-
1
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P (1997). Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 7, 261-269.
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
2
-
-
24044521010
-
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis
-
Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, et al. (2005). A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J Biol Chem 280, 18525-18535.
-
(2005)
J Biol Chem
, vol.280
, pp. 18525-18535
-
-
Anai, M.1
Shojima, N.2
Katagiri, H.3
Ogihara, T.4
Sakoda, H.5
Onishi, Y.6
Ono, H.7
Fujishiro, M.8
Fukushima, Y.9
Horike, N.10
-
3
-
-
15644381754
-
Role of translocation in the activation and function of protein kinase B
-
Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M, Cron P, Cohen P, Lucocq JM, Hemmings BA (1997). Role of translocation in the activation and function of protein kinase B. J Biol Chem 272, 31515-31524.
-
(1997)
J Biol Chem
, vol.272
, pp. 31515-31524
-
-
Andjelkovic, M.1
Alessi, D.R.2
Meier, R.3
Fernandez, A.4
Lamb, N.J.5
Frech, M.6
Cron, P.7
Cohen, P.8
Lucocq, J.M.9
Hemmings, B.A.10
-
4
-
-
23944526062
-
Activation of AKT kinases in cancer: Implications for therapeutic targeting
-
Bellacosa A, Kumar CC, Di Cristofano A, Testa JR (2005). Activation of AKT kinases in cancer: implications for therapeutic targeting. Adv Cancer Res 94, 29-86.
-
(2005)
Adv Cancer Res
, vol.94
, pp. 29-86
-
-
Bellacosa, A.1
Kumar, C.C.2
Di Cristofano, A.3
Testa, J.R.4
-
5
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME (1997). Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
6
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME (1997). Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275, 661-665.
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenberg, M.E.9
-
7
-
-
58149175555
-
The life of a cell: Apoptosis regulation by the PI3K/PKB pathway
-
Duronio V (2008). The life of a cell: apoptosis regulation by the PI3K/PKB pathway. Biochem J 415, 333-344.
-
(2008)
Biochem J
, vol.415
, pp. 333-344
-
-
Duronio, V.1
-
8
-
-
0348110375
-
IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients
-
Erbay E, Park IH, Nuzzi PD, Schoenherr CJ, Chen J (2003). IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients. J Cell Biol 163, 931-936.
-
(2003)
J Cell Biol
, vol.163
, pp. 931-936
-
-
Erbay, E.1
Park, I.H.2
Nuzzi, P.D.3
Schoenherr, C.J.4
Chen, J.5
-
9
-
-
48649088560
-
Intracellular signaling by Akt: Bound to be specific
-
Franke TF (2008). Intracellular signaling by Akt: bound to be specific. Sci Signal 1, pe29.
-
(2008)
Sci Signal
, vol.1
, pp. pe29
-
-
Franke, T.F.1
-
10
-
-
0029079275
-
The protein kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN (1995). The protein kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-736.
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
Datta, K.4
Kazlauskas, A.5
Morrison, D.K.6
Kaplan, D.R.7
Tsichlis, P.N.8
-
11
-
-
15944406764
-
PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
-
Gao T, Furnari F, Newton AC (2005). PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18, 13-24.
-
(2005)
Mol Cell
, vol.18
, pp. 13-24
-
-
Gao, T.1
Furnari, F.2
Newton, A.C.3
-
12
-
-
58649092475
-
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
-
Garcia-Martinez J M, Alessi DR (2008). mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochem J 416, 375-385.
-
(2008)
Biochem J
, vol.416
, pp. 375-385
-
-
Garcia-Martinez, J.M.1
Alessi, D.R.2
-
13
-
-
27144471347
-
Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival
-
Gyorffy B, Serra V, Jurchott K, Abdul-Ghani R, Garber M, Stein U, Petersen I, Lage H, Dietel M, Schafer R (2005). Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival. Oncogene 24, 7542-7551.
-
(2005)
Oncogene
, vol.24
, pp. 7542-7551
-
-
Gyorffy, B.1
Serra, V.2
Jurchott, K.3
Abdul-Ghani, R.4
Garber, M.5
Stein, U.6
Petersen, I.7
Lage, H.8
Dietel, M.9
Schafer, R.10
-
14
-
-
59249088869
-
Monitoring mammalian target of rapamycin (mTOR) activity
-
Ikenoue T, Hong S, Inoki K (2009). Monitoring mammalian target of rapamycin (mTOR) activity. Methods Enzymol 452, 165-180.
