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Volumn 25, Issue 24, 2014, Pages 3954-3961

Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE; LANTHIONINE; LANTHIONINE SYNTHETASE C LIKE 2 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; UNCLASSIFIED DRUG; ALANINE; LANCL2 PROTEIN, HUMAN; MEMBRANE PROTEIN; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; PROTEIN BINDING; SULFIDE; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

EID: 84913529605     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E14-01-0004     Document Type: Article
Times cited : (43)

References (36)
  • 1
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
    • Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P (1997). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 7, 261-269.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3    Holmes, A.B.4    Gaffney, P.R.5    Reese, C.B.6    Cohen, P.7
  • 4
    • 23944526062 scopus 로고    scopus 로고
    • Activation of AKT kinases in cancer: Implications for therapeutic targeting
    • Bellacosa A, Kumar CC, Di Cristofano A, Testa JR (2005). Activation of AKT kinases in cancer: implications for therapeutic targeting. Adv Cancer Res 94, 29-86.
    • (2005) Adv Cancer Res , vol.94 , pp. 29-86
    • Bellacosa, A.1    Kumar, C.C.2    Di Cristofano, A.3    Testa, J.R.4
  • 5
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME (1997). Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 7
    • 58149175555 scopus 로고    scopus 로고
    • The life of a cell: Apoptosis regulation by the PI3K/PKB pathway
    • Duronio V (2008). The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Biochem J 415, 333-344.
    • (2008) Biochem J , vol.415 , pp. 333-344
    • Duronio, V.1
  • 8
    • 0348110375 scopus 로고    scopus 로고
    • IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients
    • Erbay E, Park IH, Nuzzi PD, Schoenherr CJ, Chen J (2003). IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients. J Cell Biol 163, 931-936.
    • (2003) J Cell Biol , vol.163 , pp. 931-936
    • Erbay, E.1    Park, I.H.2    Nuzzi, P.D.3    Schoenherr, C.J.4    Chen, J.5
  • 9
    • 48649088560 scopus 로고    scopus 로고
    • Intracellular signaling by Akt: Bound to be specific
    • Franke TF (2008). Intracellular signaling by Akt: bound to be specific. Sci Signal 1, pe29.
    • (2008) Sci Signal , vol.1 , pp. pe29
    • Franke, T.F.1
  • 10
    • 0029079275 scopus 로고
    • The protein kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
    • Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN (1995). The protein kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-736.
    • (1995) Cell , vol.81 , pp. 727-736
    • Franke, T.F.1    Yang, S.I.2    Chan, T.O.3    Datta, K.4    Kazlauskas, A.5    Morrison, D.K.6    Kaplan, D.R.7    Tsichlis, P.N.8
  • 11
    • 15944406764 scopus 로고    scopus 로고
    • PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
    • Gao T, Furnari F, Newton AC (2005). PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18, 13-24.
    • (2005) Mol Cell , vol.18 , pp. 13-24
    • Gao, T.1    Furnari, F.2    Newton, A.C.3
  • 12
    • 58649092475 scopus 로고    scopus 로고
    • mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
    • Garcia-Martinez J M, Alessi DR (2008). mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J 416, 375-385.
    • (2008) Biochem J , vol.416 , pp. 375-385
    • Garcia-Martinez, J.M.1    Alessi, D.R.2
  • 13
    • 27144471347 scopus 로고    scopus 로고
    • Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival
    • Gyorffy B, Serra V, Jurchott K, Abdul-Ghani R, Garber M, Stein U, Petersen I, Lage H, Dietel M, Schafer R (2005). Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival. Oncogene 24, 7542-7551.
    • (2005) Oncogene , vol.24 , pp. 7542-7551
    • Gyorffy, B.1    Serra, V.2    Jurchott, K.3    Abdul-Ghani, R.4    Garber, M.5    Stein, U.6    Petersen, I.7    Lage, H.8    Dietel, M.9    Schafer, R.10
  • 14
    • 59249088869 scopus 로고    scopus 로고
    • Monitoring mammalian target of rapamycin (mTOR) activity
    • Ikenoue T, Hong S, Inoki K (2009). Monitoring mammalian target of rapamycin (mTOR) activity. Methods Enzymol 452, 165-180.
    • (2009) Methods Enzymol , vol.452 , pp. 165-180
    • Ikenoue, T.1    Hong, S.2    Inoki, K.3
  • 15
    • 84861649020 scopus 로고    scopus 로고
    • Discovery, biosynthesis, and engineering of lantipeptides
    • Knerr PJ, van der Donk WA (2012). Discovery, biosynthesis, and engineering of lantipeptides. Annu Rev Biochem 81, 479-505.
    • (2012) Annu Rev Biochem , vol.81 , pp. 479-505
    • Knerr, P.J.1    Van Der Donk, W.A.2
