Novel substituted benzothiophene and thienothiophene carboxanilides and quinolones: Synthesis, photochemical synthesis, DNA-binding properties, antitumor evaluation and 3D-derived QSAR analysis

Journal of Medicinal Chemistry

Volumn 55, Issue 11, 2012, Pages 5044-5060

  Aleksić, Maja ^a   Bertoša, Branimir ^b   Nhili, Raja ^c   Uzelac, Lidija ^b   Jarak, Ivana ^a,d   Depauw, Sabine ^c   David Cordonnier, Marie Hélène ^c   Kralj, Marijeta ^b   Tomić, Sanja ^b   Karminski Zamola, Grace ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b RUDER BO KOVI INSTITUTE   (Croatia)

^c JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^d UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 IMIDAZOLINYL) 5 METHYL 6 OXO 5,6 DIHYDRO[1]BENZOTHIENO[2,3 C]QUINOLIN 6 ONE; 2 (2 IMIDAZOLINYL) 6 OXO 5,6 DIHYDRO[1]BENZOTHIENO[2,3 C]QUINOLIN 6 ONE; 2,9 (2 DIIMIDAZOLINYL) 6 OXO 5,6 DIHYDRO[1]BENZOTHIENO[2,3 C]QUINOLIN 6 ONE; 6 (N'' 2 IMIDAZOLINYL) N [4' (N' 2 IMIDAZOLINYL)PHENYL] 3 CHLOROBENZO[B]THIOPHENE 2 CARBOXAMIDE; 6 (N'' 2 IMIDAZOLINYL) N PHENYL 3 CHLOROBENZO[B]THIOPHENE 2 CARBOXAMIDE; 9 (2 IMIDAZOLINYL) 6 OXO 5,6 DIHYDRO[1]BENZOTHIENO[2,3 C]QUINOLIN 6 ONE; ANTINEOPLASTIC AGENT; BENZOTHIOPHENE DERIVATIVE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); N [4' (N' 2 IMIDAZOLINYL)PHENYL] 3 CHLOROBENZO[B]THIOPHENE 2 CARBOXAMIDE; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG DNA BINDING; DRUG POTENCY; DRUG SYNTHESIS; HALOGENATION; IC 50; IN VITRO STUDY; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANILIDES; ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NUCLEIC ACID DENATURATION; PHOTOCHEMICAL PROCESSES; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINOLONES; THIOPHENES; TOPOISOMERASE I INHIBITORS; TOPOISOMERASE II INHIBITORS;

EID: 84862277249     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300505h     Document Type: Article

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