 2014, Pages 702-710

  Tréguier, Bret ^a   Lawson, Marie ^a   Bernadat, Guillaume ^a   Bignon, Jérôme ^b   Dubois, Joelle ^b   Brion, Jean Daniel ^a   Alami, Mouad ^a   Hamze, Abdallah ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b CNRS   (France)

Author keywords

antimitotic agents; bromocyclization; migratory insertion; N tosylhydrazone; palladium; styrylbenzo b thiophene

Indexed keywords

ALKYNE; ANTINEOPLASTIC AGENT; HYDRAZONE DERIVATIVE; PALLADIUM; STYRENE DERIVATIVE; THIOPHENE DERIVATIVE; TUBULIN;

CATALYSIS; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HCT116 CELL LINE; HUMAN; MOLECULAR DOCKING; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALKYNES; ANTINEOPLASTIC AGENTS; CATALYSIS; CELL SURVIVAL; HCT116 CELLS; HUMANS; HYDRAZONES; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PALLADIUM; STRUCTURE-ACTIVITY RELATIONSHIP; STYRENES; THIOPHENES; TUBULIN;

EID: 84916238517     PISSN: 21568952     EISSN: None     Source Type: Journal    
DOI: 10.1021/co500115b     Document Type: Article

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