Hedgehog-GLI pathway in medulloblastoma

Journal of Clinical Oncology

Volumn 30, Issue 17, 2012, Pages 2154-2156

  Archer, Tenley C ^a   Weeraratne, Shyamal D ^a   Pomeroy, Scott L ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CASEIN KINASE I; CYCLIC AMP DEPENDENT PROTEIN KINASE; FIBROBLAST GROWTH FACTOR; GLYCOGEN SYNTHASE KINASE 3BETA; NOTCH RECEPTOR; PROTEIN PATCHED; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WNT PROTEIN;

ARTICLE; CARCINOGENESIS; CEREBELLUM; GENE MUTATION; GENE REPRESSION; HUMAN; MEDULLOBLASTOMA; ONCOGENE; ONCOGENE C MYB; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SUFU GENE; TUMOR SUPPRESSOR GENE;

BRAIN; DEVELOPMENTAL BIOLOGY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GERM-LINE MUTATION; HEDGEHOG PROTEINS; HUMANS; MEDULLOBLASTOMA; MODELS, BIOLOGICAL; MUTATION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84863926411     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2011.41.1181     Document Type: Article

References (26)

1. Cho YJ, Tsherniak A, Tamayo P, et al: Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J Clin Oncol 29:1424-1430, 2011
2. Taylor MD, Northcott PA, Korshunov A, et al: Molecular subgroups of medulloblastoma: The current consensus. Acta Neuropathol [epub ahead of print on December 2, 2011]
3. Wang VY, Zoghbi HY: Genetic regulation of cerebellar development. Nat Rev Neurosci 2:484-491, 2001 (Pubitemid 33676583)
4. Brugières L, Remenieras A, Pierron G, et al: High frequency of germline SUFU mutations in children with desmoplatic/nodular medulloblastoma younger than 3 years of age. J Clin Oncol 30:2087-2093, 2012
5. Hatten ME: Expansion of CNS precursor pools: A new role for sonic hedgehog. Neuron 22:2-3, 1999
6. Roussel MF, Hatten ME: Cerebellum development and medulloblastoma. Curr Top Dev Biol 94:235-282, 2011
7. Ellison DW: Childhood medulloblastoma: Novel approaches to the classification of a heterogeneous disease. Acta Neuropathol 120:305-316, 2010
8. Dellovade T, Romer JT, Curran T, et al: The hedgehog pathway and neurological disorders. Annu Rev Neurosci 29:539-563, 2006 (Pubitemid 44476855)
9. Towers M, Tickle C: Growing models of vertebrate limb development. Development 136:179-190, 2009
10. Yang L, Xie G, Fan Q, et al: Activation of the hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene 29:469-481, 2010
11. Yue S, Chen Y, Cheng SY: Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway. Oncogene 28:492-499, 2009
12. Lee DY, Deng Z, Wang CH, et al: MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression. Proc Natl Acad Sci U S A 104:20350-20355, 2007
13. Teglund S, Toftgård R: Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biochim Biophys Acta 1805:181-208, 2010
14. Rohatgi R, Scott MP: Patching the gaps in hedgehog signalling. Nat Cell Biol 9:1005-1009, 2007 (Pubitemid 47338138)
15. Rohatgi R, Milenkovic L, Corcoran RB, et al: Hedgehog signal transduction by smoothened: Pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A 106:3196-3201, 2009
16. Wilson CW, Chen MH, Chuang PT: Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS ONE 4:e5182, 2009
17. Kovacs JJ, Whalen EJ, Liu R, et al: Betaarrestin-mediated localization of smoothened to the primary cilium. Science 320:1777-1781, 2008 (Pubitemid 351931292)
18. Katoh Y, Katoh M: Hedgehog target genes: Mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med 9:873-886, 2009
19. Svärd J, Heby-Henricson K, Henricson KH, et al: Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian hedgehog signaling pathway. Dev Cell 10:187-197, 2006 (Pubitemid 43174952)
20. Lee Y, Kawagoe R, Sasai K, et al: Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene 26:6442-6447, 2007 (Pubitemid 47494220)
21. Meng X, Poon R, Zhang X, et al: Suppressor of fused negatively regulates beta-catenin signaling. J Biol Chem 276:40113-40119, 2001
22. Taylor MD, Zhang X, Liu L, et al: Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling. Oncogene 23:4577-4583, 2004 (Pubitemid 38850405)
23. Takenaka K, Kise Y, Miki H: GSK3beta positively regulates hedgehog signaling through Sufu in mammalian cells. Biochem Biophys Res Commun 353:501-508, 2007 (Pubitemid 46014591)
24. Han YG, Kim HJ, Dlugosz AA, et al: Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med 15:1062-1065, 2009
25. Ng JM, Curran T: The hedgehog's tale: Developing strategies for targeting cancer. Nat Rev Cancer 11:493-501, 2011
26. Heretsch P, Tzagkaroulaki L, Giannis A: Modulators of the hedgehog signaling pathway. Bioorg Med Chem 18:6613-6624, 2010