Synthesis and antitumor activity of benzils related to combretastatin A-4

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 11, 2008, Pages 3266-3271

  Mousset, Céline ^a   Giraud, Anne ^a   Provot, Olivier ^a   Hamze, Abdallah ^a   Bignon, Jérôme ^b   Liu, Jian Miao ^b   Thoret, Sylviane ^b   Dubois, Joëlle ^b   Brion, Jean Daniel ^a   Alami, Mouâd ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b CNRS   (France)

Author keywords

Alkynes; Antiangiogenic; Antimitotic; Antiproliferative; Antitumor; Benzils; Combretastatin; Inhibition of tubulin assembly; Oxidation

Indexed keywords

ALKYNE DERIVATIVE; BENZILIC ACID DERIVATIVE; COMBRETASTATIN A4; DIMETHYL SULFOXIDE; KETONE DERIVATIVE; PALLADIUM COMPLEX; PALLADIUM IODIDE; SERINE 2 METHOXY 5 [2 (3,4,5 TRIMETHOXYPHENYL)VINYL]ANILIDE; TUBULIN; ZYBRESTAT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; MITOSIS; OXIDATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; PHENYLGLYOXAL; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 44349096338     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.053     Document Type: Article

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