메뉴 건너뛰기




Volumn 13, Issue 21, 2014, Pages 3404-3413

Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth

Author keywords

Cerebellum; DCA; Glycolysis; Hedgehog; Medulloblastoma; Metabolism

Indexed keywords

ANTINEOPLASTIC AGENT; DICHLOROACETIC ACID; GLUCOSE; HEXOKINASE; HEXOKINASE 2; LACTIC ACID; MESSENGER RNA; PYRUVATE KINASE; PYRUVATE KINASE M2; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI; UNCLASSIFIED DRUG; GLI PROTEIN; ONCOPROTEIN; PROTEIN KINASE INHIBITOR; TRANSACTIVATOR PROTEIN;

EID: 84915795126     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/15384101.2014.952973     Document Type: Article
Times cited : (41)

References (32)
  • 1
    • 41749098048 scopus 로고    scopus 로고
    • The origins of medulloblastoma subtypes
    • PMID:18039127
    • Gilbertson RJ, Ellison DW. The origins of medulloblastoma subtypes. Ann Rev Pathol 2008; 3:341-65; PMID:18039127
    • (2008) Ann Rev Pathol , vol.3 , pp. 341-365
    • Gilbertson, R.J.1    Ellison, D.W.2
  • 2
    • 48449105147 scopus 로고    scopus 로고
    • Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
    • PMID:18691547
    • Schuller U, Heine VM, Mao J, Kho AT, Dillon AK, Han YG, Huillard E, Sun T, Ligon AH, Qian Y, et al. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 2008; 14:123-34; PMID:18691547
    • (2008) Cancer Cell , vol.14 , pp. 123-134
    • Schuller, U.1    Heine, V.M.2    Mao, J.3    Kho, A.T.4    Dillon, A.K.5    Han, Y.G.6    Huillard, E.7    Sun, T.8    Ligon, A.H.9    Qian, Y.10
  • 3
    • 0032959871 scopus 로고    scopus 로고
    • Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog
    • PMID:10027293
    • Wechsler-Reya RJ, Scott MP. Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog. Neuron 1999; 22:103-14; PMID:10027293
    • (1999) Neuron , vol.22 , pp. 103-114
    • Wechsler-Reya, R.J.1    Scott, M.P.2
  • 4
    • 84863926411 scopus 로고    scopus 로고
    • Hedgehog-GLI pathway in medulloblastoma
    • PMID:22508821
    • Archer TC, Weeraratne SD, Pomeroy SL. Hedgehog-GLI pathway in medulloblastoma. J Clin Oncol 2012; 30:2154-6; PMID:22508821
    • (2012) J Clin Oncol , vol.30 , pp. 2154-2156
    • Archer, T.C.1    Weeraratne, S.D.2    Pomeroy, S.L.3
  • 5
    • 84861536500 scopus 로고    scopus 로고
    • Hedgehog secretion and signal transduction in vertebrates
    • PMID:22474285
    • Ryan KE, Chiang C. Hedgehog secretion and signal transduction in vertebrates. J Biol Chem 2012; 287:17905-13; PMID:22474285
    • (2012) J Biol Chem , vol.287 , pp. 17905-17913
    • Ryan, K.E.1    Chiang, C.2
  • 8
    • 84887512714 scopus 로고    scopus 로고
    • Unraveling the therapeutic potential of the Hedgehog pathway in cancer
    • PMID:24202394
    • Amakye D, Jagani Z, Dorsch M. Unraveling the therapeutic potential of the Hedgehog pathway in cancer. Nat Med 2013; 19:1410-22; PMID:24202394
    • (2013) Nat Med , vol.19 , pp. 1410-1422
    • Amakye, D.1    Jagani, Z.2    Dorsch, M.3
  • 9
    • 34249867843 scopus 로고    scopus 로고
    • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
    • PMID:17494766
    • Lauth M, Bergstrom A, Shimokawa T, Toftgard R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A 2007; 104:8455-60; PMID: 17494766
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 8455-8460
    • Lauth, M.1    Bergstrom, A.2    Shimokawa, T.3    Toftgard, R.4
  • 10
    • 77955804589 scopus 로고    scopus 로고
    • Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector
    • PMID:20624968
    • Kim J, Lee JJ, Kim J, Gardner D, Beachy PA. Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A 2010; 107:13432-7; PMID:20624968
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13432-13437
    • Kim, J.1    Lee, J.J.2    Kim, J.3    Gardner, D.4    Beachy, P.A.5
  • 11
    • 84872679485 scopus 로고    scopus 로고
    • Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma
    • PMID:24280107