-
(2009)
Methods Enzymol
, vol.452
, pp. 165-180
-
-
Ikenoue, T.1
Hong, S.2
Inoki, K.3
-
15
-
-
84861649020
-
Discovery, biosynthesis, and engineering of lantipeptides
-
Knerr PJ, van der Donk WA (2012). Discovery, biosynthesis, and engineering of lantipeptides. Annu Rev Biochem 81, 479-505.
-
(2012)
Annu Rev Biochem
, vol.81
, pp. 479-505
-
-
Knerr, P.J.1
Van Der Donk, W.A.2
-
16
-
-
33750511318
-
Myristoylation of human LanClike protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin
-
Landlinger C, Salzer U, Prohaska R (2006). Myristoylation of human LanClike protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin. Biochim Biophys Acta 1758, 1759-1767.
-
(2006)
Biochim Biophys Acta
, vol.1758
, pp. 1759-1767
-
-
Landlinger, C.1
Salzer, U.2
Prohaska, R.3
-
17
-
-
0034845958
-
PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?
-
Lawlor MA, Alessi DR (2001). PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 114, 2903-2910.
-
(2001)
J Cell Sci
, vol.114
, pp. 2903-2910
-
-
Lawlor, M.A.1
Alessi, D.R.2
-
18
-
-
33644854595
-
Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis
-
Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK (2006). Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science 311, 1464-1467.
-
(2006)
Science
, vol.311
, pp. 1464-1467
-
-
Li, B.1
Yu, J.P.2
Brunzelle, J.S.3
Moll, G.N.4
Van Der Donk, W.A.5
Nair, S.K.6
-
19
-
-
84857758014
-
Autocrine abscisic acid plays a key role in quartz-induced macrophage activation
-
Magnone M, Sturla L, Jacchetti E, Scarfi S, Bruzzone S, Usai C, Guida L, Salis A, Damonte G, De Flora A, et al. (2012). Autocrine abscisic acid plays a key role in quartz-induced macrophage activation. FASEB J 26, 1261-1271.
-
(2012)
FASEB J
, vol.26
, pp. 1261-1271
-
-
Magnone, M.1
Sturla, L.2
Jacchetti, E.3
Scarfi, S.4
Bruzzone, S.5
Usai, C.6
Guida, L.7
Salis, A.8
Damonte, G.9
De Flora, A.10
-
20
-
-
0033517348
-
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2
-
Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR (1999). Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 18, 4891-4898.
-
(1999)
Oncogene
, vol.18
, pp. 4891-4898
-
-
Mitsuuchi, Y.1
Johnson, S.W.2
Sonoda, G.3
Tanno, S.4
Golemis, E.A.5
Testa, J.R.6
-
21
-
-
19944408613
-
Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3
-
Murray JT, Campbell DG, Morrice N, Auld GC, Shpiro N, Marquez R, Peggie M, Bain J, Bloomberg GB, Grahammer F, et al. (2004). Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3. Biochem J 384, 477-488.
-
(2004)
Biochem J
, vol.384
, pp. 477-488
-
-
Murray, J.T.1
Campbell, D.G.2
Morrice, N.3
Auld, G.C.4
Shpiro, N.5
Marquez, R.6
Peggie, M.7
Bain, J.8
Bloomberg, G.B.9
Grahammer, F.10
-
22
-
-
0026489451
-
IRS-1 activates phosphatidylinositol 32-kinase by associating with src homology 2 domains of p85
-
Myers MG Jr., Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF (1992). IRS-1 activates phosphatidylinositol 32-kinase by associating with src homology 2 domains of p85. Proc Natl Acad Sci USA 89, 10350-10354.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 10350-10354
-
-
Myers, M.G.1
Backer, J.M.2
Sun, X.J.3
Shoelson, S.4
Hu, P.5
Schlessinger, J.6
Yoakim, M.7
Schaffhausen, B.8
White, M.F.9
-
23
-
-
52649111175
-
Freud-1/Aki1, a novel PDK1- interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling
-
Nakamura A, Naito M, Tsuruo T, Fujita N (2008). Freud-1/Aki1, a novel PDK1- interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling. Mol Cell Biol 28, 5996-6009.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 5996-6009
-
-
Nakamura, A.1
Naito, M.2
Tsuruo, T.3
Fujita, N.4
-
24
-
-
0034655803
-
Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration
-
Namikawa K, Honma M, Abe K, Takeda M, Mansur K, Obata T, Miwa A, Okado H, Kiyama H (2000). Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration. J Neurosci 20, 2875-2886.
-
(2000)
J Neurosci
, vol.20
, pp. 2875-2886
-
-
Namikawa, K.1
Honma, M.2
Abe, K.3
Takeda, M.4
Mansur, K.5
Obata, T.6
Miwa, A.7
Okado, H.8
Kiyama, H.9
-
25
-
-
0037310181
-
Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism
-
Park S, James CD (2003). Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism. Cancer Res 63, 723-727.
