메뉴 건너뛰기




Volumn 92, Issue 12, 2014, Pages 1229-1234

p53 in liver pathologies—taking the good with the bad

Author keywords

Hepatocellular carcinoma; Liver pathologies; p53

Indexed keywords

PROTEIN P53;

EID: 84914161420     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-014-1223-5     Document Type: Review
Times cited : (21)

References (53)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • COI: 1:CAS:528:DC%2BD2sXnvFOgsrw%3D, PID: 17570226
    • El-Serag HB, Rudolph KL (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132:2557–2576
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 84896706849 scopus 로고    scopus 로고
    • Multiple interactive factors in hepatocarcinogenesis
    • COI: 1:CAS:528:DC%2BC2cXjsVWlsL8%3D, PID: 24374016
    • Ding J, Wang H (2014) Multiple interactive factors in hepatocarcinogenesis. Cancer Lett 346:17–23
    • (2014) Cancer Lett , vol.346 , pp. 17-23
    • Ding, J.1    Wang, H.2
  • 3
    • 33748892142 scopus 로고    scopus 로고
    • Review article: alcoholic liver disease—pathophysiological aspects and risk factors
    • COI: 1:CAS:528:DC%2BD28Xht1WntLvJ, PID: 17014574
    • Gramenzi A, Caputo F, Biselli M, Kuria F, Loggi E, Andreone P, Bernardi M (2006) Review article: alcoholic liver disease—pathophysiological aspects and risk factors. Aliment Pharmacol Ther 24:1151–1161
    • (2006) Aliment Pharmacol Ther , vol.24 , pp. 1151-1161
    • Gramenzi, A.1    Caputo, F.2    Biselli, M.3    Kuria, F.4    Loggi, E.5    Andreone, P.6    Bernardi, M.7
  • 4
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • COI: 1:CAS:528:DC%2BD28XosVOmsLs%3D, PID: 16929323
    • Farazi PA, DePinho RA (2006) Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6:674–687
    • (2006) Nat Rev Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 5
    • 84899447215 scopus 로고    scopus 로고
    • Obesity-associated mechanisms of hepatocarcinogenesis
    • COI: 1:CAS:528:DC%2BC2cXkt1Wjs7c%3D, PID: 24629562
    • Karagozian R, Derdak Z, Baffy G (2014) Obesity-associated mechanisms of hepatocarcinogenesis. Metab Clin Exp 63:607–617
    • (2014) Metab Clin Exp , vol.63 , pp. 607-617
    • Karagozian, R.1    Derdak, Z.2    Baffy, G.3
  • 6
    • 84908888139 scopus 로고    scopus 로고
    • Could metabolic syndrome lead to hepatocarcinoma non-alcoholic fatty liver disease?
    • PID: 25071314
    • Scalera A, Tarantino G (2014) Could metabolic syndrome lead to hepatocarcinoma non-alcoholic fatty liver disease? World J Gastroenterol 20:9217–9228
    • (2014) World J Gastroenterol , vol.20 , pp. 9217-9228
    • Scalera, A.1    Tarantino, G.2
  • 7
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: old questions and new insights
    • COI: 1:CAS:528:DC%2BC3MXnsleiurY%3D, PID: 21700865
    • Cohen JC, Horton JD, Hobbs HH (2011) Human fatty liver disease: old questions and new insights. Science 332:1519–1523
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 8
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection
    • PID: 20432259
    • Starley BQ, Calcagno CJ, Harrison SA (2010) Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology 51:1820–1832
    • (2010) Hepatology , vol.51 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 9
    • 84874598132 scopus 로고    scopus 로고
    • Human hepatocyte carcinogenesis (review)
    • COI: 1:CAS:528:DC%2BC3sXmt1enurs%3D, PID: 23426905
    • Shiraha H, Yamamoto K, Namba M (2013) Human hepatocyte carcinogenesis (review). Int J Oncol 42:1133–1138