    • Gershon TR, Crowther AJ, Tikunov A, Garcia I, Annis R, Yuan H, Miller CR, Macdonald J, Olson J, Deshmukh M. Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of medulloblastoma. Cancer Metab 2013; 1 (1):1; PMID:24280107; http://dx.doi.org/10.1186/2049-3002-1-1
    • (2013) Cancer Metab , vol.1 , Issue.1 , pp. 1
    • Gershon, T.R.1    Crowther, A.J.2    Tikunov, A.3    Garcia, I.4    Annis, R.5    Yuan, H.6    Miller, C.R.7    MacDonald, J.8    Olson, J.9    Deshmukh, M.10
  • 12
    • 84920132971 scopus 로고    scopus 로고
    • Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma
    • PMID:24569090
    • Tech K, Deshmukh M, Gershon TR. Adaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastoma. Cancer Lett 2014; PMID:24569090
    • (2014) Cancer Lett
    • Tech, K.1    Deshmukh, M.2    Gershon, T.R.3
  • 13
    • 84890159876 scopus 로고    scopus 로고
    • Cancer cell metabolism: Implications for therapeutic targets
    • PMID:24091747
    • Jang M, Kim SS, Lee J. Cancer cell metabolism: implications for therapeutic targets. Exp Mole Med 2013; 45:e45; PMID:24091747
    • (2013) Exp Mole Med , vol.45 , pp. e45
    • Jang, M.1    Kim, S.S.2    Lee, J.3
  • 14
    • 34447577912 scopus 로고    scopus 로고
    • Circumventing the Crabtree effect: Replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants
    • PMID:17361016
    • Marroquin LD, Hynes J, Dykens JA, Jamieson JD, Will Y. Circumventing the Crabtree effect: replacing media glucose with galactose increases susceptibility of HepG2 cells to mitochondrial toxicants. Toxicol Sci : an official J Soc Toxicol 2007; 97:539-47; PMID: 17361016
    • (2007) Toxicol Sci : An Official J Soc Toxicol , vol.97 , pp. 539-547
    • Marroquin, L.D.1    Hynes, J.2    Dykens, J.A.3    Jamieson, J.D.4    Will, Y.5
  • 15
    • 84887430714 scopus 로고    scopus 로고
    • MTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc
    • PMID:24140020
    • Masui K, Tanaka K, Akhavan D, Babic I, Gini B, Matsutani T, Iwanami A, Liu F, Villa GR, Gu Y, et al. mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc. Cell Metab 2013; 18:726-39; PMID: 24140020
    • (2013) Cell Metab , vol.18 , pp. 726-739
    • Masui, K.1    Tanaka, K.2    Akhavan, D.3    Babic, I.4    Gini, B.5    Matsutani, T.6    Iwanami, A.7    Liu, F.8    Villa, G.R.9    Gu, Y.10
  • 16
    • 84862799616 scopus 로고    scopus 로고
    • Hedgehog-mediated regulation of PPARgamma controls metabolic patterns in neural precursors and shh-driven medulloblastoma
    • PMID:22407012
    • Bhatia B, Potts CR, Guldal C, Choi S, Korshunov A, Pfister S, Kenney AM, Nahle ZA. Hedgehog-mediated regulation of PPARgamma controls metabolic patterns in neural precursors and shh-driven medulloblastoma. Acta Neuropathol 2012; 123:587-600; PMID:22407012; http://dx.doi.org/10.1007/s00401-012-0968-6
    • (2012) Acta Neuropathol , vol.123 , pp. 587-600
    • Bhatia, B.1    Potts, C.R.2    Guldal, C.3    Choi, S.4    Korshunov, A.5    Pfister, S.6    Kenney, A.M.7    Nahle, Z.A.8
  • 21
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • PMID:19460998
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029-33; PMID:19460998; http://dx.doi.org/10.1126/science.1160809
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 22
    • 48749093935 scopus 로고    scopus 로고
    • Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation
    • PMID:18465755
    • Cao W, Yacoub S, Shiverick KT, Namiki K, Sakai Y, Porvasnik S, Urbanek C, Rosser CJ. Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation. The Prostate 2008; 68:1223-31; PMID:18465755; http://dx.doi.org/10.1002/pros.20788
    • (2008) The Prostate , vol.68 , pp. 1223-1231
    • Cao, W.1    Yacoub, S.2    Shiverick, K.T.3    Namiki, K.4    Sakai, Y.5    Porvasnik, S.6    Urbanek, C.7    Rosser, C.J.8
  • 23
    • 77953285316 scopus 로고    scopus 로고
    • Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells
    • PMID:20485289