-
(2003)
Cancer Res
, vol.63
, pp. 723-727
-
-
Park, S.1
James, C.D.2
-
26
-
-
0037436155
-
Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms
-
Park SH, Zarrinpar A, Lim WA (2003). Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science 299, 1061-1064.
-
(2003)
Science
, vol.299
, pp. 1061-1064
-
-
Park, S.H.1
Zarrinpar, A.2
Lim, W.A.3
-
27
-
-
0033514509
-
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
-
Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, Sellers WR (1999). Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci USA 96, 2110-2115.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 2110-2115
-
-
Ramaswamy, S.1
Nakamura, N.2
Vazquez, F.3
Batt, D.B.4
Perera, S.5
Roberts, T.M.6
Sellers, W.R.7
-
28
-
-
33845507061
-
Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease
-
Ries V, Henchcliffe C, Kareva T, Rzhetskaya M, Bland R, During MJ, Kholodilov N, Burke RE (2006). Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease. Proc Natl Acad Sci USA 103, 18757-18762.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 18757-18762
-
-
Ries, V.1
Henchcliffe, C.2
Kareva, T.3
Rzhetskaya, M.4
Bland, R.5
During, M.J.6
Kholodilov, N.7
Burke, R.E.8
-
29
-
-
0025020250
-
Activation of phosphatidylinositol 3-kinase by insulin
-
Ruderman NB, Kapeller R, White MF, Cantley LC (1990). Activation of phosphatidylinositol 3-kinase by insulin. Proc Natl Acad Sci USA 87, 1411-1415.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 1411-1415
-
-
Ruderman, N.B.1
Kapeller, R.2
White, M.F.3
Cantley, L.C.4
-
30
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
31
-
-
0036333737
-
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
-
Scheid MP, Marignani PA, Woodgett JR (2002). Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol 22, 6247-6260.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 6247-6260
-
-
Scheid, M.P.1
Marignani, P.A.2
Woodgett, J.R.3
-
32
-
-
70350504374
-
LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells
-
Sturla L, Fresia C, Guida L, Bruzzone S, Scarfi S, Usai C, Fruscione F, Magnone M, Millo E, Basile G, et al. (2009). LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells. J Biol Chem 284, 28045-28057.
-
(2009)
J Biol Chem
, vol.284
, pp. 28045-28057
-
-
Sturla, L.1
Fresia, C.2
Guida, L.3
Bruzzone, S.4
Scarfi, S.5
Usai, C.6
Fruscione, F.7
Magnone, M.8
Millo, E.9
Basile, G.10
-
33
-
-
18744373865
-
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP
-
Yang J, Cron P, Good VM, Thompson V, Hemmings BA, Barford D (2002). Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol 9, 940-944.
-
(2002)
Nat Struct Biol
, vol.9
, pp. 940-944
-
-
Yang, J.1
Cron, P.2
Good, V.M.3
Thompson, V.4
Hemmings, B.A.5
Barford, D.6
-
34
-
-
33751079895
-
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
-
Yang Q, Inoki K, Ikenoue T, Guan KL (2006). Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 20, 2820-2832.
-
(2006)
Genes Dev
, vol.20
, pp. 2820-2832
-
-
Yang, Q.1
Inoki, K.2
Ikenoue, T.3
Guan, K.L.4
-
35
-
-
84872574955
-
BSTA promotes mTORC2- mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation
-
Yao Y, Suraokar M, Darnay BG, Hollier BG, Shaiken TE, Asano T, Chen CH, Chang BH, Lu Y, Mills GB, et al. (2013). BSTA promotes mTORC2- mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. Sci Signal 6, ra2.
-
(2013)
Sci Signal
, vol.6
, pp. ra2
-
-
Yao, Y.1
Suraokar, M.2
Darnay, B.G.3
Hollier, B.G.4
Shaiken, T.E.5
Asano, T.6
Chen, C.H.7
Chang, B.H.8
Lu, Y.9
Mills, G.B.10
-
36
-
-
67149147296
-
Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione
-
Zhang W, Wang L, Liu Y, Xu J, Zhu G, Cang H, Li X, Bartlam M, Hensley K, Li G, et al. (2009). Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. Genes Dev 23, 1387-1392.
-
(2009)
Genes Dev
, vol.23
, pp. 1387-1392
-
-
Zhang, W.1
Wang, L.2
Liu, Y.3
Xu, J.4
Zhu, G.5
Cang, H.6
Li, X.7
Bartlam, M.8
Hensley, K.9
Li, G.10
|