Coating solid dispersions on microneedles via a molten dip-coating method: Development and in vitro evaluation for transdermal delivery of a water-insoluble drug

Journal of Pharmaceutical Sciences

Volumn 103, Issue 11, 2014, Pages 3621-3630

  Ma, Yunzhe ^a   Gill, Harvinder S ^a  

^a Department of Electrical and Computer Engineering   (United States)

Author keywords

Coating; Dissolution; Solid dispersion; Solubility; Transdermal drug delivery

Indexed keywords

EMLA; LIDOCAINE; MACROGOL; BIOCOMPATIBLE COATED MATERIAL; DRUG CARRIER; LOCAL ANESTHETIC AGENT; MACROGOL DERIVATIVE; PRILOCAINE; WATER;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG COATING; DRUG DIFFUSION; DRUG SOLUBILITY; DRUG STABILITY; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; MATERIAL COATING; MICRONEEDLE; NONHUMAN; SKIN PERMEABILITY; SOLID DISPERSION; SWINE; TEMPERATURE; THERMOGRAVIMETRY; THERMOSTABILITY; TRANSDERMAL DRUG ADMINISTRATION; VISCOMETRY; VISCOSITY; ANIMAL; CHEMICAL PHENOMENA; CHEMISTRY; COMPARATIVE STUDY; CUTANEOUS DRUG ADMINISTRATION; EQUIPMENT DESIGN; MEDICINAL CHEMISTRY; METABOLISM; MINIATURIZATION; NEEDLE; PHARMACEUTICS; PIG; PROCEDURES; SKIN; SKIN ABSORPTION; SOLUBILITY; TIME FACTOR;

ADMINISTRATION, CUTANEOUS; ANESTHETICS, LOCAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; COATED MATERIALS, BIOCOMPATIBLE; DRUG CARRIERS; DRUG STABILITY; EQUIPMENT DESIGN; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IN VITRO TECHNIQUES; LIDOCAINE; MINIATURIZATION; NEEDLES; POLYETHYLENE GLYCOLS; PRILOCAINE; SKIN; SKIN ABSORPTION; SOLUBILITY; SWINE; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; TIME FACTORS; VISCOSITY; WATER;

EID: 84914820593     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24159     Document Type: Article

References (47)