    • (2013) Int J Oncol , vol.42 , pp. 1133-1138
    • Shiraha, H.1    Yamamoto, K.2    Namba, M.3
  • 10
    • 84861197159 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace
    • PID: 22326465
    • Baffy G, Brunt EM, Caldwell SH (2012) Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. J Hepatol 56:1384–1391
    • (2012) J Hepatol , vol.56 , pp. 1384-1391
    • Baffy, G.1    Brunt, E.M.2    Caldwell, S.H.3
  • 11
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • COI: 1:CAS:528:DC%2BC3MXjsFeqtrk%3D, PID: 21376230
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 15
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: the cell’s response to p53
    • COI: 1:CAS:528:DC%2BD38XlslGqsL8%3D, PID: 12154352
    • Vousden KH, Lu X (2002) Live or let die: the cell’s response to p53. Nat Rev Cancer 2:594–604
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 16
    • 84867142011 scopus 로고    scopus 로고
    • Regulation of lipid metabolism by p53—fighting two villains with one sword
    • COI: 1:CAS:528:DC%2BC38XhtVyjsrbK, PID: 22819212
    • Goldstein I, Rotter V (2012) Regulation of lipid metabolism by p53—fighting two villains with one sword. Trends Endocrinol Metab 23:567–575
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 567-575
    • Goldstein, I.1    Rotter, V.2
  • 18
    • 84872160824 scopus 로고    scopus 로고
    • Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53
    • COI: 1:CAS:528:DC%2BC3sXktV2qtw%3D%3D, PID: 23054612
    • Goldstein I, Rivlin N, Shoshana OY, Ezra O, Madar S, Goldfinger N, Rotter V (2013) Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53. Carcinogenesis 34:190–198
    • (2013) Carcinogenesis , vol.34 , pp. 190-198
    • Goldstein, I.1    Rivlin, N.2    Shoshana, O.Y.3    Ezra, O.4    Madar, S.5    Goldfinger, N.6    Rotter, V.7
  • 19
    • 84884560637 scopus 로고    scopus 로고
    • p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production
    • PID: 24280180
    • Goldstein I, Yizhak K, Madar S, Goldfinger N, Ruppin E, Rotter V (2013) p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production. Cancer Metab 1:9
    • (2013) Cancer Metab , vol.1 , pp. 9
    • Goldstein, I.1    Yizhak, K.2    Madar, S.3    Goldfinger, N.4    Ruppin, E.5    Rotter, V.6
  • 20
    • 84876698526 scopus 로고    scopus 로고
    • p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver
    • COI: 1:CAS:528:DC%2BC3sXms1egtrs%3D, PID: 23300120
    • Kurinna S, Stratton SA, Coban Z, Schumacher JM, Grompe M, Duncan AW, Barton MC (2013) p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver. Hepatology 57:2004–2013
    • (2013) Hepatology , vol.57 , pp. 2004-2013
    • Kurinna, S.1    Stratton, S.A.2    Coban, Z.3    Schumacher, J.M.4    Grompe, M.5    Duncan, A.W.6    Barton, M.C.7
  • 21
    • 41149105243 scopus 로고    scopus 로고
    • ROS and p53: a versatile partnership
    • COI: 1:CAS:528:DC%2BD1cXktlGls7o%3D, PID: 18275858
    • Liu B, Chen Y, St Clair DK (2008) ROS and p53: a versatile partnership. Free Radic Biol Med 44:1529–1535
    • (2008) Free Radic Biol Med , vol.44 , pp. 1529-1535
    • Liu, B.1    Chen, Y.2    St Clair, D.K.3
  • 22
    • 73349136974 scopus 로고    scopus 로고
    • Role of free radicals in liver diseases
    • PID: 19941170
    • Muriel P (2009) Role of free radicals in liver diseases. Hepatol Int 3:526–536
    • (2009) Hepatol Int , vol.3 , pp. 526-536