    • Madhok BM, Yeluri S, Perry SL, Hughes TA, Jayne DG. Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells. Br J Cancer 2010; 102:1746-52; PMID:20485289; http://dx.doi.org/10.1038/sj.bjc.6605701
    • (2010) Br J Cancer , vol.102 , pp. 1746-1752
    • Madhok, B.M.1    Yeluri, S.2    Perry, S.L.3    Hughes, T.A.4    Jayne, D.G.5
  • 24
    • 74849137483 scopus 로고    scopus 로고
    • Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo
    • PMID:19543830
    • Sun RC, Fadia M, Dahlstrom JE, Parish CR, Board PG, Blackburn AC. Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo. Breast Cancer Res Treat 2010; 120:253-60; PMID:19543830; http://dx. doi.org/10.1007/s10549-009-0435-9
    • (2010) Breast Cancer Res Treat , vol.120 , pp. 253-260
    • Sun, R.C.1    Fadia, M.2    Dahlstrom, J.E.3    Parish, C.R.4    Board, P.G.5    Blackburn, A.C.6
  • 25
    • 84863006442 scopus 로고    scopus 로고
    • Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation
    • PMID:22705712
    • Kumar A, Kant S, Singh SM. Novel molecular mechanisms of antitumor action of dichloroacetate against T cell lymphoma: Implication of altered glucose metabolism, pH homeostasis and cell survival regulation. Chemico-Biolo Interact 2012; 199:29-37; PMID:22705712; http://dx.doi.org/10.1016/j.cbi.2012.06.005
    • (2012) Chemico-Biolo Interact , vol.199 , pp. 29-37
    • Kumar, A.1    Kant, S.2    Singh, S.M.3
  • 26
    • 59449106196 scopus 로고    scopus 로고
    • Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma
    • PMID:19147752
    • Sun W, Zhou S, Chang SS, McFate T, Verma A, Califano JA. Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma. Clin Cancer Res: an official J Am Assoc Cancer Res 2009; 15:476-84; PMID:19147752; http://dx.doi.org/10.1158/1078-0432.CCR-08-0930
    • (2009) Clin Cancer Res: An Official J Am Assoc Cancer Res , vol.15 , pp. 476-484
    • Sun, W.1    Zhou, S.2    Chang, S.S.3    McFate, T.4    Verma, A.5    Califano, J.A.6
  • 29
    • 80054949042 scopus 로고    scopus 로고
    • Itraconazole side chain analogues: Structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling
    • PMID:21936514
    • Shi W, Nacev BA, Aftab BT, Head S, Rudin CM, Liu JO. Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling. J Med Chem 2011; 54:7363-74; PMID:21936514; http://dx.doi.org/10.1021/jm200944b
    • (2011) J Med Chem , vol.54 , pp. 7363-7374
    • Shi, W.1    Nacev, B.A.2    Aftab, B.T.3    Head, S.4    Rudin, C.M.5    Liu, J.O.6
  • 31
    • 84878804952 scopus 로고    scopus 로고
    • Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy
    • PMID:23762415
    • Coni S, Antonucci L, D'Amico D, Di Magno L, Infante P, De Smaele E, Giannini G, Di Marcotullio L, Screpanti I, Gulino A, et al. Gli2 acetylation at lysine 757 regulates hedgehog-dependent transcriptional output by preventing its promoter occupancy. PLoS One 2013; 8:e65718; PMID:23762415; http://dx.doi.org/10.1371/journal.pone.0065718
    • (2013) PLoS One , vol.8 , pp. e65718
    • Coni, S.1    Antonucci, L.2    D'Amico, D.3    Di Magno, L.4    Infante, P.5    De Smaele, E.6    Giannini, G.7    Di Marcotullio, L.8    Screpanti, I.9    Gulino, A.10
  • 32
    • 44249098764 scopus 로고    scopus 로고
    • Simultaneous clinical monitoring of lactic acid, pyruvic acid and ketone bodies in plasma as methoxime/tert-butyldimethylsilyl derivatives by gas chromatography-mass spectrometry in selected ion monitoring mode
    • PMID:18254151
    • Paik MJ, Cho EY, Kim H, Kim KR, Choi S, Ahn YH, Lee G. Simultaneous clinical monitoring of lactic acid, pyruvic acid and ketone bodies in plasma as methoxime/tert-butyldimethylsilyl derivatives by gas chromatography-mass spectrometry in selected ion monitoring mode. Biomed Chromatogr: BMC 2008; 22:450-3; PMID:18254151; http://dx.doi.org/10.1002/bmc.966
    • (2008) Biomed Chromatogr: BMC , vol.22 , pp. 450-453
    • Paik, M.J.1    Cho, E.Y.2    Kim, H.3    Kim, K.R.4    Choi, S.5    Ahn, Y.H.6    Lee, G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.