1. Kim YC, Park JH, Prausnitz MR. 2012. Microneedles for drug and vaccine delivery. Adv Drug Deliv Rev 64(14):1547-1568.
2. van der Maaden K, Jiskoot W, Bouwstra J. 2012. Microneedle technologies for (trans)dermal drug and vaccine delivery. J Control Release 161(2):645-655.
3. Gill HS, Denson DD, Burris BA, Prausnitz MR. 2008. Effect of microneedle design on pain in human volunteers. Clin J Pain 24(7):585-594.
4. Gill HS, Prausnitz MR. 2007. Coated microneedles for transdermal delivery. J Control Release 117(2):227-237.
5. Zhang Y, Brown K, Siebenaler K, Determan A, Dohmeier D, Hansen K. 2012. Development of lidocaine-coated microneedle product for rapid, safe, and prolonged local analgesic action. Pharm Res 29(1):170-177.
6. Peters EE, Ameri M, Wang X, Maa YF, Daddona PE. 2012. Erythropoietin-coated ZP-microneedle transdermal system: Preclinical formulation, stability, and delivery. Pharm Res 29(6):1618-1626.
7. Zhu Q, Zarnitsyn VG, Ye L, Wen Z, Gao Y, Pan L, Skountzou I, Gill HS, Prausnitz MR, Yang C, Compans RW. 2009. Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge. Proc Natl Acad Sci USA 106(19):7968-7973.
8. Kommareddy S, Baudner BC, Bonificio A, Gallorini S, Palladino G, Determan AS, Dohmeier DM, Kroells KD, Sternjohn JR, Singh M, Dormitzer PR, Hansen KJ, O'Hagan DT. 2013. Influenza subunit vaccine coated microneedle patches elicit comparable immune responses to intramuscular injection in guinea pigs. Vaccine 31(34):3435-3441.
9. Daddona PE, Matriano JA, Mandema J, Maa YF. 2011. Parathyroid hormone (1-34)-coatedmicroneedle patch system: Clinical pharmacokinetics and pharmacodynamics for treatment of osteoporosis. Pharm Res 28(1):159-165.
10. Gill HS, Soderholm J, Prausnitz MR, Sallberg M. 2010. Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine. Gene Ther 17(6):811-814.
11. Luo Z, Ye T, Ma Y, Gill HS, Nitin N. 2013. Microprecision delivery of oligonucleotides in a 3D tissue model and its characterization using optical imaging. Mol Pharm 10(8):2868-2879.
12. Gill HS, Prausnitz MR. 2007. Coating formulations for microneedles. Pharm Res 24(7):1369-1380.
13. Chen X, Prow TW, Crichton ML, Jenkins DW, Roberts MS, Frazer IH, Fernando GJ, Kendall MA. 2009. Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin. J Control Release 139(3):212-220.
14. Takagi T, Ramachandran C, Bermejo M, Yamashita S, Yu LX, Amidon GL. 2006. A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain, and Japan. Mol Pharm 3(6):631-643.
15. Kawabata Y, Wada K, Nakatani M, Yamada S, Onoue S. 2011. Formulation design for poorlywater-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications. Int J Pharm 420(1):1-10.
16. Kapsi SG, Ayres JW. 2001. Processing factors in development of solid solution formulation of itraconazole for enhancement of drug dissolution and bioavailability. Int J Pharm 229(1-2):193-203.
17. Leuner C, Dressman J. 2000. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 50(1):47-60.
18. Liu X, Lu M, Guo Z, Huang L, Feng X, Wu C. 2012. Improving the chemical stability of amorphous solid dispersion with cocrystal technique by hot melt extrusion. Pharm Res 29(3):806-817.
19. Goldberg AH, Gibaldi M, Kanig JL. 1966. Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures III: Experimental evaluation of griseofulvin-succinic acid solid solution. J Pharm Sci 55(5):487-492.
20. Tatai A, Aigner Z, Ero{combining double acute accent}s I, Kata M. 2007. Preparation and investigation of mixtures containing lidocaine base and β-cyclodextrin. J Incl Phenom Macrocycl Chem 59(1-2):105-113.
21. Bergstrom CA, Luthman K, Artursson P. 2004. Accuracy of calculated pH-dependent aqueous drug solubility. Eur J Pharm Sci 22(5):387-398.
22. Sarpotdar PP, Zatz JL. 1986. Evaluation of penetration enhancement of lidocaine by nonionic surfactants through hairless mouse skin in vitro. J Pharm Sci 75(2):176-181.
23. Kreilgaard M, Kemme MB, Burggraaf J, Schoemaker R, Cohen A. 2001. Influence of a microemulsion vehicle on cutaneous bioequivalence of a lipophilic model drug assessed by microdialysis and pharmacodynamics. Pharm Res 18(5):593-599.