  • 16
    • 33750511318 scopus 로고    scopus 로고
    • Myristoylation of human LanClike protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin
    • Landlinger C, Salzer U, Prohaska R (2006). Myristoylation of human LanClike protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin. Biochim Biophys Acta 1758, 1759-1767.
    • (2006) Biochim Biophys Acta , vol.1758 , pp. 1759-1767
    • Landlinger, C.1    Salzer, U.2    Prohaska, R.3
  • 17
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?
    • Lawlor MA, Alessi DR (2001). PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114, 2903-2910.
    • (2001) J Cell Sci , vol.114 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 18
    • 33644854595 scopus 로고    scopus 로고
    • Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis
    • Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK (2006). Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science 311, 1464-1467.
    • (2006) Science , vol.311 , pp. 1464-1467
    • Li, B.1    Yu, J.P.2    Brunzelle, J.S.3    Moll, G.N.4    Van Der Donk, W.A.5    Nair, S.K.6
  • 20
    • 0033517348 scopus 로고    scopus 로고
    • Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2
    • Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR (1999). Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 18, 4891-4898.
    • (1999) Oncogene , vol.18 , pp. 4891-4898
    • Mitsuuchi, Y.1    Johnson, S.W.2    Sonoda, G.3    Tanno, S.4    Golemis, E.A.5    Testa, J.R.6
  • 23
    • 52649111175 scopus 로고    scopus 로고
    • Freud-1/Aki1, a novel PDK1- interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling
    • Nakamura A, Naito M, Tsuruo T, Fujita N (2008). Freud-1/Aki1, a novel PDK1- interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling. Mol Cell Biol 28, 5996-6009.
    • (2008) Mol Cell Biol , vol.28 , pp. 5996-6009
    • Nakamura, A.1    Naito, M.2    Tsuruo, T.3    Fujita, N.4
  • 25
    • 0037310181 scopus 로고    scopus 로고
    • Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism
    • Park S, James CD (2003). Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism. Cancer Res 63, 723-727.
    • (2003) Cancer Res , vol.63 , pp. 723-727
    • Park, S.1    James, C.D.2
  • 26
    • 0037436155 scopus 로고    scopus 로고
    • Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms
    • Park SH, Zarrinpar A, Lim WA (2003). Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science 299, 1061-1064.
    • (2003) Science , vol.299 , pp. 1061-1064
    • Park, S.H.1    Zarrinpar, A.2    Lim, W.A.3
  • 27
    • 0033514509 scopus 로고    scopus 로고
    • Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
    • Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, Sellers WR (1999). Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci USA 96, 2110-2115.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2110-2115
    • Ramaswamy, S.1    Nakamura, N.2    Vazquez, F.3    Batt, D.B.4    Perera, S.5    Roberts, T.M.6    Sellers, W.R.7
  • 30
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 31
    • 0036333737 scopus 로고    scopus 로고
    • Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
    • Scheid MP, Marignani PA, Woodgett JR (2002). Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol 22, 6247-6260.
    • (2002) Mol Cell Biol , vol.22 , pp. 6247-6260
    • Scheid, M.P.1    Marignani, P.A.2    Woodgett, J.R.3
  • 33
    • 18744373865 scopus 로고    scopus 로고
    • Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
    • Yang J, Cron P, Good VM, Thompson V, Hemmings BA, Barford D (2002). Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol 9, 940-944.
    • (2002) Nat Struct Biol , vol.9 , pp. 940-944
    • Yang, J.1    Cron, P.2    Good, V.M.3    Thompson, V.4    Hemmings, B.A.5    Barford, D.6
  • 34
    • 33751079895 scopus 로고    scopus 로고
    • Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
    • Yang Q, Inoki K, Ikenoue T, Guan KL (2006). Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 20, 2820-2832.
    • (2006) Genes Dev , vol.20 , pp. 2820-2832
    • Yang, Q.1    Inoki, K.2    Ikenoue, T.3    Guan, K.L.4
  • 36
    • 67149147296 scopus 로고    scopus 로고
    • Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione
    • Zhang W, Wang L, Liu Y, Xu J, Zhu G, Cang H, Li X, Bartlam M, Hensley K, Li G, et al. (2009). Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. Genes Dev 23, 1387-1392.
    • (2009) Genes Dev , vol.23 , pp. 1387-1392
    • Zhang, W.1    Wang, L.2    Liu, Y.3    Xu, J.4    Zhu, G.5    Cang, H.6    Li, X.7    Bartlam, M.8    Hensley, K.9    Li, G.10


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