    • Muriel, P.1
  • 23
    • 33750628734 scopus 로고    scopus 로고
    • Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BD28Xht1emtL%2FK, PID: 17036395
    • Panasiuk A, Dzieciol J, Panasiuk B, Prokopowicz D (2006) Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease. World J Gastroenterol 12:6198–6202
    • (2006) World J Gastroenterol , vol.12 , pp. 6198-6202
    • Panasiuk, A.1    Dzieciol, J.2    Panasiuk, B.3    Prokopowicz, D.4
  • 24
    • 46049084164 scopus 로고    scopus 로고
    • Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function
    • COI: 1:CAS:528:DC%2BD1cXotlajsro%3D, PID: 18555008
    • Lieber CS, Leo MA, Wang X, Decarli LM (2008) Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function. Biochem Biophys Res Commun 373:246–252
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 246-252
    • Lieber, C.S.1    Leo, M.A.2    Wang, X.3    Decarli, L.M.4
  • 28
    • 78649632422 scopus 로고    scopus 로고
    • Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease
    • COI: 1:CAS:528:DC%2BC3cXhsV2gurrM, PID: 20961644
    • Derdak Z, Lang CH, Villegas KA, Tong M, Mark NM, de la Monte SM, Wands JR (2011) Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. J Hepatol 54:164–172
    • (2011) J Hepatol , vol.54 , pp. 164-172
    • Derdak, Z.1    Lang, C.H.2    Villegas, K.A.3    Tong, M.4    Mark, N.M.5    de la Monte, S.M.6    Wands, J.R.7
  • 29
    • 84880925312 scopus 로고    scopus 로고
    • Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC3sXhslCnt70%3D, PID: 23211317
    • Derdak Z, Villegas KA, Harb R, Wu AM, Sousa A, Wands JR (2013) Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. J Hepatol 58:785–791
    • (2013) J Hepatol , vol.58 , pp. 785-791
    • Derdak, Z.1    Villegas, K.A.2    Harb, R.3    Wu, A.M.4    Sousa, A.5    Wands, J.R.6
  • 30
    • 84858797950 scopus 로고    scopus 로고
    • Sirtuins as regulators of metabolism and healthspan
    • COI: 1:CAS:528:DC%2BC38XjtlOktbw%3D, PID: 22395773
    • Houtkooper RH, Pirinen E, Auwerx J (2012) Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol 13:225–238
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 225-238
    • Houtkooper, R.H.1    Pirinen, E.2    Auwerx, J.3
  • 31
    • 0041822087 scopus 로고    scopus 로고
    • Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver
    • COI: 1:CAS:528:DC%2BD3sXnvVKjtLs%3D, PID: 12939597
    • Yeon JE, Califano S, Xu J, Wands JR, De La Monte SM (2003) Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver. Hepatology 38:703–714
    • (2003) Hepatology , vol.38 , pp. 703-714
    • Yeon, J.E.1    Califano, S.2    Xu, J.3    Wands, J.R.4    De La Monte, S.M.5
  • 33
    • 85035392112 scopus 로고    scopus 로고
    • Liver fibrosis
    • COI: 1:CAS:528:DC%2BD2MXhtFyjs70%3D, PID: 15690074
    • Bataller R, Brenner DA (2005) Liver fibrosis. J Clin Invest 115:209–218
    • (2005) J Clin Invest , vol.115 , pp. 209-218
    • Bataller, R.1    Brenner, D.A.2
  • 34
    • 68549099997 scopus 로고    scopus 로고
    • Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology
    • COI: 1:CAS:528:DC%2BD1MXos1eru78%3D, PID: 19150958
    • Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, Lowe SW (2008) Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology. Cold Spring Harb Symp Quant Biol 73:513–522
    • (2008) Cold Spring Harb Symp Quant Biol , vol.73 , pp. 513-522
    • Krizhanovsky, V.1    Xue, W.2    Zender, L.3    Yon, M.4    Hernando, E.5    Lowe, S.W.6
