Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1853, Issue 2, 2015, Pages 285-298

  Peeters, Annelies ^a   Shinde, Abhijit Babaji ^a   Dirkx, Ruud ^a   Smet, Joél ^b   De Bock, Katrien ^a,c   Espeel, Marc ^d   Vanhorebeek, Ilse ^e   Vanlander, Arnaud ^b   Van Coster, Rudy ^b   Carmeliet, Peter ^a,c   Fransen, Marc ^e   Van Veldhoven, Paul P ^e   Baes, Myriam ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d GHENT UNIVERSITY   (Belgium)

^e LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

Author keywords

Biogenesis; Mitochondrial DNA; Oxidative phosphorylation; Peroxisomes; PGC 1 ; PPAR

Indexed keywords

COMPLEX V; CYTOCHROME C OXIDASE; DNA; DOCOSAHEXAENOIC ACID; MITOCHONDRIAL DNA; MYC PROTEIN; OXIDOREDUCTASE; OXYGEN; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEX5 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; CELL RECEPTOR; LIPID; PEROXISOME-TARGETING SIGNAL 1 RECEPTOR; PPARGC1A PROTEIN, MOUSE; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CONTROLLED STUDY; GEL; GEL ELECTROPHORESIS; LIVER CELL; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PEROXISOME; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY CHAIN; STAINING; WILD TYPE; ANIMAL; CELL COMPARTMENTALIZATION; CELL RESPIRATION; CHEMISTRY; DEFICIENCY; ELECTRON TRANSPORT; GENE DELETION; KNOCKOUT MOUSE; MEMBRANE FLUIDITY; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN SUBUNIT; ULTRASTRUCTURE;

ANIMALS; CELL COMPARTMENTATION; CELL PROLIFERATION; CELL RESPIRATION; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT; GENE DELETION; HEPATOCYTES; LIPIDS; MEMBRANE FLUIDITY; MICE, KNOCKOUT; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PEROXISOMES; PPAR ALPHA; PROTEIN SUBUNITS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 84913568859     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2014.11.017     Document Type: Article

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