24. vanHal DA, Jeremiasse E, deVringer T, Junginger HE, Bouwstra JA. 1996. Encapsulation of lidocaine base and hydrochloride into nonionic surfactant vesicles (NSVs) and diffusion through human stratum corneum in vitro. Eur J Pharm Sci 4(3):147-157.
25. Repka MA, Gutta K, Prodduturi S, Munjal M, Stodghill SP. 2005. Characterization of cellulosic hot-melt extruded films containing lidocaine. Eur J Pharm Biopharm 59(1):189-196.
26. Evers H, Von Dardel O, Juhlin L, Ohlsen L, Vinnars E. 1985. Dermal effects of compositions based on the eutectic mixture of lignocaine and prilocaine (EMLA) Studies in volunteers. Br J Anaesth 57(10):997-1005.
27. Jeske AH. 1998. Xylocaine: 50 years of clinical service to dentistry. Tex Dent J 115(5):9-13.
28. Wahlgren C-F, Quiding H. 2000. Depth of cutaneous analgesia after application of a eutectic mixture of the local anesthetics lidocaine and prilocaine (EMLA cream). J Am Acad Dermatol 42(4):584-588.
29. Vanscheidt W, Sadjadi Z, Lillieborg S. 2001. EMLA anaesthetic cream for sharp leg ulcer debridement: A review of the clinical evidence for analgesic efficacy and tolerability. Eur J Dermatol 11(2):90-96.
30. Umeda Y, Fukami T, Furuishi T, Suzuki T, Makimura M, Tomono K. 2007. Molecular complex consisting of two typical external medicines: Intermolecular interaction between indomethacin and lidocaine. Chem Pharm Bull 55(5):832-836.
31. Strawbridge I, James PF. 1986. The factors affecting the thickness of sol-gel derived silica coatings prepared by dipping. J Non Cryst Solids 86(3):381-393.
32. Stokes RJ, Evans DF, Errico M. 1997. Liquid coating processes. In Fundamentals of interfacial engineering; Stokes RJ, Evans DF, Eds. Wiley-VCH, New York, USA pp 399-456.
33. Scriven LE. 1988. Physics and applications of dip coating and spin coating. In Materials research society symposium proceedings;Brinker CJ, Clark DE, Ulrich DR, Eds. Materials Research Society, pp 717-729.
34. Brinker CJ, Frye GC, Hurd AJ, Ashley CS. 1991. Fundamentals of sol-gel dip coating. Thin Solid Film 201(1):97-108.
35. Yang D, Kulkarni R, Behme RJ, Kotiyan PN. 2007. Effect of themelt granulation technique on the dissolution characteristics of griseofulvin. Int J Pharm 329(1-2):72-80.
36. Biswal S, Sahoo J, Murthy P, Giradkar R, Avari J. 2008. Enhancement of dissolution rate of gliclazide using solid dispersions with polyethylene glycol 6000. AAPS PharmSciTech 9(2):563-570.
37. Joe JH, Lee WM, Park Y-J, Joe KH, Oh DH, Seo YG, Woo JS, Yong CS, Choi H-G. 2010. Effect of the solid-dispersion method on the solubility and crystalline property of tacrolimus. Int J Pharm 395(1-2):161-166.
38. Newa M, Bhandari K, Oh D, Kim Y, Sung J, Kim J, Woo J, Choi H, Yong C. 2008. Enhanced dissolution of ibuprofen using solid dispersion with poloxamer 407. Arch Pharm Res 31(11):1497-1507.
39. Bizarria MTM, Giraldi ALFdM, de Carvalho CM, Velasco JI, d'Ávila MA, Mei LHI. 2007. Morphology and thermomechanical properties of recycled PET-Organoclay nanocomposites. J Appl Polym Sci 104(3):1839-1844.
40. Damian F, Blaton N, Naesens L, Balzarini J, Kinget R, Augustijns P, Van den Mooter G. 2000. Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14. Eur J Pharm Sci 10(4):311-322.
41. Yao W-W, Bai T-C, Sun J-P, Zhu C-W, Hu J, Zhang H-L. 2005. Thermodynamic properties for the system of silybin and poly (ethylene glycol) 6000. Thermochim Acta 437(1):17-20.
42. Blake TD, Ruschak KJ, Eds. 1997. Wetting: Static and dynamic contact lines. London, UK: Chapman & Hall, pp 63-97.
43. Muller RH, Sand ML. 1987. Optimum angle of incidence for observing thin-film interference colors. Appl Opt 26(24):5211-5220.
44. Kim YC, Quan FS, Compans RW, Kang SM, Prausnitz MR. 2010. Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity. J Control Release 142(2):187-195.
45. Liossi C. 1999. Management of paediatric procedure-related cancer pain. Pain Rev 6(4):279-302.
46. Ito Y, Ohta J, Imada K, Akamatsu S, Tsuchida N, Inoue G, Inoue N, Takada K. 2013. Dissolving microneedles to obtain rapid local anesthetic effect of lidocaine at skin tissue. J Drug Target 21(8):770-775.
47. Tuan-Mahmood T-M, McCrudden MTC, Torrisi BM, McAlister E, Garland MJ, Singh TRR, Donnelly RF. 2013. Microneedles for intradermal and transdermal drug delivery. Eur J Pharm Sci 50(5):623-637.