  • 36
  • 37
    • 0028343058 scopus 로고
    • Geographic variation of p53 mutational profile in nonmalignant human liver
    • COI: 1:CAS:528:DyaK2cXkt12jsr0%3D, PID: 8191284
    • Aguilar F, Harris CC, Sun T, Hollstein M, Cerutti P (1994) Geographic variation of p53 mutational profile in nonmalignant human liver. Science 264:1317–1319
    • (1994) Science , vol.264 , pp. 1317-1319
    • Aguilar, F.1    Harris, C.C.2    Sun, T.3    Hollstein, M.4    Cerutti, P.5
  • 38
    • 34047210411 scopus 로고    scopus 로고
    • TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer
    • COI: 1:CAS:528:DC%2BD2sXjs1yqt7o%3D, PID: 17401425
    • Hussain SP, Schwank J, Staib F, Wang XW, Harris CC (2007) TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene 26:2166–2176
    • (2007) Oncogene , vol.26 , pp. 2166-2176
    • Hussain, S.P.1    Schwank, J.2    Staib, F.3    Wang, X.W.4    Harris, C.C.5
  • 39
    • 79952286128 scopus 로고    scopus 로고
    • Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC3MXjs1Wks78%3D, PID: 21094160
    • Woo HG, Wang XW, Budhu A, Kim YH, Kwon SM, Tang ZY, Sun Z, Harris CC, Thorgeirsson SS (2011) Association of TP53 mutations with stem cell-like gene expression and survival of patients with hepatocellular carcinoma. Gastroenterology 140:1063–1070
    • (2011) Gastroenterology , vol.140 , pp. 1063-1070
    • Woo, H.G.1    Wang, X.W.2    Budhu, A.3    Kim, Y.H.4    Kwon, S.M.5    Tang, Z.Y.6    Sun, Z.7    Harris, C.C.8    Thorgeirsson, S.S.9
  • 40
    • 84866740163 scopus 로고    scopus 로고
    • Alterations of TP53 are associated with a poor outcome for patients with hepatocellular carcinoma: evidence from a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC38XkvFWhtr4%3D, PID: 22459764
    • Liu J, Ma Q, Zhang M, Wang X, Zhang D, Li W, Wang F, Wu E (2012) Alterations of TP53 are associated with a poor outcome for patients with hepatocellular carcinoma: evidence from a systematic review and meta-analysis. Eur J Cancer 48:2328–2338
    • (2012) Eur J Cancer , vol.48 , pp. 2328-2338
    • Liu, J.1    Ma, Q.2    Zhang, M.3    Wang, X.4    Zhang, D.5    Li, W.6    Wang, F.7    Wu, E.8
  • 41
    • 84914121259 scopus 로고    scopus 로고
    • TP53 mutation is associated with a poor outcome for patients with hepatocellular carcinoma: evidence from a meta-analysis
    • PID: 24570956
    • Zhan P, Ji YN, Yu LK (2013) TP53 mutation is associated with a poor outcome for patients with hepatocellular carcinoma: evidence from a meta-analysis. Hepatobiliary Surg Nutr 2:260–265
    • (2013) Hepatobiliary Surg Nutr , vol.2 , pp. 260-265
    • Zhan, P.1    Ji, Y.N.2    Yu, L.K.3
  • 42
    • 84905086482 scopus 로고    scopus 로고
    • p53: the barrier to cancer stem cell formation
    • COI: 1:CAS:528:DC%2BC2cXjtlSksbo%3D, PID: 24560790
    • Aloni-Grinstein R, Shetzer Y, Kaufman T, Rotter V (2014) p53: the barrier to cancer stem cell formation. FEBS Lett 588:2580–2589
    • (2014) FEBS Lett , vol.588 , pp. 2580-2589
    • Aloni-Grinstein, R.1    Shetzer, Y.2    Kaufman, T.3    Rotter, V.4
  • 44
    • 0028843480 scopus 로고
    • Functional inactivation but not structural mutation of p53 causes liver cancer
    • COI: 1:CAS:528:DyaK2MXjtFCrsbc%3D, PID: 7704023
    • Ueda H, Ullrich SJ, Gangemi JD, Kappel CA, Ngo L, Feitelson MA, Jay G (1995) Functional inactivation but not structural mutation of p53 causes liver cancer. Nat Genet 9:41–47
