Activation of hypoxia-inducible factor-1α in type 2 alveolar epithelial cell is a major driver of acute inflammation following lung contusion

Critical Care Medicine

Volumn 42, Issue 10, 2014, Pages e642-e653

  Suresh, Madathilparambil V ^a   Ramakrishnan, Sadeesh Kumar ^a   Thomas, Bivin ^a   Machado Aranda, David ^a   Bi, Yu ^a   Talarico, Nicholas ^a   Anderson, Erik ^a   Yatrik, Shah M ^a   Raghavendran, Krishnan ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Cytokines; Hypoxia inducible factor 1 ; Lung contusion; Oxygen dependent degradation domain luciferase mice; Type 2 cells

Indexed keywords

ACRIFLAVINE; ALBUMIN; DOXYCYCLINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LAMIN A; LAMIN B; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 5; TRANSCRIPTION FACTOR RELA; ANTIINFLAMMATORY AGENT; CYTOKINE; HIF1A PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE RELEASE; DIMERIZATION; DOWN REGULATION; FLOW CYTOMETRY; HYPOXEMIA; LUNG ALVEOLUS CELL TYPE 2; LUNG CONTUSION; LUNG HOMOGENATE; LUNG INJURY; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PNEUMONIA; PROMOTER REGION; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; COMPLICATION; CONTUSION; CYTOLOGY; DISEASE MODEL; INFLAMMATION; KNOCKOUT MOUSE; LUNG ALVEOLUS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA;

ACRIFLAVINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CONTUSIONS; CYTOKINES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DOXYCYCLINE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; LUNG INJURY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PULMONARY ALVEOLI; RESPIRATORY MUCOSA;

EID: 84914176676     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000488     Document Type: Article

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