    • (1995) Nat Genet , vol.9 , pp. 41-47
    • Ueda, H.1    Ullrich, S.J.2    Gangemi, J.D.3    Kappel, C.A.4    Ngo, L.5    Feitelson, M.A.6    Jay, G.7
  • 47
    • 84877906179 scopus 로고    scopus 로고
    • Transcriptional and translational regulation of C/EBPbeta-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1alpha proteins at the early and late stages of liver cancer
    • COI: 1:CAS:528:DC%2BC3sXnvVGqtr4%3D, PID: 23564453
    • Jin J, Iakova P, Jiang Y, Lewis K, Sullivan E, Jawanmardi N, Donehower L, Timchenko L, Timchenko NA (2013) Transcriptional and translational regulation of C/EBPbeta-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1alpha proteins at the early and late stages of liver cancer. J Biol Chem 288:14451–14462
    • (2013) J Biol Chem , vol.288 , pp. 14451-14462
    • Jin, J.1    Iakova, P.2    Jiang, Y.3    Lewis, K.4    Sullivan, E.5    Jawanmardi, N.6    Donehower, L.7    Timchenko, L.8    Timchenko, N.A.9
  • 48
    • 20844449238 scopus 로고    scopus 로고
    • AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
    • COI: 1:CAS:528:DC%2BD2MXkt1Cgtbw%3D, PID: 15866171
    • Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB (2005) AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 18:283–293
    • (2005) Mol Cell , vol.18 , pp. 283-293
    • Jones, R.G.1    Plas, D.R.2    Kubek, S.3    Buzzai, M.4    Mu, J.5    Xu, Y.6    Birnbaum, M.J.7    Thompson, C.B.8
  • 49
    • 0035929359 scopus 로고    scopus 로고
    • Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line
    • COI: 1:CAS:528:DC%2BD3MXms12qsLk%3D, PID: 11554766
    • Imamura K, Ogura T, Kishimoto A, Kaminishi M, Esumi H (2001) Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun 287:562–567
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 562-567
    • Imamura, K.1    Ogura, T.2    Kishimoto, A.3    Kaminishi, M.4    Esumi, H.5
  • 50
    • 84926313665 scopus 로고    scopus 로고
    • CD147 promotes reprogramming of glucose metabolism and cell proliferation in HCC cells by inhibiting the p53-dependent signaling pathway
    • Huang Q, Li J, Xing J, Li W, Li H, Ke X, Zhang J, Ren T, Shang Y, Yang H et al (2014) CD147 promotes reprogramming of glucose metabolism and cell proliferation in HCC cells by inhibiting the p53-dependent signaling pathway. J Hepatol DOI. doi:10.1016/j.jhep.2014.04.035
    • (2014) J Hepatol DOI
    • Huang, Q.1    Li, J.2    Xing, J.3    Li, W.4    Li, H.5    Ke, X.6    Zhang, J.7    Ren, T.8    Shang, Y.9    Yang, H.10
  • 51
    • 70349442548 scopus 로고    scopus 로고
    • The first 30 years of p53: growing ever more complex
    • COI: 1:CAS:528:DC%2BD1MXhtFKmsb%2FI, PID: 19776744
    • Levine AJ, Oren M (2009) The first 30 years of p53: growing ever more complex. Nat Rev Cancer 9:749–758
    • (2009) Nat Rev Cancer , vol.9 , pp. 749-758
    • Levine, A.J.1    Oren, M.2
  • 52
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • COI: 1:STN:280:DyaK38zhtVGmtA%3D%3D, PID: 1614522
    • Lane DP (1992) Cancer. p53, guardian of the genome. Nature 358:15–16
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 53
    • 0026561245 scopus 로고
    • The p53 tumor-suppressor gene
    • COI: 1:STN:280:DyaK383ivVShuw%3D%3D, PID: 1565147
    • Levine AJ (1992) The p53 tumor-suppressor gene. N Engl J Med 326:1350–1352
    • (1992) N Engl J Med , vol.326 , pp. 1350-1352
    • Levine, A.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.